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The map label for this gene is folE

Identifier: 17232213

GI number: 17232213

Start: 5627339

End: 5627989

Strand: Reverse

Name: folE

Synonym: all4721

Alternate gene names: 17232213

Gene position: 5627989-5627339 (Counterclockwise)

Preceding gene: 17232214

Following gene: 17232211

Centisome position: 87.75

GC content: 41.47

Gene sequence:

>651_bases
ATGACTTTATCGATTCGTCCCGATACAGTTTCTGCTGCTCAGATGGTGTCATCTTTATCTACTCAGCAAACACCAACTGT
CACAGAAGCAGAAATGGTACAGGCTGTGCGTACTTTACTAATTGGATTAGGGGAAAATCCTGACCGTGAAGGTTTGCTAG
ATACTCCTAAGCGAGTTGTAAAAGCTTTGCAGTTTTTGACTAAGGGATATAATGAATCCTTGGATGAACTGTTAAATGGT
GCAGTATTTACAGAAGATGCCAATGAGATGGTATTGATTCGGGATATCGACATTTTCAGTTCTTGCGAACATCATATTTT
ACCAATTATTGGTCGCGCTCATGTTGCCTATATTCCTAACGGTAAGGTGATAGGGTTATCTAAAATTGCGCGAGTTTGTG
AGATGTATGCTCGACGTTTACAAGTACAGGAACGTCTGACACTACAAATTGCTGATGCACTGCAAGGTTTACTCAAACCT
CAAGGGGTAGCAGTGGTAATAGAAGCAACTCATATGTGCATGGTGATGCGCGGTGTACAAAAGCCTGGTTCTTGGACTGT
TACTAGTGCAATGCGTGGTGTATTTGCGGAAGATGCTCGTACTCGTGAAGAGTTTATGAATTTGGTACGACACAATGCTA
ATTTTCACTAA

Upstream 100 bases:

>100_bases
GATTAAGAAGTGTTAAGTAATCAAACAATTCAGTTAATAGATTTTTGCCAATCTCTAACTATTAACTAACTCACAATCTC
TACCAACTAAACGAAATAAC

Downstream 100 bases:

>100_bases
ATAACCAAAACTTAGGGAACACCAAAAGATAAATTACCCGAAATTGATTATTTGGTAGGGTGCGTCAGTATGAATGATTT
CTGAGTATATTTAGGTTCTA

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I 2; GTP-CH-I 2

Number of amino acids: Translated: 216; Mature: 215

Protein sequence:

>216_residues
MTLSIRPDTVSAAQMVSSLSTQQTPTVTEAEMVQAVRTLLIGLGENPDREGLLDTPKRVVKALQFLTKGYNESLDELLNG
AVFTEDANEMVLIRDIDIFSSCEHHILPIIGRAHVAYIPNGKVIGLSKIARVCEMYARRLQVQERLTLQIADALQGLLKP
QGVAVVIEATHMCMVMRGVQKPGSWTVTSAMRGVFAEDARTREEFMNLVRHNANFH

Sequences:

>Translated_216_residues
MTLSIRPDTVSAAQMVSSLSTQQTPTVTEAEMVQAVRTLLIGLGENPDREGLLDTPKRVVKALQFLTKGYNESLDELLNG
AVFTEDANEMVLIRDIDIFSSCEHHILPIIGRAHVAYIPNGKVIGLSKIARVCEMYARRLQVQERLTLQIADALQGLLKP
QGVAVVIEATHMCMVMRGVQKPGSWTVTSAMRGVFAEDARTREEFMNLVRHNANFH
>Mature_215_residues
TLSIRPDTVSAAQMVSSLSTQQTPTVTEAEMVQAVRTLLIGLGENPDREGLLDTPKRVVKALQFLTKGYNESLDELLNGA
VFTEDANEMVLIRDIDIFSSCEHHILPIIGRAHVAYIPNGKVIGLSKIARVCEMYARRLQVQERLTLQIADALQGLLKPQ
GVAVVIEATHMCMVMRGVQKPGSWTVTSAMRGVFAEDARTREEFMNLVRHNANFH

