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The map label for this gene is fabG [H]

Identifier: 17545255

GI number: 17545255

Start: 576660

End: 578072

Strand: Reverse

Name: fabG [H]

Synonym: RSc0536

Alternate gene names: 17545255

Gene position: 578072-576660 (Counterclockwise)

Preceding gene: 17545256

Following gene: 17545254

Centisome position: 15.55

GC content: 73.96

Gene sequence:

>1413_bases
ATGCAAGACAAGTATCTCGATTTCGTCCGTTCCGGCTTCGGCAAATGGCTGTCGACCAACCTCGGCCTGCCGCAGCCGGT
CCCGCTGCGCCGCCATCGCCCCGGCGAACCCGAATTCGCCGGCCCCTTCCTGGTGGGCGCGGCGCCGGGCGGGGCACTGC
GCGAGACGCTGGCCGCGCTGTTCGCCGGGATGGGCGTGCCGACGCGCTTCCACGACAGCCACCCCGAATGGCTGGGCGCC
GCCAACCGGCAGGGGCAGATCACCGGCCGCTTCGTCGCGCCCACGGGCCAGGAAGGCGAGGCGTCCGACCGCCTCGGCGG
CATCGTGTTCGACGCGACGGGCATCGCATCGACCGAGGGGCTGGAGGCGCTGTACACCGTGTTCCACGACGGCGTGCGCG
CGATCGGCCGCTGCGGGCGCGTGGTGGTGATCGGCCGGCCGCCCGAGGGCTGCGCGGCGCCGCAGGCGGCGATCGTCCAG
CGCGCGCTGGAAGGGCTGACGCGCTCGCTCGGCAAGGAGATCCGGCGCGGCTGCACGGTGCAGCTGGTCTATGTGGCCGA
GGGCGCGGAGCCTGCGGCGGCGTCCACGCTGCGCTTCTTGCTGTCGGCGCGTTCGGCCTACGTGTCGGGGCAGGTGGTGC
GCGTGCGGCCGGCAACGGCGGCCACGGTGGACTGGCAACAGCCGCTCGCCGGACGCACGGCGCTGGTGACCGGGGCGTCG
CGCGGCATCGGCGCGGCCATCGCGCAGGTGCTGGCGCGCGACGGCGCGCGCGTGCTGTGCCTCGATGTGCCGGCCGCGCA
GCCGGCGCTCGACGGCGTCGCCAGGGCCATCGGCGGCGAGGCGCTCGCCTACGACATCGCCGAGGCCGAGACGCCCGCGC
GCCTGGCCCGACAGCTCGCGGCGATGGGCGGCATCGACATCCTGGTCCACAACGCCGGCATCACGCGCGACAAGACCATC
GCCCGCATGACCGAAGCCGCGTGGCGCAGCGTGCTGGACATCAACCTCGCCGCGCAGCTGCGCATCAACGACGCACTGCT
CGCCGCCGGCGCGCTGCATGCGGGCGGCGCGATCGTCTGCGTGTCGTCGATCAGCGGCATCGCGGGCAACCCCGGGCAGA
CCAACTACGCCACCGCCAAGGCCGGCGTGATCGGCCTGGTGCAGGCCTGCGCCCCGCTGCTGGCCGAGCGCGGCATCACC
ATCAATGCCGTGGCGCCGGGCTTCATCGAGACGCAGATGACGGCGGCGGTGCCGTTCACCATCCGCGAGGCGGGCCGGCG
CATGAATGCGATGGCCCAGGGCGGACAGCCGGTGGACGTGGCCGAAGCCATCGCGTGGCTCGCCTGCCCGGCCTCGAACG
GCGTGACCGGCAACGTCGTGCGGGTGTGCGGGCAAAGCCTGCTCGGGGCGTAG

Upstream 100 bases:

>100_bases
CGACTTCAACCTGCTGGCCGACCTGCAGCGCCGCAAGGCCGCGCTGGAGGCCCTGCAAGCGGCCGGGCAGCATGCCGCCT
GATCCCTCCCCCACCATCCG

Downstream 100 bases:

>100_bases
GCGCCGCATCGTGCGAACCGCCGCCGCGCTCACCTGCCCGATCGCCCCGCCCTGCGTCGCCGCGCCGACGTGGGTGGCCG
AAGCGCCGTCGGCCGGCGCA

Product: 3-ketoacyl-(acyl-carrier-protein) reductase

Products: NA

Alternate protein names: 3-ketoacyl-acyl carrier protein reductase [H]

Number of amino acids: Translated: 470; Mature: 470

Protein sequence:

>470_residues
MQDKYLDFVRSGFGKWLSTNLGLPQPVPLRRHRPGEPEFAGPFLVGAAPGGALRETLAALFAGMGVPTRFHDSHPEWLGA
ANRQGQITGRFVAPTGQEGEASDRLGGIVFDATGIASTEGLEALYTVFHDGVRAIGRCGRVVVIGRPPEGCAAPQAAIVQ
RALEGLTRSLGKEIRRGCTVQLVYVAEGAEPAAASTLRFLLSARSAYVSGQVVRVRPATAATVDWQQPLAGRTALVTGAS
RGIGAAIAQVLARDGARVLCLDVPAAQPALDGVARAIGGEALAYDIAEAETPARLARQLAAMGGIDILVHNAGITRDKTI
ARMTEAAWRSVLDINLAAQLRINDALLAAGALHAGGAIVCVSSISGIAGNPGQTNYATAKAGVIGLVQACAPLLAERGIT
INAVAPGFIETQMTAAVPFTIREAGRRMNAMAQGGQPVDVAEAIAWLACPASNGVTGNVVRVCGQSLLGA

Sequences:

>Translated_470_residues
MQDKYLDFVRSGFGKWLSTNLGLPQPVPLRRHRPGEPEFAGPFLVGAAPGGALRETLAALFAGMGVPTRFHDSHPEWLGA
ANRQGQITGRFVAPTGQEGEASDRLGGIVFDATGIASTEGLEALYTVFHDGVRAIGRCGRVVVIGRPPEGCAAPQAAIVQ
RALEGLTRSLGKEIRRGCTVQLVYVAEGAEPAAASTLRFLLSARSAYVSGQVVRVRPATAATVDWQQPLAGRTALVTGAS
RGIGAAIAQVLARDGARVLCLDVPAAQPALDGVARAIGGEALAYDIAEAETPARLARQLAAMGGIDILVHNAGITRDKTI
ARMTEAAWRSVLDINLAAQLRINDALLAAGALHAGGAIVCVSSISGIAGNPGQTNYATAKAGVIGLVQACAPLLAERGIT
INAVAPGFIETQMTAAVPFTIREAGRRMNAMAQGGQPVDVAEAIAWLACPASNGVTGNVVRVCGQSLLGA
>Mature_470_residues
MQDKYLDFVRSGFGKWLSTNLGLPQPVPLRRHRPGEPEFAGPFLVGAAPGGALRETLAALFAGMGVPTRFHDSHPEWLGA
ANRQGQITGRFVAPTGQEGEASDRLGGIVFDATGIASTEGLEALYTVFHDGVRAIGRCGRVVVIGRPPEGCAAPQAAIVQ
RALEGLTRSLGKEIRRGCTVQLVYVAEGAEPAAASTLRFLLSARSAYVSGQVVRVRPATAATVDWQQPLAGRTALVTGAS
RGIGAAIAQVLARDGARVLCLDVPAAQPALDGVARAIGGEALAYDIAEAETPARLARQLAAMGGIDILVHNAGITRDKTI
ARMTEAAWRSVLDINLAAQLRINDALLAAGALHAGGAIVCVSSISGIAGNPGQTNYATAKAGVIGLVQACAPLLAERGIT
INAVAPGFIETQMTAAVPFTIREAGRRMNAMAQGGQPVDVAEAIAWLACPASNGVTGNVVRVCGQSLLGA

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=256, Percent_Identity=39.0625, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI32483357, Length=249, Percent_Identity=33.7349397590361, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI40254992, Length=235, Percent_Identity=34.468085106383, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI4504505, Length=246, Percent_Identity=33.3333333333333, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI126723191, Length=186, Percent_Identity=34.4086021505376, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI5031737, Length=256, Percent_Identity=30.46875, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI126723750, Length=254, Percent_Identity=29.1338582677165, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI33667109, Length=205, Percent_Identity=33.6585365853659, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI40807363, Length=196, Percent_Identity=28.5714285714286, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI7705925, Length=241, Percent_Identity=31.1203319502075, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI31542939, Length=200, Percent_Identity=30, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI19923817, Length=253, Percent_Identity=28.8537549407115, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI20149619, Length=227, Percent_Identity=27.7533039647577, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI109715829, Length=245, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI66933014, Length=184, Percent_Identity=27.7173913043478, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1787335, Length=243, Percent_Identity=39.0946502057613, Blast_Score=148, Evalue=6e-37,
Organism=Escherichia coli, GI87082100, Length=255, Percent_Identity=32.156862745098, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1789208, Length=245, Percent_Identity=29.3877551020408, Blast_Score=95, Evalue=9e-21,
Organism=Escherichia coli, GI1790717, Length=248, Percent_Identity=29.0322580645161, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI87082160, Length=264, Percent_Identity=27.2727272727273, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI2367175, Length=248, Percent_Identity=33.8709677419355, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1789378, Length=251, Percent_Identity=31.8725099601594, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI2367365, Length=240, Percent_Identity=32.0833333333333, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1787905, Length=242, Percent_Identity=31.8181818181818, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI1786812, Length=254, Percent_Identity=26.3779527559055, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1789057, Length=262, Percent_Identity=25.9541984732824, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788459, Length=245, Percent_Identity=25.3061224489796, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1787526, Length=242, Percent_Identity=28.9256198347107, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI25147288, Length=240, Percent_Identity=37.9166666666667, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17555706, Length=240, Percent_Identity=37.9166666666667, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17561402, Length=250, Percent_Identity=29.2, Blast_Score=92, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17568967, Length=188, Percent_Identity=32.9787234042553, Blast_Score=85, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17560676, Length=245, Percent_Identity=26.530612244898, Blast_Score=82, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17559104, Length=265, Percent_Identity=29.811320754717, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71994604, Length=246, Percent_Identity=30.4878048780488, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17538182, Length=205, Percent_Identity=29.7560975609756, Blast_Score=79, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17508895, Length=199, Percent_Identity=27.6381909547739, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17564282, Length=222, Percent_Identity=28.3783783783784, Blast_Score=75, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17567345, Length=222, Percent_Identity=27.4774774774775, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71994600, Length=245, Percent_Identity=27.7551020408163, Blast_Score=72, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17562908, Length=241, Percent_Identity=29.8755186721992, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562906, Length=240, Percent_Identity=30.8333333333333, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI193203117, Length=192, Percent_Identity=28.125, Blast_Score=68, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17562990, Length=241, Percent_Identity=28.6307053941909, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193204405, Length=240, Percent_Identity=28.75, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193203115, Length=195, Percent_Identity=27.6923076923077, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17560220, Length=240, Percent_Identity=27.9166666666667, Blast_Score=66, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17531453, Length=240, Percent_Identity=28.75, Blast_Score=66, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17538486, Length=249, Percent_Identity=30.5220883534137, Blast_Score=66, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17562904, Length=246, Percent_Identity=27.6422764227642, Blast_Score=65, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=211, Percent_Identity=31.2796208530806, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24639444, Length=245, Percent_Identity=36.734693877551, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI23397609, Length=240, Percent_Identity=32.9166666666667, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI18859837, Length=186, Percent_Identity=36.0215053763441, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24644339, Length=252, Percent_Identity=33.3333333333333, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21357041, Length=239, Percent_Identity=30.9623430962343, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI21355319, Length=246, Percent_Identity=30.0813008130081, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21358495, Length=244, Percent_Identity=27.4590163934426, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI17737361, Length=251, Percent_Identity=29.4820717131474, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28571526, Length=238, Percent_Identity=30.672268907563, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI281364892, Length=169, Percent_Identity=28.9940828402367, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24643142, Length=187, Percent_Identity=32.0855614973262, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24581726, Length=199, Percent_Identity=28.1407035175879, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24649181, Length=206, Percent_Identity=25.2427184466019, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011284
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.100 [H]

