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The map label for this gene is pilA [H]

Identifier: 17545277

GI number: 17545277

Start: 602739

End: 603245

Strand: Direct

Name: pilA [H]

Synonym: RSc0558

Alternate gene names: 17545277

Gene position: 602739-603245 (Clockwise)

Preceding gene: 17545276

Following gene: 17545278

Centisome position: 16.22

GC content: 59.57

Gene sequence:

>507_bases
ATGAAGTCGATGCGTCATCTCAACAAGCGTGTCCAGAAGGGTTTCACGCTGATCGAACTGATGATCGTGGTCGCGATCGT
CGGTATTCTGGCTGCGATTGCCATTCCGGCCTATCAGGACTACACGGTTCGTGCACGCGTGACGGAAGGTCTGTCGCTGG
CTGCGCAAGCCAAGGCGCTGGTGTCGGAAAACGCTGCCAATGCACAGTCTGACCTGTCGGTGGGTTCGTCGGTGTTCACG
CCCACCAAGAACGTTGCCAACTTGACGATTGCTGGTACGGGTACTGTTCCGGGTCAGATCACCGTCACCTATACGACGGC
AGCTGGCGGCGGCACGCTGGCTCTGGTTCCGACTGCGGCTGGTACTGCACTGCCGGTTAGCTCGGCACCGTCGGGCCCGA
TCATGTGGACCTGCTACGCTCAGAATAAGGCTCAGGCTGCTAGCAGCGTTGCTCCGAGCGGTACGATGTCGCTGGCAGCG
AAGTATGCTCCGGCAGAATGCCGCTAA

Upstream 100 bases:

>100_bases
TCGCGTCAGTTTTTCGGCGACAGCCCCGGTTTTTCGGCTGGCACGGTCCCTGCTCTATCTCCCTCGCATCATCTTTAACC
ACACTTTCCGGGGGAATTTC

Downstream 100 bases:

>100_bases
GCTGTAAGCTAAGCTAGCTGCTGTAGTAAGAGCGCCTTTGGGCGCTCTTTTTGTTTCGCCATATTCGTGTCCTGCCCATC
AATGCTTCCAGTTCATCGTT

Product: type 4 fimbrial pilin signal peptide protein

Products: NA

Alternate protein names: Pilin [H]

Number of amino acids: Translated: 168; Mature: 168

Protein sequence:

>168_residues
MKSMRHLNKRVQKGFTLIELMIVVAIVGILAAIAIPAYQDYTVRARVTEGLSLAAQAKALVSENAANAQSDLSVGSSVFT
PTKNVANLTIAGTGTVPGQITVTYTTAAGGGTLALVPTAAGTALPVSSAPSGPIMWTCYAQNKAQAASSVAPSGTMSLAA
KYAPAECR

Sequences:

>Translated_168_residues
MKSMRHLNKRVQKGFTLIELMIVVAIVGILAAIAIPAYQDYTVRARVTEGLSLAAQAKALVSENAANAQSDLSVGSSVFT
PTKNVANLTIAGTGTVPGQITVTYTTAAGGGTLALVPTAAGTALPVSSAPSGPIMWTCYAQNKAQAASSVAPSGTMSLAA
KYAPAECR
>Mature_168_residues
MKSMRHLNKRVQKGFTLIELMIVVAIVGILAAIAIPAYQDYTVRARVTEGLSLAAQAKALVSENAANAQSDLSVGSSVFT
PTKNVANLTIAGTGTVPGQITVTYTTAAGGGTLALVPTAAGTALPVSSAPSGPIMWTCYAQNKAQAASSVAPSGTMSLAA
KYAPAECR

Specific function: This protein is the predominant Neisseria surface antigen, which allows adhesion of the bacterium to various host cells [H]

COG id: COG4969

COG function: function code NU; Tfp pilus assembly protein, major pilin PilA

Gene ontology:

Cell location: Fimbrium [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N-Me-Phe pilin family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001082
- InterPro:   IPR012902
- InterPro:   IPR001120 [H]

Pfam domain/function: PF07963 N_methyl; PF00114 Pilin [H]

EC number: NA

Molecular weight: Translated: 17054; Mature: 17054

Theoretical pI: Translated: 9.98; Mature: 9.98

Prosite motif: PS00409 PROKAR_NTER_METHYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSMRHLNKRVQKGFTLIELMIVVAIVGILAAIAIPAYQDYTVRARVTEGLSLAAQAKAL
CCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHH
VSENAANAQSDLSVGSSVFTPTKNVANLTIAGTGTVPGQITVTYTTAAGGGTLALVPTAA
HHCCCCCCCHHHHCCCCCCCCCCCCEEEEEEECCCCCCEEEEEEEECCCCCEEEEEECCC
GTALPVSSAPSGPIMWTCYAQNKAQAASSVAPSGTMSLAAKYAPAECR
CCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHEECCCCCCC
>Mature Secondary Structure
MKSMRHLNKRVQKGFTLIELMIVVAIVGILAAIAIPAYQDYTVRARVTEGLSLAAQAKAL
CCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHH
VSENAANAQSDLSVGSSVFTPTKNVANLTIAGTGTVPGQITVTYTTAAGGGTLALVPTAA
HHCCCCCCCHHHHCCCCCCCCCCCCEEEEEEECCCCCCEEEEEEEECCCCCEEEEEECCC
GTALPVSSAPSGPIMWTCYAQNKAQAASSVAPSGTMSLAAKYAPAECR
CCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3141743; 10710307; 8645220; 8993351; 9515697 [H]