Click here to switch to the map view.

The map label for this gene is 17231776

Identifier: 17231776

GI number: 17231776

Start: 5137189

End: 5138682

Strand: Reverse

Name: 17231776

Synonym: all4284

Alternate gene names: NA

Gene position: 5138682-5137189 (Counterclockwise)

Preceding gene: 17231777

Following gene: 17231775

Centisome position: 80.12

GC content: 41.5

Gene sequence:

>1494_bases
ATGCAAAGTTACAAATATCAACAAAAGAAAAATTTAGAAAAATCATATACTCGTGAAGACTGGCAGGGAGGGTATAAATC
TCTAAGGCAAGAGTTTGATTATTGGATTGATGATGTAGAAGGGGAAATTCCTACCGAACTGCAAGGTACTTTGTTTAGAA
ACGGGCCAGGATTGCTGGATATAAAAGGACAAAGCATTCATCATCCCTTTGATGGCGATGGCATGATTAGCCGTATTAGC
TTTGTCAATGGTCGCGCCCATTACCGTAATAGTTTTGTCAAAACAGAAGGGTATTTAGCAGAGAAAAATGCTGGTAAAAT
TCTGCATCGGGGAGTTTTTGGTACTCAAAAACCTGGTGGTTGGTTAGCTAATATTTTCGATTTCAAGCTGAAGAATATTG
CTAACACTAATGTTATCTATTGGGGTGAGAAACTATTGGCATTGTGGGAGGCGGCAGAACCCCATCGCCTTGACCCCAAA
ACGTTAGATACATTGGGCAAAGAATATTTTCATGGTGTTTTGTCAGCAGGTGAGGCTTTTGGCGCTCATCCCCGATTTGA
CCCCAGTTGTGAACAAGATAACGGCGCACCTTGCTTAGTCAATTTTTCAATTAAACCCGGATTATCTACAACAATTACGA
TTTTTGAGTTAAATGTAGCAGGCGAAGTTGTCAGAAAGCACGCTCATCATGTACCTGGGTTTTGTTTTATTCACGATTTT
GTAATTACACCTAATCACTGCATCTTCTTTCAAAATCCTGTTAGTTTTAACCCCATCCCTTTCGCTTTAGGATTACGTGG
CGCTGGGGAATGTATTCAAGTACAACCAAATCAGCCAACACGGATTATTGTCATTCCTCGCTTTCCTCAGTCAGGACAAA
AAGAAATCAAAACTTTAGAAGTAGGTTCAGGTTTCATTTTCCATCACGTTAATGCTTTTGTTGTGGGAGAGGAAATTCTT
GTAGATTCCCTTTGCTACGACTCTTTACCAGAAGTAGAGCCAGAAAGTGATTTTCGTCAAGTGGATTTTGAGGCGATCGC
ACCTGGTCAACTATGGCGTTTTTACCTTAACCTCAAAGATGGGACAGTACAAAAAAAATTAATTGAATCTCGTTGTTGTG
AGTTTCCCGCAATTCATCCCCGTAATGTAGGACGCTCTTATCGATACTTGTATATGAGTGCGGCTCATGCAGCTACAGGT
AATGCACCATTGCAAGCATTATTGAAAATAGATTTAGAGTCTGGAGAAAAACAGATCTGGAGTGTGGCACCTCGCGGTTT
TACGGGTGAGCCGATTTTTGTTCCTCGTCCAGGCTCAGAAAAAGAGGATGATGGTTGGGTACTGGCTCTAGTTTATGATG
CGGCTCATCACCGTTCAGATGTGGTAATTTTAGATGCTAGTGACTTTACTAAAGGGGCGATCGCTAGGCTACATCTCCAG
CATCACGTACCCTATGGCCTTCACGGCAACTTTACTCCCCAGGTATTTGTATAA

Upstream 100 bases:

>100_bases
ACTTGTGTCTCAATGTCTCTGTGGTTAAAAGGTTGTTTTCTCAACACGGAGACATGAAGTCACGCGGAATAATTCTTTCT
TGATTCTCACCTTTTTTTAT

Downstream 100 bases:

>100_bases
ACTAGTACTGGAAAGTGAATAAAAATGTTACTAAGTTTAAGCACATGGCAGGAAGTTGAAACCTACTTGCAAAAATCAAC
GGGAATTATTCTGCCGATTG

Product: lignostilbene-alpha,beta-dioxygenase

Products: NA

Alternate protein names: ACO; 8'-apo-beta-carotenal 15,15'-oxygenase; Diox1 [H]

Number of amino acids: Translated: 497; Mature: 497

Protein sequence:

>497_residues
MQSYKYQQKKNLEKSYTREDWQGGYKSLRQEFDYWIDDVEGEIPTELQGTLFRNGPGLLDIKGQSIHHPFDGDGMISRIS
FVNGRAHYRNSFVKTEGYLAEKNAGKILHRGVFGTQKPGGWLANIFDFKLKNIANTNVIYWGEKLLALWEAAEPHRLDPK
TLDTLGKEYFHGVLSAGEAFGAHPRFDPSCEQDNGAPCLVNFSIKPGLSTTITIFELNVAGEVVRKHAHHVPGFCFIHDF
VITPNHCIFFQNPVSFNPIPFALGLRGAGECIQVQPNQPTRIIVIPRFPQSGQKEIKTLEVGSGFIFHHVNAFVVGEEIL
VDSLCYDSLPEVEPESDFRQVDFEAIAPGQLWRFYLNLKDGTVQKKLIESRCCEFPAIHPRNVGRSYRYLYMSAAHAATG
NAPLQALLKIDLESGEKQIWSVAPRGFTGEPIFVPRPGSEKEDDGWVLALVYDAAHHRSDVVILDASDFTKGAIARLHLQ
HHVPYGLHGNFTPQVFV

Sequences:

>Translated_497_residues
MQSYKYQQKKNLEKSYTREDWQGGYKSLRQEFDYWIDDVEGEIPTELQGTLFRNGPGLLDIKGQSIHHPFDGDGMISRIS
FVNGRAHYRNSFVKTEGYLAEKNAGKILHRGVFGTQKPGGWLANIFDFKLKNIANTNVIYWGEKLLALWEAAEPHRLDPK
TLDTLGKEYFHGVLSAGEAFGAHPRFDPSCEQDNGAPCLVNFSIKPGLSTTITIFELNVAGEVVRKHAHHVPGFCFIHDF
VITPNHCIFFQNPVSFNPIPFALGLRGAGECIQVQPNQPTRIIVIPRFPQSGQKEIKTLEVGSGFIFHHVNAFVVGEEIL
VDSLCYDSLPEVEPESDFRQVDFEAIAPGQLWRFYLNLKDGTVQKKLIESRCCEFPAIHPRNVGRSYRYLYMSAAHAATG
NAPLQALLKIDLESGEKQIWSVAPRGFTGEPIFVPRPGSEKEDDGWVLALVYDAAHHRSDVVILDASDFTKGAIARLHLQ
HHVPYGLHGNFTPQVFV
>Mature_497_residues
MQSYKYQQKKNLEKSYTREDWQGGYKSLRQEFDYWIDDVEGEIPTELQGTLFRNGPGLLDIKGQSIHHPFDGDGMISRIS
FVNGRAHYRNSFVKTEGYLAEKNAGKILHRGVFGTQKPGGWLANIFDFKLKNIANTNVIYWGEKLLALWEAAEPHRLDPK
TLDTLGKEYFHGVLSAGEAFGAHPRFDPSCEQDNGAPCLVNFSIKPGLSTTITIFELNVAGEVVRKHAHHVPGFCFIHDF
VITPNHCIFFQNPVSFNPIPFALGLRGAGECIQVQPNQPTRIIVIPRFPQSGQKEIKTLEVGSGFIFHHVNAFVVGEEIL
VDSLCYDSLPEVEPESDFRQVDFEAIAPGQLWRFYLNLKDGTVQKKLIESRCCEFPAIHPRNVGRSYRYLYMSAAHAATG
NAPLQALLKIDLESGEKQIWSVAPRGFTGEPIFVPRPGSEKEDDGWVLALVYDAAHHRSDVVILDASDFTKGAIARLHLQ
HHVPYGLHGNFTPQVFV

Specific function: Cleaves a number of carotenals and carotenols in the all-trans configuration at the 15-15' double bond producing retinal or retinol, respectively. Also shows activity toward lycopenals and the corresponding alcohols. Does not cleave beta- carotene or lyco

COG id: COG3670

COG function: function code Q; Lignostilbene-alpha,beta-dioxygenase and related enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the carotenoid oxygenase family [H]

Homologues:

Organism=Homo sapiens, GI74027270, Length=518, Percent_Identity=25.8687258687259, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI4506591, Length=535, Percent_Identity=25.4205607476636, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI82617628, Length=532, Percent_Identity=25.3759398496241, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI82617624, Length=532, Percent_Identity=25.3759398496241, Blast_Score=105, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI32564756, Length=537, Percent_Identity=25.512104283054, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24646669, Length=391, Percent_Identity=26.0869565217391, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004294 [H]

Pfam domain/function: PF03055 RPE65 [H]

EC number: =1.14.99.41 [H]

Molecular weight: Translated: 55857; Mature: 55857

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSYKYQQKKNLEKSYTREDWQGGYKSLRQEFDYWIDDVEGEIPTELQGTLFRNGPGLLD
CCCCCCHHHHCHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCEEE
IKGQSIHHPFDGDGMISRISFVNGRAHYRNSFVKTEGYLAEKNAGKILHRGVFGTQKPGG
ECCCCCCCCCCCCCCEEEEEEECCCHHHHCCEEECCCEEEECCCCHHEECCCCCCCCCCC
WLANIFDFKLKNIANTNVIYWGEKLLALWEAAEPHRLDPKTLDTLGKEYFHGVLSAGEAF
HHHHHHHHHHHHCCCCCEEEECHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCHHC
GAHPRFDPSCEQDNGAPCLVNFSIKPGLSTTITIFELNVAGEVVRKHAHHVPGFCFIHDF
CCCCCCCCCCCCCCCCEEEEEEEECCCCCEEEEEEEECHHHHHHHHHHHCCCCEEEEEEE
VITPNHCIFFQNPVSFNPIPFALGLRGAGECIQVQPNQPTRIIVIPRFPQSGQKEIKTLE
EECCCEEEEECCCCCCCCCCEEEECCCCCCEEEECCCCCEEEEEEECCCCCCCHHEEEEE
VGSGFIFHHVNAFVVGEEILVDSLCYDSLPEVEPESDFRQVDFEAIAPGQLWRFYLNLKD
CCCCEEEEECEEEEECHHHHHHHHHHCCCCCCCCCCCHHHCCCEEECCCCEEEEEEECCC
GTVQKKLIESRCCEFPAIHPRNVGRSYRYLYMSAAHAATGNAPLQALLKIDLESGEKQIW
CHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEHHCCCCCCCEEEEEEEECCCCCCEEE
SVAPRGFTGEPIFVPRPGSEKEDDGWVLALVYDAAHHRSDVVILDASDFTKGAIARLHLQ
EECCCCCCCCEEEEECCCCCCCCCCEEEEEEEECCCCCCCEEEEECCCCCCCHHEEEEHH
HHVPYGLHGNFTPQVFV
HCCCCCCCCCCCCEEEC
>Mature Secondary Structure
MQSYKYQQKKNLEKSYTREDWQGGYKSLRQEFDYWIDDVEGEIPTELQGTLFRNGPGLLD
CCCCCCHHHHCHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCEEE
IKGQSIHHPFDGDGMISRISFVNGRAHYRNSFVKTEGYLAEKNAGKILHRGVFGTQKPGG
ECCCCCCCCCCCCCCEEEEEEECCCHHHHCCEEECCCEEEECCCCHHEECCCCCCCCCCC
WLANIFDFKLKNIANTNVIYWGEKLLALWEAAEPHRLDPKTLDTLGKEYFHGVLSAGEAF
HHHHHHHHHHHHCCCCCEEEECHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCHHC
GAHPRFDPSCEQDNGAPCLVNFSIKPGLSTTITIFELNVAGEVVRKHAHHVPGFCFIHDF
CCCCCCCCCCCCCCCCEEEEEEEECCCCCEEEEEEEECHHHHHHHHHHHCCCCEEEEEEE
VITPNHCIFFQNPVSFNPIPFALGLRGAGECIQVQPNQPTRIIVIPRFPQSGQKEIKTLE
EECCCEEEEECCCCCCCCCCEEEECCCCCCEEEECCCCCEEEEEEECCCCCCCHHEEEEE
VGSGFIFHHVNAFVVGEEILVDSLCYDSLPEVEPESDFRQVDFEAIAPGQLWRFYLNLKD
CCCCEEEEECEEEEECHHHHHHHHHHCCCCCCCCCCCHHHCCCEEECCCCEEEEEEECCC
GTVQKKLIESRCCEFPAIHPRNVGRSYRYLYMSAAHAATGNAPLQALLKIDLESGEKQIW
CHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEHHCCCCCCCEEEEEEEECCCCCCEEE
SVAPRGFTGEPIFVPRPGSEKEDDGWVLALVYDAAHHRSDVVILDASDFTKGAIARLHLQ
EECCCCCCCCEEEEECCCCCCCCCCEEEEEEEECCCCCCCEEEEECCCCCCCHHEEEEHH
HHVPYGLHGNFTPQVFV
HCCCCCCCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]