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The map label for this gene is merA [H]

Identifier: 17232677

GI number: 17232677

Start: 6181911

End: 6183440

Strand: Reverse

Name: merA [H]

Synonym: all5185

Alternate gene names: 17232677

Gene position: 6183440-6181911 (Counterclockwise)

Preceding gene: 17232683

Following gene: 17232676

Centisome position: 96.41

GC content: 46.41

Gene sequence:

>1530_bases
ATGTCCAATTCAGAATTAGATAGAGTCATCGTCCGCCCAGTGGATGAGTATAATCAGAAATTGGTGGCTTATGTGCATCC
GCCCGATTGGGTGAACCCCCAACCGGCTGATAATTATGACTTGGTGGTCATTGGTGCGGGGACTGCTGGCTTAGTCGTGG
CGGCGGGTGCGGCTGGTCTGGGTTTGGGTTTAAAAGTGGCGCTAATCGAAAAGCATCTCATGGGTGGAGATTGCTTGAAT
GTGGGTTGTGTACCTTCTAAAACTATTATTCGGTCTTCGCGGGTGGTGGGGGAAATCTGGAATGGGAAAAATTTGGGGGT
GAATATTCCCAGCCAGATTGATATTGATTTTCCCGCAGTTATGGCACGAATGCGACGAGTGAGGGCAGGAATTAGCCACA
ATGATTCGGCGGAACGCTTTGCATCCCTGGGAGTTGATGTATTTTTAGGTAGTGGTAGATTTGCTAGCAGCAACACCGTA
GAAGTAGCTGGTAAAACCCTTAAATTTAAAAAAGCGGTGATTGCTACTGGTGCTAGGGCTACAAAACCAGCAATTATCGG
CATTGAACAAGCTGGATATCTCACCAATGAGACGGTTTTTTCCTTAATTCAAAGACCGGAAAAGTTAGCAGTAATTGGTG
GTGGCCCCATTGGTTGCGAATTAGCCCAAGCCTTCCGACGTTTGGGGAGTGAGGTGGTGCTGATTCATAGCGGTTCCCAT
GTCCTCAACAAAGAAGATAACGACGCGGCGCAAATTGTCCAACAGACTTTAATTAAAGAAGGGATTCGCTTAGTTTTAAA
TGCCAAGGTAGAAGAAGTAGTGACGGTAACCGAGGGTAAACGGTTGTATTTTTCTACCAACGGTCATCGTGATTCGGTGA
CGGTAGATGAAATATTAGTGGGTGCAGGGCGATCGCCTAATGTGGAAGGGTTGAATTTAGAAGCTGTCGGGGTAAAATAC
GACAAGCGTCGGGGTGTGGAAGTGAATGATTACCTACAAACCACCAACCCCAAGATTTATGCTGCTGGCGATATCTGCAT
GGACTGGAAATTTACCCACGCCGCCGATGCAGCCGCGCGCATTGTGATTAAAAATACCCTGTTTTCTCCCTTTGGTTTAG
GCAGGTCGAGACTAAGTAGCTTAGTCATGCCTTGGGTGACTTATACTGACCCAGAAGTTGCCCATGTGGGACTGTACGAA
AGTCAAGACGTAGAGACAATTAAAATCCCTTTTAGTAGTGTAGACCGAGCGATCGCCGACGGACAAGAAGATGGTTTTCT
GAAAATTCACCACAAAAAAGGCTCAGATGAAATTGTCGGTGCAACCATTGTGGCAAGTCACGCCGGCGAGATGATTTCGG
AAGTCACAACAGCGATAGTCAATAAAATCGGTTTAAACAAACTCAGTAACGTGATTCATCCCTACCCCACCCAAGCCGAA
GCCATCAAAAAAGCCGCAGATACCTATCGCCGCACCCTTCTCACACCAAGAACAAAAAAACTATTGGGATTTTTAACCAA
ATTTTCTTAA

Upstream 100 bases:

>100_bases
TGCTTTTATCATCACTTTTCATCAGACCTGATTTTGAATTGCGAATTTTGTAGCTTGCTTACAATAGAATAATTCCCATT
GCTGAGAGAGGTTACACCCA

Downstream 100 bases:

>100_bases
GAAAAAACTGACAACTGTCAACTGACAACTGACAACACATCAAAGCAGAAAAAATCACGGTAAGTTTAACCTTACACCTT
CCGCTATCCCTTAGACTAGG

Product: mercuric reductase

Products: NA

Alternate protein names: Hg(II) reductase [H]

Number of amino acids: Translated: 509; Mature: 508

Protein sequence:

>509_residues
MSNSELDRVIVRPVDEYNQKLVAYVHPPDWVNPQPADNYDLVVIGAGTAGLVVAAGAAGLGLGLKVALIEKHLMGGDCLN
VGCVPSKTIIRSSRVVGEIWNGKNLGVNIPSQIDIDFPAVMARMRRVRAGISHNDSAERFASLGVDVFLGSGRFASSNTV
EVAGKTLKFKKAVIATGARATKPAIIGIEQAGYLTNETVFSLIQRPEKLAVIGGGPIGCELAQAFRRLGSEVVLIHSGSH
VLNKEDNDAAQIVQQTLIKEGIRLVLNAKVEEVVTVTEGKRLYFSTNGHRDSVTVDEILVGAGRSPNVEGLNLEAVGVKY
DKRRGVEVNDYLQTTNPKIYAAGDICMDWKFTHAADAAARIVIKNTLFSPFGLGRSRLSSLVMPWVTYTDPEVAHVGLYE
SQDVETIKIPFSSVDRAIADGQEDGFLKIHHKKGSDEIVGATIVASHAGEMISEVTTAIVNKIGLNKLSNVIHPYPTQAE
AIKKAADTYRRTLLTPRTKKLLGFLTKFS

Sequences:

>Translated_509_residues
MSNSELDRVIVRPVDEYNQKLVAYVHPPDWVNPQPADNYDLVVIGAGTAGLVVAAGAAGLGLGLKVALIEKHLMGGDCLN
VGCVPSKTIIRSSRVVGEIWNGKNLGVNIPSQIDIDFPAVMARMRRVRAGISHNDSAERFASLGVDVFLGSGRFASSNTV
EVAGKTLKFKKAVIATGARATKPAIIGIEQAGYLTNETVFSLIQRPEKLAVIGGGPIGCELAQAFRRLGSEVVLIHSGSH
VLNKEDNDAAQIVQQTLIKEGIRLVLNAKVEEVVTVTEGKRLYFSTNGHRDSVTVDEILVGAGRSPNVEGLNLEAVGVKY
DKRRGVEVNDYLQTTNPKIYAAGDICMDWKFTHAADAAARIVIKNTLFSPFGLGRSRLSSLVMPWVTYTDPEVAHVGLYE
SQDVETIKIPFSSVDRAIADGQEDGFLKIHHKKGSDEIVGATIVASHAGEMISEVTTAIVNKIGLNKLSNVIHPYPTQAE
AIKKAADTYRRTLLTPRTKKLLGFLTKFS
>Mature_508_residues
SNSELDRVIVRPVDEYNQKLVAYVHPPDWVNPQPADNYDLVVIGAGTAGLVVAAGAAGLGLGLKVALIEKHLMGGDCLNV
GCVPSKTIIRSSRVVGEIWNGKNLGVNIPSQIDIDFPAVMARMRRVRAGISHNDSAERFASLGVDVFLGSGRFASSNTVE
VAGKTLKFKKAVIATGARATKPAIIGIEQAGYLTNETVFSLIQRPEKLAVIGGGPIGCELAQAFRRLGSEVVLIHSGSHV
LNKEDNDAAQIVQQTLIKEGIRLVLNAKVEEVVTVTEGKRLYFSTNGHRDSVTVDEILVGAGRSPNVEGLNLEAVGVKYD
KRRGVEVNDYLQTTNPKIYAAGDICMDWKFTHAADAAARIVIKNTLFSPFGLGRSRLSSLVMPWVTYTDPEVAHVGLYES
QDVETIKIPFSSVDRAIADGQEDGFLKIHHKKGSDEIVGATIVASHAGEMISEVTTAIVNKIGLNKLSNVIHPYPTQAEA
IKKAADTYRRTLLTPRTKKLLGFLTKFS

Specific function: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0) [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=475, Percent_Identity=31.1578947368421, Blast_Score=195, Evalue=8e-50,
Organism=Homo sapiens, GI50301238, Length=477, Percent_Identity=26.6247379454927, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI291045266, Length=439, Percent_Identity=24.6013667425968, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI148277065, Length=455, Percent_Identity=23.956043956044, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI33519430, Length=455, Percent_Identity=23.956043956044, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI33519428, Length=455, Percent_Identity=23.956043956044, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI33519426, Length=455, Percent_Identity=23.956043956044, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI148277071, Length=455, Percent_Identity=23.956043956044, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI22035672, Length=453, Percent_Identity=22.7373068432671, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI291045268, Length=291, Percent_Identity=25.7731958762887, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1786307, Length=487, Percent_Identity=29.9794661190965, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI87081717, Length=462, Percent_Identity=27.2727272727273, Blast_Score=139, Evalue=6e-34,
Organism=Escherichia coli, GI1789915, Length=429, Percent_Identity=29.3706293706294, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI87082354, Length=474, Percent_Identity=26.5822784810127, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1789065, Length=223, Percent_Identity=26.457399103139, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI32565766, Length=481, Percent_Identity=31.1850311850312, Blast_Score=197, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17557007, Length=498, Percent_Identity=26.7068273092369, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI71983429, Length=432, Percent_Identity=27.0833333333333, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI71983419, Length=432, Percent_Identity=27.0833333333333, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI71982272, Length=483, Percent_Identity=23.3954451345756, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6321091, Length=479, Percent_Identity=27.9749478079332, Blast_Score=162, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6325166, Length=469, Percent_Identity=29.4243070362473, Blast_Score=151, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6325240, Length=486, Percent_Identity=25.3086419753086, Blast_Score=117, Evalue=5e-27,
Organism=Drosophila melanogaster, GI21358499, Length=471, Percent_Identity=32.2717622080679, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI24640549, Length=491, Percent_Identity=27.4949083503055, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24640553, Length=487, Percent_Identity=27.5154004106776, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24640551, Length=487, Percent_Identity=27.5154004106776, Blast_Score=117, Evalue=3e-26,
Organism=Drosophila melanogaster, GI17737741, Length=499, Percent_Identity=26.25250501002, Blast_Score=105, Evalue=8e-23,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR017969
- InterPro:   IPR006121
- InterPro:   IPR000815
- InterPro:   IPR021179
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00403 HMA; PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.16.1.1 [H]

Molecular weight: Translated: 54897; Mature: 54765

Theoretical pI: Translated: 8.78; Mature: 8.78

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNSELDRVIVRPVDEYNQKLVAYVHPPDWVNPQPADNYDLVVIGAGTAGLVVAAGAAGL
CCCCCCCCEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEECCCCCEEEECCCCCC
GLGLKVALIEKHLMGGDCLNVGCVPSKTIIRSSRVVGEIWNGKNLGVNIPSQIDIDFPAV
CCCEEEEEHHHHHCCCCEEECCCCCCHHHHHHCHHEEEECCCCCCCCCCCCCCCCCHHHH
MARMRRVRAGISHNDSAERFASLGVDVFLGSGRFASSNTVEVAGKTLKFKKAVIATGARA
HHHHHHHHCCCCCCCHHHHHHHCCEEEEECCCCCCCCCEEEECCCHHHHHHHHHCCCCCC
TKPAIIGIEQAGYLTNETVFSLIQRPEKLAVIGGGPIGCELAQAFRRLGSEVVLIHSGSH
CCCEEEEECCCCCCCHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCE
VLNKEDNDAAQIVQQTLIKEGIRLVLNAKVEEVVTVTEGKRLYFSTNGHRDSVTVDEILV
ECCCCCCHHHHHHHHHHHHHHHHEEECCCHHHEEEEECCCEEEEECCCCCCCCCHHHHHC
GAGRSPNVEGLNLEAVGVKYDKRRGVEVNDYLQTTNPKIYAAGDICMDWKFTHAADAAAR
CCCCCCCCCCEEEEEEEEEECCCCCCCHHHHHHCCCCEEEEECCEEEECEECCHHHHHHE
IVIKNTLFSPFGLGRSRLSSLVMPWVTYTDPEVAHVGLYESQDVETIKIPFSSVDRAIAD
EEEECCCCCCCCCCHHHHHHHHHCCEECCCCCEEEEECCCCCCCEEEECCHHHHHHHHHC
GQEDGFLKIHHKKGSDEIVGATIVASHAGEMISEVTTAIVNKIGLNKLSNVIHPYPTQAE
CCCCCEEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCHHH
AIKKAADTYRRTLLTPRTKKLLGFLTKFS
HHHHHHHHHHHHHCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SNSELDRVIVRPVDEYNQKLVAYVHPPDWVNPQPADNYDLVVIGAGTAGLVVAAGAAGL
CCCCCCCEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEECCCCCEEEECCCCCC
GLGLKVALIEKHLMGGDCLNVGCVPSKTIIRSSRVVGEIWNGKNLGVNIPSQIDIDFPAV
CCCEEEEEHHHHHCCCCEEECCCCCCHHHHHHCHHEEEECCCCCCCCCCCCCCCCCHHHH
MARMRRVRAGISHNDSAERFASLGVDVFLGSGRFASSNTVEVAGKTLKFKKAVIATGARA
HHHHHHHHCCCCCCCHHHHHHHCCEEEEECCCCCCCCCEEEECCCHHHHHHHHHCCCCCC
TKPAIIGIEQAGYLTNETVFSLIQRPEKLAVIGGGPIGCELAQAFRRLGSEVVLIHSGSH
CCCEEEEECCCCCCCHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCE
VLNKEDNDAAQIVQQTLIKEGIRLVLNAKVEEVVTVTEGKRLYFSTNGHRDSVTVDEILV
ECCCCCCHHHHHHHHHHHHHHHHEEECCCHHHEEEEECCCEEEEECCCCCCCCCHHHHHC
GAGRSPNVEGLNLEAVGVKYDKRRGVEVNDYLQTTNPKIYAAGDICMDWKFTHAADAAAR
CCCCCCCCCCEEEEEEEEEECCCCCCCHHHHHHCCCCEEEEECCEEEECEECCHHHHHHE
IVIKNTLFSPFGLGRSRLSSLVMPWVTYTDPEVAHVGLYESQDVETIKIPFSSVDRAIAD
EEEECCCCCCCCCCHHHHHHHHHCCEECCCCCEEEEECCCCCCCEEEECCHHHHHHHHHC
GQEDGFLKIHHKKGSDEIVGATIVASHAGEMISEVTTAIVNKIGLNKLSNVIHPYPTQAE
CCCCCEEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCHHH
AIKKAADTYRRTLLTPRTKKLLGFLTKFS
HHHHHHHHHHHHHCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3037534 [H]