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The map label for this gene is ahcY [H]

Identifier: 17544812

GI number: 17544812

Start: 106034

End: 107458

Strand: Reverse

Name: ahcY [H]

Synonym: RSc0093

Alternate gene names: 17544812

Gene position: 107458-106034 (Counterclockwise)

Preceding gene: 17544813

Following gene: 17544811

Centisome position: 2.89

GC content: 64.28

Gene sequence:

>1425_bases
ATGAACGCTGTGACCGATCTGAAACACGACTACCTCGTCGCCGACATCAAGCTGGCCGACTGGGGCCGCAAGGAAATCGC
CATCGCCGAGACCGAAATGCCGGGCCTGATGGCGATCCGCGACGAATTTGCCGCCAGCCAGCCGCTCAAGGGCGCGCGCA
TCGCCGGCTCGCTGCACATGACCATCCAGACCGCCGTGCTGATCGAGACGCTCAAGGCGCTCGGCGCCGACGTGCGCTGG
GCCTCGTGCAACATCTTCTCGACGCAGGACCACGCCGCCGCCGCCATCGCTGCATCGGGTACGCCGGTGTTCGCGTTCAA
GGGCGAGTCGCTCAAGGAATACTGGGACTTCACGCACCGCATCTTCGAATGGGCCGACGGCGGCACGCCCAACATGATCC
TGGACGACGGCGGCGACGCCACGCTGCTGCTGCACCTGGGCGCCAAGGCTGAGCAGGACGCCTCGGTGATCGCCAAGCCG
GGCAGCGAGGAAGAAACCTTCCTGTTCGCCGCGATCAAGGAAAAGCTGGCCAAGGACGCGACGTTCTACAGCCGCAACCT
CGACGCCATCAAGGGCGTGACCGAAGAGACCACCACCGGCGTGCACCGCCTGTACCAGATGGCCCAGCGCGGCGAGCTGC
GCTTCCCGGCCATCAACGTCAACGACTCGGTCACCAAGAGCAAGTTCGACAACCTGTACGGCTGCCGTGAATCGCTGGTC
GACGGCATCAAGCGCGCGACCGACGTGATGATCGCCGGCAAGGTGGCCGTCGTGGCCGGCTACGGCGATGTGGGCAAGGG
CTCGGCGCAGGCGCTGCGCGCGCTGTCGGCGCAGGTGTGGGTGACCGAAATCGACCCGATCTGCGCGCTGCAGGCCGCCA
TGGAAGGCTACCGCGTGGTGACCATGGACTACGCCGCCGAGCACGGCGACATCTTCGTCACCTGCACCGGCAACTACCAC
GTCATCACGCACGACCACATGGCCAAGATGAAAGACCAGGCCATCGTCTGCAACATCGGCCACTTCGACAACGAGATCGA
CATCGCCTCGGTCGAGCAGTACCAGTGGGAAGAAATCAAGCCGCAGGTCGATCACGTGATCTTCCCCGACGGCAAGAAGA
TCATCATCCTGGCCAAGGGCCGCCTGGTGAACCTGGGCTGCGCCACCGGCCATCCGTCGTACGTGATGAGCAGTTCGTTC
GCCAACCAGACCATCGCCCAGATCGAGCTGTGGACCGAGGCGCAGAAGGGCTCGAGCAAGTACCCGGTGGGCGTCTACAC
GCTGCCCAAGCATCTCGACGAGAAGGTCGCGCGCCTGCAGCTCAAGAAGCTGAACGCGCAGCTGACCGTGCTGACCGACA
AACAGGCCGCCTACATCGGCGTGAGCAAGGAAGGCCCGTACAAGGCCGACCACTATCGCTATTAA

Upstream 100 bases:

>100_bases
CGTATCCATCCGGGGCATCGGCCCCGTTCCACCGGCACCCGCGCAACCCGCGGCCGGGCGATCTCCCCAGCGTGCGGTCA
CCTTTTTTCCGGAGTGATCC

Downstream 100 bases:

>100_bases
GCTGCCCGCAGTATCCGCCCGCCGGTGCATCCCGCGCCGGCGGCGGCATTCAACCCGAGGCTCACCATGAGACTGCTCGC
TGTCTGGGTCATCAACGCGC

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MNAVTDLKHDYLVADIKLADWGRKEIAIAETEMPGLMAIRDEFAASQPLKGARIAGSLHMTIQTAVLIETLKALGADVRW
ASCNIFSTQDHAAAAIAASGTPVFAFKGESLKEYWDFTHRIFEWADGGTPNMILDDGGDATLLLHLGAKAEQDASVIAKP
GSEEETFLFAAIKEKLAKDATFYSRNLDAIKGVTEETTTGVHRLYQMAQRGELRFPAINVNDSVTKSKFDNLYGCRESLV
DGIKRATDVMIAGKVAVVAGYGDVGKGSAQALRALSAQVWVTEIDPICALQAAMEGYRVVTMDYAAEHGDIFVTCTGNYH
VITHDHMAKMKDQAIVCNIGHFDNEIDIASVEQYQWEEIKPQVDHVIFPDGKKIIILAKGRLVNLGCATGHPSYVMSSSF
ANQTIAQIELWTEAQKGSSKYPVGVYTLPKHLDEKVARLQLKKLNAQLTVLTDKQAAYIGVSKEGPYKADHYRY

Sequences:

>Translated_474_residues
MNAVTDLKHDYLVADIKLADWGRKEIAIAETEMPGLMAIRDEFAASQPLKGARIAGSLHMTIQTAVLIETLKALGADVRW
ASCNIFSTQDHAAAAIAASGTPVFAFKGESLKEYWDFTHRIFEWADGGTPNMILDDGGDATLLLHLGAKAEQDASVIAKP
GSEEETFLFAAIKEKLAKDATFYSRNLDAIKGVTEETTTGVHRLYQMAQRGELRFPAINVNDSVTKSKFDNLYGCRESLV
DGIKRATDVMIAGKVAVVAGYGDVGKGSAQALRALSAQVWVTEIDPICALQAAMEGYRVVTMDYAAEHGDIFVTCTGNYH
VITHDHMAKMKDQAIVCNIGHFDNEIDIASVEQYQWEEIKPQVDHVIFPDGKKIIILAKGRLVNLGCATGHPSYVMSSSF
ANQTIAQIELWTEAQKGSSKYPVGVYTLPKHLDEKVARLQLKKLNAQLTVLTDKQAAYIGVSKEGPYKADHYRY
>Mature_474_residues
MNAVTDLKHDYLVADIKLADWGRKEIAIAETEMPGLMAIRDEFAASQPLKGARIAGSLHMTIQTAVLIETLKALGADVRW
ASCNIFSTQDHAAAAIAASGTPVFAFKGESLKEYWDFTHRIFEWADGGTPNMILDDGGDATLLLHLGAKAEQDASVIAKP
GSEEETFLFAAIKEKLAKDATFYSRNLDAIKGVTEETTTGVHRLYQMAQRGELRFPAINVNDSVTKSKFDNLYGCRESLV
DGIKRATDVMIAGKVAVVAGYGDVGKGSAQALRALSAQVWVTEIDPICALQAAMEGYRVVTMDYAAEHGDIFVTCTGNYH
VITHDHMAKMKDQAIVCNIGHFDNEIDIASVEQYQWEEIKPQVDHVIFPDGKKIIILAKGRLVNLGCATGHPSYVMSSSF
ANQTIAQIELWTEAQKGSSKYPVGVYTLPKHLDEKVARLQLKKLNAQLTVLTDKQAAYIGVSKEGPYKADHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=469, Percent_Identity=60.7675906183369, Blast_Score=539, Evalue=1e-153,
Organism=Homo sapiens, GI239937451, Length=444, Percent_Identity=60.5855855855856, Blast_Score=511, Evalue=1e-145,
Organism=Homo sapiens, GI298286489, Length=467, Percent_Identity=49.4646680942184, Blast_Score=466, Evalue=1e-131,
Organism=Homo sapiens, GI195539337, Length=467, Percent_Identity=49.4646680942184, Blast_Score=466, Evalue=1e-131,
Organism=Homo sapiens, GI24308043, Length=467, Percent_Identity=49.4646680942184, Blast_Score=466, Evalue=1e-131,
Organism=Homo sapiens, GI195539349, Length=467, Percent_Identity=49.4646680942184, Blast_Score=466, Evalue=1e-131,
Organism=Homo sapiens, GI21361647, Length=467, Percent_Identity=47.96573875803, Blast_Score=439, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI17506425, Length=469, Percent_Identity=58.63539445629, Blast_Score=533, Evalue=1e-151,
Organism=Saccharomyces cerevisiae, GI6320882, Length=479, Percent_Identity=57.6200417536534, Blast_Score=514, Evalue=1e-146,
Organism=Drosophila melanogaster, GI24642172, Length=469, Percent_Identity=60.1279317697228, Blast_Score=529, Evalue=1e-150,
Organism=Drosophila melanogaster, GI24656245, Length=456, Percent_Identity=49.3421052631579, Blast_Score=445, Evalue=1e-125,
Organism=Drosophila melanogaster, GI45553387, Length=467, Percent_Identity=47.96573875803, Blast_Score=428, Evalue=1e-120,
Organism=Drosophila melanogaster, GI45553385, Length=466, Percent_Identity=47.8540772532189, Blast_Score=426, Evalue=1e-119,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 51950; Mature: 51950

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAVTDLKHDYLVADIKLADWGRKEIAIAETEMPGLMAIRDEFAASQPLKGARIAGSLHM
CCCCCCCCCCEEEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCEEECEEEE
TIQTAVLIETLKALGADVRWASCNIFSTQDHAAAAIAASGTPVFAFKGESLKEYWDFTHR
HHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCEEEEEECCCEEEEECCCHHHHHHHHHHH
IFEWADGGTPNMILDDGGDATLLLHLGAKAEQDASVIAKPGSEEETFLFAAIKEKLAKDA
HHHHCCCCCCCEEEECCCCEEEEEEECCCCCCCCCEEECCCCCCCCEEHHHHHHHHHHCH
TFYSRNLDAIKGVTEETTTGVHRLYQMAQRGELRFPAINVNDSVTKSKFDNLYGCRESLV
HHHHCCCHHHCCCCHHHHHHHHHHHHHHHCCCEECCEECCCCCHHHHHHHHHHHHHHHHH
DGIKRATDVMIAGKVAVVAGYGDVGKGSAQALRALSAQVWVTEIDPICALQAAMEGYRVV
HHHHHHHHEEEECCEEEEEECCCCCCCHHHHHHHHHHEEEEEECCHHHHHHHHHCCCEEE
TMDYAAEHGDIFVTCTGNYHVITHDHMAKMKDQAIVCNIGHFDNEIDIASVEQYQWEEIK
EEEECCCCCCEEEEEECCEEEEECHHHHHCCCCEEEEEECCCCCCCCEEECCHHHHHHCC
PQVDHVIFPDGKKIIILAKGRLVNLGCATGHPSYVMSSSFANQTIAQIELWTEAQKGSSK
CCCCEEECCCCCEEEEEECCEEEEEEECCCCCCHHHCCHHCCCEEEEEEEEEHHCCCCCC
YPVGVYTLPKHLDEKVARLQLKKLNAQLTVLTDKQAAYIGVSKEGPYKADHYRY
CCEEEEECHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MNAVTDLKHDYLVADIKLADWGRKEIAIAETEMPGLMAIRDEFAASQPLKGARIAGSLHM
CCCCCCCCCCEEEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCEEECEEEE
TIQTAVLIETLKALGADVRWASCNIFSTQDHAAAAIAASGTPVFAFKGESLKEYWDFTHR
HHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCEEEEEECCCEEEEECCCHHHHHHHHHHH
IFEWADGGTPNMILDDGGDATLLLHLGAKAEQDASVIAKPGSEEETFLFAAIKEKLAKDA
HHHHCCCCCCCEEEECCCCEEEEEEECCCCCCCCCEEECCCCCCCCEEHHHHHHHHHHCH
TFYSRNLDAIKGVTEETTTGVHRLYQMAQRGELRFPAINVNDSVTKSKFDNLYGCRESLV
HHHHCCCHHHCCCCHHHHHHHHHHHHHHHCCCEECCEECCCCCHHHHHHHHHHHHHHHHH
DGIKRATDVMIAGKVAVVAGYGDVGKGSAQALRALSAQVWVTEIDPICALQAAMEGYRVV
HHHHHHHHEEEECCEEEEEECCCCCCCHHHHHHHHHHEEEEEECCHHHHHHHHHCCCEEE
TMDYAAEHGDIFVTCTGNYHVITHDHMAKMKDQAIVCNIGHFDNEIDIASVEQYQWEEIK
EEEECCCCCCEEEEEECCEEEEECHHHHHCCCCEEEEEECCCCCCCCEEECCHHHHHHCC
PQVDHVIFPDGKKIIILAKGRLVNLGCATGHPSYVMSSSFANQTIAQIELWTEAQKGSSK
CCCCEEECCCCCEEEEEECCEEEEEEECCCCCCHHHCCHHCCCEEEEEEEEEHHCCCCCC
YPVGVYTLPKHLDEKVARLQLKKLNAQLTVLTDKQAAYIGVSKEGPYKADHYRY
CCEEEEECHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA