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The map label for this gene is rnc2 [H]

Identifier: 17231599

GI number: 17231599

Start: 4949468

End: 4950076

Strand: Reverse

Name: rnc2 [H]

Synonym: all4107

Alternate gene names: 17231599

Gene position: 4950076-4949468 (Counterclockwise)

Preceding gene: 17231601

Following gene: 17231598

Centisome position: 77.18

GC content: 47.78

Gene sequence:

>609_bases
GTGTCTGAATCAGCTAATTATGAACAGTTGGAGTTTGTTGGTGATGCGGTGGTGCGGTTAGCGGCGGCTGTGATGCTGTG
GGAGACTTATCCTGATTGCCCTGTGGGAGATTTTGCGGCAATTCGTTCGGTATTAGTGAGCGATCGCATCCTCGCCCAAT
TAGCCAGAGAATATGGTTTAGAATTACATTTACTAGTTGCTGGCAGTGCCACCAGTGACAAAATTGGTCAAGAGTCCCGA
TTGGCAGATGCTTTTGAAGCTGTTTTAGGTGCGCTTTATCTCAGCACTTCTAATCTAGAACTCATTCGCCCTTGGTTAGA
CCATCACTTTCGCCAACTAGCAGCCGAAATTCGCCTCGACCCCGCCAGACTCAACTACAAAGCCGCACTACAGGAATGGA
CGCAAGCACAATTTAAGGTTTTACCTGAATATCGAGTCGTCGAAATCAATCAAGCAAATCGCACTCAAGAACGTTTCGCC
GCCGAAGTTTGGTTACACGGTAACAAACTCGGTGAAGGCAAAGGACGCTCTATCAAAGCCGCCGAACAAGCCGCCGCCAA
AGTAGCCTTTTTGGCTATCACTCCTCCAGAAGAAATTGCTAATCAATAG

Upstream 100 bases:

>100_bases
CCGTCAGAGGCAACTTGAAAGTTTAGTAAGAAAATTAGGTCTGCCAATAACAGCACCCATTAAGTGGGAATTGCTGGATT
TAGCATTGACTCATCCTACT

Downstream 100 bases:

>100_bases
TTTATAGTCCATAGTCAAAAGCAATTACACGTAACTATTGACGCTTAATCATTTACCAGTGACTATTAACTAATAACAAA
CATAAGAGATATTTCACGCA

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III 2; RNase III 2 [H]

Number of amino acids: Translated: 202; Mature: 201

Protein sequence:

>202_residues
MSESANYEQLEFVGDAVVRLAAAVMLWETYPDCPVGDFAAIRSVLVSDRILAQLAREYGLELHLLVAGSATSDKIGQESR
LADAFEAVLGALYLSTSNLELIRPWLDHHFRQLAAEIRLDPARLNYKAALQEWTQAQFKVLPEYRVVEINQANRTQERFA
AEVWLHGNKLGEGKGRSIKAAEQAAAKVAFLAITPPEEIANQ

Sequences:

>Translated_202_residues
MSESANYEQLEFVGDAVVRLAAAVMLWETYPDCPVGDFAAIRSVLVSDRILAQLAREYGLELHLLVAGSATSDKIGQESR
LADAFEAVLGALYLSTSNLELIRPWLDHHFRQLAAEIRLDPARLNYKAALQEWTQAQFKVLPEYRVVEINQANRTQERFA
AEVWLHGNKLGEGKGRSIKAAEQAAAKVAFLAITPPEEIANQ
>Mature_201_residues
SESANYEQLEFVGDAVVRLAAAVMLWETYPDCPVGDFAAIRSVLVSDRILAQLAREYGLELHLLVAGSATSDKIGQESRL
ADAFEAVLGALYLSTSNLELIRPWLDHHFRQLAAEIRLDPARLNYKAALQEWTQAQFKVLPEYRVVEINQANRTQERFAA
EVWLHGNKLGEGKGRSIKAAEQAAAKVAFLAITPPEEIANQ

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030236, Length=195, Percent_Identity=26.1538461538462, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI155030234, Length=195, Percent_Identity=26.1538461538462, Blast_Score=70, Evalue=8e-13,
Organism=Escherichia coli, GI1788920, Length=155, Percent_Identity=32.258064516129, Blast_Score=75, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 22434; Mature: 22303

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSESANYEQLEFVGDAVVRLAAAVMLWETYPDCPVGDFAAIRSVLVSDRILAQLAREYGL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
ELHLLVAGSATSDKIGQESRLADAFEAVLGALYLSTSNLELIRPWLDHHFRQLAAEIRLD
EEEEEEECCCCCHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCC
PARLNYKAALQEWTQAQFKVLPEYRVVEINQANRTQERFAAEVWLHGNKLGEGKGRSIKA
HHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHEECCEECCCCCCCCHH
AEQAAAKVAFLAITPPEEIANQ
HHHHHHHEEEEEECCHHHHCCC
>Mature Secondary Structure 
SESANYEQLEFVGDAVVRLAAAVMLWETYPDCPVGDFAAIRSVLVSDRILAQLAREYGL
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
ELHLLVAGSATSDKIGQESRLADAFEAVLGALYLSTSNLELIRPWLDHHFRQLAAEIRLD
EEEEEEECCCCCHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCC
PARLNYKAALQEWTQAQFKVLPEYRVVEINQANRTQERFAAEVWLHGNKLGEGKGRSIKA
HHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHEECCEECCCCCCCCHH
AEQAAAKVAFLAITPPEEIANQ
HHHHHHHEEEEEECCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]