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The map label for this gene is ctaB [H]

Identifier: 17545091

GI number: 17545091

Start: 399615

End: 400547

Strand: Direct

Name: ctaB [H]

Synonym: RSc0372

Alternate gene names: 17545091

Gene position: 399615-400547 (Clockwise)

Preceding gene: 17545090

Following gene: 17545092

Centisome position: 10.75

GC content: 65.92

Gene sequence:

>933_bases
ATGAATACCGTGGCTTCCACTTCAACGTCGACCCAACCCTCCGGCTGGCGACACACCGCGTCGCAATATGCGGCGCTGAC
CAAACCGCGTGTGACGCAACTGGCTGTGTTCTGCGCCGTGATCGGCATGTTTCTCGCCACGCCGGGCATGGTGCCGTGGC
CGGTGCTGATCGGCGGCGCCGTCGGCATCTGGCTGTTTGCCGGCGCCGCCTTCGCCATCAACTGCCTGGTCGAGCGCAAG
ATCGACGCGATGATGCGCCGCACGGCCTGGCGCCCGTCGGCCAGCGGCGAGCTGGGGGCGCGGCAGATCCTGCTGTTCTC
GCTGGTGCTCGGCGGCGCGGGCATGTGGACGCTGCATGTGTTCGCCAACGACCTGACGATGTGGCTGACCTTCGCCACCT
TCATCGGCTACGCCATCATCTACACGCTGCTGCTCAAGCCGGCCACGCCGCAGAACATCGTGATCGGCGGCCTGTCGGGC
GCGATGCCGCCGGCGCTGGGGTGGGCTGCGGTGGCCAACAGCGTGCCGGCCGAGGCGTGGATCCTGGTGCTGATCATCTT
TACCTGGACGCCGCCGCATTTCTGGGCACTGGCGCTGTATCGCCGCGCCGACTACGCCAAGTCCGGCCTGCCCATGCTGC
CGATCACGCACGGCGAGAAATTCACGCTGCTGCACATCCTGCTGTACACGCTGATCATGGTCGCCGCCACCATCCTGCCG
TTCGTGCATGGCATGAGCGGCTATCTCTACCTGGCGGTGGCGCTGGTGCTCGGCTTCGGCTTCCTCGTCCATGCGTGGCG
GATGTACCGCAACTATTCGGATGCGCTGGCGCAGAAGACGTTCCGGTACTCGATCGTCTACCTGTCGCTGCTGTTCGCGG
CGCTGCTGATTGACCACTACTTCAAGTTCGGGCCGCAGGGCGCGGCGCTGTGA

Upstream 100 bases:

>100_bases
GCTGCTGTTGCTGCTGATGGTGCGCTTGCATTACCTGATCGGCCTCGCGCAGGCGCGCGCGCCGATGTCTGCGGCAGTGG
CCGCTGTCTGACTGTTTTCT

Downstream 100 bases:

>100_bases
CGCATCGGGCTGTCGGCAAGGGCGCGCGGTTGGCGCTACGCTAGATGGCCGCCTTCGACACGATCCACCATGCTCGTCTT
CCGATTCTTCCGCACCGCGC

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase [H]

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MNTVASTSTSTQPSGWRHTASQYAALTKPRVTQLAVFCAVIGMFLATPGMVPWPVLIGGAVGIWLFAGAAFAINCLVERK
IDAMMRRTAWRPSASGELGARQILLFSLVLGGAGMWTLHVFANDLTMWLTFATFIGYAIIYTLLLKPATPQNIVIGGLSG
AMPPALGWAAVANSVPAEAWILVLIIFTWTPPHFWALALYRRADYAKSGLPMLPITHGEKFTLLHILLYTLIMVAATILP
FVHGMSGYLYLAVALVLGFGFLVHAWRMYRNYSDALAQKTFRYSIVYLSLLFAALLIDHYFKFGPQGAAL

Sequences:

>Translated_310_residues
MNTVASTSTSTQPSGWRHTASQYAALTKPRVTQLAVFCAVIGMFLATPGMVPWPVLIGGAVGIWLFAGAAFAINCLVERK
IDAMMRRTAWRPSASGELGARQILLFSLVLGGAGMWTLHVFANDLTMWLTFATFIGYAIIYTLLLKPATPQNIVIGGLSG
AMPPALGWAAVANSVPAEAWILVLIIFTWTPPHFWALALYRRADYAKSGLPMLPITHGEKFTLLHILLYTLIMVAATILP
FVHGMSGYLYLAVALVLGFGFLVHAWRMYRNYSDALAQKTFRYSIVYLSLLFAALLIDHYFKFGPQGAAL
>Mature_310_residues
MNTVASTSTSTQPSGWRHTASQYAALTKPRVTQLAVFCAVIGMFLATPGMVPWPVLIGGAVGIWLFAGAAFAINCLVERK
IDAMMRRTAWRPSASGELGARQILLFSLVLGGAGMWTLHVFANDLTMWLTFATFIGYAIIYTLLLKPATPQNIVIGGLSG
AMPPALGWAAVANSVPAEAWILVLIIFTWTPPHFWALALYRRADYAKSGLPMLPITHGEKFTLLHILLYTLIMVAATILP
FVHGMSGYLYLAVALVLGFGFLVHAWRMYRNYSDALAQKTFRYSIVYLSLLFAALLIDHYFKFGPQGAAL

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group [H]

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI17921982, Length=194, Percent_Identity=34.5360824742268, Blast_Score=95, Evalue=9e-20,
Organism=Escherichia coli, GI1786631, Length=279, Percent_Identity=32.6164874551971, Blast_Score=141, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI71998235, Length=294, Percent_Identity=27.5510204081633, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6325085, Length=194, Percent_Identity=31.4432989690722, Blast_Score=79, Evalue=6e-16,
Organism=Drosophila melanogaster, GI19921064, Length=282, Percent_Identity=29.4326241134752, Blast_Score=105, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006369
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.-

Molecular weight: Translated: 33936; Mature: 33936

Theoretical pI: Translated: 10.04; Mature: 10.04

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTVASTSTSTQPSGWRHTASQYAALTKPRVTQLAVFCAVIGMFLATPGMVPWPVLIGGA
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
VGIWLFAGAAFAINCLVERKIDAMMRRTAWRPSASGELGARQILLFSLVLGGAGMWTLHV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCEEHHH
FANDLTMWLTFATFIGYAIIYTLLLKPATPQNIVIGGLSGAMPPALGWAAVANSVPAEAW
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHCCCCHHHH
ILVLIIFTWTPPHFWALALYRRADYAKSGLPMLPITHGEKFTLLHILLYTLIMVAATILP
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHH
FVHGMSGYLYLAVALVLGFGFLVHAWRMYRNYSDALAQKTFRYSIVYLSLLFAALLIDHY
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FKFGPQGAAL
HHCCCCCCCC
>Mature Secondary Structure
MNTVASTSTSTQPSGWRHTASQYAALTKPRVTQLAVFCAVIGMFLATPGMVPWPVLIGGA
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
VGIWLFAGAAFAINCLVERKIDAMMRRTAWRPSASGELGARQILLFSLVLGGAGMWTLHV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCEEHHH
FANDLTMWLTFATFIGYAIIYTLLLKPATPQNIVIGGLSGAMPPALGWAAVANSVPAEAW
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHCCCCHHHH
ILVLIIFTWTPPHFWALALYRRADYAKSGLPMLPITHGEKFTLLHILLYTLIMVAATILP
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHH
FVHGMSGYLYLAVALVLGFGFLVHAWRMYRNYSDALAQKTFRYSIVYLSLLFAALLIDHY
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FKFGPQGAAL
HHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]