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The map label for this gene is mutM

Identifier: 17231812

GI number: 17231812

Start: 5172791

End: 5173642

Strand: Direct

Name: mutM

Synonym: alr4320

Alternate gene names: 17231812

Gene position: 5172791-5173642 (Clockwise)

Preceding gene: 17231811

Following gene: 17231813

Centisome position: 80.65

GC content: 44.95

Gene sequence:

>852_bases
ATGCCTGAATTGCCTGAAGTTGAAACAGTGCGGCGGGGTTTAAACCAACTAACCCTGAACCGAAAAATTACGGGTGGAGA
TGTGTTGCTTCATCGCACCATCGCCCACCCTTTTTCTGTTGGTGATTTTTTGAATGGGATTACCGGGAGTACCATTAGTA
CTTGGCATCGTCGCGGTAAATATCTCCTCGCGGAACTCTCTGCGTCTCCCTCCACTACTTCCATCCCTTGGCTAGGTGTG
CATCTGAGGATGACTGGTCAATTACTTTGGCTAAACCAAGATGAGCCTTTACACAAGCATACGCGGGTAAGAATATTTTT
TGAGGAAGAGCAGGAATTACGCTTTGTTGACCAGCGAACTTTCGGTCAAATGTGGTGGGTTCCACCAGGAATAGCTGTAG
AAAGCGTGATTACTGGTTTAGCTAAACTTGCTGTAGATCCCTTTTCACCTGAATTTACTGTTGAGTACTTAGCAAATAAG
CTGCATAATCGTCGCCGTCCCATCAAAACCGCCCTATTAGACCAGTCGGTTGTTGCAGGATTAGGTAACATCTATGCTGA
CGAAGCATTGTTTAAAAGTGGTGTGTTACCAGAAACTCTATGTACAGAAGTGCAGTTAAAGCAAATTAAGCTTTTGCGAA
CGGCGATTATTCAAGTTTTGGAAACCAGTATTGAGGCTGGTGGTACAACTTTTAGTAATTTCCTCAACGTTAAAGGGGTC
AATGGTAATTATGGTGGTGTCGCCTGGGTGTACAATCGCGCGGGGGAACCATGTAAAGTTTGTGGTGATGTAATTCAGCG
CATCAAGTTAGGTGGAAGATCCAGCCATTTTTGCCGCCAGTGTCAAGTTTAG

Upstream 100 bases:

>100_bases
ACGGATTCTGCTGGGTAGTGCAACCAAAACTTAAAGTGTCTATATTCTTTCTCGTTTTAATTTCCAAAAAGTATTCCCAC
TGCTTGCTCAATCCGCTTAA

Downstream 100 bases:

>100_bases
GGGTGTATAAAAAACATAATTGTTTCCATCGAAAGTATTGATACTTGTTGCACCCTTGGTGAGTTGAACTTTTGTACTCG
ACTGCAAGCTAAAATCCTCT

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MPELPEVETVRRGLNQLTLNRKITGGDVLLHRTIAHPFSVGDFLNGITGSTISTWHRRGKYLLAELSASPSTTSIPWLGV
HLRMTGQLLWLNQDEPLHKHTRVRIFFEEEQELRFVDQRTFGQMWWVPPGIAVESVITGLAKLAVDPFSPEFTVEYLANK
LHNRRRPIKTALLDQSVVAGLGNIYADEALFKSGVLPETLCTEVQLKQIKLLRTAIIQVLETSIEAGGTTFSNFLNVKGV
NGNYGGVAWVYNRAGEPCKVCGDVIQRIKLGGRSSHFCRQCQV

Sequences:

>Translated_283_residues
MPELPEVETVRRGLNQLTLNRKITGGDVLLHRTIAHPFSVGDFLNGITGSTISTWHRRGKYLLAELSASPSTTSIPWLGV
HLRMTGQLLWLNQDEPLHKHTRVRIFFEEEQELRFVDQRTFGQMWWVPPGIAVESVITGLAKLAVDPFSPEFTVEYLANK
LHNRRRPIKTALLDQSVVAGLGNIYADEALFKSGVLPETLCTEVQLKQIKLLRTAIIQVLETSIEAGGTTFSNFLNVKGV
NGNYGGVAWVYNRAGEPCKVCGDVIQRIKLGGRSSHFCRQCQV
>Mature_282_residues
PELPEVETVRRGLNQLTLNRKITGGDVLLHRTIAHPFSVGDFLNGITGSTISTWHRRGKYLLAELSASPSTTSIPWLGVH
LRMTGQLLWLNQDEPLHKHTRVRIFFEEEQELRFVDQRTFGQMWWVPPGIAVESVITGLAKLAVDPFSPEFTVEYLANKL
HNRRRPIKTALLDQSVVAGLGNIYADEALFKSGVLPETLCTEVQLKQIKLLRTAIIQVLETSIEAGGTTFSNFLNVKGVN
GNYGGVAWVYNRAGEPCKVCGDVIQRIKLGGRSSHFCRQCQV

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger

Homologues:

Organism=Escherichia coli, GI1790066, Length=285, Percent_Identity=36.4912280701754, Blast_Score=172, Evalue=2e-44,
Organism=Escherichia coli, GI1786932, Length=148, Percent_Identity=27.7027027027027, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FPG_NOSS1 (Q8YP80)

Other databases:

- EMBL:   BA000019
- PIR:   AI2345
- RefSeq:   NP_488360.1
- ProteinModelPortal:   Q8YP80
- SMR:   Q8YP80
- STRING:   Q8YP80
- GeneID:   1107922
- GenomeReviews:   BA000019_GR
- KEGG:   ana:alr4320
- NMPDR:   fig|103690.1.peg.4627
- eggNOG:   COG0266
- HOGENOM:   HBG690070
- OMA:   RMTGQLL
- PhylomeDB:   Q8YP80
- ProtClustDB:   PRK13945
- BioCyc:   NSP103690:ALR4320-MONOMER
- HAMAP:   MF_00103
- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663
- SMART:   SM00898
- TIGRFAMs:   TIGR00577

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS; SSF81624 Form_DNAglyc_cat; SSF46946 Ribosomal_H2TH

EC number: =3.2.2.23; =4.2.99.18

Molecular weight: Translated: 31618; Mature: 31487

Theoretical pI: Translated: 8.99; Mature: 8.99

Prosite motif: PS51068 FPG_CAT; PS01242 ZF_FPG_1; PS51066 ZF_FPG_2

Important sites: ACT_SITE 2-2 ACT_SITE 3-3 ACT_SITE 60-60 ACT_SITE 273-273 BINDING 100-100 BINDING 119-119 BINDING 164-164

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETVRRGLNQLTLNRKITGGDVLLHRTIAHPFSVGDFLNGITGSTISTWHRRGK
CCCCCCHHHHHHHHHHHHHCCCCCCCHHEEHHHHCCCCHHHHHHCCCCCCHHHHHHHCCC
YLLAELSASPSTTSIPWLGVHLRMTGQLLWLNQDEPLHKHTRVRIFFEEEQELRFVDQRT
EEEEEECCCCCCCCCCEEEEEEEEEEEEEEECCCCCCCCCCEEEEEEECCCHHHHHHHHH
FGQMWWVPPGIAVESVITGLAKLAVDPFSPEFTVEYLANKLHNRRRPIKTALLDQSVVAG
CCCEEECCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
LGNIYADEALFKSGVLPETLCTEVQLKQIKLLRTAIIQVLETSIEAGGTTFSNFLNVKGV
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHEEEECC
NGNYGGVAWVYNRAGEPCKVCGDVIQRIKLGGRSSHFCRQCQV
CCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCHHHHHHCCC
>Mature Secondary Structure 
PELPEVETVRRGLNQLTLNRKITGGDVLLHRTIAHPFSVGDFLNGITGSTISTWHRRGK
CCCCCHHHHHHHHHHHHHCCCCCCCHHEEHHHHCCCCHHHHHHCCCCCCHHHHHHHCCC
YLLAELSASPSTTSIPWLGVHLRMTGQLLWLNQDEPLHKHTRVRIFFEEEQELRFVDQRT
EEEEEECCCCCCCCCCEEEEEEEEEEEEEEECCCCCCCCCCEEEEEEECCCHHHHHHHHH
FGQMWWVPPGIAVESVITGLAKLAVDPFSPEFTVEYLANKLHNRRRPIKTALLDQSVVAG
CCCEEECCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
LGNIYADEALFKSGVLPETLCTEVQLKQIKLLRTAIIQVLETSIEAGGTTFSNFLNVKGV
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHEEEECC
NGNYGGVAWVYNRAGEPCKVCGDVIQRIKLGGRSSHFCRQCQV
CCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840