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family

Homologues:

Organism=Homo sapiens, GI66932968, Length=179, Percent_Identity=59.7765363128492, Blast_Score=239, Evalue=2e-63,
Organism=Homo sapiens, GI4503949, Length=179, Percent_Identity=59.7765363128492, Blast_Score=239, Evalue=2e-63,
Organism=Homo sapiens, GI66932970, Length=148, Percent_Identity=53.3783783783784, Blast_Score=181, Evalue=4e-46,
Organism=Homo sapiens, GI66932972, Length=139, Percent_Identity=56.1151079136691, Blast_Score=180, Evalue=8e-46,
Organism=Escherichia coli, GI1788476, Length=208, Percent_Identity=36.5384615384615, Blast_Score=125, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17560486, Length=178, Percent_Identity=58.9887640449438, Blast_Score=234, Evalue=3e-62,
Organism=Saccharomyces cerevisiae, GI6321706, Length=176, Percent_Identity=61.3636363636364, Blast_Score=225, Evalue=5e-60,
Organism=Drosophila melanogaster, GI24656782, Length=194, Percent_Identity=56.701030927835, Blast_Score=224, Evalue=3e-59,
Organism=Drosophila melanogaster, GI24656791, Length=194, Percent_Identity=56.701030927835, Blast_Score=223, Evalue=6e-59,
Organism=Drosophila melanogaster, GI24656796, Length=194, Percent_Identity=56.701030927835, Blast_Score=223, Evalue=6e-59,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): GCH12_NOSS1 (Q8YN49)

Other databases:

- EMBL:   BA000019
- PIR:   AI2395
- RefSeq:   NP_488761.1
- ProteinModelPortal:   Q8YN49
- SMR:   Q8YN49
- STRING:   Q8YN49
- GeneID:   1108322
- GenomeReviews:   BA000019_GR
- KEGG:   ana:all4721
- NMPDR:   fig|103690.1.peg.5028
- eggNOG:   COG0302
- HOGENOM:   HBG370191
- OMA:   LTTTFTG
- PhylomeDB:   Q8YN49
- ProtClustDB:   PRK09347
- BioCyc:   NSP103690:ALL4721-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00223
- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234
- TIGRFAMs:   TIGR00063

Pfam domain/function: PF01227 GTP_cyclohydroI

EC number: =3.5.4.16

Molecular weight: Translated: 23942; Mature: 23811

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00859 GTP_CYCLOHYDROL_1_1; PS00860 GTP_CYCLOHYDROL_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLSIRPDTVSAAQMVSSLSTQQTPTVTEAEMVQAVRTLLIGLGENPDREGLLDTPKRVV
CEEECCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
KALQFLTKGYNESLDELLNGAVFTEDANEMVLIRDIDIFSSCEHHILPIIGRAHVAYIPN
HHHHHHHCCCCHHHHHHHCCCEEECCCCCEEEEEECHHHHCCCHHHHHHHCCCEEEECCC
GKVIGLSKIARVCEMYARRLQVQERLTLQIADALQGLLKPQGVAVVIEATHMCMVMRGVQ
CCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHCC
KPGSWTVTSAMRGVFAEDARTREEFMNLVRHNANFH
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TLSIRPDTVSAAQMVSSLSTQQTPTVTEAEMVQAVRTLLIGLGENPDREGLLDTPKRVV
EEECCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
KALQFLTKGYNESLDELLNGAVFTEDANEMVLIRDIDIFSSCEHHILPIIGRAHVAYIPN
HHHHHHHCCCCHHHHHHHCCCEEECCCCCEEEEEECHHHHCCCHHHHHHHCCCEEEECCC
GKVIGLSKIARVCEMYARRLQVQERLTLQIADALQGLLKPQGVAVVIEATHMCMVMRGVQ
CCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHCC
KPGSWTVTSAMRGVFAEDARTREEFMNLVRHNANFH
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840