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The map label for this gene is glmS

Identifier: 17544897

GI number: 17544897

Start: 200835

End: 202673

Strand: Direct

Name: glmS

Synonym: RSc0178

Alternate gene names: 17544897

Gene position: 200835-202673 (Clockwise)

Preceding gene: 17544896

Following gene: 17544901

Centisome position: 5.4

GC content: 69.0

Gene sequence:

>1839_bases
ATGTGCGGCATCGTCGGCGCGGTTTCCACGCGCAATATCGTTCCCGTCCTGATCGAAGGCCTGCGCCGCCTGGAGTACCG
CGGCTATGACTCCTGCGGCGTGGCCGTGCAGCGCGACGGCCAGCTGGAGCGCGCCCGCACCGTCTCGCGCGTGGCCGACC
TGGACACGCAGGCGCAGTCGAGCCACCTGGACGGCGCCATCGGCATCGCCCACACCCGCTGGGCCACGCACGGCCGGCCG
GACACCGTCAACGCCCACCCGCACTTCTCGGGCGACACCATCGCCCTGGTGCACAACGGCATCATCGAGAACTACGAAAC
GCTGCGCGAAGAGCTGAAGGCCGTCGGCTACGGCTTCGAATCGCAGACCGATACCGAGGTGGTCGCCCACCTGATCCACC
AGGCCTACACCTACCCGAGCAGCGCCACGCGCGGCCACCTGTTCGCCTCGGTGCGCGCGGTGGTCAAGCGCCTGCACGGC
GCCTACGCGATCGCCGTGTTCGCGCGCGACAACCCCGACGTGGTGGTGGGCGCGCGCGCCGGCTCGCCGCTGGTGGTGGC
GCTGGGCGACAACGAATCGTTCCTGGCCTCCGACGCACTGGCCGTGGCCGGCACCGCCAACCGCATCGTCTACCTGGAAG
AGGGCGATGTGGTCGAGCTCACCCGCGAGGGCCTCACCGTGGCCGACGCGCGCGACCACGTGGTCGAGCGCGAGGTCAAG
GTGGTCGAGGCGCACGCCGCCGCCGTGGAGCTGGGTCCGTACCGCCACTTCATGCAGAAGGAAATCTTCGAGCAGCCGCG
CGCGCTGGGCGACACGCTGGAAGGCGTGCAGGGCTTCGCGCCCGACCTGTTCGGGCCGCGCGCCGCCGAGGTGCTGCCCA
AGGTCGACAGCGTGCTGATCCTGGCCTGCGGCACCAGCTACTACTCGGGCTGCACCGCCAAGTACTGGCTCGAATCGATC
GCCAAGATCCCCACCCAGGTGGAAGTGGCCAGCGAATACCGCTACCGCGACACGGTGCCCAACCCCAACGCGCTCGTCGT
CGTGATCTCGCAATCGGGTGAAACCGCCGACACGCTGGCCGCGCTGCGCCACGCGCGCGAGCTGGGCCACACGCACACGC
TGGCCATCTGCAACGTGGCGACCAGCGCCATGGTGCGCGAGACCGAGCTCAGGTTCCTCACGCGCGCCGGCACCGAGATC
GGCGTGGCGTCCACCAAGGCCTTCACCACGCAGCTCGCCGCGCTGTACATGCTGGCGCTGACGTTCGCCAAGCTGCGCGG
CCACTTGAAGGCCGAGGCCGAGGAAGTCGCGTTGCGCCAGCTGCGCCACCTGCCGTCGGCGCTCAACGCGGTGCTGGCGC
TCGAGCCGCAGATCATCGCGTGGTCGGAAGAATTCACCCGCCGCGAGAACGCGCTGTTCCTCGGCCGCGGCCTGCACTTC
CCGATCGCCATGGAAGGCGCGCTCAAGCTCAAGGAGATCTCCTACATCCACGCCGAGGCGTACCCCGCCGGCGAACTCAA
GCACGGCCCGCTCGCGCTGGTGACCGAGCAGATGCCGGTGGTGACGGTCGCGCCCAACGACGCGCTGCTGGAGAAGCTCA
AGTCCAACATCCAGGAAGTGCGCGCGCGCGGCGGCAAGCTCTACGTGTTCGCCGATGCCGACACGCATATCCAGTCGAGC
GACGGCATCCAGGTGATCCGCATGCCCGAGCACTATGGGCAGCTGTCGCCGATCCTGCACGTGGTGCCGCTGCAGCTGCT
GGCGTATCACACCGCCGTGGCGCGCGGGACGGATGTGGATAAGCCGCGGAATTTGGCTAAGTCTGTGACGGTGGAGTGA

Upstream 100 bases:

>100_bases
TGCGCCGAACAGCGGATGCCGTTGCGGCGCCTGAGCATCGATACTGAATGAAGATCGAGTGCAGCGCGCTGCGCGCTGTG
CTCCAACCGGAGAAATCAAC

Downstream 100 bases:

>100_bases
GGGGGCGGTAGTGCTGTTGTCCTTGTAACGGCAGACAAAAAAGTCTGTACCAGGTCCGCAGTTGAAACGTATAGGCACCG
GTCTGCCCCGATTAAGCGGG

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase

Number of amino acids: Translated: 612; Mature: 612

Protein sequence:

>612_residues
MCGIVGAVSTRNIVPVLIEGLRRLEYRGYDSCGVAVQRDGQLERARTVSRVADLDTQAQSSHLDGAIGIAHTRWATHGRP
DTVNAHPHFSGDTIALVHNGIIENYETLREELKAVGYGFESQTDTEVVAHLIHQAYTYPSSATRGHLFASVRAVVKRLHG
AYAIAVFARDNPDVVVGARAGSPLVVALGDNESFLASDALAVAGTANRIVYLEEGDVVELTREGLTVADARDHVVEREVK
VVEAHAAAVELGPYRHFMQKEIFEQPRALGDTLEGVQGFAPDLFGPRAAEVLPKVDSVLILACGTSYYSGCTAKYWLESI
AKIPTQVEVASEYRYRDTVPNPNALVVVISQSGETADTLAALRHARELGHTHTLAICNVATSAMVRETELRFLTRAGTEI
GVASTKAFTTQLAALYMLALTFAKLRGHLKAEAEEVALRQLRHLPSALNAVLALEPQIIAWSEEFTRRENALFLGRGLHF
PIAMEGALKLKEISYIHAEAYPAGELKHGPLALVTEQMPVVTVAPNDALLEKLKSNIQEVRARGGKLYVFADADTHIQSS
DGIQVIRMPEHYGQLSPILHVVPLQLLAYHTAVARGTDVDKPRNLAKSVTVE

Sequences:

>Translated_612_residues
MCGIVGAVSTRNIVPVLIEGLRRLEYRGYDSCGVAVQRDGQLERARTVSRVADLDTQAQSSHLDGAIGIAHTRWATHGRP
DTVNAHPHFSGDTIALVHNGIIENYETLREELKAVGYGFESQTDTEVVAHLIHQAYTYPSSATRGHLFASVRAVVKRLHG
AYAIAVFARDNPDVVVGARAGSPLVVALGDNESFLASDALAVAGTANRIVYLEEGDVVELTREGLTVADARDHVVEREVK
VVEAHAAAVELGPYRHFMQKEIFEQPRALGDTLEGVQGFAPDLFGPRAAEVLPKVDSVLILACGTSYYSGCTAKYWLESI
AKIPTQVEVASEYRYRDTVPNPNALVVVISQSGETADTLAALRHARELGHTHTLAICNVATSAMVRETELRFLTRAGTEI
GVASTKAFTTQLAALYMLALTFAKLRGHLKAEAEEVALRQLRHLPSALNAVLALEPQIIAWSEEFTRRENALFLGRGLHF
PIAMEGALKLKEISYIHAEAYPAGELKHGPLALVTEQMPVVTVAPNDALLEKLKSNIQEVRARGGKLYVFADADTHIQSS
DGIQVIRMPEHYGQLSPILHVVPLQLLAYHTAVARGTDVDKPRNLAKSVTVE
>Mature_612_residues
MCGIVGAVSTRNIVPVLIEGLRRLEYRGYDSCGVAVQRDGQLERARTVSRVADLDTQAQSSHLDGAIGIAHTRWATHGRP
DTVNAHPHFSGDTIALVHNGIIENYETLREELKAVGYGFESQTDTEVVAHLIHQAYTYPSSATRGHLFASVRAVVKRLHG
AYAIAVFARDNPDVVVGARAGSPLVVALGDNESFLASDALAVAGTANRIVYLEEGDVVELTREGLTVADARDHVVEREVK
VVEAHAAAVELGPYRHFMQKEIFEQPRALGDTLEGVQGFAPDLFGPRAAEVLPKVDSVLILACGTSYYSGCTAKYWLESI
AKIPTQVEVASEYRYRDTVPNPNALVVVISQSGETADTLAALRHARELGHTHTLAICNVATSAMVRETELRFLTRAGTEI
GVASTKAFTTQLAALYMLALTFAKLRGHLKAEAEEVALRQLRHLPSALNAVLALEPQIIAWSEEFTRRENALFLGRGLHF
PIAMEGALKLKEISYIHAEAYPAGELKHGPLALVTEQMPVVTVAPNDALLEKLKSNIQEVRARGGKLYVFADADTHIQSS
DGIQVIRMPEHYGQLSPILHVVPLQLLAYHTAVARGTDVDKPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains

Homologues:

Organism=Homo sapiens, GI4826742, Length=686, Percent_Identity=36.8804664723032, Blast_Score=414, Evalue=1e-115,
Organism=Homo sapiens, GI205277386, Length=688, Percent_Identity=36.4825581395349, Blast_Score=405, Evalue=1e-113,
Organism=Escherichia coli, GI1790167, Length=616, Percent_Identity=54.3831168831169, Blast_Score=647, Evalue=0.0,
Organism=Escherichia coli, GI87082251, Length=322, Percent_Identity=22.9813664596273, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17539970, Length=718, Percent_Identity=35.2367688022284, Blast_Score=369, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17532899, Length=715, Percent_Identity=33.986013986014, Blast_Score=354, Evalue=9e-98,
Organism=Caenorhabditis elegans, GI17532897, Length=429, Percent_Identity=38.2284382284382, Blast_Score=284, Evalue=9e-77,
Organism=Caenorhabditis elegans, GI17554892, Length=248, Percent_Identity=26.2096774193548, Blast_Score=69, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6322745, Length=444, Percent_Identity=38.5135135135135, Blast_Score=276, Evalue=6e-75,
Organism=Saccharomyces cerevisiae, GI6323731, Length=433, Percent_Identity=30.4849884526559, Blast_Score=204, Evalue=5e-53,
Organism=Saccharomyces cerevisiae, GI6323730, Length=207, Percent_Identity=37.1980676328502, Blast_Score=119, Evalue=1e-27,
Organism=Drosophila melanogaster, GI21357745, Length=690, Percent_Identity=36.231884057971, Blast_Score=399, Evalue=1e-111,
Organism=Drosophila melanogaster, GI28573187, Length=264, Percent_Identity=26.8939393939394, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24659598, Length=264, Percent_Identity=24.6212121212121, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMS_RALSO (Q8Y303)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_518299.1
- ProteinModelPortal:   Q8Y303
- SMR:   Q8Y303
- GeneID:   1218981
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc0178
- NMPDR:   fig|267608.1.peg.178
- HOGENOM:   HBG645312
- OMA:   LGIGENF
- ProtClustDB:   PRK00331
- BioCyc:   RSOL267608:RSC0178-MONOMER
- BRENDA:   2.6.1.16
- GO:   GO:0005737
- HAMAP:   MF_00164
- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347
- TIGRFAMs:   TIGR01135

