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The map label for this gene is ndhD [H]

Identifier: 17231449

GI number: 17231449

Start: 4776833

End: 4778410

Strand: Direct

Name: ndhD [H]

Synonym: alr3957

Alternate gene names: 17231449

Gene position: 4776833-4778410 (Clockwise)

Preceding gene: 17231448

Following gene: 17231450

Centisome position: 74.48

GC content: 46.01

Gene sequence:

>1578_bases
ATGAATACAGCTAATTTTCCGTGGCTGACGACAATTATTTTATTACCGATAGCCGCGTCGCTACTGATTCCCATCATTCC
CGATAAAGATGGCAAAACCATCCGTTGGTACGCTCTGACTGTAGGTTTGATTGATTTCGCTCTCATTGTTTACGCTTTTT
ATACCAGTTACGACTTCGCCAACCCCGATTTGCAACTGGTGGAGAGTTACCCCTGGGTTCCGCAGCTAGATTTGAATTGG
TCAGTGGGGGCAGATGGCTTGTCTATGCCCCTGATTATTTTGACTGGATTCATTACCACCCTAGCCACCTTAGCAGCCTG
GCCTGTCACCTTAAAGCCCAGGCTATTTTACTTTCTACTCCTGGCTATGTATGGCGGTCAAATCGCTGTATTTGCCGTTC
AGGATATGCTGCTATTCTTTTTGGTGTGGGAATTGGAATTAATCCCCGTTTACTTACTGCTAGCAATTTGGGGAGGTAAA
AAACGGCAATACGCAGCCACCAAATTTATTTTGTACACGGCTGGCGGTTCGCTATTTATTTTACTGGCATCTTTGACAAT
GGCCTTTTATGGGGATACAGTCACCTTTGATATGCGATCGCTCGCTCTCAAAGATTACGCCCTAAATTTCCAATTGTTGC
TATACGCTGGCTTCCTTATTGCCTACGCCATCAAATTACCCATCATTCCCCTGCATACTTGGTTGCCAGATGCCCACGGC
GAAGCTACAGCCCCCGCGCATATGTTGCTGGCAGGTATTTTGCTGAAAATGGGTGGTTATGCCCTGATTCGCATGAATGC
TGGCATTCTACCTGATGCCCATGCTTATTTCGCCCCTGTGCTGGTTGTCTTGGGGGTAGTTAACATCATCTACGCTGCTT
TGACATCCTTTGCCCAGCGTAACCTCAAGCGGAAGATTGCCTACTCCTCGATTTCCCACATGGGCTTTGTGATTATCGGG
TTTGCTTCCTTTACCGATTTGGGTTTGAGTGGAGCGGTGTTACAAATGGTGTCCCACGGCTTAATCGGGGCAAGTTTATT
CTTCCTCGTCGGTGCGACTTATGACCGGACACATACCCTGATGTTAGATGAAATGGGCGGTGTCGGTAAGCGGATGCCCA
AAATTTTCGCTATGTTCACAGCTTGTTCAATGGCTTCTTTAGCATTGCCGGGAATGAGTGGCTTCGTAGCAGAATTAATG
GTATTCGTCGGCTTTGCTACCAGCGATGCTTATAGCTCCACATTTAAGGTCATCGTGGTATTCCTCATGGCAGTTGGGGT
AATTTTAACTCCGATTTATCTCCTGTCCATGTTGCGGGAAATTTTCTACGGCAAAGAAAACGAAGAATTAGTTTCTCATC
AGCAACTAATAGATGCCGAACCCCGCGAAGTCTTTGTTATTGCTTGTCTACTGGTGCCAATTATTGGTATTGGTTTCTAT
CCCAAGCTACTAACTCAGATGTACGACGCTACAACTGTACAACTGACAGCAAGATTACGTGATTCCGTCCCAACTTTGGC
ACAGGAAAAACAAGAGGTAGCACGAGTTTCTTTAAGTGCGCCAGTAATTGGTAATTAA

Upstream 100 bases:

>100_bases
TTAAATCAACCTAACATTCAATGCCAAATCCTCAAAAAGCTGTTAGTTAATAAGCTAGTGGCTCATTGGCAAACATGAAT
TTAATAGCAGACGAATTGTG

Downstream 100 bases:

>100_bases
CTGGTGCTTAATCCTTTCTACCTATATTGTTGTAAGAGCGGGTATTATACCTGCTCTTTTTTTACTACGTAAGGAAAGTA
TCATCGTAGATATTGCTGTT

Product: NAD(P)H-quinone oxidoreductase subunit 4

Products: NAD+; ubiquinol

Alternate protein names: NAD(P)H dehydrogenase I, chain 4 1; NDH-1, chain 4 1 [H]

Number of amino acids: Translated: 525; Mature: 525

Protein sequence:

>525_residues
MNTANFPWLTTIILLPIAASLLIPIIPDKDGKTIRWYALTVGLIDFALIVYAFYTSYDFANPDLQLVESYPWVPQLDLNW
SVGADGLSMPLIILTGFITTLATLAAWPVTLKPRLFYFLLLAMYGGQIAVFAVQDMLLFFLVWELELIPVYLLLAIWGGK
KRQYAATKFILYTAGGSLFILLASLTMAFYGDTVTFDMRSLALKDYALNFQLLLYAGFLIAYAIKLPIIPLHTWLPDAHG
EATAPAHMLLAGILLKMGGYALIRMNAGILPDAHAYFAPVLVVLGVVNIIYAALTSFAQRNLKRKIAYSSISHMGFVIIG
FASFTDLGLSGAVLQMVSHGLIGASLFFLVGATYDRTHTLMLDEMGGVGKRMPKIFAMFTACSMASLALPGMSGFVAELM
VFVGFATSDAYSSTFKVIVVFLMAVGVILTPIYLLSMLREIFYGKENEELVSHQQLIDAEPREVFVIACLLVPIIGIGFY
PKLLTQMYDATTVQLTARLRDSVPTLAQEKQEVARVSLSAPVIGN

Sequences:

>Translated_525_residues
MNTANFPWLTTIILLPIAASLLIPIIPDKDGKTIRWYALTVGLIDFALIVYAFYTSYDFANPDLQLVESYPWVPQLDLNW
SVGADGLSMPLIILTGFITTLATLAAWPVTLKPRLFYFLLLAMYGGQIAVFAVQDMLLFFLVWELELIPVYLLLAIWGGK
KRQYAATKFILYTAGGSLFILLASLTMAFYGDTVTFDMRSLALKDYALNFQLLLYAGFLIAYAIKLPIIPLHTWLPDAHG
EATAPAHMLLAGILLKMGGYALIRMNAGILPDAHAYFAPVLVVLGVVNIIYAALTSFAQRNLKRKIAYSSISHMGFVIIG
FASFTDLGLSGAVLQMVSHGLIGASLFFLVGATYDRTHTLMLDEMGGVGKRMPKIFAMFTACSMASLALPGMSGFVAELM
VFVGFATSDAYSSTFKVIVVFLMAVGVILTPIYLLSMLREIFYGKENEELVSHQQLIDAEPREVFVIACLLVPIIGIGFY
PKLLTQMYDATTVQLTARLRDSVPTLAQEKQEVARVSLSAPVIGN
>Mature_525_residues
MNTANFPWLTTIILLPIAASLLIPIIPDKDGKTIRWYALTVGLIDFALIVYAFYTSYDFANPDLQLVESYPWVPQLDLNW
SVGADGLSMPLIILTGFITTLATLAAWPVTLKPRLFYFLLLAMYGGQIAVFAVQDMLLFFLVWELELIPVYLLLAIWGGK
KRQYAATKFILYTAGGSLFILLASLTMAFYGDTVTFDMRSLALKDYALNFQLLLYAGFLIAYAIKLPIIPLHTWLPDAHG
EATAPAHMLLAGILLKMGGYALIRMNAGILPDAHAYFAPVLVVLGVVNIIYAALTSFAQRNLKRKIAYSSISHMGFVIIG
FASFTDLGLSGAVLQMVSHGLIGASLFFLVGATYDRTHTLMLDEMGGVGKRMPKIFAMFTACSMASLALPGMSGFVAELM
VFVGFATSDAYSSTFKVIVVFLMAVGVILTPIYLLSMLREIFYGKENEELVSHQQLIDAEPREVFVIACLLVPIIGIGFY
PKLLTQMYDATTVQLTARLRDSVPTLAQEKQEVARVSLSAPVIGN

Specific function: NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton tran

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cellular thylakoid membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=376, Percent_Identity=28.7234042553192, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI251831117, Length=331, Percent_Identity=25.3776435045317, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1788613, Length=516, Percent_Identity=37.015503875969, Blast_Score=297, Evalue=1e-81,
Organism=Escherichia coli, GI1788827, Length=285, Percent_Identity=25.6140350877193, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1788831, Length=304, Percent_Identity=27.9605263157895, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1788829, Length=303, Percent_Identity=29.042904290429, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1788614, Length=486, Percent_Identity=25.1028806584362, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI2367154, Length=247, Percent_Identity=26.7206477732794, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI145693160, Length=217, Percent_Identity=31.3364055299539, Blast_Score=73, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022997
- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: 1.6.5.3

Molecular weight: Translated: 57683; Mature: 57683

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTANFPWLTTIILLPIAASLLIPIIPDKDGKTIRWYALTVGLIDFALIVYAFYTSYDFA
CCCCCCHHHHHHHHHHHHHHHHEECCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCC
NPDLQLVESYPWVPQLDLNWSVGADGLSMPLIILTGFITTLATLAAWPVTLKPRLFYFLL
CCCHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LAMYGGQIAVFAVQDMLLFFLVWELELIPVYLLLAIWGGKKRQYAATKFILYTAGGSLFI
HHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHEEEEEEECCCHHHH
LLASLTMAFYGDTVTFDMRSLALKDYALNFQLLLYAGFLIAYAIKLPIIPLHTWLPDAHG
HHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHCCCCCCC
EATAPAHMLLAGILLKMGGYALIRMNAGILPDAHAYFAPVLVVLGVVNIIYAALTSFAQR
CCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLKRKIAYSSISHMGFVIIGFASFTDLGLSGAVLQMVSHGLIGASLFFLVGATYDRTHTL
HHHHHHHHHHHHHCCEEEEEEHHHHHCCCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCEE
MLDEMGGVGKRMPKIFAMFTACSMASLALPGMSGFVAELMVFVGFATSDAYSSTFKVIVV
EEHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHH
FLMAVGVILTPIYLLSMLREIFYGKENEELVSHQQLIDAEPREVFVIACLLVPIIGIGFY
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHH
PKLLTQMYDATTVQLTARLRDSVPTLAQEKQEVARVSLSAPVIGN
HHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MNTANFPWLTTIILLPIAASLLIPIIPDKDGKTIRWYALTVGLIDFALIVYAFYTSYDFA
CCCCCCHHHHHHHHHHHHHHHHEECCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCC
NPDLQLVESYPWVPQLDLNWSVGADGLSMPLIILTGFITTLATLAAWPVTLKPRLFYFLL
CCCHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LAMYGGQIAVFAVQDMLLFFLVWELELIPVYLLLAIWGGKKRQYAATKFILYTAGGSLFI
HHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHEEEEEEECCCHHHH
LLASLTMAFYGDTVTFDMRSLALKDYALNFQLLLYAGFLIAYAIKLPIIPLHTWLPDAHG
HHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHCCCCCCC
EATAPAHMLLAGILLKMGGYALIRMNAGILPDAHAYFAPVLVVLGVVNIIYAALTSFAQR
CCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLKRKIAYSSISHMGFVIIGFASFTDLGLSGAVLQMVSHGLIGASLFFLVGATYDRTHTL
HHHHHHHHHHHHHCCEEEEEEHHHHHCCCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCEE
MLDEMGGVGKRMPKIFAMFTACSMASLALPGMSGFVAELMVFVGFATSDAYSSTFKVIVV
EEHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHH
FLMAVGVILTPIYLLSMLREIFYGKENEELVSHQQLIDAEPREVFVIACLLVPIIGIGFY
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHH
PKLLTQMYDATTVQLTARLRDSVPTLAQEKQEVARVSLSAPVIGN
HHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA