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The map label for this gene is mutY [H]

Identifier: 17545120

GI number: 17545120

Start: 429960

End: 431048

Strand: Direct

Name: mutY [H]

Synonym: RSc0401

Alternate gene names: 17545120

Gene position: 429960-431048 (Clockwise)

Preceding gene: 17545119

Following gene: 17545133

Centisome position: 11.57

GC content: 71.53

Gene sequence:

>1089_bases
TTGCCCGAGGATTTCGCTGTCCGCGTGATCGCCTGGCAGCGCCGCCACGGCCGCCATCACCTGCCGTGGCAGAACACCGG
TGACGCCTATCGCGTGTGGCTGTCGGAGATCATGCTGCAGCAGACGCAGGTGTCGGCGGTGCTGGGCTACTACGCCCGCT
TCGTGGAGCGGTTCCCGACCGTGCAGGCACTGGCCGCGGCACCCGCGGACGACGTGATGGCCGCCTGGGCGGGCCTGGGC
TACTACACCCGCGCGCGCAATCTGCACCGCTGCGCGCAGATCGTGGTGGCCGAGCATGGCGGTGCGTTTCCGCGCGATCC
CGAGGCGCTGGCGGCGCTGCCGGGCATCGGGCGCTCCACCGCCGCGGCCATCGCCGCGTTTTCGTACGGCGTGCGCGCGG
CCATCCTCGACGGCAACGTCAAGCGCGTGTTTGCGCGCGTCTTCGGCATCGACGGCTTTCCCGGCGACAAGCGCGTCGAG
GAAACGATGTGGCGCATCGCCGAGACCGTGCTGCCCCCGGCGGACGGCATCCAGTCGTACACGCAGGGCCTGATGGACCT
GGGCGCCACGGTCTGCACGCGCGGCAGGCCGGCATGCCTGACCGGCGAGCGCGCATGTCCGCTCGAATCGCTGTGCGAGG
CGCGCCGGACCGGGCGCGTGATGGAACTGCCCGTGCCGCGTCCGCGCAAGGCCATCCCCGAGCGCGCGGCGACCCTGCTG
ATGGCGCTGCATGACGGCGCGGTGCTGCTCCAGCGCCGTCCGCAGCGCGGCATCTGGGGCGGGCTGTGGTCGCTGCCGCT
GGTGGGCGACATGGACACGGCGCTCGATGCGCATCCGGTGGCGACGGACGTGGCGCATGCCGCTGCGCAGGCCTACGGTA
CGGTGTCATCGATCGAGTCGGCCGGCGTGCTCATGCATACCTTTACGCATTTCCGCCTGCAGATGCACCTGCTGCGCGCG
GACATCCGCCAGCCCGCCGCGCTGGGCGACGACTGGCGCTGGGTGCCGCTCGTGCGGTTCGATACCGTGGGAATGCCGGC
GCCCGTGAAGCTGGCGCTGGAGATGCTGGCGCAGCCGAGCCTGGTGTGA

Upstream 100 bases:

>100_bases
CCAGCGCAGCCTGCCTGCGCGCCGTCTCCCCATCACACGCATGACCACTACACCCCGCCGTTCGCGCCGCGCCGCGCCGT
CCGCCCCCGCCCTGCCGCCC

Downstream 100 bases:

>100_bases
TGGCCGGCGGTTGCCGCGCTACAGGATGTGGTGCTGCTTCATATAGCGATGGACGATCTCGATGCGCATGCCGGCATCCA
TCAGTTCCATCAGCTTCTGC

Product: A/G-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 362; Mature: 361

Protein sequence:

>362_residues
MPEDFAVRVIAWQRRHGRHHLPWQNTGDAYRVWLSEIMLQQTQVSAVLGYYARFVERFPTVQALAAAPADDVMAAWAGLG
YYTRARNLHRCAQIVVAEHGGAFPRDPEALAALPGIGRSTAAAIAAFSYGVRAAILDGNVKRVFARVFGIDGFPGDKRVE
ETMWRIAETVLPPADGIQSYTQGLMDLGATVCTRGRPACLTGERACPLESLCEARRTGRVMELPVPRPRKAIPERAATLL
MALHDGAVLLQRRPQRGIWGGLWSLPLVGDMDTALDAHPVATDVAHAAAQAYGTVSSIESAGVLMHTFTHFRLQMHLLRA
DIRQPAALGDDWRWVPLVRFDTVGMPAPVKLALEMLAQPSLV

Sequences:

>Translated_362_residues
MPEDFAVRVIAWQRRHGRHHLPWQNTGDAYRVWLSEIMLQQTQVSAVLGYYARFVERFPTVQALAAAPADDVMAAWAGLG
YYTRARNLHRCAQIVVAEHGGAFPRDPEALAALPGIGRSTAAAIAAFSYGVRAAILDGNVKRVFARVFGIDGFPGDKRVE
ETMWRIAETVLPPADGIQSYTQGLMDLGATVCTRGRPACLTGERACPLESLCEARRTGRVMELPVPRPRKAIPERAATLL
MALHDGAVLLQRRPQRGIWGGLWSLPLVGDMDTALDAHPVATDVAHAAAQAYGTVSSIESAGVLMHTFTHFRLQMHLLRA
DIRQPAALGDDWRWVPLVRFDTVGMPAPVKLALEMLAQPSLV
>Mature_361_residues
PEDFAVRVIAWQRRHGRHHLPWQNTGDAYRVWLSEIMLQQTQVSAVLGYYARFVERFPTVQALAAAPADDVMAAWAGLGY
YTRARNLHRCAQIVVAEHGGAFPRDPEALAALPGIGRSTAAAIAAFSYGVRAAILDGNVKRVFARVFGIDGFPGDKRVEE
TMWRIAETVLPPADGIQSYTQGLMDLGATVCTRGRPACLTGERACPLESLCEARRTGRVMELPVPRPRKAIPERAATLLM
ALHDGAVLLQRRPQRGIWGGLWSLPLVGDMDTALDAHPVATDVAHAAAQAYGTVSSIESAGVLMHTFTHFRLQMHLLRAD
IRQPAALGDDWRWVPLVRFDTVGMPAPVKLALEMLAQPSLV

Specific function: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine:7,8-dihydro-8- oxoguanine (8-oxo-dGTP) [H]

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI115298648, Length=404, Percent_Identity=32.4257425742574, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI6912520, Length=404, Percent_Identity=32.4257425742574, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI115298654, Length=404, Percent_Identity=32.4257425742574, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI115298652, Length=404, Percent_Identity=32.4257425742574, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI190358497, Length=404, Percent_Identity=32.4257425742574, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI115298650, Length=404, Percent_Identity=32.4257425742574, Blast_Score=180, Evalue=2e-45,
Organism=Escherichia coli, GI1789331, Length=355, Percent_Identity=41.6901408450704, Blast_Score=286, Evalue=2e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF10576 EndIII_4Fe-2S; PF00633 HHH; PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 39649; Mature: 39518

Theoretical pI: Translated: 8.73; Mature: 8.73

Prosite motif: PS01155 ENDONUCLEASE_III_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEDFAVRVIAWQRRHGRHHLPWQNTGDAYRVWLSEIMLQQTQVSAVLGYYARFVERFPT
CCCCCEEHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
VQALAAAPADDVMAAWAGLGYYTRARNLHRCAQIVVAEHGGAFPRDPEALAALPGIGRST
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCHHH
AAAIAAFSYGVRAAILDGNVKRVFARVFGIDGFPGDKRVEETMWRIAETVLPPADGIQSY
HHHHHHHHHCCEEEEECCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHH
TQGLMDLGATVCTRGRPACLTGERACPLESLCEARRTGRVMELPVPRPRKAIPERAATLL
HHHHHHHHHHHHCCCCCCEECCCCCCCHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHH
MALHDGAVLLQRRPQRGIWGGLWSLPLVGDMDTALDAHPVATDVAHAAAQAYGTVSSIES
HHHHCCHHEECCCCCCCCCCCHHCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
AGVLMHTFTHFRLQMHLLRADIRQPAALGDDWRWVPLVRFDTVGMPAPVKLALEMLAQPS
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHCCCC
LV
CC
>Mature Secondary Structure 
PEDFAVRVIAWQRRHGRHHLPWQNTGDAYRVWLSEIMLQQTQVSAVLGYYARFVERFPT
CCCCEEHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
VQALAAAPADDVMAAWAGLGYYTRARNLHRCAQIVVAEHGGAFPRDPEALAALPGIGRST
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCHHH
AAAIAAFSYGVRAAILDGNVKRVFARVFGIDGFPGDKRVEETMWRIAETVLPPADGIQSY
HHHHHHHHHCCEEEEECCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHH
TQGLMDLGATVCTRGRPACLTGERACPLESLCEARRTGRVMELPVPRPRKAIPERAATLL
HHHHHHHHHHHHCCCCCCEECCCCCCCHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHH
MALHDGAVLLQRRPQRGIWGGLWSLPLVGDMDTALDAHPVATDVAHAAAQAYGTVSSIES
HHHHCCHHEECCCCCCCCCCCHHCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
AGVLMHTFTHFRLQMHLLRADIRQPAALGDDWRWVPLVRFDTVGMPAPVKLALEMLAQPS
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHCCCC
LV
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2197596; 2001994; 9278503; 9846876 [H]