Pfam domain/function: PF00310 GATase_2; PF01380 SIS

EC number: =2.6.1.16

Molecular weight: Translated: 66556; Mature: 66556

Theoretical pI: Translated: 6.48; Mature: 6.48

Prosite motif: PS51278 GATASE_TYPE_2; PS51464 SIS; PS00443 GATASE_TYPE_II

Important sites: ACT_SITE 2-2 ACT_SITE 607-607

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGAVSTRNIVPVLIEGLRRLEYRGYDSCGVAVQRDGQLERARTVSRVADLDTQAQS
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHCCCHHHH
SHLDGAIGIAHTRWATHGRPDTVNAHPHFSGDTIALVHNGIIENYETLREELKAVGYGFE
CCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCCC
SQTDTEVVAHLIHQAYTYPSSATRGHLFASVRAVVKRLHGAYAIAVFARDNPDVVVGARA
CCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEECC
GSPLVVALGDNESFLASDALAVAGTANRIVYLEEGDVVELTREGLTVADARDHVVEREVK
CCCEEEEECCCCCCHHCCCEEEECCCCEEEEEECCCEEEEHHCCCEEECHHHHHHHHHHH
VVEAHAAAVELGPYRHFMQKEIFEQPRALGDTLEGVQGFAPDLFGPRAAEVLPKVDSVLI
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCEEE
LACGTSYYSGCTAKYWLESIAKIPTQVEVASEYRYRDTVPNPNALVVVISQSGETADTLA
EEECCHHHCCCCHHHHHHHHHHCCCEEEHHHHCHHCCCCCCCCEEEEEEECCCCHHHHHH
ALRHARELGHTHTLAICNVATSAMVRETELRFLTRAGTEIGVASTKAFTTQLAALYMLAL
HHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
TFAKLRGHLKAEAEEVALRQLRHLPSALNAVLALEPQIIAWSEEFTRRENALFLGRGLHF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHCCCEEEEECCCCC
PIAMEGALKLKEISYIHAEAYPAGELKHGPLALVTEQMPVVTVAPNDALLEKLKSNIQEV
CEEECCCEEEHHHHEEEECCCCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHH
RARGGKLYVFADADTHIQSSDGIQVIRMPEHYGQLSPILHVVPLQLLAYHTAVARGTDVD
HHCCCEEEEEECCCCCEECCCCEEEEECCHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
KPRNLAKSVTVE
CHHHHHHHCCCC
>Mature Secondary Structure
MCGIVGAVSTRNIVPVLIEGLRRLEYRGYDSCGVAVQRDGQLERARTVSRVADLDTQAQS
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHCCCHHHH
SHLDGAIGIAHTRWATHGRPDTVNAHPHFSGDTIALVHNGIIENYETLREELKAVGYGFE
CCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCCC
SQTDTEVVAHLIHQAYTYPSSATRGHLFASVRAVVKRLHGAYAIAVFARDNPDVVVGARA
CCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEECC
GSPLVVALGDNESFLASDALAVAGTANRIVYLEEGDVVELTREGLTVADARDHVVEREVK
CCCEEEEECCCCCCHHCCCEEEECCCCEEEEEECCCEEEEHHCCCEEECHHHHHHHHHHH
VVEAHAAAVELGPYRHFMQKEIFEQPRALGDTLEGVQGFAPDLFGPRAAEVLPKVDSVLI
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCEEE
LACGTSYYSGCTAKYWLESIAKIPTQVEVASEYRYRDTVPNPNALVVVISQSGETADTLA
EEECCHHHCCCCHHHHHHHHHHCCCEEEHHHHCHHCCCCCCCCEEEEEEECCCCHHHHHH
ALRHARELGHTHTLAICNVATSAMVRETELRFLTRAGTEIGVASTKAFTTQLAALYMLAL
HHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
TFAKLRGHLKAEAEEVALRQLRHLPSALNAVLALEPQIIAWSEEFTRRENALFLGRGLHF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHCCCEEEEECCCCC
PIAMEGALKLKEISYIHAEAYPAGELKHGPLALVTEQMPVVTVAPNDALLEKLKSNIQEV
CEEECCCEEEHHHHEEEECCCCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHH
RARGGKLYVFADADTHIQSSDGIQVIRMPEHYGQLSPILHVVPLQLLAYHTAVARGTDVD
HHCCCEEEEEECCCCCEECCCCEEEEECCHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
KPRNLAKSVTVE
CHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852