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The map label for this gene is lysN [H]

Identifier: 17544948

GI number: 17544948

Start: 250678

End: 251886

Strand: Direct

Name: lysN [H]

Synonym: RSc0229

Alternate gene names: 17544948

Gene position: 250678-251886 (Clockwise)

Preceding gene: 17544947

Following gene: 17544951

Centisome position: 6.75

GC content: 71.38

Gene sequence:

>1209_bases
ATGGATTTCCTGCAATCGTTGCTCGCCCCCCGCCTGCAAAACGTCGAGACTTCGGCCATCCGCGAACTCTTCAAGGTGCT
CGGCAAGCCGGGCCTGATTTCGTTTGCCGGCGGCTTTCCGGATGCGGCGCTGTTCGACGTCGAGGGCCTGAAGGCCGCCG
CCGACAGCGCGCTCGCCACCGACGCGGCGCGCGCGCTGCAATACGGCGCCACCGAGGGGTTCGAGCCGCTGCGCGAAGCC
ATCGTCACGCTGATGCAGGCGCGCGGCGCCACGGTGGCCAACACCGACATCCTCGTCACCACCGGCTCGCAGCAGGGGCT
GGACCTGCTGGGCAAGGTGCTGATCGGCGAAGGCGACACGGTGCTGACCGAGGCCCCGACCTTCCTCGCCGCCATCCAGG
CCTTCAAGCTGTATGGCGCCAAGGTGGCCGGCGTGCCGACCGATGAAGACGGCCTGGACCTCGATGCGCTGGAGCGCGCG
CTCGCCGCCGGCCGCCCCAAGTTCCTCTACGTGATCCCCAACTTCGGCAACCCGAGCGGCGCGCTGATGAGCCTGGAGCG
CCGCCGGCGCCTGCTGGCGCTGGCCGTGCGCCATGACCTGCTGATCGTCGAGGACGACCCGTATGGCGAGCTGTACTTCG
ACGCGCCGCCGCCGCCTTCGCTGTTCGCGCTCAGCCAGCAGACCGACGGCGCGCAGGGCCGCGTGGTCTACCTGGGCAGC
CTGTCCAAGGTGGTGGCGCCGGGCCTGCGGGTGGGCTGGATGATCGCGCCGTCGCTGGTGCTGTCCAACGCGGTGATGGT
CAAGCAGTTTGCCGACGCGCACACCTCCACCTTCGCGCAGGCCACCGCCGCCGCCTACCTGCGCAGCCAGCGCATGGAGA
CCGTGCTGCCGCGCACGCGCGCCGCCTATGCCGAGCGCGCCCACGCCATGGCCGACGGCCTGCGCGCGCTGCTGCCCGAG
GCCGAACTGACCTTCAACCGTCCGCGCGGCGGCATGTTCCTGTGGGGTCGCCTGCCCGGCCGCAACGCGGCGGACGTCGC
CCGGATCGCCATCGAGCGCGGCGTGGCCTTCGTGCCGGGGGCGGCGTTCTATCCGGTCGATCCGGACCGCTCGACGCTGC
GCCTGTCGTATGCCACCTCGTCGCTTGCCCAGGTGGAGGAGGGGGTACGCAAGCTGGCGGGGGCGATCGGCGAGCTGGCG
GCCGCCTGA

Upstream 100 bases:

>100_bases
CATCGCCGGCATCCGGCGTAATCCGCATGCGCGCGCGAGCGACATCACGTAAAGTGCGGGCACTCGAATCTGATTTCCCT
TTCTTCATTTCCCGCACGCC

Downstream 100 bases:

>100_bases
GGGGGGCGTCGCTCTGCACCAGCGCTCTCATGAGGTGGGGCGCTGATTCGTCATCTGGCATCGGCCGTGCGGGATAGGGC
GGGCGCTTCGACGGCACGTC

Product: AMINNO transferase

Products: NA

Alternate protein names: 2-aminoadipate aminotransferase; Alpha-aminoadipate aminotransferase; AAA-AT; AadAT [H]

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MDFLQSLLAPRLQNVETSAIRELFKVLGKPGLISFAGGFPDAALFDVEGLKAAADSALATDAARALQYGATEGFEPLREA
IVTLMQARGATVANTDILVTTGSQQGLDLLGKVLIGEGDTVLTEAPTFLAAIQAFKLYGAKVAGVPTDEDGLDLDALERA
LAAGRPKFLYVIPNFGNPSGALMSLERRRRLLALAVRHDLLIVEDDPYGELYFDAPPPPSLFALSQQTDGAQGRVVYLGS
LSKVVAPGLRVGWMIAPSLVLSNAVMVKQFADAHTSTFAQATAAAYLRSQRMETVLPRTRAAYAERAHAMADGLRALLPE
AELTFNRPRGGMFLWGRLPGRNAADVARIAIERGVAFVPGAAFYPVDPDRSTLRLSYATSSLAQVEEGVRKLAGAIGELA
AA

Sequences:

>Translated_402_residues
MDFLQSLLAPRLQNVETSAIRELFKVLGKPGLISFAGGFPDAALFDVEGLKAAADSALATDAARALQYGATEGFEPLREA
IVTLMQARGATVANTDILVTTGSQQGLDLLGKVLIGEGDTVLTEAPTFLAAIQAFKLYGAKVAGVPTDEDGLDLDALERA
LAAGRPKFLYVIPNFGNPSGALMSLERRRRLLALAVRHDLLIVEDDPYGELYFDAPPPPSLFALSQQTDGAQGRVVYLGS
LSKVVAPGLRVGWMIAPSLVLSNAVMVKQFADAHTSTFAQATAAAYLRSQRMETVLPRTRAAYAERAHAMADGLRALLPE
AELTFNRPRGGMFLWGRLPGRNAADVARIAIERGVAFVPGAAFYPVDPDRSTLRLSYATSSLAQVEEGVRKLAGAIGELA
AA
>Mature_402_residues
MDFLQSLLAPRLQNVETSAIRELFKVLGKPGLISFAGGFPDAALFDVEGLKAAADSALATDAARALQYGATEGFEPLREA
IVTLMQARGATVANTDILVTTGSQQGLDLLGKVLIGEGDTVLTEAPTFLAAIQAFKLYGAKVAGVPTDEDGLDLDALERA
LAAGRPKFLYVIPNFGNPSGALMSLERRRRLLALAVRHDLLIVEDDPYGELYFDAPPPPSLFALSQQTDGAQGRVVYLGS
LSKVVAPGLRVGWMIAPSLVLSNAVMVKQFADAHTSTFAQATAAAYLRSQRMETVLPRTRAAYAERAHAMADGLRALLPE
AELTFNRPRGGMFLWGRLPGRNAADVARIAIERGVAFVPGAAFYPVDPDRSTLRLSYATSSLAQVEEGVRKLAGAIGELA
AA

Specific function: Catalyzes the transfer of an amino group between 2- oxoadipate (2-OA) and glutamate (Glu) to yield alpha-aminodipate (AAA). It can also transaminate glutamate, leucine, and aromatic amino acids. It also conbtributes in the biosynthesis of other amino acid

COG id: COG1167

COG function: function code KE; Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7705897, Length=417, Percent_Identity=29.4964028776978, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI33469970, Length=417, Percent_Identity=29.4964028776978, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI95147551, Length=430, Percent_Identity=23.7209302325581, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI169881279, Length=430, Percent_Identity=23.7209302325581, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI4507369, Length=250, Percent_Identity=26.8, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1790797, Length=368, Percent_Identity=29.3478260869565, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI1787710, Length=384, Percent_Identity=28.6458333333333, Blast_Score=148, Evalue=5e-37,
Organism=Escherichia coli, GI1788722, Length=344, Percent_Identity=28.7790697674419, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1786816, Length=392, Percent_Identity=24.234693877551, Blast_Score=62, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6321236, Length=400, Percent_Identity=25.5, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6321000, Length=439, Percent_Identity=26.1958997722096, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6321929, Length=320, Percent_Identity=25, Blast_Score=100, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6322401, Length=241, Percent_Identity=25.7261410788382, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21356535, Length=383, Percent_Identity=26.8929503916449, Blast_Score=132, Evalue=5e-31,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.39 [H]

Molecular weight: Translated: 42724; Mature: 42724

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFLQSLLAPRLQNVETSAIRELFKVLGKPGLISFAGGFPDAALFDVEGLKAAADSALAT
CHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEECCCCCCCEEEECCCHHHHHHHHHHH
DAARALQYGATEGFEPLREAIVTLMQARGATVANTDILVTTGSQQGLDLLGKVLIGEGDT
HHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEECCEEEEECCCCCCHHHHHHHHCCCCCE
VLTEAPTFLAAIQAFKLYGAKVAGVPTDEDGLDLDALERALAAGRPKFLYVIPNFGNPSG
EEECCHHHHHHHHHHHHHCCEEECCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCH
ALMSLERRRRLLALAVRHDLLIVEDDPYGELYFDAPPPPSLFALSQQTDGAQGRVVYLGS
HHHHHHHHHHHHHHHHHCCEEEEECCCCCCEEECCCCCCCEEEECCCCCCCCCEEEEECC
LSKVVAPGLRVGWMIAPSLVLSNAVMVKQFADAHTSTFAQATAAAYLRSQRMETVLPRTR
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAYAERAHAMADGLRALLPEAELTFNRPRGGMFLWGRLPGRNAADVARIAIERGVAFVPG
HHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEECCCCCHHHHHHHHHHCCCEECCC
AAFYPVDPDRSTLRLSYATSSLAQVEEGVRKLAGAIGELAAA
CEECCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDFLQSLLAPRLQNVETSAIRELFKVLGKPGLISFAGGFPDAALFDVEGLKAAADSALAT
CHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEECCCCCCCEEEECCCHHHHHHHHHHH
DAARALQYGATEGFEPLREAIVTLMQARGATVANTDILVTTGSQQGLDLLGKVLIGEGDT
HHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEECCEEEEECCCCCCHHHHHHHHCCCCCE
VLTEAPTFLAAIQAFKLYGAKVAGVPTDEDGLDLDALERALAAGRPKFLYVIPNFGNPSG
EEECCHHHHHHHHHHHHHCCEEECCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCH
ALMSLERRRRLLALAVRHDLLIVEDDPYGELYFDAPPPPSLFALSQQTDGAQGRVVYLGS
HHHHHHHHHHHHHHHHHCCEEEEECCCCCCEEECCCCCCCEEEECCCCCCCCCEEEEECC
LSKVVAPGLRVGWMIAPSLVLSNAVMVKQFADAHTSTFAQATAAAYLRSQRMETVLPRTR
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAYAERAHAMADGLRALLPEAELTFNRPRGGMFLWGRLPGRNAADVARIAIERGVAFVPG
HHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEECCCCCHHHHHHHHHHCCCEECCC
AAFYPVDPDRSTLRLSYATSSLAQVEEGVRKLAGAIGELAAA
CEECCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA