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The map label for this gene is glyA [H]

Identifier: 17545448

GI number: 17545448

Start: 776547

End: 777794

Strand: Reverse

Name: glyA [H]

Synonym: RSc0729

Alternate gene names: 17545448

Gene position: 777794-776547 (Counterclockwise)

Preceding gene: 17545459

Following gene: 17545447

Centisome position: 20.93

GC content: 64.5

Gene sequence:

>1248_bases
ATGTTCGAACGCAACCGCTATACGATCGACCAGATCGACCCAGAAGTCTTCGCCGCCATCCAGCAGGAAAACCAGCGCCA
GGAAGACCACATCGAGCTGATCGCCTCCGAGAACTACACCTCGCCGGCCGTGATGGCCGCCCAGGGCTCGCAGCTGACCA
ACAAGTATGCCGAGGGCTATCCCGGCAAGCGCTACTACGGTGGCTGCGAATACGTGGACGTGGTCGAGCAGCTCGCCATC
GACCGCGTGAAGCAACTGTTCGGCGCCGAGGCCGCCAACGTGCAGCCGAACTCCGGCTCGCAGGCCAACCAGGGCGTGTT
CTTCGCCATGCTCAAGCCGGGCGACACCATCATGGGCATGAGCCTGGCCGAAGGCGGCCACCTGACGCACGGCATGGCGC
TCAACATGAGCGGCAAGTGGTTCAACGTCGTCAGCTACGGCCTGAACGCGCAGGAAGACATCGACTACGATGCCCTCGAA
GCGCTGGCACAAGAGAAGAAGCCCAAGCTGATCATCGCCGGCGCCTCCGCGTTTGCGCTGCGCATCGACTTCGAGCGCAT
CGCCAAGGTGGCCAAGGCCGTCGGCGCGTACTTCATGGTTGACATGGCCCACTACGCCGGCCTGATCGCCGCGGGCGTCT
ACCCGAACCCGGTGCCGCACGCCGATTTCGTGACCACCACCACCCACAAGAGCCTGCGCGGCCCGCGCGGCGGCGTGATC
CTGATGAAGGCCGAGCACGAGAAGGCCATCAACTCGGCGATCTTCCCCGGCATCCAGGGCGGCCCGCTGATGCACGTGAT
CGCCGGCAAGGCGGTGGCGTTCAAGGAAGCCCAGTCGCCCACGTTCAAGGCCTACCAGGAACAGGTGGTGAAAAACGCCC
GCGCCATGGCCGAAACGCTGATGGCCCGCGGCCTGCGCATCGTCTCCGGCCGCACCGAAAGCCACGTGATGCTGGTCGAC
CTGCGCGCGAAGAGCATTACCGGCAAGGAAGCCGAGAAGGTGCTGGGCGACGCGCATATCACCGTCAACAAAAACGCCAT
CCCGAACGATCCGGAGAAGCCCTTCGTGACCTCGGGCATCCGCCTGGGCTCGCCGGCCATGACCACGCGAGGCTTCAAGG
AGGGTGAGGCCGTGAAGGTAGCCCACCTGATCGCCGATGTGCTTGATAATCCGCATGACGAAGCCAACATCGCGGCCGTG
CGCGCCAAGGTGGCCGAGCTGACCAAGCAGTTCCCGGTCTACGCATGA

Upstream 100 bases:

>100_bases
GCTGCCGCCGGACAAGCCGGCGCAACCGCCCGAGCCGCGCGTTTCCCCGCCTCGCCCGATCCCCCGCCGTTTCCGTTTCG
TTTCAGACCAGACACTCGCC

Downstream 100 bases:

>100_bases
CCATTGGCCGGGTGACCGGCCAGGCTGTACCCTGCTCTGCCGCGATGCGCCCACCCGGGCCGTCGCGGCGTTGTTTTTTG
TGTAGCGCGTTCTTTGAGGT

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT 1; Serine methylase 1 [H]

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MFERNRYTIDQIDPEVFAAIQQENQRQEDHIELIASENYTSPAVMAAQGSQLTNKYAEGYPGKRYYGGCEYVDVVEQLAI
DRVKQLFGAEAANVQPNSGSQANQGVFFAMLKPGDTIMGMSLAEGGHLTHGMALNMSGKWFNVVSYGLNAQEDIDYDALE
ALAQEKKPKLIIAGASAFALRIDFERIAKVAKAVGAYFMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVI
LMKAEHEKAINSAIFPGIQGGPLMHVIAGKAVAFKEAQSPTFKAYQEQVVKNARAMAETLMARGLRIVSGRTESHVMLVD
LRAKSITGKEAEKVLGDAHITVNKNAIPNDPEKPFVTSGIRLGSPAMTTRGFKEGEAVKVAHLIADVLDNPHDEANIAAV
RAKVAELTKQFPVYA

Sequences:

>Translated_415_residues
MFERNRYTIDQIDPEVFAAIQQENQRQEDHIELIASENYTSPAVMAAQGSQLTNKYAEGYPGKRYYGGCEYVDVVEQLAI
DRVKQLFGAEAANVQPNSGSQANQGVFFAMLKPGDTIMGMSLAEGGHLTHGMALNMSGKWFNVVSYGLNAQEDIDYDALE
ALAQEKKPKLIIAGASAFALRIDFERIAKVAKAVGAYFMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVI
LMKAEHEKAINSAIFPGIQGGPLMHVIAGKAVAFKEAQSPTFKAYQEQVVKNARAMAETLMARGLRIVSGRTESHVMLVD
LRAKSITGKEAEKVLGDAHITVNKNAIPNDPEKPFVTSGIRLGSPAMTTRGFKEGEAVKVAHLIADVLDNPHDEANIAAV
RAKVAELTKQFPVYA
>Mature_415_residues
MFERNRYTIDQIDPEVFAAIQQENQRQEDHIELIASENYTSPAVMAAQGSQLTNKYAEGYPGKRYYGGCEYVDVVEQLAI
DRVKQLFGAEAANVQPNSGSQANQGVFFAMLKPGDTIMGMSLAEGGHLTHGMALNMSGKWFNVVSYGLNAQEDIDYDALE
ALAQEKKPKLIIAGASAFALRIDFERIAKVAKAVGAYFMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVI
LMKAEHEKAINSAIFPGIQGGPLMHVIAGKAVAFKEAQSPTFKAYQEQVVKNARAMAETLMARGLRIVSGRTESHVMLVD
LRAKSITGKEAEKVLGDAHITVNKNAIPNDPEKPFVTSGIRLGSPAMTTRGFKEGEAVKVAHLIADVLDNPHDEANIAAV
RAKVAELTKQFPVYA

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI19923315, Length=452, Percent_Identity=42.4778761061947, Blast_Score=348, Evalue=7e-96,
Organism=Homo sapiens, GI261862352, Length=452, Percent_Identity=42.4778761061947, Blast_Score=347, Evalue=1e-95,
Organism=Homo sapiens, GI261862350, Length=452, Percent_Identity=42.4778761061947, Blast_Score=347, Evalue=1e-95,
Organism=Homo sapiens, GI261862348, Length=452, Percent_Identity=42.4778761061947, Blast_Score=347, Evalue=1e-95,
Organism=Homo sapiens, GI261862346, Length=451, Percent_Identity=41.9068736141907, Blast_Score=339, Evalue=3e-93,
Organism=Homo sapiens, GI22547186, Length=424, Percent_Identity=44.5754716981132, Blast_Score=326, Evalue=2e-89,
Organism=Homo sapiens, GI22547189, Length=409, Percent_Identity=42.5427872860636, Blast_Score=293, Evalue=3e-79,
Organism=Escherichia coli, GI1788902, Length=415, Percent_Identity=62.8915662650602, Blast_Score=529, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI25144732, Length=415, Percent_Identity=45.5421686746988, Blast_Score=352, Evalue=3e-97,
Organism=Caenorhabditis elegans, GI25144729, Length=415, Percent_Identity=45.5421686746988, Blast_Score=352, Evalue=3e-97,
Organism=Saccharomyces cerevisiae, GI6319739, Length=401, Percent_Identity=45.1371571072319, Blast_Score=347, Evalue=2e-96,
Organism=Saccharomyces cerevisiae, GI6323087, Length=427, Percent_Identity=43.3255269320843, Blast_Score=334, Evalue=2e-92,
Organism=Drosophila melanogaster, GI24640005, Length=450, Percent_Identity=42.4444444444444, Blast_Score=360, Evalue=1e-100,
Organism=Drosophila melanogaster, GI221329721, Length=450, Percent_Identity=42.4444444444444, Blast_Score=360, Evalue=1e-99,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 44974; Mature: 44974

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFERNRYTIDQIDPEVFAAIQQENQRQEDHIELIASENYTSPAVMAAQGSQLTNKYAEGY
CCCCCCCCHHHCCHHHHHHHHHHCCCCCCCEEEEECCCCCCCEEEEECCCHHHHHHHCCC
PGKRYYGGCEYVDVVEQLAIDRVKQLFGAEAANVQPNSGSQANQGVFFAMLKPGDTIMGM
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEE
SLAEGGHLTHGMALNMSGKWFNVVSYGLNAQEDIDYDALEALAQEKKPKLIIAGASAFAL
EECCCCCEECCEEEECCCCEEEHHEECCCCCCCCCHHHHHHHHHCCCCCEEEECCCEEEE
RIDFERIAKVAKAVGAYFMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVI
EECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCHHHHCCCCCCEE
LMKAEHEKAINSAIFPGIQGGPLMHVIAGKAVAFKEAQSPTFKAYQEQVVKNARAMAETL
EEECCHHHHHHHHHCCCCCCCCEEEEECCCHHEECCCCCCHHHHHHHHHHHHHHHHHHHH
MARGLRIVSGRTESHVMLVDLRAKSITGKEAEKVLGDAHITVNKNAIPNDPEKPFVTSGI
HHCCEEEECCCCCCEEEEEEECCCCCCCHHHHHHHCCCEEEEECCCCCCCCCCCEEECCE
RLGSPAMTTRGFKEGEAVKVAHLIADVLDNPHDEANIAAVRAKVAELTKQFPVYA
ECCCCCHHCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MFERNRYTIDQIDPEVFAAIQQENQRQEDHIELIASENYTSPAVMAAQGSQLTNKYAEGY
CCCCCCCCHHHCCHHHHHHHHHHCCCCCCCEEEEECCCCCCCEEEEECCCHHHHHHHCCC
PGKRYYGGCEYVDVVEQLAIDRVKQLFGAEAANVQPNSGSQANQGVFFAMLKPGDTIMGM
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEE
SLAEGGHLTHGMALNMSGKWFNVVSYGLNAQEDIDYDALEALAQEKKPKLIIAGASAFAL
EECCCCCEECCEEEECCCCEEEHHEECCCCCCCCCHHHHHHHHHCCCCCEEEECCCEEEE
RIDFERIAKVAKAVGAYFMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVI
EECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCHHHHCCCCCCEE
LMKAEHEKAINSAIFPGIQGGPLMHVIAGKAVAFKEAQSPTFKAYQEQVVKNARAMAETL
EEECCHHHHHHHHHCCCCCCCCEEEEECCCHHEECCCCCCHHHHHHHHHHHHHHHHHHHH
MARGLRIVSGRTESHVMLVDLRAKSITGKEAEKVLGDAHITVNKNAIPNDPEKPFVTSGI
HHCCEEEECCCCCCEEEEEEECCCCCCCHHHHHHHCCCEEEEECCCCCCCCCCCEEECCE
RLGSPAMTTRGFKEGEAVKVAHLIADVLDNPHDEANIAAVRAKVAELTKQFPVYA
ECCCCCHHCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA