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The map label for this gene is acsA [H]

Identifier: 17231749

GI number: 17231749

Start: 5106361

End: 5107935

Strand: Reverse

Name: acsA [H]

Synonym: all4257

Alternate gene names: 17231749

Gene position: 5107935-5106361 (Counterclockwise)

Preceding gene: 17231752

Following gene: 17231748

Centisome position: 79.64

GC content: 48.13

Gene sequence:

>1575_bases
ATGTCTCAGCCAACTATAGAGTCAATTCTGCAAGAAAAACGTTTATTTCCTCCCAGTACCGAGTTTTCCCAAAATGCCCA
GATTAAAAGTCTAGAAGATTACCAACGTCTTTATGACAAAGCCAAAGCTGATCCGCAAAAATTTTGGGCAGAATTAGCCG
AAACAGAATTGCACTGGTTCCAAAAATGGGACACAGTACTAGATTGGCAAGCACCTTTTGCTAAGTGGTTCGTGGGTGGG
AAGATTAACATTTCCTACAACTGTTTAGATAGACATCTCACAACCTGGCGGAAAAATAAAGCCGCGTTGATTTGGGAAGG
GGAACCAGGAGATTCCCGTACTTTAACTTATGCCCAATTGCATCGGGAAGTTTGCCAGTTCGCCAACGTCTTGAAACAAC
TGGGAGTGCAGAAAGGCGATCGCGTCGGTATTTATATGCCGATGATACCGGAAGCCGCGATCGCTATGTTAGCCTGTGCC
AGAATTGGCGCGCCTCATAGTGTGGTATTTGGTGGGTTTAGTGCGGAAGCATTGCGCGATCGCTTAATTGATGCCCAAGC
CAAGGTAGTAGTTACAGCTGATGGTGGTTGGCGTAAAGATGCGATCGTTCCCTTGAAAGAACAGGTAGACAAAGCCTTGG
CTGATGACGCTGTTCCCAGTGTGGAGAATGTCCTGGTTGTCAAGCGTACCGGACAAGATATTTATATGCAGTTGGGAGGA
CGAGATCATTGGTGGCACGATTTACAAAAAGGTGCATCGGCAGATTGTCCCGCCGAACCAATGGACAGCGAGGATTTACT
CTTTGTCCTCTACACTTCTGGTAGCACAGGCAAACCCAAAGGTGTTGTCCACACCACTGGCGGTTATAACCTATATACTC
ACATGACCACCAAATGGATTTTCGACCTACAAGACACAGATGTATATTGGTGTACTGCCGATGTAGGCTGGATTACCGGA
CACAGTTACATTGTTTACGGCCCCCTCTCCAACGGTGCAACCACTCTGATGTATGAAGGTGCGCCTCGTGCCTCTAATCC
TGGGTGTTTCTGGGATGTAATTGAAAAATACGGCGTGAATATTTTCTACACCGCACCCACCGCAATTCGCGCCTTCATTA
AAATGGGCGAACACCATCCCAACGCCCGTAATCTTTCTTCTTTAAGATTATTAGGAACCGTCGGCGAACCCATCAACCCA
GAAGCTTGGATGTGGTATCACAAAGTAATTGGTGGTGAACGCTGCCCCATAGTTGATACTTGGTGGCAAACGGAAACTGG
CGGTATCATGATTACGCCTCTACCAGGGGCAATTTCCACTAAACCCGGTTCCGCTACCCTTCCCTTCCCCGGCATCCTGG
CCGACATCGTTGATTTAGAAGGTAACACTGTACCGGAAAACGAAGGTGGTTACTTAGCAGTGCGTTATCCCTGGCCTGGG
ATGATGCGGACTGTCTACGGCGATCCGGAACGCTTCCGCCGCACCTACTGGGAACACATCCCCCCAAAGATGGGAATTAT
ACTTACTTTGCCGGCGATGGTGCAAGAAAAGATGAAGACGGCTATTTCTGGGTAA

Upstream 100 bases:

>100_bases
GGTAATTACCGCTTACTTAGCTTAATGAAAATCTAAATATTGTTGGACACAACTCCGATAAAAATAGTTTTCAGTAACAA
TACTACTCATCCTTATAACT

Downstream 100 bases:

>100_bases
TGGGGCGTGTGGATGATGTATTGAATGTGTCAGGACATCGCCTCGGTACAATGGAAGTAGAATCAGCTTTAGTGTCTCAC
CCAGCCGTAGCTGAGGCGGC

Product: acetyl-coenzyme A synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 524; Mature: 523

Protein sequence:

>524_residues
MSQPTIESILQEKRLFPPSTEFSQNAQIKSLEDYQRLYDKAKADPQKFWAELAETELHWFQKWDTVLDWQAPFAKWFVGG
KINISYNCLDRHLTTWRKNKAALIWEGEPGDSRTLTYAQLHREVCQFANVLKQLGVQKGDRVGIYMPMIPEAAIAMLACA
RIGAPHSVVFGGFSAEALRDRLIDAQAKVVVTADGGWRKDAIVPLKEQVDKALADDAVPSVENVLVVKRTGQDIYMQLGG
RDHWWHDLQKGASADCPAEPMDSEDLLFVLYTSGSTGKPKGVVHTTGGYNLYTHMTTKWIFDLQDTDVYWCTADVGWITG
HSYIVYGPLSNGATTLMYEGAPRASNPGCFWDVIEKYGVNIFYTAPTAIRAFIKMGEHHPNARNLSSLRLLGTVGEPINP
EAWMWYHKVIGGERCPIVDTWWQTETGGIMITPLPGAISTKPGSATLPFPGILADIVDLEGNTVPENEGGYLAVRYPWPG
MMRTVYGDPERFRRTYWEHIPPKMGIILTLPAMVQEKMKTAISG

Sequences:

>Translated_524_residues
MSQPTIESILQEKRLFPPSTEFSQNAQIKSLEDYQRLYDKAKADPQKFWAELAETELHWFQKWDTVLDWQAPFAKWFVGG
KINISYNCLDRHLTTWRKNKAALIWEGEPGDSRTLTYAQLHREVCQFANVLKQLGVQKGDRVGIYMPMIPEAAIAMLACA
RIGAPHSVVFGGFSAEALRDRLIDAQAKVVVTADGGWRKDAIVPLKEQVDKALADDAVPSVENVLVVKRTGQDIYMQLGG
RDHWWHDLQKGASADCPAEPMDSEDLLFVLYTSGSTGKPKGVVHTTGGYNLYTHMTTKWIFDLQDTDVYWCTADVGWITG
HSYIVYGPLSNGATTLMYEGAPRASNPGCFWDVIEKYGVNIFYTAPTAIRAFIKMGEHHPNARNLSSLRLLGTVGEPINP
EAWMWYHKVIGGERCPIVDTWWQTETGGIMITPLPGAISTKPGSATLPFPGILADIVDLEGNTVPENEGGYLAVRYPWPG
MMRTVYGDPERFRRTYWEHIPPKMGIILTLPAMVQEKMKTAISG
>Mature_523_residues
SQPTIESILQEKRLFPPSTEFSQNAQIKSLEDYQRLYDKAKADPQKFWAELAETELHWFQKWDTVLDWQAPFAKWFVGGK
INISYNCLDRHLTTWRKNKAALIWEGEPGDSRTLTYAQLHREVCQFANVLKQLGVQKGDRVGIYMPMIPEAAIAMLACAR
IGAPHSVVFGGFSAEALRDRLIDAQAKVVVTADGGWRKDAIVPLKEQVDKALADDAVPSVENVLVVKRTGQDIYMQLGGR
DHWWHDLQKGASADCPAEPMDSEDLLFVLYTSGSTGKPKGVVHTTGGYNLYTHMTTKWIFDLQDTDVYWCTADVGWITGH
SYIVYGPLSNGATTLMYEGAPRASNPGCFWDVIEKYGVNIFYTAPTAIRAFIKMGEHHPNARNLSSLRLLGTVGEPINPE
AWMWYHKVIGGERCPIVDTWWQTETGGIMITPLPGAISTKPGSATLPFPGILADIVDLEGNTVPENEGGYLAVRYPWPGM
MRTVYGDPERFRRTYWEHIPPKMGIILTLPAMVQEKMKTAISG

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=520, Percent_Identity=47.5, Blast_Score=493, Evalue=1e-139,
Organism=Homo sapiens, GI253970489, Length=533, Percent_Identity=46.5290806754221, Blast_Score=489, Evalue=1e-138,
Organism=Homo sapiens, GI28416953, Length=476, Percent_Identity=47.8991596638655, Blast_Score=431, Evalue=1e-120,
Organism=Homo sapiens, GI13375727, Length=485, Percent_Identity=36.9072164948454, Blast_Score=303, Evalue=4e-82,
Organism=Homo sapiens, GI31982927, Length=437, Percent_Identity=25.629290617849, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI42544132, Length=394, Percent_Identity=26.3959390862944, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI38505220, Length=417, Percent_Identity=25.8992805755396, Blast_Score=119, Evalue=8e-27,
Organism=Homo sapiens, GI42544134, Length=359, Percent_Identity=26.7409470752089, Blast_Score=109, Evalue=7e-24,
Organism=Homo sapiens, GI122937307, Length=408, Percent_Identity=24.7549019607843, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI58082049, Length=403, Percent_Identity=24.317617866005, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI115511026, Length=399, Percent_Identity=23.5588972431078, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI195947378, Length=348, Percent_Identity=25.2873563218391, Blast_Score=90, Evalue=7e-18,
Organism=Homo sapiens, GI157311624, Length=403, Percent_Identity=23.0769230769231, Blast_Score=84, Evalue=5e-16,
Organism=Homo sapiens, GI157311622, Length=403, Percent_Identity=23.0769230769231, Blast_Score=84, Evalue=5e-16,
Organism=Escherichia coli, GI1790505, Length=473, Percent_Identity=53.9112050739958, Blast_Score=509, Evalue=1e-145,
Organism=Escherichia coli, GI1786529, Length=470, Percent_Identity=38.2978723404255, Blast_Score=311, Evalue=9e-86,
Organism=Escherichia coli, GI221142682, Length=286, Percent_Identity=27.6223776223776, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71983001, Length=501, Percent_Identity=47.9041916167665, Blast_Score=450, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI71982997, Length=503, Percent_Identity=47.713717693837, Blast_Score=450, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI17569507, Length=494, Percent_Identity=20.0404858299595, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6323182, Length=483, Percent_Identity=46.3768115942029, Blast_Score=434, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6319264, Length=498, Percent_Identity=43.9759036144578, Blast_Score=406, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24667955, Length=512, Percent_Identity=49.609375, Blast_Score=492, Evalue=1e-139,
Organism=Drosophila melanogaster, GI62472339, Length=402, Percent_Identity=54.4776119402985, Blast_Score=434, Evalue=1e-122,
Organism=Drosophila melanogaster, GI24667959, Length=368, Percent_Identity=53.2608695652174, Blast_Score=387, Evalue=1e-107,
Organism=Drosophila melanogaster, GI21355225, Length=481, Percent_Identity=35.966735966736, Blast_Score=288, Evalue=5e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 58688; Mature: 58556

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQPTIESILQEKRLFPPSTEFSQNAQIKSLEDYQRLYDKAKADPQKFWAELAETELHWF
CCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
QKWDTVLDWQAPFAKWFVGGKINISYNCLDRHLTTWRKNKAALIWEGEPGDSRTLTYAQL
HHHHHHCCCCCCHHHEEECCEEEEEHHHHHHHHHHHCCCCEEEEECCCCCCCCEEHHHHH
HREVCQFANVLKQLGVQKGDRVGIYMPMIPEAAIAMLACARIGAPHSVVFGGFSAEALRD
HHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCEEEEECCCHHHHHH
RLIDAQAKVVVTADGGWRKDAIVPLKEQVDKALADDAVPSVENVLVVKRTGQDIYMQLGG
HHCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCEEEEEECC
RDHWWHDLQKGASADCPAEPMDSEDLLFVLYTSGSTGKPKGVVHTTGGYNLYTHMTTKWI
CCHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCEEECCCCCEEEEEEEEEEE
FDLQDTDVYWCTADVGWITGHSYIVYGPLSNGATTLMYEGAPRASNPGCFWDVIEKYGVN
EEECCCCEEEEECCCCEEECCCEEEEEECCCCCEEEEECCCCCCCCCCHHHHHHHHHCCE
IFYTAPTAIRAFIKMGEHHPNARNLSSLRLLGTVGEPINPEAWMWYHKVIGGERCPIVDT
EEEECHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCEEEC
WWQTETGGIMITPLPGAISTKPGSATLPFPGILADIVDLEGNTVPENEGGYLAVRYPWPG
CCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCEEEEEECCCC
MMRTVYGDPERFRRTYWEHIPPKMGIILTLPAMVQEKMKTAISG
HHHHHCCCHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHCC
>Mature Secondary Structure 
SQPTIESILQEKRLFPPSTEFSQNAQIKSLEDYQRLYDKAKADPQKFWAELAETELHWF
CCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
QKWDTVLDWQAPFAKWFVGGKINISYNCLDRHLTTWRKNKAALIWEGEPGDSRTLTYAQL
HHHHHHCCCCCCHHHEEECCEEEEEHHHHHHHHHHHCCCCEEEEECCCCCCCCEEHHHHH
HREVCQFANVLKQLGVQKGDRVGIYMPMIPEAAIAMLACARIGAPHSVVFGGFSAEALRD
HHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCEEEEECCCHHHHHH
RLIDAQAKVVVTADGGWRKDAIVPLKEQVDKALADDAVPSVENVLVVKRTGQDIYMQLGG
HHCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCEEEEEECC
RDHWWHDLQKGASADCPAEPMDSEDLLFVLYTSGSTGKPKGVVHTTGGYNLYTHMTTKWI
CCHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCEEECCCCCEEEEEEEEEEE
FDLQDTDVYWCTADVGWITGHSYIVYGPLSNGATTLMYEGAPRASNPGCFWDVIEKYGVN
EEECCCCEEEEECCCCEEECCCEEEEEECCCCCEEEEECCCCCCCCCCHHHHHHHHHCCE
IFYTAPTAIRAFIKMGEHHPNARNLSSLRLLGTVGEPINPEAWMWYHKVIGGERCPIVDT
EEEECHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCEEEC
WWQTETGGIMITPLPGAISTKPGSATLPFPGILADIVDLEGNTVPENEGGYLAVRYPWPG
CCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCEEEEEECCCC
MMRTVYGDPERFRRTYWEHIPPKMGIILTLPAMVQEKMKTAISG
HHHHHCCCHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12240834 [H]