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The map label for this gene is luxQ [H]

Identifier: 17231477

GI number: 17231477

Start: 4799618

End: 4801462

Strand: Reverse

Name: luxQ [H]

Synonym: all3985

Alternate gene names: 17231477

Gene position: 4801462-4799618 (Counterclockwise)

Preceding gene: 17231478

Following gene: 17231476

Centisome position: 74.86

GC content: 44.82

Gene sequence:

>1845_bases
GTGGAAAGAGAAAGCCCAAGAAGTGATTCTTGGAATCCCCCGTTTTCTAAACGGGGGAGGATGTCAACCTATCGCCAAGC
ATTTGCAGGCATCAGCTCCCGTTTTGAAGCACCCTATGGACATCGCGTTTATGAAGTCCATGTTTTACCTGTGAGGAATG
ATGATGGTGAGATTTTTGCGGGAATGACCATTACCCAGGAAATCACAGAGCGTAAACAATCTGAATTGGCTTTGCAAAAT
GCCCTACAGCTTTTAAATCTACACATAGATACTACTCCTTTGGCAGTAGTGCAGTGGGATTGCCACTTGTGCGTTACCCG
TTGGTCATCGGCTGCTGAAAAAATCTTTGGCTGGCTGGCAGAAGAAGTAATAGGAAAATACATTCAAGATTTGCATATAG
TTTATGAGGAAGATATGACAGCAGTCGCAGAGGTGAGCGATCGCCTCCTCAGTGGCCAAGAAGCGCAAATTATCCAATAC
AATCGCAACTATACCAAAGATGGCAGAGTCATTTATTGCGAATGGTACAACTCCAGCATTACTAATGAAGAAGGTAGTGT
TACCTCTGTGCTATCACTAGTGTTAGATGTAACAGAGCGCATACAAGCAGAAAAAGCACTACGCCAAAGCGAATTAATGG
TAACTGAAGAGCGGGCGCAAGCTTTAGAACGAGAACGGGCAGCTCGTATAGAACTGGAAAGAGCCAGTCGTATGAAAGAT
GAATTTTTAGCGATAGTTTCCCATGAATTGCGATCGCCCCTCAATGGTATTTTAGGCTGGTCGCGCCTGCTCCGCACCCG
CAAACTGTCACCAGAAAAGATTGAACAAGCTTTAGAATCCATTGAGCGCAATGCTCAAGCCCAAACTCAATTAATTGAAG
ACTTACTCGATATTTCCCGGATTATTCGCGGTAACATTCGCTTGCTTGTGCGCCCCACAAAATTGATTCCGGTAATTCAA
GCCGCACTAGATACCGTCCGCCCAATTGCCAATACCAAATCAATCCAAATTATATCTCGCCTGAATTTTGATATTGGTTT
AGTTTCTGCCGACCCAGAACGTTTACAGCAAGTGATTTGGAACCTACTTTCCAATGCAGTCAAGTTTACTCCTGAAGGTG
GACGGGTAGAAATTTGCCTAGAACAAGTAGAGACTAATGTGCAGATTCAGGTAATTGACACAGGTACAGGCATCAGTCCT
GAGTTTTTGCCTTATGTGTTTGACCGTTTCCGCCAAGCAGATGCTACCACAACCAGAAATCAAGGAGGACTGGGTTTAGG
TCTGGCGATCGTGCGTAATCTCGTTGAGCTTCACAATGGTAAAGTATCAGTTGCTAGCCCAGGAGAAGGACAAGGAGCCA
CATTTACAGTCCAACTACCACTTTTAGCAACTTACTCCACACTCACCCCAGAAGAACCCTTGATTCAACGACAGACAGCC
TGGGATACTAAAGTCCAAATCAAAGGACTAAAAATCTTAGCAGTTGATGATGAACCAGATACTAGAGAATTTCTCAAAAC
TGCCTTAGAGCAATACGGAGCAATTGTAACAACCGCAGCCTCCACCCGTGAAGCCTTAAAACTGTTGCAATTAGTGAAGC
CTGATGTGCTATTAAGTGATATTGGGATGCCTAATGAAGATGGCTACGCTCTCATTCGGCAAATTCGAGCGCTATCATCA
GAACAAGGGGGAAATGTCCCAGCCGCCGCCCTTACCGCTTACACCAGACAAAGCGATCGCCTCCAAGCCCTAACCGCCGG
ATTTCAAATTCATATATCCAAACCAATTGAGCCAATCCAGTTATTAAAAATTGTTGCTACCCTGGCTGGCAACAACTCGA
ATTAA

Upstream 100 bases:

>100_bases
CTTGAACTAGGACTACGTACTGTGGGACACACAGGATCTCAAGTCTCTGGAGATATCGACCTCTGTTTGGGTGAGGTAAC
TCCTCCAAATAAGTCGAGTC

Downstream 100 bases:

>100_bases
AAGGAAGCAGGAGAGGAAATGAATTCAGCCCACAAAATTCAAACTTAATAACCCCCCACTCCTGGGGAATATGCCCAAAG
AACGGTTTAAACAGAGTAAG

Product: two-component hybrid sensor and regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 614; Mature: 614

