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The map label for this gene is sucC [H]

Identifier: 17545273

GI number: 17545273

Start: 598777

End: 599943

Strand: Direct

Name: sucC [H]

Synonym: RSc0554

Alternate gene names: 17545273

Gene position: 598777-599943 (Clockwise)

Preceding gene: 17545272

Following gene: 17545274

Centisome position: 16.11

GC content: 63.07

Gene sequence:

>1167_bases
ATGAATATCCATGAGTACCAAGGCAAGGAAATCCTGCGCAAATACAATGTGCCGGTTCCGCGCGGCATTCCGGCTTTTTC
GGTCGAAGAGGCCCTGAAGGCCGCTGAAACCCTGGGCGGCCCGGTGTGGGTCGTGAAGGCGCAGATTCATGCGGGCGGCC
GCGGCAAGGGCGGCGGCGTGAAGGTTGCCAAGAGCATGGACGAGGTGAAGACCTACGCCAGCAACATCCTGGGCATGACC
CTGGTGACGCACCAGACCGGCCCGGAAGGCAAGAAGGTCAACCGCCTGCTGATCGAAGAAGGCGCGGACATCAAGAAGGA
ACTGTACGTGTCGCTGGTGGTGGACCGCGTCTCGCAGAAGGTCGCCCTGATGGCCTCCAGCGAAGGCGGCATGGACATCG
AAGAAGTCGCTGCCCACACCCCGGAAAAGATCCACACGCTGATCGTCGATCCGCAAATCGGCCTGCAAGACGCTGAAGCC
GACGACATCGCCCGCAAGATCGGCGTGCCCGACGCGAGCGTGCCGCAAGCCCGCCAAGCCCTGCAAGGCCTGTACAAGGC
ATTCTGGGAAACCGACGCTTCGCTGGCGGAAATCAACCCGCTGATCCTGACCGGCGACGGTAAGGTCATCGCGCTGGACG
CCAAGTTCAACTTCGACTCCAACGCGCTGTTCCGTCACCCGGAAATCGTCGCCTACCGCGACCTGGATGAAGAAGACGCC
AACGAAATCGAAGCCTCGAAGTTCGATCTGGCCTACATCTCGCTCGACGGCAACATCGGCTGCCTGGTGAACGGCGCCGG
CCTGGCCATGGCCACCATGGACACCATCAAGCTGTTCGGCGGCGAGCCGGCCAACTTCCTCGACGTGGGCGGCGGCGCCA
CCACCGAGAAGGTCACCGAAGCCTTCAAGCTGATGCTGAAGAACCCGGGCCTGAAGGCCATCCTGGTGAACATCTTCGGC
GGCATCATGCGCTGCGACGTGATCGCCGAAGGCGTGATCGCCGCGTCGAAGGCCGTGTCGCTGTCGGTGCCGCTGGTGGT
CCGCATGAAGGGCACCAACGAAGACCTCGGCAAGAAGATGCTGGCCGACTCGGGTCTGCCCATCATCGCCGCCGACACGA
TGGAAGAGGCCGCCCAGAAGGTCGTGGCCGCAGCCGCCGGCAAGTAA

Upstream 100 bases:

>100_bases
AATCGCCGAGCCGTCATCGGGGACGTCGTCCTGACGGGTTTCCGGGCGCTCGCGTTTTCAACCTTCATCACACTCATCCA
GCCTAGCAAAGGAAACACGC

Downstream 100 bases:

>100_bases
GCCGCCCGCTGAACGAACCATACGCGAACGCGAGCGGCACCCGGCCACCGGGAGGCGGCTCGCAGCCAAGCAAAGGATTA
CAGCATGTCGATTCTGATCA

Product: succinyl-CoA synthetase subunit beta

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit beta; SCS-beta [H]

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MNIHEYQGKEILRKYNVPVPRGIPAFSVEEALKAAETLGGPVWVVKAQIHAGGRGKGGGVKVAKSMDEVKTYASNILGMT
LVTHQTGPEGKKVNRLLIEEGADIKKELYVSLVVDRVSQKVALMASSEGGMDIEEVAAHTPEKIHTLIVDPQIGLQDAEA
DDIARKIGVPDASVPQARQALQGLYKAFWETDASLAEINPLILTGDGKVIALDAKFNFDSNALFRHPEIVAYRDLDEEDA
NEIEASKFDLAYISLDGNIGCLVNGAGLAMATMDTIKLFGGEPANFLDVGGGATTEKVTEAFKLMLKNPGLKAILVNIFG
GIMRCDVIAEGVIAASKAVSLSVPLVVRMKGTNEDLGKKMLADSGLPIIAADTMEEAAQKVVAAAAGK

Sequences:

>Translated_388_residues
MNIHEYQGKEILRKYNVPVPRGIPAFSVEEALKAAETLGGPVWVVKAQIHAGGRGKGGGVKVAKSMDEVKTYASNILGMT
LVTHQTGPEGKKVNRLLIEEGADIKKELYVSLVVDRVSQKVALMASSEGGMDIEEVAAHTPEKIHTLIVDPQIGLQDAEA
DDIARKIGVPDASVPQARQALQGLYKAFWETDASLAEINPLILTGDGKVIALDAKFNFDSNALFRHPEIVAYRDLDEEDA
NEIEASKFDLAYISLDGNIGCLVNGAGLAMATMDTIKLFGGEPANFLDVGGGATTEKVTEAFKLMLKNPGLKAILVNIFG
GIMRCDVIAEGVIAASKAVSLSVPLVVRMKGTNEDLGKKMLADSGLPIIAADTMEEAAQKVVAAAAGK
>Mature_388_residues
MNIHEYQGKEILRKYNVPVPRGIPAFSVEEALKAAETLGGPVWVVKAQIHAGGRGKGGGVKVAKSMDEVKTYASNILGMT
LVTHQTGPEGKKVNRLLIEEGADIKKELYVSLVVDRVSQKVALMASSEGGMDIEEVAAHTPEKIHTLIVDPQIGLQDAEA
DDIARKIGVPDASVPQARQALQGLYKAFWETDASLAEINPLILTGDGKVIALDAKFNFDSNALFRHPEIVAYRDLDEEDA
NEIEASKFDLAYISLDGNIGCLVNGAGLAMATMDTIKLFGGEPANFLDVGGGATTEKVTEAFKLMLKNPGLKAILVNIFG
GIMRCDVIAEGVIAASKAVSLSVPLVVRMKGTNEDLGKKMLADSGLPIIAADTMEEAAQKVVAAAAGK

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0045

COG function: function code C; Succinyl-CoA synthetase, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Homo sapiens, GI11321583, Length=389, Percent_Identity=47.8149100257069, Blast_Score=355, Evalue=4e-98,
Organism=Homo sapiens, GI157779135, Length=383, Percent_Identity=45.6919060052219, Blast_Score=323, Evalue=2e-88,
Organism=Homo sapiens, GI294862256, Length=359, Percent_Identity=45.9610027855153, Blast_Score=305, Evalue=4e-83,
Organism=Escherichia coli, GI1786948, Length=388, Percent_Identity=52.8350515463918, Blast_Score=402, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17539378, Length=393, Percent_Identity=45.29262086514, Blast_Score=345, Evalue=2e-95,
Organism=Caenorhabditis elegans, GI17567829, Length=388, Percent_Identity=46.1340206185567, Blast_Score=333, Evalue=1e-91,
Organism=Saccharomyces cerevisiae, GI6321683, Length=393, Percent_Identity=46.0559796437659, Blast_Score=347, Evalue=3e-96,
Organism=Drosophila melanogaster, GI21356231, Length=396, Percent_Identity=45.7070707070707, Blast_Score=330, Evalue=1e-90,
Organism=Drosophila melanogaster, GI161078106, Length=392, Percent_Identity=44.8979591836735, Blast_Score=321, Evalue=7e-88,
Organism=Drosophila melanogaster, GI24645208, Length=392, Percent_Identity=44.8979591836735, Blast_Score=321, Evalue=7e-88,
Organism=Drosophila melanogaster, GI281361397, Length=393, Percent_Identity=45.0381679389313, Blast_Score=320, Evalue=2e-87,
Organism=Drosophila melanogaster, GI281361395, Length=393, Percent_Identity=45.0381679389313, Blast_Score=320, Evalue=2e-87,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2361 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013650
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR005811
- InterPro:   IPR017866
- InterPro:   IPR005809
- InterPro:   IPR016102 [H]

Pfam domain/function: PF08442 ATP-grasp_2; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 41175; Mature: 41175

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS50975 ATP_GRASP ; PS01217 SUCCINYL_COA_LIG_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIHEYQGKEILRKYNVPVPRGIPAFSVEEALKAAETLGGPVWVVKAQIHAGGRGKGGGV
CCCCHHCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCC
KVAKSMDEVKTYASNILGMTLVTHQTGPEGKKVNRLLIEEGADIKKELYVSLVVDRVSQK
HHHHHHHHHHHHHHHHHEEEEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
VALMASSEGGMDIEEVAAHTPEKIHTLIVDPQIGLQDAEADDIARKIGVPDASVPQARQA
EEEEECCCCCCCHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHCCCCCCCHHHHHH
LQGLYKAFWETDASLAEINPLILTGDGKVIALDAKFNFDSNALFRHPEIVAYRDLDEEDA
HHHHHHHHHCCCCCHHHCCCEEEECCCEEEEEEEEECCCCCCEECCCCEEEECCCCCCCH
NEIEASKFDLAYISLDGNIGCLVNGAGLAMATMDTIKLFGGEPANFLDVGGGATTEKVTE
HHHCCCEEEEEEEEECCCEEEEEECCCEEEHHHHHHHCCCCCCCCEEECCCCCCHHHHHH
AFKLMLKNPGLKAILVNIFGGIMRCDVIAEGVIAASKAVSLSVPLVVRMKGTNEDLGKKM
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCEEEEECCCCHHHHHHH
LADSGLPIIAADTMEEAAQKVVAAAAGK
HHCCCCCEEEHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNIHEYQGKEILRKYNVPVPRGIPAFSVEEALKAAETLGGPVWVVKAQIHAGGRGKGGGV
CCCCHHCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCC
KVAKSMDEVKTYASNILGMTLVTHQTGPEGKKVNRLLIEEGADIKKELYVSLVVDRVSQK
HHHHHHHHHHHHHHHHHEEEEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
VALMASSEGGMDIEEVAAHTPEKIHTLIVDPQIGLQDAEADDIARKIGVPDASVPQARQA
EEEEECCCCCCCHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHCCCCCCCHHHHHH
LQGLYKAFWETDASLAEINPLILTGDGKVIALDAKFNFDSNALFRHPEIVAYRDLDEEDA
HHHHHHHHHCCCCCHHHCCCEEEECCCEEEEEEEEECCCCCCEECCCCEEEECCCCCCCH
NEIEASKFDLAYISLDGNIGCLVNGAGLAMATMDTIKLFGGEPANFLDVGGGATTEKVTE
HHHCCCEEEEEEEEECCCEEEEEECCCEEEHHHHHHHCCCCCCCCEEECCCCCCHHHHHH
AFKLMLKNPGLKAILVNIFGGIMRCDVIAEGVIAASKAVSLSVPLVVRMKGTNEDLGKKM
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCEEEEECCCCHHHHHHH
LADSGLPIIAADTMEEAAQKVVAAAAGK
HHCCCCCEEEHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA