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The map label for this gene is moeA

Identifier: 17232628

GI number: 17232628

Start: 6131152

End: 6132462

Strand: Reverse

Name: moeA

Synonym: all5136

Alternate gene names: 17232628

Gene position: 6132462-6131152 (Counterclockwise)

Preceding gene: 17232629

Following gene: 17232625

Centisome position: 95.61

GC content: 44.09

Gene sequence:

>1311_bases
ATTCAAAATAAATTGAGTTGTGAAGTGAAGAGAAACCCTCACACCCCTAAACCCTTACACCCCTACACCCCCATGCCATC
AGTCAGGGATACAGCAAATATCATTTTCAATTTAGTCCCAAAGCTGGATAGTCAACAAGATACAGAAATTGTCGATTTAT
GGGCAGCAAATGGGCGCATTTTGGCCACACCTGTAAATAGCACCCTAGATTTTCCTCATTGGGATAATTCAGCGATGGAT
GGCTATGCGGTACGTTATGAAGATGTACACAACTCCAACGCCGAACAGCCAGTTAGCCTAGAAGTTGTTGCAGAAATTCC
CGCAGGCTATCAACCCAAATTTACCCTACAACCAGGACAAGCCGCCCGGATCTTTACTGGCGCAGTCATGCCCAGTGGTG
GTGATACTGTAGTCATGCAAGAGAAGACACGCCAAGAGAATAACCGCGTCTTCATCCTCACAACACCAAAACCAGGGGAA
TTTGTCAGGCTGAAAGCAGCTTATTACCAAGCCGGGACACAATTATTACCAGCTAATACCCAATTAAATGCAGCCGAAAT
CGCTATATTAGCCGCTTCTCAATGCCCACAGGTAAAAGTTTATCGCCGTCCTCGTGTAGCAATTTTTTCCACTGGGGATG
AATTAGTAACACTTGACCAGCCTTTACAACCAGGGCAAATAGTTGATTCTAATCAGTATGCCCTAGCAGCTTTAGTAAAG
CAAAATGGTGCAGAACCTATATTATTCGGCATTGTCAAAGACAACCCAACCGCCCTTGGGGAAACAATCAGCAAAGCCAT
AGCTAACGCCGATATAGTCATTTCTTCCGGTGGCGTTTCCGTTGGTGATTATGATTACGTTGACCAAATTCTAGCTTCCT
TAGGGGCTAAAATTCACATCCGTTCTGTAGAAATGCGCCCAGGAAAACCCCTCACTGTCGCCACCTTCCCTACACCCCCA
GCCCCCATTTATTTGGGTTTACCAGGAAACCCTGCGGCTGTTTTGGTAACATTTTGGCGATTTGTGCAGCCAGTAATTCG
GAAATTAGGGGGATTAGCTAAAGGTTGGGAACCAGTATTTGTAAAAGTGCGATCGCATGATGAGTTACACTCAGACGGTA
AGCGTGAAACTTATATTTGGGGAAGTCTGCATCTAGTTGATGGATTATACGAGTTTCACAAAGCTGGTGGTAGCCATAGT
TCCGGTAATTTGATTAATCTAGCTCAAACTAATGCTTTAGCTGTTTTACCACTAGGTGAAACATTCATTTCATCAGGAAA
AGATGTATTGGTTTTACAACTACCAATTTAA

Upstream 100 bases:

>100_bases
ATTAGATGTAAATAATTGGGCAAGTCTCAACTTTAGTTTTCAAGTAGCGTAAGTCAATTCAAAATTCAACATACCCTGCG
GGAAGCGCACGCGCTACAAA

Downstream 100 bases:

>100_bases
CGACATAAACAGACTCTATAGTCCAATTACCAATTACCCATTCCCAATTACCAGTTACCAAAATCCCTTGATTGTAAAAA
CTATAGTGTCTGTTCAGAAT

Product: molybdopterin biosynthesis protein

Products: NA

Alternate protein names: MPT Mo-transferase

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MQNKLSCEVKRNPHTPKPLHPYTPMPSVRDTANIIFNLVPKLDSQQDTEIVDLWAANGRILATPVNSTLDFPHWDNSAMD
GYAVRYEDVHNSNAEQPVSLEVVAEIPAGYQPKFTLQPGQAARIFTGAVMPSGGDTVVMQEKTRQENNRVFILTTPKPGE
FVRLKAAYYQAGTQLLPANTQLNAAEIAILAASQCPQVKVYRRPRVAIFSTGDELVTLDQPLQPGQIVDSNQYALAALVK
QNGAEPILFGIVKDNPTALGETISKAIANADIVISSGGVSVGDYDYVDQILASLGAKIHIRSVEMRPGKPLTVATFPTPP
APIYLGLPGNPAAVLVTFWRFVQPVIRKLGGLAKGWEPVFVKVRSHDELHSDGKRETYIWGSLHLVDGLYEFHKAGGSHS
SGNLINLAQTNALAVLPLGETFISSGKDVLVLQLPI

Sequences:

>Translated_436_residues
MQNKLSCEVKRNPHTPKPLHPYTPMPSVRDTANIIFNLVPKLDSQQDTEIVDLWAANGRILATPVNSTLDFPHWDNSAMD
GYAVRYEDVHNSNAEQPVSLEVVAEIPAGYQPKFTLQPGQAARIFTGAVMPSGGDTVVMQEKTRQENNRVFILTTPKPGE
FVRLKAAYYQAGTQLLPANTQLNAAEIAILAASQCPQVKVYRRPRVAIFSTGDELVTLDQPLQPGQIVDSNQYALAALVK
QNGAEPILFGIVKDNPTALGETISKAIANADIVISSGGVSVGDYDYVDQILASLGAKIHIRSVEMRPGKPLTVATFPTPP
APIYLGLPGNPAAVLVTFWRFVQPVIRKLGGLAKGWEPVFVKVRSHDELHSDGKRETYIWGSLHLVDGLYEFHKAGGSHS
SGNLINLAQTNALAVLPLGETFISSGKDVLVLQLPI
>Mature_436_residues
MQNKLSCEVKRNPHTPKPLHPYTPMPSVRDTANIIFNLVPKLDSQQDTEIVDLWAANGRILATPVNSTLDFPHWDNSAMD
GYAVRYEDVHNSNAEQPVSLEVVAEIPAGYQPKFTLQPGQAARIFTGAVMPSGGDTVVMQEKTRQENNRVFILTTPKPGE
FVRLKAAYYQAGTQLLPANTQLNAAEIAILAASQCPQVKVYRRPRVAIFSTGDELVTLDQPLQPGQIVDSNQYALAALVK
QNGAEPILFGIVKDNPTALGETISKAIANADIVISSGGVSVGDYDYVDQILASLGAKIHIRSVEMRPGKPLTVATFPTPP
APIYLGLPGNPAAVLVTFWRFVQPVIRKLGGLAKGWEPVFVKVRSHDELHSDGKRETYIWGSLHLVDGLYEFHKAGGSHS
SGNLINLAQTNALAVLPLGETFISSGKDVLVLQLPI

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family

Homologues:

Organism=Homo sapiens, GI10880983, Length=414, Percent_Identity=34.5410628019324, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI66932975, Length=414, Percent_Identity=34.5410628019324, Blast_Score=197, Evalue=2e-50,
Organism=Escherichia coli, GI1787049, Length=375, Percent_Identity=40.2666666666667, Blast_Score=223, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI25147659, Length=351, Percent_Identity=33.6182336182336, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17562606, Length=336, Percent_Identity=25.8928571428571, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI17136978, Length=347, Percent_Identity=31.4121037463977, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24638841, Length=347, Percent_Identity=31.4121037463977, Blast_Score=133, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MOEA_NOSS1 (Q44243)

Other databases:

- EMBL:   U34309
- EMBL:   BA000019
- PIR:   AH2447
- RefSeq:   NP_489176.1
- ProteinModelPortal:   Q44243
- SMR:   Q44243
- STRING:   Q44243
- GeneID:   1108740
- GenomeReviews:   BA000019_GR
- KEGG:   ana:all5136
- NMPDR:   fig|103690.1.peg.5443
- eggNOG:   COG0303
- HOGENOM:   HBG731522
- OMA:   LLQRTEP
- PhylomeDB:   Q44243
- ProtClustDB:   CLSK896330
- BioCyc:   NSP103690:ALL5136-MONOMER
- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453
- Gene3D:   G3DSA:3.40.980.10
- SMART:   SM00852
- TIGRFAMs:   TIGR00177

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N; SSF53218 MoCF_biosynth; SSF63867 MoeA_C; SSF63882 MoeA_N

EC number: NA

Molecular weight: Translated: 47333; Mature: 47333

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNKLSCEVKRNPHTPKPLHPYTPMPSVRDTANIIFNLVPKLDSQQDTEIVDLWAANGRI
CCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEEECCCEE
LATPVNSTLDFPHWDNSAMDGYAVRYEDVHNSNAEQPVSLEVVAEIPAGYQPKFTLQPGQ
EEECCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEEEEECCCCCCCEEEECCCC
AARIFTGAVMPSGGDTVVMQEKTRQENNRVFILTTPKPGEFVRLKAAYYQAGTQLLPANT
CEEEEEEEECCCCCCEEEEEHHHHCCCCEEEEEECCCCCCEEEEEEEEECCCCEEECCCC
QLNAAEIAILAASQCPQVKVYRRPRVAIFSTGDELVTLDQPLQPGQIVDSNQYALAALVK
CCCCEEEEEEECCCCCCEEEECCCEEEEEECCCCEEEECCCCCCCEEECCCCCEEEEEEH
QNGAEPILFGIVKDNPTALGETISKAIANADIVISSGGVSVGDYDYVDQILASLGAKIHI
HCCCCEEEEEEECCCCHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHCCCEEEE
RSVEMRPGKPLTVATFPTPPAPIYLGLPGNPAAVLVTFWRFVQPVIRKLGGLAKGWEPVF
EEEEECCCCCEEEEECCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
VKVRSHDELHSDGKRETYIWGSLHLVDGLYEFHKAGGSHSSGNLINLAQTNALAVLPLGE
EEEECCCCHHCCCCEEEEEEEEHHHHHHHHHHHHCCCCCCCCCEEEEECCCEEEEEECCH
TFISSGKDVLVLQLPI
HHHCCCCCEEEEEECC
>Mature Secondary Structure
MQNKLSCEVKRNPHTPKPLHPYTPMPSVRDTANIIFNLVPKLDSQQDTEIVDLWAANGRI
CCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEEECCCEE
LATPVNSTLDFPHWDNSAMDGYAVRYEDVHNSNAEQPVSLEVVAEIPAGYQPKFTLQPGQ
EEECCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEEEEECCCCCCCEEEECCCC
AARIFTGAVMPSGGDTVVMQEKTRQENNRVFILTTPKPGEFVRLKAAYYQAGTQLLPANT
CEEEEEEEECCCCCCEEEEEHHHHCCCCEEEEEECCCCCCEEEEEEEEECCCCEEECCCC
QLNAAEIAILAASQCPQVKVYRRPRVAIFSTGDELVTLDQPLQPGQIVDSNQYALAALVK
CCCCEEEEEEECCCCCCEEEECCCEEEEEECCCCEEEECCCCCCCEEECCCCCEEEEEEH
QNGAEPILFGIVKDNPTALGETISKAIANADIVISSGGVSVGDYDYVDQILASLGAKIHI
HCCCCEEEEEEECCCCHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHCCCEEEE
RSVEMRPGKPLTVATFPTPPAPIYLGLPGNPAAVLVTFWRFVQPVIRKLGGLAKGWEPVF
EEEEECCCCCEEEEECCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
VKVRSHDELHSDGKRETYIWGSLHLVDGLYEFHKAGGSHSSGNLINLAQTNALAVLPLGE
EEEECCCCHHCCCCEEEEEEEEHHHHHHHHHHHHCCCCCCCCCEEEEECCCEEEEEECCH
TFISSGKDVLVLQLPI
HHHCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8682795; 11759840