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The map label for this gene is mrdA [H]

Identifier: 17544781

GI number: 17544781

Start: 67285

End: 69690

Strand: Direct

Name: mrdA [H]

Synonym: RSc0062

Alternate gene names: 17544781

Gene position: 67285-69690 (Clockwise)

Preceding gene: 17544780

Following gene: 17544782

Centisome position: 1.81

GC content: 69.62

Gene sequence:

>2406_bases
ATGACCGAGATCCGCAACGTCGAACAGGAGCTGTCGCGCTTTCGCGTGCGGCTGGCCGCGGCCGCGCTGTTCGTGCTGGT
GTGCTTCGGGCTGCTGCTGGTGCGCTTCTTCTGGCTGCAGTCGGTCAAGCACGAGCAGTACTCGGCCAAGGCCGAGGACA
ACCGCATCTCGGTGGCGCCGATCGAGCCCAACCGCGGCATCATCATGGACCGCAACGGGGTGGTGCTGGCGCGCAACTAC
TCGGCCTACACGCTGGAGGTCACCCCGTCCAAGCTGCAGGACACGCTGGACAACACCATCGACCAGCTCGCCCAGGTGAT
CGACATCCAGCCGCGCGACCGTCGCCGCTTCAAGCGCCTGATGGAAGACGCGCGCAGCTTCGAGAGCCTGCCGATCCGCA
GCCAGCTGACCGACCAGGAGGTGGCGCGCTTCTCGGCACAGCGCTTCCGCTTCCCGGGCGTGGACGTGCACGCTAGGCTG
TTCCGCCAGTACCCGTTGGGCGAGGCGGCGGCGCACGTGATCGGCTACATCGGCCGCATCTCCGAGCGCGACCTCGAGCG
CATCGACGACATGAGCGAGGCCAACAGCCAGCCCAACGTCACCTACGATCCGCGCAAGGACGCCAACAACTACAGCGGCA
CCGAGTACATCGGCAAGGTCGGCATCGAGCAGAGCTACGAGACCGAGCTGCACGGCCTGACCGGCTACGAAGAAGTCGAG
GTCAGCGCGGGCGGGCGGCCGATCCGCACGCTGTCCACCTCGCAGGCCACGCCCGGCAACAACCTGATCCTGTCGCTCGA
CATCAACCTGCAGCGGCTGGCCGAGCAGCTGTTCGGCAACCGCCGCGGCGCGCTGGTGGCGATCGAGCCCGAGACCGGCG
ACATCCTCGCCTTCGTCTCCAAGCCCACCTTCGACCCGAACCTCTTCATCGAAGGTATCGACAGCGCCACCTGGAGCGAG
CTGAACGGCTCGCCCGACAAGCCGCTGCTGAACCGCCCGCTGCGCGGCACGTATCCGCCGGGCTCGACCTACAAGCCGTT
CATGGCGCTGGCCGCGCTGGAGCTGGGCAAGCGCACGCCGCAATGGGGCATGGCCGATCCCGGCTCGTTCACGCTGGGCA
ACCACACCTTCCGCGACGACGTGCCGGGCGGCCACGGCTGGGTCGACATGTACCGCTCCATCGTGGTGTCGTGCGACACG
TACTACTACAAGCTCGCCAACGACATGGGCGTCAACGCCATCCACGATTTCATGAAGCCGCTCGGCTTCGGCCAGGTCAC
CGGCATCGACATCGAGGGCGAGCGCACCGGCATCCTGCCCTCCACCGAGTGGAAGCGCAAAGCCTACAAGCGTCCCGAGC
AGCAGAAGTGGTACGACGGCGAAACCATCTCGCTGGGCATCGGCCAGGGCTACAACAACTTCACCATCCTCCAGCTGGCG
CATGCGGTGGCGACGCTGGCCAACAACGGCGGCGTGATGAAGCCCCACCTGGTCAAGGCCGTCGAGGATTCCGTCAACAA
GGCCCGCACGCTGACGGTGCCGACCGAGAGCTACCGGATTCCGCTCAAGCAGGCCAACATCGACGTGATCAAGCGCGCGA
TGGCCGGGGTGGTCCAGGCCGGCACGGCGGCCAAGGCGTTTGCCGGCGCGCAATATGCCGCGGCGGGCAAGACCGGCACG
GCGCAGGTGTTCTCGCTCGGCAAGGGCGAGAAGTACAACCACCATGCCATTCCCGAATACAAGCGCGACCACGCGCTGTT
CGAGGCCTTCGCGCCGACCGACCACCCGAAGATCGCGGTGGCGCTGATCGTCGAGAACGCGGGCTTCGGCGCCACCTCGG
CCGCGCCGATCGCGCGCGCGGTGTTCGACTACTACCTGCAGGGCAAGTGGCCGGCCGAGCTGGCGGCCATCGCGCCCAAG
GTCCAGCCGCAGCCGCCGGTCGATACGCCGAGCGTGTTCTCCACCGGCAAGACCGCCACCATCGCCAGCGCCACGGCCAC
GCCGCAGGCAGCCGCGGAGGCGGTGGCGCAGAGCGCGGCCCTGGCCGCGGCCGCATCCGGCGAGCAGGCTGCCGATGCAG
CCACGGTGGGCGGCGCGTCCGCGCCGGGCGCTTCGGCCGTGGCGGCCGGCGCACCGCGCGCCGCGCCGGCGATGTCGTCC
GATCGGGTCGCGCCCGCGCTGCGCGAGGCCGGCACCAGCGCCCAGGCGGTCGCTCCGGCCACGCTGGACGCCCAGGTGCT
GCAGGCGCTGTCGCACGTCCAGCCCGCCCCCGACCTGCCGAGCCCGCGCGGCCGCAACCTGCCGGCGGCACCGGCTTCCG
CGCCGGCCGCCTCGCCCAAGGACCGCAAGCCCGCGGTCAAGCCCAATCCCAAGCCTGCGCCCAAACCGGCACGGGCCGCT
CCCTGA

Upstream 100 bases:

>100_bases
CTGTGGCCCGTCGCGAACGCCATCCTGCTGGCGCCGCAGCGCCGTCCGGAGAGCGTCGACGAGACGCGCCCGATCTGATG
CACGCATCCGGGCCGCAGGC

Downstream 100 bases:

>100_bases
CTCTCGCGCTTGAGGAACGCACCATGGACAAGCGCCGCGCATTCAACGTCATCAAGTCGCTCTTCACCGGCTTCGACAAG
CCGCTGGCGCTGATCGTCTT

Product: substrate-binding transmembrane protein

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 801; Mature: 800

Protein sequence:

>801_residues
MTEIRNVEQELSRFRVRLAAAALFVLVCFGLLLVRFFWLQSVKHEQYSAKAEDNRISVAPIEPNRGIIMDRNGVVLARNY
SAYTLEVTPSKLQDTLDNTIDQLAQVIDIQPRDRRRFKRLMEDARSFESLPIRSQLTDQEVARFSAQRFRFPGVDVHARL
FRQYPLGEAAAHVIGYIGRISERDLERIDDMSEANSQPNVTYDPRKDANNYSGTEYIGKVGIEQSYETELHGLTGYEEVE
VSAGGRPIRTLSTSQATPGNNLILSLDINLQRLAEQLFGNRRGALVAIEPETGDILAFVSKPTFDPNLFIEGIDSATWSE
LNGSPDKPLLNRPLRGTYPPGSTYKPFMALAALELGKRTPQWGMADPGSFTLGNHTFRDDVPGGHGWVDMYRSIVVSCDT
YYYKLANDMGVNAIHDFMKPLGFGQVTGIDIEGERTGILPSTEWKRKAYKRPEQQKWYDGETISLGIGQGYNNFTILQLA
HAVATLANNGGVMKPHLVKAVEDSVNKARTLTVPTESYRIPLKQANIDVIKRAMAGVVQAGTAAKAFAGAQYAAAGKTGT
AQVFSLGKGEKYNHHAIPEYKRDHALFEAFAPTDHPKIAVALIVENAGFGATSAAPIARAVFDYYLQGKWPAELAAIAPK
VQPQPPVDTPSVFSTGKTATIASATATPQAAAEAVAQSAALAAAASGEQAADAATVGGASAPGASAVAAGAPRAAPAMSS
DRVAPALREAGTSAQAVAPATLDAQVLQALSHVQPAPDLPSPRGRNLPAAPASAPAASPKDRKPAVKPNPKPAPKPARAA
P

Sequences:

>Translated_801_residues
MTEIRNVEQELSRFRVRLAAAALFVLVCFGLLLVRFFWLQSVKHEQYSAKAEDNRISVAPIEPNRGIIMDRNGVVLARNY
SAYTLEVTPSKLQDTLDNTIDQLAQVIDIQPRDRRRFKRLMEDARSFESLPIRSQLTDQEVARFSAQRFRFPGVDVHARL
FRQYPLGEAAAHVIGYIGRISERDLERIDDMSEANSQPNVTYDPRKDANNYSGTEYIGKVGIEQSYETELHGLTGYEEVE
VSAGGRPIRTLSTSQATPGNNLILSLDINLQRLAEQLFGNRRGALVAIEPETGDILAFVSKPTFDPNLFIEGIDSATWSE
LNGSPDKPLLNRPLRGTYPPGSTYKPFMALAALELGKRTPQWGMADPGSFTLGNHTFRDDVPGGHGWVDMYRSIVVSCDT
YYYKLANDMGVNAIHDFMKPLGFGQVTGIDIEGERTGILPSTEWKRKAYKRPEQQKWYDGETISLGIGQGYNNFTILQLA
HAVATLANNGGVMKPHLVKAVEDSVNKARTLTVPTESYRIPLKQANIDVIKRAMAGVVQAGTAAKAFAGAQYAAAGKTGT
AQVFSLGKGEKYNHHAIPEYKRDHALFEAFAPTDHPKIAVALIVENAGFGATSAAPIARAVFDYYLQGKWPAELAAIAPK
VQPQPPVDTPSVFSTGKTATIASATATPQAAAEAVAQSAALAAAASGEQAADAATVGGASAPGASAVAAGAPRAAPAMSS
DRVAPALREAGTSAQAVAPATLDAQVLQALSHVQPAPDLPSPRGRNLPAAPASAPAASPKDRKPAVKPNPKPAPKPARAA
P
>Mature_800_residues
TEIRNVEQELSRFRVRLAAAALFVLVCFGLLLVRFFWLQSVKHEQYSAKAEDNRISVAPIEPNRGIIMDRNGVVLARNYS
AYTLEVTPSKLQDTLDNTIDQLAQVIDIQPRDRRRFKRLMEDARSFESLPIRSQLTDQEVARFSAQRFRFPGVDVHARLF
RQYPLGEAAAHVIGYIGRISERDLERIDDMSEANSQPNVTYDPRKDANNYSGTEYIGKVGIEQSYETELHGLTGYEEVEV
SAGGRPIRTLSTSQATPGNNLILSLDINLQRLAEQLFGNRRGALVAIEPETGDILAFVSKPTFDPNLFIEGIDSATWSEL
NGSPDKPLLNRPLRGTYPPGSTYKPFMALAALELGKRTPQWGMADPGSFTLGNHTFRDDVPGGHGWVDMYRSIVVSCDTY
YYKLANDMGVNAIHDFMKPLGFGQVTGIDIEGERTGILPSTEWKRKAYKRPEQQKWYDGETISLGIGQGYNNFTILQLAH
AVATLANNGGVMKPHLVKAVEDSVNKARTLTVPTESYRIPLKQANIDVIKRAMAGVVQAGTAAKAFAGAQYAAAGKTGTA
QVFSLGKGEKYNHHAIPEYKRDHALFEAFAPTDHPKIAVALIVENAGFGATSAAPIARAVFDYYLQGKWPAELAAIAPKV
QPQPPVDTPSVFSTGKTATIASATATPQAAAEAVAQSAALAAAASGEQAADAATVGGASAPGASAVAAGAPRAAPAMSSD
RVAPALREAGTSAQAVAPATLDAQVLQALSHVQPAPDLPSPRGRNLPAAPASAPAASPKDRKPAVKPNPKPAPKPARAAP

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=642, Percent_Identity=39.8753894080997, Blast_Score=468, Evalue=1e-133,
Organism=Escherichia coli, GI1786272, Length=637, Percent_Identity=23.2339089481947, Blast_Score=136, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 86175; Mature: 86044

Theoretical pI: Translated: 8.71; Mature: 8.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEIRNVEQELSRFRVRLAAAALFVLVCFGLLLVRFFWLQSVKHEQYSAKAEDNRISVAP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEE
IEPNRGIIMDRNGVVLARNYSAYTLEVTPSKLQDTLDNTIDQLAQVIDIQPRDRRRFKRL
ECCCCCEEECCCCEEEEECCCEEEEEECHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
MEDARSFESLPIRSQLTDQEVARFSAQRFRFPGVDVHARLFRQYPLGEAAAHVIGYIGRI
HHHHHHHHCCCCHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCC
SERDLERIDDMSEANSQPNVTYDPRKDANNYSGTEYIGKVGIEQSYETELHGLTGYEEVE
CHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCHHHHHCCCCCCCEEE
VSAGGRPIRTLSTSQATPGNNLILSLDINLQRLAEQLFGNRRGALVAIEPETGDILAFVS
ECCCCCEEEEECCCCCCCCCCEEEEECCCHHHHHHHHHCCCCCCEEEECCCCCCEEEEEE
KPTFDPNLFIEGIDSATWSELNGSPDKPLLNRPLRGTYPPGSTYKPFMALAALELGKRTP
CCCCCCCCEEECCCCCCHHHCCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCC
QWGMADPGSFTLGNHTFRDDVPGGHGWVDMYRSIVVSCDTYYYKLANDMGVNAIHDFMKP
CCCCCCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEHHCCCCHHHHHHHHHH
LGFGQVTGIDIEGERTGILPSTEWKRKAYKRPEQQKWYDGETISLGIGQGYNNFTILQLA
CCCCCEEEEEECCCCCCCCCCCHHHHHHHCCCCHHCCCCCCEEEEECCCCCCCCHHHHHH
HAVATLANNGGVMKPHLVKAVEDSVNKARTLTVPTESYRIPLKQANIDVIKRAMAGVVQA
HHHHHHHCCCCCCCHHHHHHHHHHHHCCEEEEECCCCCCCCHHHCCHHHHHHHHHHHHHC
GTAAKAFAGAQYAAAGKTGTAQVFSLGKGEKYNHHAIPEYKRDHALFEAFAPTDHPKIAV
CCHHHHHHCCHHHCCCCCCCHHHEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEE
ALIVENAGFGATSAAPIARAVFDYYLQGKWPAELAAIAPKVQPQPPVDTPSVFSTGKTAT
EEEEECCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCHHCCCCCEE
IASATATPQAAAEAVAQSAALAAAASGEQAADAATVGGASAPGASAVAAGAPRAAPAMSS
EEECCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCHHHCCCCCCCCCCCC
DRVAPALREAGTSAQAVAPATLDAQVLQALSHVQPAPDLPSPRGRNLPAAPASAPAASPK
CCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC
DRKPAVKPNPKPAPKPARAAP
CCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TEIRNVEQELSRFRVRLAAAALFVLVCFGLLLVRFFWLQSVKHEQYSAKAEDNRISVAP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEE
IEPNRGIIMDRNGVVLARNYSAYTLEVTPSKLQDTLDNTIDQLAQVIDIQPRDRRRFKRL
ECCCCCEEECCCCEEEEECCCEEEEEECHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
MEDARSFESLPIRSQLTDQEVARFSAQRFRFPGVDVHARLFRQYPLGEAAAHVIGYIGRI
HHHHHHHHCCCCHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCC
SERDLERIDDMSEANSQPNVTYDPRKDANNYSGTEYIGKVGIEQSYETELHGLTGYEEVE
CHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCHHHHHCCCCCCCEEE
VSAGGRPIRTLSTSQATPGNNLILSLDINLQRLAEQLFGNRRGALVAIEPETGDILAFVS
ECCCCCEEEEECCCCCCCCCCEEEEECCCHHHHHHHHHCCCCCCEEEECCCCCCEEEEEE
KPTFDPNLFIEGIDSATWSELNGSPDKPLLNRPLRGTYPPGSTYKPFMALAALELGKRTP
CCCCCCCCEEECCCCCCHHHCCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCC
QWGMADPGSFTLGNHTFRDDVPGGHGWVDMYRSIVVSCDTYYYKLANDMGVNAIHDFMKP
CCCCCCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEHHCCCCHHHHHHHHHH
LGFGQVTGIDIEGERTGILPSTEWKRKAYKRPEQQKWYDGETISLGIGQGYNNFTILQLA
CCCCCEEEEEECCCCCCCCCCCHHHHHHHCCCCHHCCCCCCEEEEECCCCCCCCHHHHHH
HAVATLANNGGVMKPHLVKAVEDSVNKARTLTVPTESYRIPLKQANIDVIKRAMAGVVQA
HHHHHHHCCCCCCCHHHHHHHHHHHHCCEEEEECCCCCCCCHHHCCHHHHHHHHHHHHHC
GTAAKAFAGAQYAAAGKTGTAQVFSLGKGEKYNHHAIPEYKRDHALFEAFAPTDHPKIAV
CCHHHHHHCCHHHCCCCCCCHHHEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEE
ALIVENAGFGATSAAPIARAVFDYYLQGKWPAELAAIAPKVQPQPPVDTPSVFSTGKTAT
EEEEECCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCHHCCCCCEE
IASATATPQAAAEAVAQSAALAAAASGEQAADAATVGGASAPGASAVAAGAPRAAPAMSS
EEECCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCHHHCCCCCCCCCCCC
DRVAPALREAGTSAQAVAPATLDAQVLQALSHVQPAPDLPSPRGRNLPAAPASAPAASPK
CCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC
DRKPAVKPNPKPAPKPARAAP
CCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]