Click here to switch to the map view.

The map label for this gene is apxIIID [H]

Identifier: 17231732

GI number: 17231732

Start: 5083872

End: 5085443

Strand: Direct

Name: apxIIID [H]

Synonym: alr4240

Alternate gene names: 17231732

Gene position: 5083872-5085443 (Clockwise)

Preceding gene: 17231731

Following gene: 17231733

Centisome position: 79.26

GC content: 36.83

Gene sequence:

>1572_bases
ATGACTCAACTCAATAGCGATCGCCGTAACGGTAATAATAGTAATGGGAAGCAAAATAAGATGATCAAAATTGATGGTCA
AGCTTCACCAGAGACAAGCAAAGCTTTAGTTAAATTTAATCAAAATGACTTTGAGCAATCGGTAGTACTGCGCCAATCTC
CTATTTGGTCACGCACAATTATGCTGACCTTGATAGGGTTAGCTTGTGTGGGTATTGGTTGGGCATATTTTGCAAAAATC
GAACAGGTAGTACCAGCTACTGGTCAACTGAAACCAGAAGGTACAGTTAAAGAAGTACAAGCACCAGTGAATGGTGTAGT
GAAGGAGGTTTTTGTTAAAAATGGAGAAACAGTTAATAAAGGTGATCTACTATTAACCTTTGATCAAGTTACCACCGTCG
CCCAGTTAAACTCATTAGAAAAGGTTAGACGTGCCTTAACTCAAGAAAATCAGACCTATCGCCGCTTAATGAGATCAACT
GGTGGTATTGCTTCTGAACTAGAATTTGTTCGCAGTCGATTACCACAAGAAGCAACTTTTCTGTTAAGAAGTCGTGCAGC
ACTAGTTGCAGAAAATGAATTGCTGCGTACTCAATTAAATAATGCTACCACGGGTATAGGTTTAGATAGTGATGAACAAA
AACAGCTACAAGTTGCCAAAACTGAATTAGATTCTCGTGCAGCAGCCGCAGGACTAGAAGTTTCCAAAATTCAAAAACAA
CTAACTCAAACAACGGTAAAGCTACAAGATACTCAATCTAGTTTGGCAATCCAACAAAGGATTTTAGATAAGATTAAAAT
CTTAGCAGAAGAAGGTGGTATTTCGCAGTTACAATATCTAAATCAACAACAGCAGGTACAAACTACAGCAGCAGAAGTCG
CTCAATTAGTTGAAGAACAAAAACGCCTGCAATTTGATATTGAAAAAAATCAACAGCAAGTTACTAATACAGTTGCTAAT
TCTGATAAAAATATTTTAGAGAAAATTGCTGATAACAAAAAACGTATTGCAGAAATTGATAGTCAGTTCATGAGAATTGT
CTTAGATAATGAACGCAATTTAGCCGATATCACAAGCAAAATTTCTCAAGCTCAACAGGATCTTAAATATCAAGAATTAC
GCGCTCCTGTAGCTGGCACAATCTTTGATTTAAAAGCAAACAATACTGGATTTGTGGCGAACCCTACACAAAAATTATTG
CAAATCGTCCCTAATGAAAACTTTATTGCTGAGGTTTTCATCACTAATAAAGATATTGGTTTTGTCCGCAAAGGAATGAA
AGTAGATGTCAGAATTGACTCTTTTCCTTTCAGCCAGTTTGGTGATATCAAAGGTGAAATAATTGATATTGGCTCAGATG
CGTTGCAACCAGATGAAATATATAAGTTTTATCGCTTCCCTGCCAGAATTAAACTCAATCAACAATACTTACAAGTCCAA
GATAAGCACATTTCCTTGCAGTCGGGTATGTCAATTAGCGCTAATATCAAAGTCAGGGAAGAACGGACAGTCCTAAGTCT
GTTTACGGAAATGTTTACCAATCAAGTTGATAGTTTAAAACAGGTGCGTTAA

Upstream 100 bases:

>100_bases
TATTTTTACCTGTACCAACAACAGGAAGTAAATTTGTAATTGGTTATTCCCAATCCCCAGTCCCCAATCCCCAATCCCCA
GTCCCTTATTCAAAAATACT

Downstream 100 bases:

>100_bases
ATATTTCAGATGTCAGGCATCGAATTTACACATCTTTTGGTGTTGACAGTTGACAGTTGACCCTTATCCTGTTTGGCTTT
CCTGATTTTGAATTTTGAAT

Product: RTX toxin transporter

Products: NA

Alternate protein names: APX-IIID; Cytolysin IIID; CLY-IIID; Toxin RTX-III secretion protein D [H]

Number of amino acids: Translated: 523; Mature: 522

Protein sequence:

>523_residues
MTQLNSDRRNGNNSNGKQNKMIKIDGQASPETSKALVKFNQNDFEQSVVLRQSPIWSRTIMLTLIGLACVGIGWAYFAKI
EQVVPATGQLKPEGTVKEVQAPVNGVVKEVFVKNGETVNKGDLLLTFDQVTTVAQLNSLEKVRRALTQENQTYRRLMRST
GGIASELEFVRSRLPQEATFLLRSRAALVAENELLRTQLNNATTGIGLDSDEQKQLQVAKTELDSRAAAAGLEVSKIQKQ
LTQTTVKLQDTQSSLAIQQRILDKIKILAEEGGISQLQYLNQQQQVQTTAAEVAQLVEEQKRLQFDIEKNQQQVTNTVAN
SDKNILEKIADNKKRIAEIDSQFMRIVLDNERNLADITSKISQAQQDLKYQELRAPVAGTIFDLKANNTGFVANPTQKLL
QIVPNENFIAEVFITNKDIGFVRKGMKVDVRIDSFPFSQFGDIKGEIIDIGSDALQPDEIYKFYRFPARIKLNQQYLQVQ
DKHISLQSGMSISANIKVREERTVLSLFTEMFTNQVDSLKQVR

Sequences:

>Translated_523_residues
MTQLNSDRRNGNNSNGKQNKMIKIDGQASPETSKALVKFNQNDFEQSVVLRQSPIWSRTIMLTLIGLACVGIGWAYFAKI
EQVVPATGQLKPEGTVKEVQAPVNGVVKEVFVKNGETVNKGDLLLTFDQVTTVAQLNSLEKVRRALTQENQTYRRLMRST
GGIASELEFVRSRLPQEATFLLRSRAALVAENELLRTQLNNATTGIGLDSDEQKQLQVAKTELDSRAAAAGLEVSKIQKQ
LTQTTVKLQDTQSSLAIQQRILDKIKILAEEGGISQLQYLNQQQQVQTTAAEVAQLVEEQKRLQFDIEKNQQQVTNTVAN
SDKNILEKIADNKKRIAEIDSQFMRIVLDNERNLADITSKISQAQQDLKYQELRAPVAGTIFDLKANNTGFVANPTQKLL
QIVPNENFIAEVFITNKDIGFVRKGMKVDVRIDSFPFSQFGDIKGEIIDIGSDALQPDEIYKFYRFPARIKLNQQYLQVQ
DKHISLQSGMSISANIKVREERTVLSLFTEMFTNQVDSLKQVR
>Mature_522_residues
TQLNSDRRNGNNSNGKQNKMIKIDGQASPETSKALVKFNQNDFEQSVVLRQSPIWSRTIMLTLIGLACVGIGWAYFAKIE
QVVPATGQLKPEGTVKEVQAPVNGVVKEVFVKNGETVNKGDLLLTFDQVTTVAQLNSLEKVRRALTQENQTYRRLMRSTG
GIASELEFVRSRLPQEATFLLRSRAALVAENELLRTQLNNATTGIGLDSDEQKQLQVAKTELDSRAAAAGLEVSKIQKQL
TQTTVKLQDTQSSLAIQQRILDKIKILAEEGGISQLQYLNQQQQVQTTAAEVAQLVEEQKRLQFDIEKNQQQVTNTVANS
DKNILEKIADNKKRIAEIDSQFMRIVLDNERNLADITSKISQAQQDLKYQELRAPVAGTIFDLKANNTGFVANPTQKLLQ
IVPNENFIAEVFITNKDIGFVRKGMKVDVRIDSFPFSQFGDIKGEIIDIGSDALQPDEIYKFYRFPARIKLNQQYLQVQD
KHISLQSGMSISANIKVREERTVLSLFTEMFTNQVDSLKQVR

Specific function: Involved in the transport of the toxin RTX-III [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003997
- InterPro:   IPR006143
- InterPro:   IPR006144
- InterPro:   IPR010129 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 58750; Mature: 58619

Theoretical pI: Translated: 9.49; Mature: 9.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQLNSDRRNGNNSNGKQNKMIKIDGQASPETSKALVKFNQNDFEQSVVLRQSPIWSRTI
CCCCCCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHEECCCCHHHHHHHHHCCCCHHHHH
MLTLIGLACVGIGWAYFAKIEQVVPATGQLKPEGTVKEVQAPVNGVVKEVFVKNGETVNK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEECC
GDLLLTFDQVTTVAQLNSLEKVRRALTQENQTYRRLMRSTGGIASELEFVRSRLPQEATF
CCEEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHCCHHHHH
LLRSRAALVAENELLRTQLNNATTGIGLDSDEQKQLQVAKTELDSRAAAAGLEVSKIQKQ
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
LTQTTVKLQDTQSSLAIQQRILDKIKILAEEGGISQLQYLNQQQQVQTTAAEVAQLVEEQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KRLQFDIEKNQQQVTNTVANSDKNILEKIADNKKRIAEIDSQFMRIVLDNERNLADITSK
HHHEECHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHH
ISQAQQDLKYQELRAPVAGTIFDLKANNTGFVANPTQKLLQIVPNENFIAEVFITNKDIG
HHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEECHHHHHHHHCCCCCEEEEEEEECCCHH
FVRKGMKVDVRIDSFPFSQFGDIKGEIIDIGSDALQPDEIYKFYRFPARIKLNQQYLQVQ
HHHCCCEEEEEECCCCCHHHCCCCCEEEECCCCCCCHHHHHHHHHCCCEEEECHHHHHHH
DKHISLQSGMSISANIKVREERTVLSLFTEMFTNQVDSLKQVR
HHHEEHHCCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TQLNSDRRNGNNSNGKQNKMIKIDGQASPETSKALVKFNQNDFEQSVVLRQSPIWSRTI
CCCCCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHEECCCCHHHHHHHHHCCCCHHHHH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HHHEEHHCCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8494611; 7927703 [H]