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The map label for this gene is folP [H]

Identifier: 17231878

GI number: 17231878

Start: 5258159

End: 5259022

Strand: Direct

Name: folP [H]

Synonym: alr4386

Alternate gene names: 17231878

Gene position: 5258159-5259022 (Clockwise)

Preceding gene: 17231877

Following gene: 17231884

Centisome position: 81.98

GC content: 42.13

Gene sequence:

>864_bases
ATGTGCAGTAAATTGATCATAGGCGATCGCTGTTTCCACTGGGGACAGCGTACTTATTTAATGGGCATTTTAAATGTAAC
GCCAGATAGTTTTAGTGATGGTGGTAAATTTAATACTACATCTGCCGCTTTAGCCCAGGCAAAAGCCCTAGTAGCTTCTG
GTGCTGATATTATCGATGTCGGTGGTCAATCTACTAGACCAGGCGCAGAGCAAATCACCCTGACAGAAGAACTGGAGCGG
GTATTGCCAATAGTCCAGATATTGCGATCGCAAATTTCTGTACCCATATCAGTGGATACAACTAGGGCAGTCGTAGCTAA
AGCATCTATAGAAGCTGGAGCAAATATTATTAATGATATTTCTGGTGGCACATTTGACCCCCAAATGTTGCCCACAGTGG
CAACTTTAGGCGTGCCAATTATATTGATGCACATCCGTGGTACACCACAGACTATGCAGCAATTTACCGATTATCAAGAT
TTAATGGGAGAAATTTCTAGTTTTTTAGCTAACCAAATTACCACAGCCACAACTTTGGGTATTCAACCCGAAAAAATTAT
CATTGATCCTGGTATTGGCTTTGCTAAAAACTACGAACAAAATTTAGAAATACTACGCCACTTACGTTCATTACGGGCGC
TAAATTGTCCTATTTTAGTAGGGGCATCCCGTAAAAGTTTTATCGGTCGAATTTTAAATCAACCAGATCCCAAAGCACGA
GTTTGGGGAACGACTGCGGCTTGTTGCGCTGCTATTTTCAACGGAGCTGATATCCTGCGAGTACATGATGTTCAAGAGAT
GCGTGATGTATCCCTAGTTGCTGATGCACTCTTTCGGGGTGAGGTATTGAGTTCTGAAAATTGA

Upstream 100 bases:

>100_bases
GCAAGTCTAGAAGCTGCAAGTTTCGCTAGGATAGTCAACTATCTCTAAAGAGTCCACTCTAATGTACAGACGTTGCCCGC
AACGTCTCTACTAAATAATT

Downstream 100 bases:

>100_bases
GTTATTGTCCCCTGCTCCTCTGCCCCCTGCTCCCCACTGTCTACCCATGCTCCCCACTCTTCCCATTACCATCAGTATTT
ACGGTCTCAGCCATGACCTC

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MCSKLIIGDRCFHWGQRTYLMGILNVTPDSFSDGGKFNTTSAALAQAKALVASGADIIDVGGQSTRPGAEQITLTEELER
VLPIVQILRSQISVPISVDTTRAVVAKASIEAGANIINDISGGTFDPQMLPTVATLGVPIILMHIRGTPQTMQQFTDYQD
LMGEISSFLANQITTATTLGIQPEKIIIDPGIGFAKNYEQNLEILRHLRSLRALNCPILVGASRKSFIGRILNQPDPKAR
VWGTTAACCAAIFNGADILRVHDVQEMRDVSLVADALFRGEVLSSEN

Sequences:

>Translated_287_residues
MCSKLIIGDRCFHWGQRTYLMGILNVTPDSFSDGGKFNTTSAALAQAKALVASGADIIDVGGQSTRPGAEQITLTEELER
VLPIVQILRSQISVPISVDTTRAVVAKASIEAGANIINDISGGTFDPQMLPTVATLGVPIILMHIRGTPQTMQQFTDYQD
LMGEISSFLANQITTATTLGIQPEKIIIDPGIGFAKNYEQNLEILRHLRSLRALNCPILVGASRKSFIGRILNQPDPKAR
VWGTTAACCAAIFNGADILRVHDVQEMRDVSLVADALFRGEVLSSEN
>Mature_287_residues
MCSKLIIGDRCFHWGQRTYLMGILNVTPDSFSDGGKFNTTSAALAQAKALVASGADIIDVGGQSTRPGAEQITLTEELER
VLPIVQILRSQISVPISVDTTRAVVAKASIEAGANIINDISGGTFDPQMLPTVATLGVPIILMHIRGTPQTMQQFTDYQD
LMGEISSFLANQITTATTLGIQPEKIIIDPGIGFAKNYEQNLEILRHLRSLRALNCPILVGASRKSFIGRILNQPDPKAR
VWGTTAACCAAIFNGADILRVHDVQEMRDVSLVADALFRGEVLSSEN

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=258, Percent_Identity=44.5736434108527, Blast_Score=230, Evalue=8e-62,
Organism=Saccharomyces cerevisiae, GI6324073, Length=319, Percent_Identity=35.7366771159875, Blast_Score=178, Evalue=1e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 30948; Mature: 30948

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCSKLIIGDRCFHWGQRTYLMGILNVTPDSFSDGGKFNTTSAALAQAKALVASGADIIDV
CCCCEEECCHHHHCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEC
GGQSTRPGAEQITLTEELERVLPIVQILRSQISVPISVDTTRAVVAKASIEAGANIINDI
CCCCCCCCCHHEEHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHCHHHHHHC
SGGTFDPQMLPTVATLGVPIILMHIRGTPQTMQQFTDYQDLMGEISSFLANQITTATTLG
CCCCCCHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
IQPEKIIIDPGIGFAKNYEQNLEILRHLRSLRALNCPILVGASRKSFIGRILNQPDPKAR
CCCCEEEEECCCCCHHCHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHCCCCCCCE
VWGTTAACCAAIFNGADILRVHDVQEMRDVSLVADALFRGEVLSSEN
ECCCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHCCHHCCCC
>Mature Secondary Structure
MCSKLIIGDRCFHWGQRTYLMGILNVTPDSFSDGGKFNTTSAALAQAKALVASGADIIDV
CCCCEEECCHHHHCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEC
GGQSTRPGAEQITLTEELERVLPIVQILRSQISVPISVDTTRAVVAKASIEAGANIINDI
CCCCCCCCCHHEEHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHCHHHHHHC
SGGTFDPQMLPTVATLGVPIILMHIRGTPQTMQQFTDYQDLMGEISSFLANQITTATTLG
CCCCCCHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
IQPEKIIIDPGIGFAKNYEQNLEILRHLRSLRALNCPILVGASRKSFIGRILNQPDPKAR
CCCCEEEEECCCCCHHCHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHCCCCCCCE
VWGTTAACCAAIFNGADILRVHDVQEMRDVSLVADALFRGEVLSSEN
ECCCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]