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The map label for this gene is phoP [H]

Identifier: 17232219

GI number: 17232219

Start: 5634737

End: 5635453

Strand: Reverse

Name: phoP [H]

Synonym: all4727

Alternate gene names: 17232219

Gene position: 5635453-5634737 (Counterclockwise)

Preceding gene: 17232220

Following gene: 17232218

Centisome position: 87.86

GC content: 43.1

Gene sequence:

>717_bases
ATGGACATTCTAATTGTTGAGGATGAATCAGAAATTGCTCAGTTAATTCAACATTCTTTAGAAAAAGAGGGCTTTTCCTG
TCGGACTAGCCGCGATGGGATCAATGCTCTACAAATGTTTCACGAACGACCACCAGATTTAATCATCCTAGACCTGATGA
TTCCTGGGCTGGATGGGTTGGAAGTTTGCGCGAGAATTCGCCAGAAACCTGGGGCAAAAGACCCTTATATACTAATGCTC
ACAGCTAAAGGTGAGGAAATAGACCGGGTAATCGGCTTGTCTACGGGTGCTGATGACTATATGGTTAAACCCTTCAGCCC
TAGAGAGTTGGTGGCGCGTGTCAGGGCGCTTCTACGGCGCAGCTTACGTCAAGGGGGACAAAATCAGGTAAATCGGACTC
AACACTTTATAGTAGATTTAGACCAACGAACTGCCAGTCGTCAAATAGATTCCCATCAACCAGAAGCTTTAGATTTAACC
ACTTTAGAATTTAATTTATTAAGCACTTTTGTCAGCAATCCTGGGCGAGTGTGGAACCGTACCCAACTAATTGACAAATT
GTGGGGAGATAATTTTTTTGGTGATGAGCGTGTTGTAGATACTCATGTAGCTAGGCTCAGGAAAAAAATTGAACCTGATC
CCACCAATCCCAGTTTTATTAAAACTGTTGTCGGAGTTGGCTATAAATTTGAAGACTCTCCTGTAATTTCCGCATGA

Upstream 100 bases:

>100_bases
AACTAAAAACATAAGTGTTAAATTAATTACTATCAGAACTCTTGCAGTTGCTGGAATAAAATAACAACCAAAGAAATTAC
GCTGCGTACCTTACGTCAAA

Downstream 100 bases:

>100_bases
TTAAAAAAGGTTGGCGTTGGACAAAATCCCTACCTTTAGCATCCCGCTTGTTTGTCTCCCACTTAGTGGTGATGATAGTG
GGATTAATTAGTCTTGTCAT

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MDILIVEDESEIAQLIQHSLEKEGFSCRTSRDGINALQMFHERPPDLIILDLMIPGLDGLEVCARIRQKPGAKDPYILML
TAKGEEIDRVIGLSTGADDYMVKPFSPRELVARVRALLRRSLRQGGQNQVNRTQHFIVDLDQRTASRQIDSHQPEALDLT
TLEFNLLSTFVSNPGRVWNRTQLIDKLWGDNFFGDERVVDTHVARLRKKIEPDPTNPSFIKTVVGVGYKFEDSPVISA

Sequences:

>Translated_238_residues
MDILIVEDESEIAQLIQHSLEKEGFSCRTSRDGINALQMFHERPPDLIILDLMIPGLDGLEVCARIRQKPGAKDPYILML
TAKGEEIDRVIGLSTGADDYMVKPFSPRELVARVRALLRRSLRQGGQNQVNRTQHFIVDLDQRTASRQIDSHQPEALDLT
TLEFNLLSTFVSNPGRVWNRTQLIDKLWGDNFFGDERVVDTHVARLRKKIEPDPTNPSFIKTVVGVGYKFEDSPVISA
>Mature_238_residues
MDILIVEDESEIAQLIQHSLEKEGFSCRTSRDGINALQMFHERPPDLIILDLMIPGLDGLEVCARIRQKPGAKDPYILML
TAKGEEIDRVIGLSTGADDYMVKPFSPRELVARVRALLRRSLRQGGQNQVNRTQHFIVDLDQRTASRQIDSHQPEALDLT
TLEFNLLSTFVSNPGRVWNRTQLIDKLWGDNFFGDERVVDTHVARLRKKIEPDPTNPSFIKTVVGVGYKFEDSPVISA

Specific function: Member of the two-component regulatory system phoP/phoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788394, Length=229, Percent_Identity=43.2314410480349, Blast_Score=175, Evalue=2e-45,
Organism=Escherichia coli, GI1786599, Length=228, Percent_Identity=40.7894736842105, Blast_Score=172, Evalue=1e-44,
Organism=Escherichia coli, GI1789809, Length=234, Percent_Identity=38.4615384615385, Blast_Score=160, Evalue=9e-41,
Organism=Escherichia coli, GI1790860, Length=228, Percent_Identity=41.2280701754386, Blast_Score=156, Evalue=1e-39,
Organism=Escherichia coli, GI1786784, Length=231, Percent_Identity=38.5281385281385, Blast_Score=140, Evalue=6e-35,
Organism=Escherichia coli, GI1790863, Length=230, Percent_Identity=33.0434782608696, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1786911, Length=229, Percent_Identity=34.9344978165939, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI87082012, Length=230, Percent_Identity=36.5217391304348, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=37.8854625550661, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1789402, Length=230, Percent_Identity=37.3913043478261, Blast_Score=124, Evalue=5e-30,
Organism=Escherichia coli, GI1787375, Length=231, Percent_Identity=34.1991341991342, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI1790552, Length=230, Percent_Identity=34.3478260869565, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI1787229, Length=232, Percent_Identity=31.8965517241379, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI145693140, Length=236, Percent_Identity=29.6610169491525, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788550, Length=123, Percent_Identity=34.1463414634146, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1790299, Length=112, Percent_Identity=33.0357142857143, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26949; Mature: 26949

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDILIVEDESEIAQLIQHSLEKEGFSCRTSRDGINALQMFHERPPDLIILDLMIPGLDGL
CCEEEECCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCHH
EVCARIRQKPGAKDPYILMLTAKGEEIDRVIGLSTGADDYMVKPFSPRELVARVRALLRR
HHHHHHHHCCCCCCCEEEEEEECCCHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHHHHH
SLRQGGQNQVNRTQHFIVDLDQRTASRQIDSHQPEALDLTTLEFNLLSTFVSNPGRVWNR
HHHCCCCHHHHHHHHHEEECHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHCCCCCHHHH
TQLIDKLWGDNFFGDERVVDTHVARLRKKIEPDPTNPSFIKTVVGVGYKFEDSPVISA
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCEEECCCCCCCC
>Mature Secondary Structure
MDILIVEDESEIAQLIQHSLEKEGFSCRTSRDGINALQMFHERPPDLIILDLMIPGLDGL
CCEEEECCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCHH
EVCARIRQKPGAKDPYILMLTAKGEEIDRVIGLSTGADDYMVKPFSPRELVARVRALLRR
HHHHHHHHCCCCCCCEEEEEEECCCHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHHHHH
SLRQGGQNQVNRTQHFIVDLDQRTASRQIDSHQPEALDLTTLEFNLLSTFVSNPGRVWNR
HHHCCCCHHHHHHHHHEEECHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHCCCCCHHHH
TQLIDKLWGDNFFGDERVVDTHVARLRKKIEPDPTNPSFIKTVVGVGYKFEDSPVISA
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1454550; 3036763; 9387221; 9384377; 8045898; 3142862 [H]