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The map label for this gene is mprA [H]

Identifier: 17232561

GI number: 17232561

Start: 6040568

End: 6041305

Strand: Reverse

Name: mprA [H]

Synonym: all5069

Alternate gene names: 17232561

Gene position: 6041305-6040568 (Counterclockwise)

Preceding gene: 17232564

Following gene: 17232556

Centisome position: 94.19

GC content: 40.51

Gene sequence:

>738_bases
ATGGAGCTTGTAGAAATAATCTCAGTAAAAAATAATGCTAGGGGTGTATTGTCCATGCCCTTGACGATCCTTGTAGTGGA
TGACGATCTGGGCACTCGTCTGTCTATTAGTGATTACCTAGAACTGTCTGGCTATTCAGTAATTACGGCTAATGATGGTC
AAGAAGCTTTGACTATGGTGGAAGCATACCATCCTGATTTAATCGTGACTGATATTGTTATGCCAAGAATGAACGGTTAT
GAGTTGGTGCGTCGAGTTCGTCAGCAACCTCCATTCCGTTTATTACCTGTAATTTTATTAACAGCGCGTACGAGAACCCA
GGAAAGAATTCTTGGTTATCAATCAGGATGTGATTTATATTTGCCTAAACCTTTTGAACTAGAAGAGTTAGCAGCAGCGA
TTCGTAATTTGCTGGAGCGATCGCAAATCATTCAATCTGAATACCGATTTTCTCAAAAAGACAATTTAGGCAGTCCTCTC
CCTAGCAAAATTGTAGAGAGTCATCACTCCGTATTTACTCATGTGGAAAAATCGCACCTACTCTCATCTTTAACGCCTAG
AGAGCAAGAAGTCTTAGAAATGTTGACTCATGGTTTGTCTAATATCGAAATAGGGCATCAATTACACTTGAGTCCCAGAA
CTGTGGAAAAATACGTTAGTAGTCTACTGAGAAAAACTACCACCAGCAATCGGGCCGAACTGGTGCGTTTTGCCATTACA
CATGGTTTAGTAGAGTAA

Upstream 100 bases:

>100_bases
AATTTAAGATTTTCTTTATAAATTACTTTTAGACCCGTCATTAGCTGCTAATCCTGTCATAGTATGAAACATGAGAACAC
TATTTCATGGGTGTTCATAG

Downstream 100 bases:

>100_bases
CATCTGTATCTAATTCGAGTTGCTAGTTATGCTTCTAGTTGCTGGCTAGTAATATGTTGCAGTAAACCCTCACAGGCATC
AACCAGCAAATCAATGACCT

Product: two-component response regulator

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MELVEIISVKNNARGVLSMPLTILVVDDDLGTRLSISDYLELSGYSVITANDGQEALTMVEAYHPDLIVTDIVMPRMNGY
ELVRRVRQQPPFRLLPVILLTARTRTQERILGYQSGCDLYLPKPFELEELAAAIRNLLERSQIIQSEYRFSQKDNLGSPL
PSKIVESHHSVFTHVEKSHLLSSLTPREQEVLEMLTHGLSNIEIGHQLHLSPRTVEKYVSSLLRKTTTSNRAELVRFAIT
HGLVE

Sequences:

>Translated_245_residues
MELVEIISVKNNARGVLSMPLTILVVDDDLGTRLSISDYLELSGYSVITANDGQEALTMVEAYHPDLIVTDIVMPRMNGY
ELVRRVRQQPPFRLLPVILLTARTRTQERILGYQSGCDLYLPKPFELEELAAAIRNLLERSQIIQSEYRFSQKDNLGSPL
PSKIVESHHSVFTHVEKSHLLSSLTPREQEVLEMLTHGLSNIEIGHQLHLSPRTVEKYVSSLLRKTTTSNRAELVRFAIT
HGLVE
>Mature_245_residues
MELVEIISVKNNARGVLSMPLTILVVDDDLGTRLSISDYLELSGYSVITANDGQEALTMVEAYHPDLIVTDIVMPRMNGY
ELVRRVRQQPPFRLLPVILLTARTRTQERILGYQSGCDLYLPKPFELEELAAAIRNLLERSQIIQSEYRFSQKDNLGSPL
PSKIVESHHSVFTHVEKSHLLSSLTPREQEVLEMLTHGLSNIEIGHQLHLSPRTVEKYVSSLLRKTTTSNRAELVRFAIT
HGLVE

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI2367329, Length=137, Percent_Identity=38.6861313868613, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790299, Length=119, Percent_Identity=36.1344537815126, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1790863, Length=119, Percent_Identity=38.655462184874, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1788713, Length=227, Percent_Identity=30.8370044052863, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1786599, Length=122, Percent_Identity=32.7868852459016, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1786784, Length=172, Percent_Identity=29.6511627906977, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1788394, Length=212, Percent_Identity=28.7735849056604, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1788222, Length=226, Percent_Identity=29.2035398230088, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1789809, Length=120, Percent_Identity=37.5, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI145693157, Length=108, Percent_Identity=40.7407407407407, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1786911, Length=119, Percent_Identity=35.2941176470588, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87082012, Length=131, Percent_Identity=31.2977099236641, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788550, Length=117, Percent_Identity=33.3333333333333, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI1790860, Length=119, Percent_Identity=33.6134453781513, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1790552, Length=120, Percent_Identity=37.5, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1787229, Length=141, Percent_Identity=31.9148936170213, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1787375, Length=127, Percent_Identity=30.7086614173228, Blast_Score=70, Evalue=9e-14,
Organism=Escherichia coli, GI1788905, Length=181, Percent_Identity=29.8342541436464, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1789402, Length=122, Percent_Identity=31.9672131147541, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI1788191, Length=121, Percent_Identity=31.404958677686, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790437, Length=205, Percent_Identity=26.3414634146341, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1788521, Length=216, Percent_Identity=28.7037037037037, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27738; Mature: 27738

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELVEIISVKNNARGVLSMPLTILVVDDDLGTRLSISDYLELSGYSVITANDGQEALTMV
CCHHHEEECCCCCCEEEECCEEEEEEECCCCCEECHHHHHHHCCCEEEEECCCHHHHHHH
EAYHPDLIVTDIVMPRMNGYELVRRVRQQPPFRLLPVILLTARTRTQERILGYQSGCDLY
HHHCCCEEEEHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHCCCCCEE
LPKPFELEELAAAIRNLLERSQIIQSEYRFSQKDNLGSPLPSKIVESHHSVFTHVEKSHL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LSSLTPREQEVLEMLTHGLSNIEIGHQLHLSPRTVEKYVSSLLRKTTTSNRAELVRFAIT
HHHCCCCHHHHHHHHHCCCCCCCCCCEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
HGLVE
HHCCC
>Mature Secondary Structure
MELVEIISVKNNARGVLSMPLTILVVDDDLGTRLSISDYLELSGYSVITANDGQEALTMV
CCHHHEEECCCCCCEEEECCEEEEEEECCCCCEECHHHHHHHCCCEEEEECCCHHHHHHH
EAYHPDLIVTDIVMPRMNGYELVRRVRQQPPFRLLPVILLTARTRTQERILGYQSGCDLY
HHHCCCEEEEHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHCCCCCEE
LPKPFELEELAAAIRNLLERSQIIQSEYRFSQKDNLGSPLPSKIVESHHSVFTHVEKSHL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LSSLTPREQEVLEMLTHGLSNIEIGHQLHLSPRTVEKYVSSLLRKTTTSNRAELVRFAIT
HHHCCCCHHHHHHHHHCCCCCCCCCCEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
HGLVE
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA