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The map label for this gene is acsA [H]

Identifier: 17231748

GI number: 17231748

Start: 5105963

End: 5106361

Strand: Reverse

Name: acsA [H]

Synonym: all4256

Alternate gene names: 17231748

Gene position: 5106361-5105963 (Counterclockwise)

Preceding gene: 17231749

Following gene: 17231746

Centisome position: 79.62

GC content: 49.12

Gene sequence:

>399_bases
ATGGGGCGTGTGGATGATGTATTGAATGTGTCAGGACATCGCCTCGGTACAATGGAAGTAGAATCAGCTTTAGTGTCTCA
CCCAGCCGTAGCTGAGGCGGCAGTAGTGGGCAAACCAGATGACTTAAAAGGCGAAGAAGTGGTAGCTTTTGTCACCCTAG
AAGGAACTTATCAAGCCAGCGAAGACTTGAGTAAAGCCCTCAAACAGCACGTAGTTCAGGAAATTGGGGCGATCGCTCGT
CCTGGGGAAATCCGCTTTACTGACGCATTACCAAAGACGCGATCGGGTAAAATCATGCGCCGCTTACTACGAAATCTCGC
CGCCGGACAAGAAGTTTCTGGCGATACTTCCACTCTGGAAGATAGAAGTGTCTTAGATAAATTACGCGAAGGTGCGTAA

Upstream 100 bases:

>100_bases
TCCGCCGCACCTACTGGGAACACATCCCCCCAAAGATGGGAATTATACTTACTTTGCCGGCGATGGTGCAAGAAAAGATG
AAGACGGCTATTTCTGGGTA

Downstream 100 bases:

>100_bases
TTAAAATACGAAGGTGCGTTACGGAAATTAGTCCTAACGCACCGAAAATCTAGGAGAGTAGGGAGTAAAATCTGGCGCTG
CATAATTGTGAGATGATTTC

Product: acetyl-coenzyme A synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 132; Mature: 131

Protein sequence:

>132_residues
MGRVDDVLNVSGHRLGTMEVESALVSHPAVAEAAVVGKPDDLKGEEVVAFVTLEGTYQASEDLSKALKQHVVQEIGAIAR
PGEIRFTDALPKTRSGKIMRRLLRNLAAGQEVSGDTSTLEDRSVLDKLREGA

Sequences:

>Translated_132_residues
MGRVDDVLNVSGHRLGTMEVESALVSHPAVAEAAVVGKPDDLKGEEVVAFVTLEGTYQASEDLSKALKQHVVQEIGAIAR
PGEIRFTDALPKTRSGKIMRRLLRNLAAGQEVSGDTSTLEDRSVLDKLREGA
>Mature_131_residues
GRVDDVLNVSGHRLGTMEVESALVSHPAVAEAAVVGKPDDLKGEEVVAFVTLEGTYQASEDLSKALKQHVVQEIGAIARP
GEIRFTDALPKTRSGKIMRRLLRNLAAGQEVSGDTSTLEDRSVLDKLREGA

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI253970489, Length=127, Percent_Identity=55.1181102362205, Blast_Score=131, Evalue=1e-31,
Organism=Homo sapiens, GI8923896, Length=127, Percent_Identity=55.1181102362205, Blast_Score=131, Evalue=1e-31,
Organism=Homo sapiens, GI28416953, Length=129, Percent_Identity=49.6124031007752, Blast_Score=124, Evalue=3e-29,
Organism=Homo sapiens, GI115511026, Length=112, Percent_Identity=48.2142857142857, Blast_Score=108, Evalue=2e-24,
Organism=Homo sapiens, GI38505220, Length=112, Percent_Identity=46.4285714285714, Blast_Score=99, Evalue=9e-22,
Organism=Homo sapiens, GI122937307, Length=107, Percent_Identity=45.7943925233645, Blast_Score=99, Evalue=1e-21,
Organism=Homo sapiens, GI58082049, Length=107, Percent_Identity=47.6635514018692, Blast_Score=99, Evalue=1e-21,
Organism=Homo sapiens, GI157311624, Length=107, Percent_Identity=47.6635514018692, Blast_Score=99, Evalue=1e-21,
Organism=Homo sapiens, GI157311622, Length=107, Percent_Identity=47.6635514018692, Blast_Score=99, Evalue=1e-21,
Organism=Homo sapiens, GI13375727, Length=131, Percent_Identity=41.9847328244275, Blast_Score=94, Evalue=3e-20,
Organism=Homo sapiens, GI42544132, Length=106, Percent_Identity=45.2830188679245, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1790505, Length=130, Percent_Identity=58.4615384615385, Blast_Score=149, Evalue=9e-38,
Organism=Escherichia coli, GI1786529, Length=136, Percent_Identity=44.8529411764706, Blast_Score=100, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI71983001, Length=131, Percent_Identity=54.1984732824427, Blast_Score=111, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI71982997, Length=131, Percent_Identity=54.1984732824427, Blast_Score=111, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17538037, Length=118, Percent_Identity=33.0508474576271, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17557194, Length=109, Percent_Identity=33.9449541284404, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17560140, Length=105, Percent_Identity=35.2380952380952, Blast_Score=63, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6319264, Length=136, Percent_Identity=49.2647058823529, Blast_Score=119, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6323182, Length=137, Percent_Identity=47.4452554744526, Blast_Score=108, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6319699, Length=103, Percent_Identity=34.9514563106796, Blast_Score=74, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24667959, Length=127, Percent_Identity=49.6062992125984, Blast_Score=121, Evalue=1e-28,
Organism=Drosophila melanogaster, GI62472339, Length=127, Percent_Identity=49.6062992125984, Blast_Score=121, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24667955, Length=127, Percent_Identity=49.6062992125984, Blast_Score=121, Evalue=1e-28,
Organism=Drosophila melanogaster, GI21355225, Length=131, Percent_Identity=33.587786259542, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21355181, Length=114, Percent_Identity=32.4561403508772, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24581924, Length=100, Percent_Identity=36, Blast_Score=63, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 14149; Mature: 14018

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRVDDVLNVSGHRLGTMEVESALVSHPAVAEAAVVGKPDDLKGEEVVAFVTLEGTYQAS
CCCCCCHHCCCCCCCCHHHHHHHHHCCCCHHHHHHCCCCCCCCCCEEEEEEEECCCCCCH
EDLSKALKQHVVQEIGAIARPGEIRFTDALPKTRSGKIMRRLLRNLAAGQEVSGDTSTLE
HHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHH
DRSVLDKLREGA
HHHHHHHHHCCC
>Mature Secondary Structure 
GRVDDVLNVSGHRLGTMEVESALVSHPAVAEAAVVGKPDDLKGEEVVAFVTLEGTYQAS
CCCCCHHCCCCCCCCHHHHHHHHHCCCCHHHHHHCCCCCCCCCCEEEEEEEECCCCCCH
EDLSKALKQHVVQEIGAIARPGEIRFTDALPKTRSGKIMRRLLRNLAAGQEVSGDTSTLE
HHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHH
DRSVLDKLREGA
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12240834 [H]