Protein sequence:

>614_residues
MERESPRSDSWNPPFSKRGRMSTYRQAFAGISSRFEAPYGHRVYEVHVLPVRNDDGEIFAGMTITQEITERKQSELALQN
ALQLLNLHIDTTPLAVVQWDCHLCVTRWSSAAEKIFGWLAEEVIGKYIQDLHIVYEEDMTAVAEVSDRLLSGQEAQIIQY
NRNYTKDGRVIYCEWYNSSITNEEGSVTSVLSLVLDVTERIQAEKALRQSELMVTEERAQALERERAARIELERASRMKD
EFLAIVSHELRSPLNGILGWSRLLRTRKLSPEKIEQALESIERNAQAQTQLIEDLLDISRIIRGNIRLLVRPTKLIPVIQ
AALDTVRPIANTKSIQIISRLNFDIGLVSADPERLQQVIWNLLSNAVKFTPEGGRVEICLEQVETNVQIQVIDTGTGISP
EFLPYVFDRFRQADATTTRNQGGLGLGLAIVRNLVELHNGKVSVASPGEGQGATFTVQLPLLATYSTLTPEEPLIQRQTA
WDTKVQIKGLKILAVDDEPDTREFLKTALEQYGAIVTTAASTREALKLLQLVKPDVLLSDIGMPNEDGYALIRQIRALSS
EQGGNVPAAALTAYTRQSDRLQALTAGFQIHISKPIEPIQLLKIVATLAGNNSN

Sequences:

>Translated_614_residues
MERESPRSDSWNPPFSKRGRMSTYRQAFAGISSRFEAPYGHRVYEVHVLPVRNDDGEIFAGMTITQEITERKQSELALQN
ALQLLNLHIDTTPLAVVQWDCHLCVTRWSSAAEKIFGWLAEEVIGKYIQDLHIVYEEDMTAVAEVSDRLLSGQEAQIIQY
NRNYTKDGRVIYCEWYNSSITNEEGSVTSVLSLVLDVTERIQAEKALRQSELMVTEERAQALERERAARIELERASRMKD
EFLAIVSHELRSPLNGILGWSRLLRTRKLSPEKIEQALESIERNAQAQTQLIEDLLDISRIIRGNIRLLVRPTKLIPVIQ
AALDTVRPIANTKSIQIISRLNFDIGLVSADPERLQQVIWNLLSNAVKFTPEGGRVEICLEQVETNVQIQVIDTGTGISP
EFLPYVFDRFRQADATTTRNQGGLGLGLAIVRNLVELHNGKVSVASPGEGQGATFTVQLPLLATYSTLTPEEPLIQRQTA
WDTKVQIKGLKILAVDDEPDTREFLKTALEQYGAIVTTAASTREALKLLQLVKPDVLLSDIGMPNEDGYALIRQIRALSS
EQGGNVPAAALTAYTRQSDRLQALTAGFQIHISKPIEPIQLLKIVATLAGNNSN
>Mature_614_residues
MERESPRSDSWNPPFSKRGRMSTYRQAFAGISSRFEAPYGHRVYEVHVLPVRNDDGEIFAGMTITQEITERKQSELALQN
ALQLLNLHIDTTPLAVVQWDCHLCVTRWSSAAEKIFGWLAEEVIGKYIQDLHIVYEEDMTAVAEVSDRLLSGQEAQIIQY
NRNYTKDGRVIYCEWYNSSITNEEGSVTSVLSLVLDVTERIQAEKALRQSELMVTEERAQALERERAARIELERASRMKD
EFLAIVSHELRSPLNGILGWSRLLRTRKLSPEKIEQALESIERNAQAQTQLIEDLLDISRIIRGNIRLLVRPTKLIPVIQ
AALDTVRPIANTKSIQIISRLNFDIGLVSADPERLQQVIWNLLSNAVKFTPEGGRVEICLEQVETNVQIQVIDTGTGISP
EFLPYVFDRFRQADATTTRNQGGLGLGLAIVRNLVELHNGKVSVASPGEGQGATFTVQLPLLATYSTLTPEEPLIQRQTA
WDTKVQIKGLKILAVDDEPDTREFLKTALEQYGAIVTTAASTREALKLLQLVKPDVLLSDIGMPNEDGYALIRQIRALSS
EQGGNVPAAALTAYTRQSDRLQALTAGFQIHISKPIEPIQLLKIVATLAGNNSN

Specific function: At low cell density, in absence of AI-2 (autoinducer 2), luxQ has a kinase activity and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is t

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788713, Length=390, Percent_Identity=33.0769230769231, Blast_Score=175, Evalue=9e-45,
Organism=Escherichia coli, GI48994928, Length=551, Percent_Identity=26.497277676951, Blast_Score=142, Evalue=5e-35,
Organism=Escherichia coli, GI1789149, Length=268, Percent_Identity=35.8208955223881, Blast_Score=142, Evalue=7e-35,
Organism=Escherichia coli, GI145693157, Length=419, Percent_Identity=28.1622911694511, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI87081816, Length=338, Percent_Identity=32.5443786982249, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1788393, Length=232, Percent_Identity=33.1896551724138, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1786600, Length=234, Percent_Identity=32.9059829059829, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI1790436, Length=218, Percent_Identity=32.1100917431193, Blast_Score=106, Evalue=5e-24,
Organism=Escherichia coli, GI1786783, Length=222, Percent_Identity=28.8288288288288, Blast_Score=105, Evalue=1e-23,
Organism=Escherichia coli, GI1788549, Length=399, Percent_Identity=26.5664160401003, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1786912, Length=252, Percent_Identity=34.1269841269841, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790861, Length=241, Percent_Identity=33.195020746888, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI1790346, Length=232, Percent_Identity=31.8965517241379, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1788279, Length=246, Percent_Identity=28.0487804878049, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1790300, Length=313, Percent_Identity=26.1980830670927, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI87082128, Length=229, Percent_Identity=30.1310043668122, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787894, Length=231, Percent_Identity=27.7056277056277, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1786911, Length=105, Percent_Identity=38.0952380952381, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI1789403, Length=209, Percent_Identity=27.2727272727273, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 68652; Mature: 68652

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERESPRSDSWNPPFSKRGRMSTYRQAFAGISSRFEAPYGHRVYEVHVLPVRNDDGEIFA
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEECCCCCEEE
GMTITQEITERKQSELALQNALQLLNLHIDTTPLAVVQWDCHLCVTRWSSAAEKIFGWLA
CCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEEECHHHHHHHHHHHHHHHHHHHH
EEVIGKYIQDLHIVYEEDMTAVAEVSDRLLSGQEAQIIQYNRNYTKDGRVIYCEWYNSSI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEEECCCCC
TNEEGSVTSVLSLVLDVTERIQAEKALRQSELMVTEERAQALERERAARIELERASRMKD
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHH
EFLAIVSHELRSPLNGILGWSRLLRTRKLSPEKIEQALESIERNAQAQTQLIEDLLDISR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIRGNIRLLVRPTKLIPVIQAALDTVRPIANTKSIQIISRLNFDIGLVSADPERLQQVIW
HHCCCCEEEEECHHHHHHHHHHHHHHHHCCCCCCEEEHHHCCCCEEEECCCHHHHHHHHH
NLLSNAVKFTPEGGRVEICLEQVETNVQIQVIDTGTGISPEFLPYVFDRFRQADATTTRN
HHHHHHEEECCCCCEEEEEEEHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCC
QGGLGLGLAIVRNLVELHNGKVSVASPGEGQGATFTVQLPLLATYSTLTPEEPLIQRQTA
CCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCEEEEEECHHHHHCCCCCCCCHHHHHCC
WDTKVQIKGLKILAVDDEPDTREFLKTALEQYGAIVTTAASTREALKLLQLVKPDVLLSD
CCCEEEEEEEEEEEECCCCCHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHCCCHHHHH
IGMPNEDGYALIRQIRALSSEQGGNVPAAALTAYTRQSDRLQALTAGFQIHISKPIEPIQ
CCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHCCEEEEECCCCCHHH
LLKIVATLAGNNSN
HHHHHHHHCCCCCC
>Mature Secondary Structure
MERESPRSDSWNPPFSKRGRMSTYRQAFAGISSRFEAPYGHRVYEVHVLPVRNDDGEIFA
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEECCCCCEEE
GMTITQEITERKQSELALQNALQLLNLHIDTTPLAVVQWDCHLCVTRWSSAAEKIFGWLA
CCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEEECHHHHHHHHHHHHHHHHHHHH
EEVIGKYIQDLHIVYEEDMTAVAEVSDRLLSGQEAQIIQYNRNYTKDGRVIYCEWYNSSI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEEECCCCC
TNEEGSVTSVLSLVLDVTERIQAEKALRQSELMVTEERAQALERERAARIELERASRMKD
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHH
EFLAIVSHELRSPLNGILGWSRLLRTRKLSPEKIEQALESIERNAQAQTQLIEDLLDISR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIRGNIRLLVRPTKLIPVIQAALDTVRPIANTKSIQIISRLNFDIGLVSADPERLQQVIW
HHCCCCEEEEECHHHHHHHHHHHHHHHHCCCCCCEEEHHHCCCCEEEECCCHHHHHHHHH
NLLSNAVKFTPEGGRVEICLEQVETNVQIQVIDTGTGISPEFLPYVFDRFRQADATTTRN
HHHHHHEEECCCCCEEEEEEEHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCC
QGGLGLGLAIVRNLVELHNGKVSVASPGEGQGATFTVQLPLLATYSTLTPEEPLIQRQTA
CCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCEEEEEECHHHHHCCCCCCCCHHHHHCC
WDTKVQIKGLKILAVDDEPDTREFLKTALEQYGAIVTTAASTREALKLLQLVKPDVLLSD
CCCEEEEEEEEEEEECCCCCHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHCCCHHHHH
IGMPNEDGYALIRQIRALSSEQGGNVPAAALTAYTRQSDRLQALTAGFQIHISKPIEPIQ
CCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHCCEEEEECCCCCHHH
LLKIVATLAGNNSN
HHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301; 12176318 [H]