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The map label for this gene is deoA [C]

Identifier: 17544923

GI number: 17544923

Start: 225922

End: 227445

Strand: Direct

Name: deoA [C]

Synonym: RSc0204

Alternate gene names: 17544923

Gene position: 225922-227445 (Clockwise)

Preceding gene: 17544922

Following gene: 17544925

Centisome position: 6.08

GC content: 63.12

Gene sequence:

>1524_bases
ATGCTCGCTCCGCCTGAGGTGGCAGCACTGCCCGATCGGCTTACCTTCAAGCCGTTGGGCATCGACACTTGGCAGGAGCA
CGTCATCTACATGCATCCGGATTGCGCAATCTGCCGGGCTGAGGGGTTCACTGCACAAGCTCGGGTGGAGGTGCGGATCG
GTCTGCGCTCCTTGATTGCCACACTCAATCTCGTCGGCTCAGGCTTGCTGGAGATGTGTGAGGTCAGCTTGTCCGTCAGC
GCCGTCGAGACGCTGATGGCGAGGCCCGGCGATATTGTGACTGTCAGTCACGCGCCCGCGCTGGAGTCGCTGCGGGCGGT
ACGCGCCAAGATCTATGGGGCGCATCTGGATACGCATCAACTGGCTAGCGTCGTCGGTGATATTGCCAAAGAGCGGTATG
CCGACGTCCACATTGCGGCGTTCCTGAGCGCCTGCGCAGGCGGGCGAATGAGCGTCAAGGAGACAATCGATCTCACCCAG
GCCATGGTCGACTCGGGCGAATGTCTCGAATGGGATCGCGAGATCGTCGCGGACAAGCACTGTGTGGGCGGCTTGCCGGG
CAACCGTACCAGTCCCATCGTGGTCGCCATCGCTGCCGCTGCAGGCTTGTTGCTACCTAAGACCTCGTCGCGCGCCATCA
CGTCACCCGCCGGTACCGCCGACACGATGGAGACACTCACGCGTGTTGCTCTGAGCGCCACGGAGTTGCGACGCGTCGTT
GATCGGGTTGGAGCTTCGCTCGCGTGGGGCGGTGCGCTCAGCCTTAGCCCCGCCGACGACGTGCTCATTCGCGTGGAGCG
GGCGTTGGATGTGGATAGCGATGCCCAACTTGCGGCCTCCATTCTGTCGAAGAAGATCGCGGCCGGGTCAACCCATGTCT
TGATCGACGTGCCCGTGGGGCCGACGGCCAAGGTGCGCAGTCTGCAGGATTTGGAGCGCCTGCGTATGCTGCTCGAGCGC
GTAGCGCGGTCGTTCGGCGTGCGCGTCACGATCGTGCGCACGGACGGCTCGCAGCCGGTTGGCAGGGGAATTGGTCCGGC
GCTTGAAGCACGAGACGTCTTGGCCGTGCTTCAACGCTCTCCTGCGGCGCCGTTCGACCTGCGGGAGCGGTCGTTGTTGC
TGGCTGCGACTCTGCTAGAGTTTTGTGGGGCGGTGGAGCAGGGGGCAGGGCTTGAGATGGCCACAGGCGTGCTGGACAGT
GGTGCGGCGTGGCGGAAGTTCGAGGAAATCTGCGAAGCGCAGGGAGGCCTGCGTGTGCCAGGTGAGGCCATCTTCCGTCG
TGATGTGGTAGCTGAGCAAGACGGCATCGTCACCGAGATCGACAACCGACATCTTGCTCGTATCGCGAAACTCGCGGGGG
CTCCGATGCGCCAAGTGGCAGGCGTGGAGATGCACGTGAGACTACACGACCAGGTTAAGGCGGGGCGGCCTCTCTTTACC
ATCCATGCCCAGGCTTCAGGTGAACTGGAATATTCCGTAGCTTATGCACTGATGCACCCAGCGGTTTCCATCGCCCCGAC
TTGA

Upstream 100 bases:

>100_bases
GTTGCCCGAGCCATGTTCGAGATGACAGGGTCCAAACAGATCACCCTGCATAGCGGCCACTTCCGCTTTCGCTTGTGAGT
CGTCTTGAAGAGTCGTCGCC

Downstream 100 bases:

>100_bases
AAGGGTTGATGTCGAGAGCCACTGAATTCTGAACCTGTGGGACGGGATTTATAGGCGTTCCCGGCAGAGGTGCTCGGCCA
ACTTTGAACGCTTGGTTCGC

Product: thymidine phosphorylase

Products: NA

Alternate protein names: TdRPase

Number of amino acids: Translated: 507; Mature: 507

Protein sequence:

>507_residues
MLAPPEVAALPDRLTFKPLGIDTWQEHVIYMHPDCAICRAEGFTAQARVEVRIGLRSLIATLNLVGSGLLEMCEVSLSVS
AVETLMARPGDIVTVSHAPALESLRAVRAKIYGAHLDTHQLASVVGDIAKERYADVHIAAFLSACAGGRMSVKETIDLTQ
AMVDSGECLEWDREIVADKHCVGGLPGNRTSPIVVAIAAAAGLLLPKTSSRAITSPAGTADTMETLTRVALSATELRRVV
DRVGASLAWGGALSLSPADDVLIRVERALDVDSDAQLAASILSKKIAAGSTHVLIDVPVGPTAKVRSLQDLERLRMLLER
VARSFGVRVTIVRTDGSQPVGRGIGPALEARDVLAVLQRSPAAPFDLRERSLLLAATLLEFCGAVEQGAGLEMATGVLDS
GAAWRKFEEICEAQGGLRVPGEAIFRRDVVAEQDGIVTEIDNRHLARIAKLAGAPMRQVAGVEMHVRLHDQVKAGRPLFT
IHAQASGELEYSVAYALMHPAVSIAPT

Sequences:

>Translated_507_residues
MLAPPEVAALPDRLTFKPLGIDTWQEHVIYMHPDCAICRAEGFTAQARVEVRIGLRSLIATLNLVGSGLLEMCEVSLSVS
AVETLMARPGDIVTVSHAPALESLRAVRAKIYGAHLDTHQLASVVGDIAKERYADVHIAAFLSACAGGRMSVKETIDLTQ
AMVDSGECLEWDREIVADKHCVGGLPGNRTSPIVVAIAAAAGLLLPKTSSRAITSPAGTADTMETLTRVALSATELRRVV
DRVGASLAWGGALSLSPADDVLIRVERALDVDSDAQLAASILSKKIAAGSTHVLIDVPVGPTAKVRSLQDLERLRMLLER
VARSFGVRVTIVRTDGSQPVGRGIGPALEARDVLAVLQRSPAAPFDLRERSLLLAATLLEFCGAVEQGAGLEMATGVLDS
GAAWRKFEEICEAQGGLRVPGEAIFRRDVVAEQDGIVTEIDNRHLARIAKLAGAPMRQVAGVEMHVRLHDQVKAGRPLFT
IHAQASGELEYSVAYALMHPAVSIAPT
>Mature_507_residues
MLAPPEVAALPDRLTFKPLGIDTWQEHVIYMHPDCAICRAEGFTAQARVEVRIGLRSLIATLNLVGSGLLEMCEVSLSVS
AVETLMARPGDIVTVSHAPALESLRAVRAKIYGAHLDTHQLASVVGDIAKERYADVHIAAFLSACAGGRMSVKETIDLTQ
AMVDSGECLEWDREIVADKHCVGGLPGNRTSPIVVAIAAAAGLLLPKTSSRAITSPAGTADTMETLTRVALSATELRRVV
DRVGASLAWGGALSLSPADDVLIRVERALDVDSDAQLAASILSKKIAAGSTHVLIDVPVGPTAKVRSLQDLERLRMLLER
VARSFGVRVTIVRTDGSQPVGRGIGPALEARDVLAVLQRSPAAPFDLRERSLLLAATLLEFCGAVEQGAGLEMATGVLDS
GAAWRKFEEICEAQGGLRVPGEAIFRRDVVAEQDGIVTEIDNRHLARIAKLAGAPMRQVAGVEMHVRLHDQVKAGRPLFT
IHAQASGELEYSVAYALMHPAVSIAPT

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI166158925, Length=406, Percent_Identity=30.0492610837438, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI4503445, Length=406, Percent_Identity=30.0492610837438, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI166158922, Length=406, Percent_Identity=30.0492610837438, Blast_Score=120, Evalue=4e-27,
Organism=Escherichia coli, GI1790842, Length=400, Percent_Identity=28.75, Blast_Score=115, Evalue=6e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TYPH_RALSO (Q8Y2X7)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_518325.1
- ProteinModelPortal:   Q8Y2X7
- SMR:   Q8Y2X7
- GeneID:   1219007
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc0204
- NMPDR:   fig|267608.1.peg.204
- HOGENOM:   HBG460532
- OMA:   GGTADLM
- ProtClustDB:   PRK04350
- BioCyc:   RSOL267608:RSC0204-MONOMER
- BRENDA:   2.4.2.4
- HAMAP:   MF_00703
- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR000053
- InterPro:   IPR017872
- InterPro:   IPR013466
- Gene3D:   G3DSA:1.20.970.10
- Gene3D:   G3DSA:3.40.1030.10
- PANTHER:   PTHR10515
- PIRSF:   PIRSF000478
- SMART:   SM00941
- TIGRFAMs:   TIGR02645

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C; SSF47648 Glyco_trans_3; SSF52418 Glyco_trans_3; SSF54680 PYNP_C

EC number: =2.4.2.4

Molecular weight: Translated: 53887; Mature: 53887

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAPPEVAALPDRLTFKPLGIDTWQEHVIYMHPDCAICRAEGFTAQARVEVRIGLRSLIA
CCCCCCCCCCCCCCEEEECCCCCHHCCEEEECCCCEEEECCCCCEEEEEEEEHHHHHHHH
TLNLVGSGLLEMCEVSLSVSAVETLMARPGDIVTVSHAPALESLRAVRAKIYGAHLDTHQ
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCHHH
LASVVGDIAKERYADVHIAAFLSACAGGRMSVKETIDLTQAMVDSGECLEWDREIVADKH
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCH
CVGGLPGNRTSPIVVAIAAAAGLLLPKTSSRAITSPAGTADTMETLTRVALSATELRRVV
HCCCCCCCCCCCCEEEEEHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
DRVGASLAWGGALSLSPADDVLIRVERALDVDSDAQLAASILSKKIAAGSTHVLIDVPVG
HHHCCCEECCCEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCC
PTAKVRSLQDLERLRMLLERVARSFGVRVTIVRTDGSQPVGRGIGPALEARDVLAVLQRS
CCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCC
PAAPFDLRERSLLLAATLLEFCGAVEQGAGLEMATGVLDSGAAWRKFEEICEAQGGLRVP
CCCCCCHHHHHHHHHHHHHHHHCCHHCCCCCHHHHCCCCCCHHHHHHHHHHHHCCCCCCC
GEAIFRRDVVAEQDGIVTEIDNRHLARIAKLAGAPMRQVAGVEMHVRLHDQVKAGRPLFT
HHHHHHHHHHHCCCCCEEECCCHHHHHHHHHCCCCHHHHCCCEEEEEEHHHHCCCCCEEE
IHAQASGELEYSVAYALMHPAVSIAPT
EEECCCCCCHHHHHHHHHCCCEECCCC
>Mature Secondary Structure
MLAPPEVAALPDRLTFKPLGIDTWQEHVIYMHPDCAICRAEGFTAQARVEVRIGLRSLIA
CCCCCCCCCCCCCCEEEECCCCCHHCCEEEECCCCEEEECCCCCEEEEEEEEHHHHHHHH
TLNLVGSGLLEMCEVSLSVSAVETLMARPGDIVTVSHAPALESLRAVRAKIYGAHLDTHQ
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCHHH
LASVVGDIAKERYADVHIAAFLSACAGGRMSVKETIDLTQAMVDSGECLEWDREIVADKH
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCH
CVGGLPGNRTSPIVVAIAAAAGLLLPKTSSRAITSPAGTADTMETLTRVALSATELRRVV
HCCCCCCCCCCCCEEEEEHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
DRVGASLAWGGALSLSPADDVLIRVERALDVDSDAQLAASILSKKIAAGSTHVLIDVPVG
HHHCCCEECCCEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCC
PTAKVRSLQDLERLRMLLERVARSFGVRVTIVRTDGSQPVGRGIGPALEARDVLAVLQRS
CCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCC
PAAPFDLRERSLLLAATLLEFCGAVEQGAGLEMATGVLDSGAAWRKFEEICEAQGGLRVP
CCCCCCHHHHHHHHHHHHHHHHCCHHCCCCCHHHHCCCCCCHHHHHHHHHHHHCCCCCCC
GEAIFRRDVVAEQDGIVTEIDNRHLARIAKLAGAPMRQVAGVEMHVRLHDQVKAGRPLFT
HHHHHHHHHHHCCCCCEEECCCHHHHHHHHHCCCCHHHHCCCEEEEEEHHHHCCCCCEEE
IHAQASGELEYSVAYALMHPAVSIAPT
EEECCCCCCHHHHHHHHHCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852