Molecular weight: Translated: 48429; Mature: 48429

Theoretical pI: Translated: 8.58; Mature: 8.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDKYLDFVRSGFGKWLSTNLGLPQPVPLRRHRPGEPEFAGPFLVGAAPGGALRETLAAL
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHH
FAGMGVPTRFHDSHPEWLGAANRQGQITGRFVAPTGQEGEASDRLGGIVFDATGIASTEG
HHCCCCCCCCCCCCCHHHCCCCCCCCEEEEEECCCCCCCCCCHHHCCEEEECCCCCCHHH
LEALYTVFHDGVRAIGRCGRVVVIGRPPEGCAAPQAAIVQRALEGLTRSLGKEIRRGCTV
HHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEE
QLVYVAEGAEPAAASTLRFLLSARSAYVSGQVVRVRPATAATVDWQQPLAGRTALVTGAS
EEEEEECCCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCEEECCCCCCCCCCEEEEECCC
RGIGAAIAQVLARDGARVLCLDVPAAQPALDGVARAIGGEALAYDIAEAETPARLARQLA
CCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHCCHHHEEHHHHCCCHHHHHHHHH
AMGGIDILVHNAGITRDKTIARMTEAAWRSVLDINLAAQLRINDALLAAGALHAGGAIVC
HHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHEECEEEEEEECHHHHHHHHHHCCCEEEE
VSSISGIAGNPGQTNYATAKAGVIGLVQACAPLLAERGITINAVAPGFIETQMTAAVPFT
EECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHCCHH
IREAGRRMNAMAQGGQPVDVAEAIAWLACPASNGVTGNVVRVCGQSLLGA
HHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MQDKYLDFVRSGFGKWLSTNLGLPQPVPLRRHRPGEPEFAGPFLVGAAPGGALRETLAAL
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHH
FAGMGVPTRFHDSHPEWLGAANRQGQITGRFVAPTGQEGEASDRLGGIVFDATGIASTEG
HHCCCCCCCCCCCCCHHHCCCCCCCCEEEEEECCCCCCCCCCHHHCCEEEECCCCCCHHH
LEALYTVFHDGVRAIGRCGRVVVIGRPPEGCAAPQAAIVQRALEGLTRSLGKEIRRGCTV
HHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEE
QLVYVAEGAEPAAASTLRFLLSARSAYVSGQVVRVRPATAATVDWQQPLAGRTALVTGAS
EEEEEECCCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCEEECCCCCCCCCCEEEEECCC
RGIGAAIAQVLARDGARVLCLDVPAAQPALDGVARAIGGEALAYDIAEAETPARLARQLA
CCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHCCHHHEEHHHHCCCHHHHHHHHH
AMGGIDILVHNAGITRDKTIARMTEAAWRSVLDINLAAQLRINDALLAAGALHAGGAIVC
HHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHEECEEEEEEECHHHHHHHHHHCCCEEEE
VSSISGIAGNPGQTNYATAKAGVIGLVQACAPLLAERGITINAVAPGFIETQMTAAVPFT
EECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHCCHH
IREAGRRMNAMAQGGQPVDVAEAIAWLACPASNGVTGNVVRVCGQSLLGA
HHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759840; 9384377; 9534248; 8654983 [H]