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The map label for this gene is rocD [H]

Identifier: 17544878

GI number: 17544878

Start: 178653

End: 179879

Strand: Reverse

Name: rocD [H]

Synonym: RSc0159

Alternate gene names: 17544878

Gene position: 179879-178653 (Counterclockwise)

Preceding gene: 17544880

Following gene: 17544877

Centisome position: 4.84

GC content: 71.56

Gene sequence:

>1227_bases
ATGACGACCGCAGCCACTCACCCCAGCTATGCCCTGGAAACACGCTACGGCGCGCGCAACTACGCGCCGCTGCCGGTGAT
GCTGGAACGCGGCGAAGGCGTCTGGCTGTTCGACACGGCGGGCCGGCGCTACCTCGACATGATGTCGGCCTACTCCGCCG
TCAGCTTCGGCCATTCGCACCCGCGGCTGGTCGCCGCGCTGGTCGAACAGGCCGGCCGGCTGACGCTGACTTCGCGCGCC
TTCCACAACACCGAGCTCGGGCCGTTCCTGGCCGACGTGTGCCGCATCACGCGCATGGACCGCGCGCTGCCGATGAACAC
CGGCGCCGAGGCCGTGGAGACCGCCATCAAGGCGGCCCGCAAATGGGCCCGCGAGGTCAAGGGCACCCCGCCGGACGCCG
CCGAGATCATCGTCTTCGACAACAACTTCCACGGCCGCACCACCACCATCGTCGGCTTCTCGTCGCACGAGCAGTACCGC
TACGGCTTCGGCCCGTTCGCGGCGGGTTTCCGCCGCATCCCGTTCGGCGATGCCGAGGCGCTGAAGGCCGCCATCGGCCC
CCATACCGGCGCCATCCTGATCGAGCCGATCCAGGGCGAGGGCGGCATCGTGGTGCCGCCGCCCGGCTACCTGAAGCTCG
CGCGCGACCTGGCGACGCAGCACAACGCCCTGCTCGTCTGCGATGAGGTGCAGACCGGGCTGGGCCGCACGGGCGACGTG
CTCGCCAGCTGGCACGAGGACGTGCAGCCCGACCTGGTGGTGCTGGGCAAGGCGCTCGGCGGCGGCATGGTGCCGGTGTC
GGCCATCGCGGGGCGGGAAGACGTGATCGGCGTATTCCAGCCGGGCGACCACGGCTCCACCTTCGGCGGCAACCCGCTGG
CCGCGCACATCGGCCGCGCGGCACTGGCCTTGCTGCAGGAAGCGCAGTTGCCGCGGCACGCGGCCCGCCTGGGCGAAGCC
TTCATCGCCGAACTGCAATCGCTGATCGGGCACGGCGTGCGGCAGGTGCGCGGGCGCGGCCTGATGATCGGCCTGCAGCT
CGACGCCGACATCGATGCGCACGATTTCGCGGCCGCGCTGGCCGGGCACGGCGTACTGACCAAGGACACCTACGGCAACG
TGGTCCGCCTGACCCCGCCGCTGGTGATCGCGCAGCAGGAGCTGGAGCTGGCGCGGGACGTCATCCGCCGCACGCTGGCC
GACTGGCCGCGCCGCAAGGCGGCCTGA

Upstream 100 bases:

>100_bases
CGAAAAACGAAAAACATTCGATTTGATTTTGAGTTTGGCAGATCGCACAATCCGTCGCAAGCGAGCAGCGAGACCGATCC
CATCCCAGCCGGAGGCCATC

Downstream 100 bases:

>100_bases
GCCGGCGCATCGCACCGCATCCGGATTCACGGGGAATCGACATGACCATCATCGACCTGATCGGCGCGGCCATCGGCTGC
GGAGCGCGGGACGACGGCTG

Product: acetylornithine aminotransferase

Products: NA

Alternate protein names: OAT; Ornithine--oxo-acid aminotransferase [H]

Number of amino acids: Translated: 408; Mature: 407

Protein sequence:

>408_residues
MTTAATHPSYALETRYGARNYAPLPVMLERGEGVWLFDTAGRRYLDMMSAYSAVSFGHSHPRLVAALVEQAGRLTLTSRA
FHNTELGPFLADVCRITRMDRALPMNTGAEAVETAIKAARKWAREVKGTPPDAAEIIVFDNNFHGRTTTIVGFSSHEQYR
YGFGPFAAGFRRIPFGDAEALKAAIGPHTGAILIEPIQGEGGIVVPPPGYLKLARDLATQHNALLVCDEVQTGLGRTGDV
LASWHEDVQPDLVVLGKALGGGMVPVSAIAGREDVIGVFQPGDHGSTFGGNPLAAHIGRAALALLQEAQLPRHAARLGEA
FIAELQSLIGHGVRQVRGRGLMIGLQLDADIDAHDFAAALAGHGVLTKDTYGNVVRLTPPLVIAQQELELARDVIRRTLA
DWPRRKAA

Sequences:

>Translated_408_residues
MTTAATHPSYALETRYGARNYAPLPVMLERGEGVWLFDTAGRRYLDMMSAYSAVSFGHSHPRLVAALVEQAGRLTLTSRA
FHNTELGPFLADVCRITRMDRALPMNTGAEAVETAIKAARKWAREVKGTPPDAAEIIVFDNNFHGRTTTIVGFSSHEQYR
YGFGPFAAGFRRIPFGDAEALKAAIGPHTGAILIEPIQGEGGIVVPPPGYLKLARDLATQHNALLVCDEVQTGLGRTGDV
LASWHEDVQPDLVVLGKALGGGMVPVSAIAGREDVIGVFQPGDHGSTFGGNPLAAHIGRAALALLQEAQLPRHAARLGEA
FIAELQSLIGHGVRQVRGRGLMIGLQLDADIDAHDFAAALAGHGVLTKDTYGNVVRLTPPLVIAQQELELARDVIRRTLA
DWPRRKAA
>Mature_407_residues
TTAATHPSYALETRYGARNYAPLPVMLERGEGVWLFDTAGRRYLDMMSAYSAVSFGHSHPRLVAALVEQAGRLTLTSRAF
HNTELGPFLADVCRITRMDRALPMNTGAEAVETAIKAARKWAREVKGTPPDAAEIIVFDNNFHGRTTTIVGFSSHEQYRY
GFGPFAAGFRRIPFGDAEALKAAIGPHTGAILIEPIQGEGGIVVPPPGYLKLARDLATQHNALLVCDEVQTGLGRTGDVL
ASWHEDVQPDLVVLGKALGGGMVPVSAIAGREDVIGVFQPGDHGSTFGGNPLAAHIGRAALALLQEAQLPRHAARLGEAF
IAELQSLIGHGVRQVRGRGLMIGLQLDADIDAHDFAAALAGHGVLTKDTYGNVVRLTPPLVIAQQELELARDVIRRTLAD
WPRRKAA

Specific function: Catalyzes the interconversion of ornithine to glutamate semialdehyde [H]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. OAT subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=390, Percent_Identity=46.9230769230769, Blast_Score=361, Evalue=1e-100,
Organism=Homo sapiens, GI284507298, Length=298, Percent_Identity=45.6375838926174, Blast_Score=257, Evalue=1e-68,
Organism=Homo sapiens, GI13994255, Length=445, Percent_Identity=27.1910112359551, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI24119277, Length=423, Percent_Identity=27.6595744680851, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI37574042, Length=439, Percent_Identity=25.7403189066059, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI226442705, Length=439, Percent_Identity=25.0569476082005, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI226442709, Length=404, Percent_Identity=25.2475247524752, Blast_Score=117, Evalue=2e-26,
Organism=Escherichia coli, GI1788044, Length=378, Percent_Identity=37.8306878306878, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI1789759, Length=373, Percent_Identity=37.5335120643432, Blast_Score=236, Evalue=3e-63,
Organism=Escherichia coli, GI145693181, Length=385, Percent_Identity=33.2467532467532, Blast_Score=225, Evalue=5e-60,
Organism=Escherichia coli, GI1789016, Length=414, Percent_Identity=31.1594202898551, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1787560, Length=418, Percent_Identity=30.3827751196172, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI1786991, Length=410, Percent_Identity=28.780487804878, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1786349, Length=292, Percent_Identity=29.4520547945205, Blast_Score=114, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI25144271, Length=394, Percent_Identity=43.9086294416244, Blast_Score=381, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI25144274, Length=276, Percent_Identity=41.6666666666667, Blast_Score=246, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI32564660, Length=445, Percent_Identity=28.5393258426966, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI71981843, Length=165, Percent_Identity=44.8484848484849, Blast_Score=167, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI71992977, Length=428, Percent_Identity=25, Blast_Score=130, Evalue=9e-31,
Organism=Caenorhabditis elegans, GI17541228, Length=431, Percent_Identity=23.8979118329466, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6323470, Length=417, Percent_Identity=42.6858513189448, Blast_Score=335, Evalue=1e-92,
Organism=Saccharomyces cerevisiae, GI6324432, Length=395, Percent_Identity=26.5822784810127, Blast_Score=154, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6324386, Length=427, Percent_Identity=25.0585480093677, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI21357415, Length=391, Percent_Identity=47.3145780051151, Blast_Score=376, Evalue=1e-104,
Organism=Drosophila melanogaster, GI28574759, Length=439, Percent_Identity=28.9293849658314, Blast_Score=169, Evalue=5e-42,
Organism=Drosophila melanogaster, GI161085790, Length=443, Percent_Identity=28.2167042889391, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI21356575, Length=417, Percent_Identity=26.378896882494, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI281366494, Length=428, Percent_Identity=24.5327102803738, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24667139, Length=428, Percent_Identity=24.5327102803738, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24667143, Length=428, Percent_Identity=24.5327102803738, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR010164
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.13 [H]

Molecular weight: Translated: 43769; Mature: 43637

Theoretical pI: Translated: 7.28; Mature: 7.28

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTAATHPSYALETRYGARNYAPLPVMLERGEGVWLFDTAGRRYLDMMSAYSAVSFGHSH
CCCCCCCCCEEEEECCCCCCCCCCCEEEECCCCEEEEECCCHHHHHHHHHHHHHHCCCCC
PRLVAALVEQAGRLTLTSRAFHNTELGPFLADVCRITRMDRALPMNTGAEAVETAIKAAR
HHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
KWAREVKGTPPDAAEIIVFDNNFHGRTTTIVGFSSHEQYRYGFGPFAAGFRRIPFGDAEA
HHHHHHCCCCCCCEEEEEECCCCCCCEEEEEEECCCCCCCCCCCHHHHCCCCCCCCCHHH
LKAAIGPHTGAILIEPIQGEGGIVVPPPGYLKLARDLATQHNALLVCDEVQTGLGRTGDV
HHHHHCCCCCEEEEEEECCCCCEEECCCCHHHHHHHHHHCCCEEEEECCHHHCCCCCHHH
LASWHEDVQPDLVVLGKALGGGMVPVSAIAGREDVIGVFQPGDHGSTFGGNPLAAHIGRA
HHHHHHCCCCCCEEEEHHHCCCCCCHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHH
ALALLQEAQLPRHAARLGEAFIAELQSLIGHGVRQVRGRGLMIGLQLDADIDAHDFAAAL
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHH
AGHGVLTKDTYGNVVRLTPPLVIAQQELELARDVIRRTLADWPRRKAA
HCCCEEEECCCCCEEEECCCEEEHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TTAATHPSYALETRYGARNYAPLPVMLERGEGVWLFDTAGRRYLDMMSAYSAVSFGHSH
CCCCCCCCEEEEECCCCCCCCCCCEEEECCCCEEEEECCCHHHHHHHHHHHHHHCCCCC
PRLVAALVEQAGRLTLTSRAFHNTELGPFLADVCRITRMDRALPMNTGAEAVETAIKAAR
HHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
KWAREVKGTPPDAAEIIVFDNNFHGRTTTIVGFSSHEQYRYGFGPFAAGFRRIPFGDAEA
HHHHHHCCCCCCCEEEEEECCCCCCCEEEEEEECCCCCCCCCCCHHHHCCCCCCCCCHHH
LKAAIGPHTGAILIEPIQGEGGIVVPPPGYLKLARDLATQHNALLVCDEVQTGLGRTGDV
HHHHHCCCCCEEEEEEECCCCCEEECCCCHHHHHHHHHHCCCEEEEECCHHHCCCCCHHH
LASWHEDVQPDLVVLGKALGGGMVPVSAIAGREDVIGVFQPGDHGSTFGGNPLAAHIGRA
HHHHHHCCCCCCEEEEHHHCCCCCCHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHH
ALALLQEAQLPRHAARLGEAFIAELQSLIGHGVRQVRGRGLMIGLQLDADIDAHDFAAAL
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHH
AGHGVLTKDTYGNVVRLTPPLVIAQQELELARDVIRRTLADWPRRKAA
HCCCEEEECCCCCEEEECCCEEEHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]