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The map label for this gene is pdxH1

Identifier: 17545486

GI number: 17545486

Start: 809440

End: 810078

Strand: Reverse

Name: pdxH1

Synonym: RSc0767

Alternate gene names: 17545486

Gene position: 810078-809440 (Counterclockwise)

Preceding gene: 17545492

Following gene: 17545485

Centisome position: 21.8

GC content: 70.42

Gene sequence:

>639_bases
ATGACTTCCATCGCCGACATCCGCACCGACTACGCCCGCGCCTCCCTCGACATCGCCGACGTCGATCCCAACCCGCTGCG
GCAGTTCCGCCGCTGGTTCGACGAAGCCATCCGGGCCGAAGTGGCCGAGGTCAACGCCATGACGCTGGCCACCGTGGACC
CGCAAGGCCAGCCGTCCGCCCGTATCGTCCTGCTGAAGAACCTGGACGAGCGCGGCTTCACCTTCTTCACCAACTACTGC
AGCCACAAGGGCGAGGAACTGGCCGCCAACCCGCACGCGGCGCTGCTGTTCCACTGGATCGGGCTGGAGCGCCAGGTGCG
CGTCCAGGGCGTGGTGGAAAAAGTGAGCGAAGCCGAGAGCGATGCCTACTACCACTCGCGCCCGCTCGGCTCGCGCCTGG
GCGCCTGGGCCTCGGAGCAGAGCAGCGAGGTGCCCGACCGCGCCGTGCTGGAGGCGCGCGAGGCCGAATACCGCGAACGC
TTCGGCGACGCGCCGCCGCGTCCGCCGCACTGGGGCGGCTACCGGCTGCTGCCGGAACGCATCGAGTTCTGGCAGGGCCG
GCCCTCGCGGCTGCACGATCGGCTGGAATACCGCCGCCAGCCGGACGGCGGCTGGCACATCGTCCGTCTCGCCCCCTGA

Upstream 100 bases:

>100_bases
CGGACGCGCCAGCCGGCTTGCGCCCGCGCAAATGGCGGCCGCCGCCTTTGTCTATACTCGGCCCGTTGTACGTACTACGC
CGCACCCCGTTTCCCGCACC

Downstream 100 bases:

>100_bases
CGCCCCGCTCCGCGCAGTGCCGTATTGCGCACCGCATCATCCGGGAACGGCGCCTGCTACATGGAACGAGACCATCCCGC
GCGGGCGCATGACCCGCACA

Product: pyridoxamine 5'-phosphate oxidase

Products: NA

Alternate protein names: PNP/PMP oxidase 1; PNPOx 1; Pyridoxal 5'-phosphate synthase 1

Number of amino acids: Translated: 212; Mature: 211

Protein sequence:

>212_residues
MTSIADIRTDYARASLDIADVDPNPLRQFRRWFDEAIRAEVAEVNAMTLATVDPQGQPSARIVLLKNLDERGFTFFTNYC
SHKGEELAANPHAALLFHWIGLERQVRVQGVVEKVSEAESDAYYHSRPLGSRLGAWASEQSSEVPDRAVLEAREAEYRER
FGDAPPRPPHWGGYRLLPERIEFWQGRPSRLHDRLEYRRQPDGGWHIVRLAP

Sequences:

>Translated_212_residues
MTSIADIRTDYARASLDIADVDPNPLRQFRRWFDEAIRAEVAEVNAMTLATVDPQGQPSARIVLLKNLDERGFTFFTNYC
SHKGEELAANPHAALLFHWIGLERQVRVQGVVEKVSEAESDAYYHSRPLGSRLGAWASEQSSEVPDRAVLEAREAEYRER
FGDAPPRPPHWGGYRLLPERIEFWQGRPSRLHDRLEYRRQPDGGWHIVRLAP
>Mature_211_residues
TSIADIRTDYARASLDIADVDPNPLRQFRRWFDEAIRAEVAEVNAMTLATVDPQGQPSARIVLLKNLDERGFTFFTNYCS
HKGEELAANPHAALLFHWIGLERQVRVQGVVEKVSEAESDAYYHSRPLGSRLGAWASEQSSEVPDRAVLEAREAEYRERF
GDAPPRPPHWGGYRLLPERIEFWQGRPSRLHDRLEYRRQPDGGWHIVRLAP

Specific function: Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)

COG id: COG0259

COG function: function code H; Pyridoxamine-phosphate oxidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxamine 5'-phosphate oxidase family

Homologues:

Organism=Homo sapiens, GI8922498, Length=178, Percent_Identity=49.438202247191, Blast_Score=183, Evalue=1e-46,
Organism=Escherichia coli, GI1787926, Length=213, Percent_Identity=46.0093896713615, Blast_Score=192, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17553712, Length=220, Percent_Identity=41.3636363636364, Blast_Score=166, Evalue=8e-42,
Organism=Saccharomyces cerevisiae, GI6319509, Length=210, Percent_Identity=44.7619047619048, Blast_Score=179, Evalue=4e-46,
Organism=Drosophila melanogaster, GI45551845, Length=205, Percent_Identity=43.9024390243902, Blast_Score=169, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24644901, Length=205, Percent_Identity=43.9024390243902, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24644903, Length=163, Percent_Identity=28.2208588957055, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXH1_RALSO (Q8Y1C3)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_518888.1
- ProteinModelPortal:   Q8Y1C3
- SMR:   Q8Y1C3
- GeneID:   1219574
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc0767
- NMPDR:   fig|267608.1.peg.767
- HOGENOM:   HBG327559
- OMA:   FTFFTNY
- ProtClustDB:   PRK05679
- BioCyc:   RSOL267608:RSC0767-MONOMER
- BRENDA:   1.4.3.5
- HAMAP:   MF_01629
- InterPro:   IPR000659
- InterPro:   IPR019740
- InterPro:   IPR019576
- InterPro:   IPR011576
- InterPro:   IPR012349
- InterPro:   IPR009002
- Gene3D:   G3DSA:2.30.110.10
- PANTHER:   PTHR10851
- PIRSF:   PIRSF000190
- TIGRFAMs:   TIGR00558

Pfam domain/function: PF10590 PNPOx_C; PF01243 Pyridox_oxidase; SSF50475 FMN_binding

EC number: =1.4.3.5

Molecular weight: Translated: 24330; Mature: 24199

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS01064 PYRIDOX_OXIDASE

Important sites: BINDING 61-61 BINDING 64-64 BINDING 66-66 BINDING 83-83 BINDING 123-123 BINDING 127-127 BINDING 131-131

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSIADIRTDYARASLDIADVDPNPLRQFRRWFDEAIRAEVAEVNAMTLATVDPQGQPSA
CCCHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCE
RIVLLKNLDERGFTFFTNYCSHKGEELAANPHAALLFHWIGLERQVRVQGVVEKVSEAES
EEEEEECCCCCCHHHHHHHHHCCCCHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHH
DAYYHSRPLGSRLGAWASEQSSEVPDRAVLEAREAEYRERFGDAPPRPPHWGGYRLLPER
CHHHHCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECHHH
IEFWQGRPSRLHDRLEYRRQPDGGWHIVRLAP
HHHHCCCHHHHHHHHHHCCCCCCCEEEEEECC
>Mature Secondary Structure 
TSIADIRTDYARASLDIADVDPNPLRQFRRWFDEAIRAEVAEVNAMTLATVDPQGQPSA
CCHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCE
RIVLLKNLDERGFTFFTNYCSHKGEELAANPHAALLFHWIGLERQVRVQGVVEKVSEAES
EEEEEECCCCCCHHHHHHHHHCCCCHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHH
DAYYHSRPLGSRLGAWASEQSSEVPDRAVLEAREAEYRERFGDAPPRPPHWGGYRLLPER
CHHHHCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECHHH
IEFWQGRPSRLHDRLEYRRQPDGGWHIVRLAP
HHHHCCCHHHHHHHHHHCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852