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The map label for this gene is trxA [H]

Identifier: 17545498

GI number: 17545498

Start: 823489

End: 824331

Strand: Reverse

Name: trxA [H]

Synonym: RSc0779

Alternate gene names: 17545498

Gene position: 824331-823489 (Counterclockwise)

Preceding gene: 17545500

Following gene: 17545497

Centisome position: 22.18

GC content: 68.33

Gene sequence:

>843_bases
ATGAGCGACGTCACCTCACAGAATTTCGCACAGGAAGTGATCGAAACCTCTCGCCAAGTCCCGGTGCTGGTCGATTTCTG
GGCGCCATGGTGCGGCCCCTGCCGGACCCTCGGCCCGATGCTGGAAAAGCTGGAGCACGAATACGCCGGCAAGTGGAAGC
TCGCCAAGGTCAATTCGGACGAGAGCCCCGAACTGTCGGCGCACTTCAACGTGCGCAGCATTCCCCACGTGGTGGCCTTC
GTGGACGGCAAGCCGGTCGACCAGTTCGTCGGCGTGCTGCCGGAATCGCAGCTGCGCGGGTTCCTCGACCGCGTGATCCC
GCAGCCGGCCGAAGTAGCCTACCGCGAGGGCCTGGCCGCGCACCAGGCGAACGCGCTCGCGCACGCGCGCGAAGCCTTCC
AGAATGCGCTCGCCTACGACCCCGGCTTCGATGCGGCCCGGTTCGCGCTGATCGACCTGCTGCTCGACACCGGCGATGTC
CGTGCCGCGCAGAATGAATTCGCGCTGCTGTCGTCCAGGGCCCCGCAAGACGAGCGCCATGCGCCGCTGCAGACCCGCCT
CGAGGCCGCCGAGCACGCCGGCGCCCTGCCCGATGCCGATGCGCTGCACCGGCGCATCGCCGCCGCGCCGGACGACCTGC
AGGCCCGCCTGGACCTGGCGCAGCAGTACATCGCCCGCCAGGACTACGAGGCCGCGCTCGAACAGCTGCTCGCCATCGTC
GAGCGCGACCGCGCGTTCCGCGATGACATCGGCCGCAAGACCATGGTCTCGGTATTCGATCTGATGCGCGACCCGCAGGC
GGTCTCGCTCTGGCGCCGTCAGTTGGCGTCCAGGTTGAACTGA

Upstream 100 bases:

>100_bases
GCATGCCTCGGAAAACGCGCCGGCAGGCCCCAAGTAGAATGCAGGACACCCCCGCCGGCATGCGTCGTGCCGGCCGCTTT
TTTCCTGGAGAACCCCGCCG

Downstream 100 bases:

>100_bases
GGCTGCCGATGCGACTGATCTACGTTGCCGATCCGATGTGCTCGTGGTGCTACGGCTTCGGCCCGCAGCTGGCGGACCTG
CGCGCGCGGCTGGCCGACAC

Product: thioredoxin protein

Products: NA

Alternate protein names: Trx-1; Thioredoxin-M [H]

Number of amino acids: Translated: 280; Mature: 279

Protein sequence:

>280_residues
MSDVTSQNFAQEVIETSRQVPVLVDFWAPWCGPCRTLGPMLEKLEHEYAGKWKLAKVNSDESPELSAHFNVRSIPHVVAF
VDGKPVDQFVGVLPESQLRGFLDRVIPQPAEVAYREGLAAHQANALAHAREAFQNALAYDPGFDAARFALIDLLLDTGDV
RAAQNEFALLSSRAPQDERHAPLQTRLEAAEHAGALPDADALHRRIAAAPDDLQARLDLAQQYIARQDYEAALEQLLAIV
ERDRAFRDDIGRKTMVSVFDLMRDPQAVSLWRRQLASRLN

Sequences:

>Translated_280_residues
MSDVTSQNFAQEVIETSRQVPVLVDFWAPWCGPCRTLGPMLEKLEHEYAGKWKLAKVNSDESPELSAHFNVRSIPHVVAF
VDGKPVDQFVGVLPESQLRGFLDRVIPQPAEVAYREGLAAHQANALAHAREAFQNALAYDPGFDAARFALIDLLLDTGDV
RAAQNEFALLSSRAPQDERHAPLQTRLEAAEHAGALPDADALHRRIAAAPDDLQARLDLAQQYIARQDYEAALEQLLAIV
ERDRAFRDDIGRKTMVSVFDLMRDPQAVSLWRRQLASRLN
>Mature_279_residues
SDVTSQNFAQEVIETSRQVPVLVDFWAPWCGPCRTLGPMLEKLEHEYAGKWKLAKVNSDESPELSAHFNVRSIPHVVAFV
DGKPVDQFVGVLPESQLRGFLDRVIPQPAEVAYREGLAAHQANALAHAREAFQNALAYDPGFDAARFALIDLLLDTGDVR
AAQNEFALLSSRAPQDERHAPLQTRLEAAEHAGALPDADALHRRIAAAPDDLQARLDLAQQYIARQDYEAALEQLLAIVE
RDRAFRDDIGRKTMVSVFDLMRDPQAVSLWRRQLASRLN

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG3118

COG function: function code O; Thioredoxin domain-containing protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=99, Percent_Identity=42.4242424242424, Blast_Score=88, Evalue=7e-18,
Organism=Escherichia coli, GI87081747, Length=277, Percent_Identity=31.0469314079422, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI1788936, Length=84, Percent_Identity=42.8571428571429, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI87082331, Length=107, Percent_Identity=38.3177570093458, Blast_Score=89, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI212646193, Length=100, Percent_Identity=42, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28573567, Length=105, Percent_Identity=41.9047619047619, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI21358065, Length=104, Percent_Identity=37.5, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24639826, Length=70, Percent_Identity=38.5714285714286, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24664269, Length=70, Percent_Identity=40, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 31253; Mature: 31121

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS50293 TPR_REGION ; PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDVTSQNFAQEVIETSRQVPVLVDFWAPWCGPCRTLGPMLEKLEHEYAGKWKLAKVNSD
CCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCC
ESPELSAHFNVRSIPHVVAFVDGKPVDQFVGVLPESQLRGFLDRVIPQPAEVAYREGLAA
CCCCCEECCCHHHCCCEEEEECCCCHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHH
HQANALAHAREAFQNALAYDPGFDAARFALIDLLLDTGDVRAAQNEFALLSSRAPQDERH
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCC
APLQTRLEAAEHAGALPDADALHRRIAAAPDDLQARLDLAQQYIARQDYEAALEQLLAIV
CCHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
ERDRAFRDDIGRKTMVSVFDLMRDPQAVSLWRRQLASRLN
HHHHHHHHHHCHHHHHHHHHHHCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SDVTSQNFAQEVIETSRQVPVLVDFWAPWCGPCRTLGPMLEKLEHEYAGKWKLAKVNSD
CCCCHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCC
ESPELSAHFNVRSIPHVVAFVDGKPVDQFVGVLPESQLRGFLDRVIPQPAEVAYREGLAA
CCCCCEECCCHHHCCCEEEEECCCCHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHH
HQANALAHAREAFQNALAYDPGFDAARFALIDLLLDTGDVRAAQNEFALLSSRAPQDERH
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCC
APLQTRLEAAEHAGALPDADALHRRIAAAPDDLQARLDLAQQYIARQDYEAALEQLLAIV
CCHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
ERDRAFRDDIGRKTMVSVFDLMRDPQAVSLWRRQLASRLN
HHHHHHHHHHCHHHHHHHHHHHCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2492995 [H]