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The map label for this gene is mtrB [H]

Identifier: 17232218

GI number: 17232218

Start: 5633625

End: 5634740

Strand: Reverse

Name: mtrB [H]

Synonym: all4726

Alternate gene names: 17232218

Gene position: 5634740-5633625 (Counterclockwise)

Preceding gene: 17232219

Following gene: 17232217

Centisome position: 87.85

GC content: 43.28

Gene sequence:

>1116_bases
ATGATTAAAAAAGGTTGGCGTTGGACAAAATCCCTACCTTTAGCATCCCGCTTGTTTGTCTCCCACTTAGTGGTGATGAT
AGTGGGATTAATTAGTCTTGTCATTATTAGTAAAGTTTCGTCGCCCCGCTTTTTTGTCCTGCACTTAGAAAGATTGGAAA
GTGAAGGGGTGAATTTAATTAATGTTCGTGCAGATTTAGTCCAAGGGTTTGAGATAGCTTGGCGCAGCAGCACTATTTGG
TCAGTCTTAGTCGGTAGCACGGCTGCGGGAGGCTTGAGTTACTGGGTTTCTAAAAGGATTATGCAGCGATTAACTGAGAT
GGAACAAATAACTCAACAGTTTGCTGCTGGTCATCTACAAGCGCGGCTACCTTTGTCTGACATCCCCGAACTCAATCGCT
TGGGTACGAGTTTTAACCGCATGGCTGCCAGTTTGGAAGGGGTGGAAGCACGACGGCGGGAACTGATAGGTGATATGACT
CATGAACTACGCACACCGTTAACAGTTGTGCGTGGTTATTTAGAAGAACTTGCCGATGGTGAAATTGAACCATCCCCAGA
GGTTTATCGGCGCTTGGCGAAAGAAACTAGACGTTTAGAACGATTAGTCAACGATTTACAAGAATTATCGAAGGCAGAAG
CTGGTTATTTACCTATTAGAATACAGTCTGTCAATTTATATCCTTTATTAGAGTCTTTAGTTGAAAGATTTAGCGATCAA
TTGTTAGAGGATGGCCCAGTATTACTTGCGGAATTGACACCCCAAATGCCTCTTGTATTAGCAGATATCGATCGCACAGA
ACAAATATTAGTCAACTTGCTAGGTAACGCCATCCGTTATACTACAACAGGTTCAATTACTATCCGTACATGGACAGAAA
ACAGGCAACTCTGGATTGCTGTGATTGATACAGGTATTGGTATTGCTTCCGAGGATATACCCCATGTATTTGAGCGTTTT
TGGCGAGCTGATCAATCGCGCGATCGCCACTCCGGTGGCACAGGTATTGGCTTAACTATCACTAAACACCTAGTAGAACT
ACAAAGTGGCGAAATTCATCTAGATAGTGAACTAGGTATTGGCAGCACGTTCCGCTTTTGTTTGCCTTTAGCATAA

Upstream 100 bases:

>100_bases
GGCTCAGGAAAAAAATTGAACCTGATCCCACCAATCCCAGTTTTATTAAAACTGTTGTCGGAGTTGGCTATAAATTTGAA
GACTCTCCTGTAATTTCCGC

Downstream 100 bases:

>100_bases
GCACGAGTTCATAGATCCCCGACTTTTTAAAAAAGTCGGGGATCTGAGCGTTCCTACAACACAAAATGAACGGCTTCCAT
TATGATAATGGTTATCAATC

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MIKKGWRWTKSLPLASRLFVSHLVVMIVGLISLVIISKVSSPRFFVLHLERLESEGVNLINVRADLVQGFEIAWRSSTIW
SVLVGSTAAGGLSYWVSKRIMQRLTEMEQITQQFAAGHLQARLPLSDIPELNRLGTSFNRMAASLEGVEARRRELIGDMT
HELRTPLTVVRGYLEELADGEIEPSPEVYRRLAKETRRLERLVNDLQELSKAEAGYLPIRIQSVNLYPLLESLVERFSDQ
LLEDGPVLLAELTPQMPLVLADIDRTEQILVNLLGNAIRYTTTGSITIRTWTENRQLWIAVIDTGIGIASEDIPHVFERF
WRADQSRDRHSGGTGIGLTITKHLVELQSGEIHLDSELGIGSTFRFCLPLA

Sequences:

>Translated_371_residues
MIKKGWRWTKSLPLASRLFVSHLVVMIVGLISLVIISKVSSPRFFVLHLERLESEGVNLINVRADLVQGFEIAWRSSTIW
SVLVGSTAAGGLSYWVSKRIMQRLTEMEQITQQFAAGHLQARLPLSDIPELNRLGTSFNRMAASLEGVEARRRELIGDMT
HELRTPLTVVRGYLEELADGEIEPSPEVYRRLAKETRRLERLVNDLQELSKAEAGYLPIRIQSVNLYPLLESLVERFSDQ
LLEDGPVLLAELTPQMPLVLADIDRTEQILVNLLGNAIRYTTTGSITIRTWTENRQLWIAVIDTGIGIASEDIPHVFERF
WRADQSRDRHSGGTGIGLTITKHLVELQSGEIHLDSELGIGSTFRFCLPLA
>Mature_371_residues
MIKKGWRWTKSLPLASRLFVSHLVVMIVGLISLVIISKVSSPRFFVLHLERLESEGVNLINVRADLVQGFEIAWRSSTIW
SVLVGSTAAGGLSYWVSKRIMQRLTEMEQITQQFAAGHLQARLPLSDIPELNRLGTSFNRMAASLEGVEARRRELIGDMT
HELRTPLTVVRGYLEELADGEIEPSPEVYRRLAKETRRLERLVNDLQELSKAEAGYLPIRIQSVNLYPLLESLVERFSDQ
LLEDGPVLLAELTPQMPLVLADIDRTEQILVNLLGNAIRYTTTGSITIRTWTENRQLWIAVIDTGIGIASEDIPHVFERF
WRADQSRDRHSGGTGIGLTITKHLVELQSGEIHLDSELGIGSTFRFCLPLA

Specific function: Member of the two-component regulatory system mtrA/mtrB. Seems to function as a membrane-associated protein kinase that phosphorylates mtrA in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=243, Percent_Identity=37.037037037037, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1786600, Length=233, Percent_Identity=33.4763948497854, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1787894, Length=270, Percent_Identity=33.7037037037037, Blast_Score=117, Evalue=9e-28,
Organism=Escherichia coli, GI1789149, Length=226, Percent_Identity=34.070796460177, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI145693157, Length=251, Percent_Identity=29.0836653386454, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1786783, Length=263, Percent_Identity=32.319391634981, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI48994928, Length=270, Percent_Identity=30, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI87081816, Length=246, Percent_Identity=31.3008130081301, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI87082128, Length=245, Percent_Identity=28.5714285714286, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1790346, Length=269, Percent_Identity=29.7397769516729, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788713, Length=227, Percent_Identity=28.6343612334802, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1790861, Length=304, Percent_Identity=27.3026315789474, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1790436, Length=233, Percent_Identity=30.0429184549356, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1786912, Length=238, Percent_Identity=31.0924369747899, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1788549, Length=223, Percent_Identity=29.5964125560538, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1788279, Length=317, Percent_Identity=25.8675078864353, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1789808, Length=301, Percent_Identity=27.2425249169435, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1790551, Length=274, Percent_Identity=27.7372262773723, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1790300, Length=232, Percent_Identity=29.3103448275862, Blast_Score=63, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=81, Percent_Identity=43.2098765432099, Blast_Score=68, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 41797; Mature: 41797

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKKGWRWTKSLPLASRLFVSHLVVMIVGLISLVIISKVSSPRFFVLHLERLESEGVNLI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHCCCCEE
NVRADLVQGFEIAWRSSTIWSVLVGSTAAGGLSYWVSKRIMQRLTEMEQITQQFAAGHLQ
EEHHHHHCCHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
ARLPLSDIPELNRLGTSFNRMAASLEGVEARRRELIGDMTHELRTPLTVVRGYLEELADG
ECCCHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCC
EIEPSPEVYRRLAKETRRLERLVNDLQELSKAEAGYLPIRIQSVNLYPLLESLVERFSDQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHH
LLEDGPVLLAELTPQMPLVLADIDRTEQILVNLLGNAIRYTTTGSITIRTWTENRQLWIA
HHHCCCEEEEECCCCCCEEEECCCHHHHHHHHHHCCHHEEEECCCEEEEEECCCCEEEEE
VIDTGIGIASEDIPHVFERFWRADQSRDRHSGGTGIGLTITKHLVELQSGEIHLDSELGI
EEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEECCCCCC
GSTFRFCLPLA
CCHHHHHCCCC
>Mature Secondary Structure
MIKKGWRWTKSLPLASRLFVSHLVVMIVGLISLVIISKVSSPRFFVLHLERLESEGVNLI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHCCCCEE
NVRADLVQGFEIAWRSSTIWSVLVGSTAAGGLSYWVSKRIMQRLTEMEQITQQFAAGHLQ
EEHHHHHCCHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
ARLPLSDIPELNRLGTSFNRMAASLEGVEARRRELIGDMTHELRTPLTVVRGYLEELADG
ECCCHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCC
EIEPSPEVYRRLAKETRRLERLVNDLQELSKAEAGYLPIRIQSVNLYPLLESLVERFSDQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHH
LLEDGPVLLAELTPQMPLVLADIDRTEQILVNLLGNAIRYTTTGSITIRTWTENRQLWIA
HHHCCCEEEEECCCCCCEEEECCCHHHHHHHHHHCCHHEEEECCCEEEEEECCCCEEEEE
VIDTGIGIASEDIPHVFERFWRADQSRDRHSGGTGIGLTITKHLVELQSGEIHLDSELGI
EEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEECCCCCC
GSTFRFCLPLA
CCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA