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The map label for this gene is fkpA [H]

Identifier: 17545503

GI number: 17545503

Start: 828338

End: 828691

Strand: Reverse

Name: fkpA [H]

Synonym: RSc0784

Alternate gene names: 17545503

Gene position: 828691-828338 (Counterclockwise)

Preceding gene: 17545504

Following gene: 17545501

Centisome position: 22.3

GC content: 66.38

Gene sequence:

>354_bases
ATGACCATCACCACCACCCAGAGCGGCCTGCAATACGAAGACGTCACCGTGGGCGACGGCGCCGAAGCCACCGCCGGCAA
GTACGTCACCGTGCACTACACCGGCTGGCTGTACGAGAACGGCCAGGCCGGCCGCAAGTTCGATTCCAGCAAGGACCGCA
ACGATCCGTTCGCCTTCCCGCTGGGCGCCGGCCACGTCATCAAGGGCTGGGACGAAGGCGTGCAGGGCATGAAGGTCGGC
GGCACGCGCAAGCTGATCATCCCGGCCGAGCTGGGCTACGGTGCGCGCGGCGCGGGTGGGGTGATTCCCCCGAACGCAAC
GCTGCTTTTCGAGGTCGATCTGCTGGAAGTCTGA

Upstream 100 bases:

>100_bases
ATCGCCGACGACGCGGACAACATCCAGGTCCGGCTCGATACGCTCAAGGCCGCCGGCGCCTGAGCCCCTCTCTCTCAACC
TTTCCCACACGAGGCTCACC

Downstream 100 bases:

>100_bases
TCCTGCGCTAAAATCGCGGCCGGCCGATGCTGCATCGCACGGGCGCCGGCCGATCCCTCCCCTGGCGGGGTGGCAGAGTG
GTCAATGCTGCGGCTTGCAA

Product: FKBP-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: Peptidyl-prolyl cis-trans isomerase; PPIase; Rotamase [H]

Number of amino acids: Translated: 117; Mature: 116

Protein sequence:

>117_residues
MTITTTQSGLQYEDVTVGDGAEATAGKYVTVHYTGWLYENGQAGRKFDSSKDRNDPFAFPLGAGHVIKGWDEGVQGMKVG
GTRKLIIPAELGYGARGAGGVIPPNATLLFEVDLLEV

Sequences:

>Translated_117_residues
MTITTTQSGLQYEDVTVGDGAEATAGKYVTVHYTGWLYENGQAGRKFDSSKDRNDPFAFPLGAGHVIKGWDEGVQGMKVG
GTRKLIIPAELGYGARGAGGVIPPNATLLFEVDLLEV
>Mature_116_residues
TITTTQSGLQYEDVTVGDGAEATAGKYVTVHYTGWLYENGQAGRKFDSSKDRNDPFAFPLGAGHVIKGWDEGVQGMKVGG
TRKLIIPAELGYGARGAGGVIPPNATLLFEVDLLEV

Specific function: PPIases accelerate the folding of proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cytoplasm And Periplasmic Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI17149836, Length=110, Percent_Identity=50, Blast_Score=105, Evalue=1e-23,
Organism=Homo sapiens, GI4503725, Length=110, Percent_Identity=50, Blast_Score=105, Evalue=1e-23,
Organism=Homo sapiens, GI4758380, Length=110, Percent_Identity=48.1818181818182, Blast_Score=102, Evalue=8e-23,
Organism=Homo sapiens, GI206725530, Length=96, Percent_Identity=53.125, Blast_Score=99, Evalue=5e-22,
Organism=Homo sapiens, GI17149844, Length=96, Percent_Identity=53.125, Blast_Score=99, Evalue=5e-22,
Organism=Homo sapiens, GI17149842, Length=96, Percent_Identity=53.125, Blast_Score=99, Evalue=5e-22,
Organism=Homo sapiens, GI4503729, Length=100, Percent_Identity=51, Blast_Score=94, Evalue=2e-20,
Organism=Homo sapiens, GI224809331, Length=101, Percent_Identity=50.4950495049505, Blast_Score=91, Evalue=2e-19,
Organism=Homo sapiens, GI224809329, Length=101, Percent_Identity=50.4950495049505, Blast_Score=89, Evalue=5e-19,
Organism=Homo sapiens, GI224809327, Length=101, Percent_Identity=50.4950495049505, Blast_Score=89, Evalue=5e-19,
Organism=Homo sapiens, GI4758384, Length=101, Percent_Identity=50.4950495049505, Blast_Score=89, Evalue=5e-19,
Organism=Homo sapiens, GI192448443, Length=96, Percent_Identity=47.9166666666667, Blast_Score=88, Evalue=1e-18,
Organism=Homo sapiens, GI150010552, Length=115, Percent_Identity=37.3913043478261, Blast_Score=87, Evalue=3e-18,
Organism=Homo sapiens, GI8923659, Length=94, Percent_Identity=47.8723404255319, Blast_Score=84, Evalue=2e-17,
Organism=Homo sapiens, GI33469985, Length=114, Percent_Identity=39.4736842105263, Blast_Score=77, Evalue=3e-15,
Organism=Homo sapiens, GI206725547, Length=97, Percent_Identity=41.2371134020619, Blast_Score=73, Evalue=6e-14,
Organism=Homo sapiens, GI31317231, Length=98, Percent_Identity=41.8367346938776, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI87082390, Length=115, Percent_Identity=46.9565217391304, Blast_Score=96, Evalue=5e-22,
Organism=Escherichia coli, GI1789745, Length=115, Percent_Identity=43.4782608695652, Blast_Score=78, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71993519, Length=92, Percent_Identity=55.4347826086957, Blast_Score=96, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17540882, Length=96, Percent_Identity=47.9166666666667, Blast_Score=92, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17561782, Length=93, Percent_Identity=50.5376344086022, Blast_Score=85, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17561778, Length=97, Percent_Identity=42.2680412371134, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6320727, Length=96, Percent_Identity=57.2916666666667, Blast_Score=107, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6324194, Length=112, Percent_Identity=49.1071428571429, Blast_Score=101, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6323566, Length=111, Percent_Identity=47.7477477477478, Blast_Score=89, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6323482, Length=111, Percent_Identity=42.3423423423423, Blast_Score=80, Evalue=7e-17,
Organism=Drosophila melanogaster, GI281363946, Length=96, Percent_Identity=57.2916666666667, Blast_Score=115, Evalue=4e-27,
Organism=Drosophila melanogaster, GI17352457, Length=96, Percent_Identity=57.2916666666667, Blast_Score=115, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24655568, Length=110, Percent_Identity=52.7272727272727, Blast_Score=108, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24647110, Length=113, Percent_Identity=50.4424778761062, Blast_Score=100, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24583150, Length=108, Percent_Identity=44.4444444444444, Blast_Score=83, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21356629, Length=97, Percent_Identity=55.6701030927835, Blast_Score=82, Evalue=5e-17,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179 [H]

Pfam domain/function: PF00254 FKBP_C [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 12418; Mature: 12287

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTITTTQSGLQYEDVTVGDGAEATAGKYVTVHYTGWLYENGQAGRKFDSSKDRNDPFAFP
CEEECCCCCCEECEEEECCCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCCEEEE
LGAGHVIKGWDEGVQGMKVGGTRKLIIPAELGYGARGAGGVIPPNATLLFEVDLLEV
CCCCCEEECCCCCCCCEEECCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEEECC
>Mature Secondary Structure 
TITTTQSGLQYEDVTVGDGAEATAGKYVTVHYTGWLYENGQAGRKFDSSKDRNDPFAFP
EEECCCCCCEECEEEECCCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCCEEEE
LGAGHVIKGWDEGVQGMKVGGTRKLIIPAELGYGARGAGGVIPPNATLLFEVDLLEV
CCCCCEEECCCCCCCCEEECCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]