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The map label for this gene is lysS

Identifier: 17545747

GI number: 17545747

Start: 1079620

End: 1081152

Strand: Reverse

Name: lysS

Synonym: RSc1028

Alternate gene names: 17545747

Gene position: 1081152-1079620 (Counterclockwise)

Preceding gene: 17545748

Following gene: 17545746

Centisome position: 29.09

GC content: 66.08

Gene sequence:

>1533_bases
ATGACCGAACCGAACACCCCGGCCGCACCCACTGGACAGGCGCAAGACGACAACCAGATCATGGCCGAGCGCCGCGAGAA
GCTCGCCGCGCTGCGCCAGCAGGGCGTCGCCTATCCCAACGATTTCTGCCCGACCCACCACGCGGCCGACCTGCACACCC
GCTACAGCGAGACCGACCAGCCCGCGCTGGAAGCGGCCAATGTCGAGGTCGCCCTCGCCGGGCGCATGATGCTCAAGCGC
GTGATGGGCAAGGCCAGCTTCGCCACCGTGCAGGACGGCAGCGGCCAGATCCAGTTCTACATCACGCGCGACCGCGTGGG
CGAAGACGTCTACGCCGCCTTCAAGCATTGGGACCTCGGCGACATCGTCGCCGCGCGCGGCGTGCTGTTCCGCACCAACA
AGGGCGAGCTGTCGGTGCAGGTGCAGGAGCTGCGCCTGCTGTCGAAGTCGCTGCGTCCGCTGCCGGACAAGTTCCACGGC
CTGGCCGACCAGGAAATGAAGTACCGCCAGCGCTACGTTGACCTGATCGTCTCGCCCGAGACGCGCAACACCTTCCGCGC
CCGCACCAAGGCCATCGCCTCGCTGCGCCACCACATGAGCGATGCCGGCTTCATGGAAGTGGAAACGCCGATGCTGCACC
CGATTCCGGGCGGCGCGGCGGCCAAGCCCTTCATCACGCACCACAACGCGCTGGACATGCAGATGTTCCTGCGCATCGCC
CCGGAGCTGTACCTCAAGCGCCTGATCGTCGGCGGCTTCGAGCGCGTGTACGAGATCAACCGCAACTTCCGCAACGAGGG
CGTGTCGCCACGGCACAACCCCGAGTTCACGATGATGGAGTTCTATGCAGCCTACACGGACTACCGCTGGCTGATGGACT
ACACCGAGAACCTGATCCGCCAGGCCGCCATCGATGCCACCGGCAGCGCCGCCCTCAACTACCAGGGTCGCGAGCTGGAC
CTGTCCAAGCCCTTCCACCGCCTGACCATCTGCCAGGCCATCCAGAAGTACGCGCCGCAGTACACCGACGCGCAACTGGC
CGACGCCAACTTCCTGCGTGCCGAGCTCAAGAAGTTCAAGATCGACACCAACGCGCCGCAGTTCCTGAACGCCGGCGTGG
GCACGCTGCAGCTCGTCCTGTTCGAAGAGACGGCCGAGTCGCAACTGTGGGAGCCGACCTTCATCGTCGACTACCCGGTC
GAGGTGTCGCCGCTGGCACGCGGCTCGGACACGCTGCCCGGCATCACCGAGCGCTTCGAGCTGTTCATCACCGGCCGCGA
GATCGCCAACGGCTTCTCCGAGCTGAACGACCCCGAAGACCAGGCCGAACGCTTCCGCAAGCAGGTCGAACAGAAGGACG
CCGGCGACGAGGAAGCCATGTTCTACGATGCCGACTACATCCGCGCGCTGGAATACGGCATGCCCCCGACCGGCGGCTGC
GGCATCGGCATCGACCGCCTGGTGATGCTGCTGACCGACAGCCCCAACATCCGCGACGTGATCCTCTTCCCGCACCTGCG
CCGCGAAGACTGA

Upstream 100 bases:

>100_bases
CCGGCGCATCGTCGCCTACCTCGCCCGGCCGGATTTCGGCGCGACCGAACTCGACGATCTGCGCAACATCGCCTGACACG
ACTCTCCCTACACAATCATC

Downstream 100 bases:

>100_bases
TCGTTCCGGCGACGGCCCGCAAAGCGAAACGCCCCAGCAATGGGGCGTTTTTTATTGGGCGCGCCGGACAGCGCCCGCAA
ATCGCACACCGAGCCCCGCC

Product: lysyl-tRNA synthetase

Products: NA

Alternate protein names: Lysine--tRNA ligase; LysRS

Number of amino acids: Translated: 510; Mature: 509

Protein sequence:

>510_residues
MTEPNTPAAPTGQAQDDNQIMAERREKLAALRQQGVAYPNDFCPTHHAADLHTRYSETDQPALEAANVEVALAGRMMLKR
VMGKASFATVQDGSGQIQFYITRDRVGEDVYAAFKHWDLGDIVAARGVLFRTNKGELSVQVQELRLLSKSLRPLPDKFHG
LADQEMKYRQRYVDLIVSPETRNTFRARTKAIASLRHHMSDAGFMEVETPMLHPIPGGAAAKPFITHHNALDMQMFLRIA
PELYLKRLIVGGFERVYEINRNFRNEGVSPRHNPEFTMMEFYAAYTDYRWLMDYTENLIRQAAIDATGSAALNYQGRELD
LSKPFHRLTICQAIQKYAPQYTDAQLADANFLRAELKKFKIDTNAPQFLNAGVGTLQLVLFEETAESQLWEPTFIVDYPV
EVSPLARGSDTLPGITERFELFITGREIANGFSELNDPEDQAERFRKQVEQKDAGDEEAMFYDADYIRALEYGMPPTGGC
GIGIDRLVMLLTDSPNIRDVILFPHLRRED

Sequences:

>Translated_510_residues
MTEPNTPAAPTGQAQDDNQIMAERREKLAALRQQGVAYPNDFCPTHHAADLHTRYSETDQPALEAANVEVALAGRMMLKR
VMGKASFATVQDGSGQIQFYITRDRVGEDVYAAFKHWDLGDIVAARGVLFRTNKGELSVQVQELRLLSKSLRPLPDKFHG
LADQEMKYRQRYVDLIVSPETRNTFRARTKAIASLRHHMSDAGFMEVETPMLHPIPGGAAAKPFITHHNALDMQMFLRIA
PELYLKRLIVGGFERVYEINRNFRNEGVSPRHNPEFTMMEFYAAYTDYRWLMDYTENLIRQAAIDATGSAALNYQGRELD
LSKPFHRLTICQAIQKYAPQYTDAQLADANFLRAELKKFKIDTNAPQFLNAGVGTLQLVLFEETAESQLWEPTFIVDYPV
EVSPLARGSDTLPGITERFELFITGREIANGFSELNDPEDQAERFRKQVEQKDAGDEEAMFYDADYIRALEYGMPPTGGC
GIGIDRLVMLLTDSPNIRDVILFPHLRRED
>Mature_509_residues
TEPNTPAAPTGQAQDDNQIMAERREKLAALRQQGVAYPNDFCPTHHAADLHTRYSETDQPALEAANVEVALAGRMMLKRV
MGKASFATVQDGSGQIQFYITRDRVGEDVYAAFKHWDLGDIVAARGVLFRTNKGELSVQVQELRLLSKSLRPLPDKFHGL
ADQEMKYRQRYVDLIVSPETRNTFRARTKAIASLRHHMSDAGFMEVETPMLHPIPGGAAAKPFITHHNALDMQMFLRIAP
ELYLKRLIVGGFERVYEINRNFRNEGVSPRHNPEFTMMEFYAAYTDYRWLMDYTENLIRQAAIDATGSAALNYQGRELDL
SKPFHRLTICQAIQKYAPQYTDAQLADANFLRAELKKFKIDTNAPQFLNAGVGTLQLVLFEETAESQLWEPTFIVDYPVE
VSPLARGSDTLPGITERFELFITGREIANGFSELNDPEDQAERFRKQVEQKDAGDEEAMFYDADYIRALEYGMPPTGGCG
IGIDRLVMLLTDSPNIRDVILFPHLRRED

Specific function: Also Can Synthesize A Number Of Adenyl Dinucleotides (In Particular Appppa). These Dinucleotides Have Been Proposed To Act As Modulators Of The Heat-Shock Response And Stress Response. [C]

COG id: COG1190

COG function: function code J; Lysyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI5031815, Length=519, Percent_Identity=40.2697495183044, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI194272210, Length=519, Percent_Identity=40.2697495183044, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI40789249, Length=322, Percent_Identity=22.360248447205, Blast_Score=80, Evalue=5e-15,
Organism=Escherichia coli, GI1790571, Length=508, Percent_Identity=58.2677165354331, Blast_Score=603, Evalue=1e-174,
Organism=Escherichia coli, GI1789256, Length=493, Percent_Identity=59.2292089249493, Blast_Score=600, Evalue=1e-173,
Organism=Escherichia coli, GI87082379, Length=326, Percent_Identity=31.5950920245399, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1788173, Length=249, Percent_Identity=24.8995983935743, Blast_Score=79, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17535927, Length=487, Percent_Identity=41.8891170431211, Blast_Score=360, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17535925, Length=487, Percent_Identity=41.8891170431211, Blast_Score=360, Evalue=1e-99,
Organism=Caenorhabditis elegans, GI71994340, Length=487, Percent_Identity=41.8891170431211, Blast_Score=359, Evalue=1e-99,
Organism=Caenorhabditis elegans, GI32566633, Length=299, Percent_Identity=23.4113712374582, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320242, Length=526, Percent_Identity=40.8745247148289, Blast_Score=350, Evalue=3e-97,
Organism=Saccharomyces cerevisiae, GI6324256, Length=550, Percent_Identity=30.3636363636364, Blast_Score=184, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24640849, Length=488, Percent_Identity=41.1885245901639, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24640851, Length=488, Percent_Identity=41.1885245901639, Blast_Score=361, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24584738, Length=360, Percent_Identity=23.6111111111111, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYK_RALSO (Q8Y0L5)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_519149.1
- ProteinModelPortal:   Q8Y0L5
- SMR:   Q8Y0L5
- GeneID:   1219837
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc1028
- NMPDR:   fig|267608.1.peg.1028
- HOGENOM:   HBG631383
- OMA:   LFITIRS
- ProtClustDB:   PRK00484
- BioCyc:   RSOL267608:RSC1028-MONOMER
- BRENDA:   6.1.1.6
- GO:   GO:0005737
- HAMAP:   MF_00252
- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR002313
- InterPro:   IPR018149
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365
- Gene3D:   G3DSA:2.40.50.140
- PANTHER:   PTHR22594
- PANTHER:   PTHR22594:SF4
- PRINTS:   PR00982
- TIGRFAMs:   TIGR00499

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti; SSF50249 Nucleic_acid_OB

EC number: =6.1.1.6

Molecular weight: Translated: 57837; Mature: 57706

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEPNTPAAPTGQAQDDNQIMAERREKLAALRQQGVAYPNDFCPTHHAADLHTRYSETDQ
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCCCC
PALEAANVEVALAGRMMLKRVMGKASFATVQDGSGQIQFYITRDRVGEDVYAAFKHWDLG
CHHHHCCEEEEHHHHHHHHHHHCCCCEEEEECCCCEEEEEEECCCCCHHHHHHHHCCCHH
DIVAARGVLFRTNKGELSVQVQELRLLSKSLRPLPDKFHGLADQEMKYRQRYVDLIVSPE
HHHHHCCEEEECCCCCEEEEHHHHHHHHHHCCCCCHHHCCCCHHHHHHHHHHHHEEECCC
TRNTFRARTKAIASLRHHMSDAGFMEVETPMLHPIPGGAAAKPFITHHNALDMQMFLRIA
CCHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHH
PELYLKRLIVGGFERVYEINRNFRNEGVSPRHNPEFTMMEFYAAYTDYRWLMDYTENLIR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
QAAIDATGSAALNYQGRELDLSKPFHRLTICQAIQKYAPQYTDAQLADANFLRAELKKFK
HHHCCCCCCEEECCCCCEECCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHC
IDTNAPQFLNAGVGTLQLVLFEETAESQLWEPTFIVDYPVEVSPLARGSDTLPGITERFE
CCCCCCHHHHCCCCEEEEEEEECHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCHHHEEE
LFITGREIANGFSELNDPEDQAERFRKQVEQKDAGDEEAMFYDADYIRALEYGMPPTGGC
EEEECHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHCCCCCCCCC
GIGIDRLVMLLTDSPNIRDVILFPHLRRED
CCCHHHEEEEEECCCCCCEEEEECCCCCCC
>Mature Secondary Structure 
TEPNTPAAPTGQAQDDNQIMAERREKLAALRQQGVAYPNDFCPTHHAADLHTRYSETDQ
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCCCC
PALEAANVEVALAGRMMLKRVMGKASFATVQDGSGQIQFYITRDRVGEDVYAAFKHWDLG
CHHHHCCEEEEHHHHHHHHHHHCCCCEEEEECCCCEEEEEEECCCCCHHHHHHHHCCCHH
DIVAARGVLFRTNKGELSVQVQELRLLSKSLRPLPDKFHGLADQEMKYRQRYVDLIVSPE
HHHHHCCEEEECCCCCEEEEHHHHHHHHHHCCCCCHHHCCCCHHHHHHHHHHHHEEECCC
TRNTFRARTKAIASLRHHMSDAGFMEVETPMLHPIPGGAAAKPFITHHNALDMQMFLRIA
CCHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHH
PELYLKRLIVGGFERVYEINRNFRNEGVSPRHNPEFTMMEFYAAYTDYRWLMDYTENLIR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
QAAIDATGSAALNYQGRELDLSKPFHRLTICQAIQKYAPQYTDAQLADANFLRAELKKFK
HHHCCCCCCEEECCCCCEECCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHC
IDTNAPQFLNAGVGTLQLVLFEETAESQLWEPTFIVDYPVEVSPLARGSDTLPGITERFE
CCCCCCHHHHCCCCEEEEEEEECHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCHHHEEE
LFITGREIANGFSELNDPEDQAERFRKQVEQKDAGDEEAMFYDADYIRALEYGMPPTGGC
EEEECHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHCCCCCCCCC
GIGIDRLVMLLTDSPNIRDVILFPHLRRED
CCCHHHEEEEEECCCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852