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The map label for this gene is trpB

Identifier: 17231286

GI number: 17231286

Start: 4585269

End: 4586510

Strand: Reverse

Name: trpB

Synonym: all3794

Alternate gene names: 17231286

Gene position: 4586510-4585269 (Counterclockwise)

Preceding gene: 17231289

Following gene: 17231285

Centisome position: 71.51

GC content: 49.19

Gene sequence:

>1242_bases
GTGACTACCACTCCCCTTTCTCCAAGTACCCCCTCAAATGTTCAGGTTCCCGATATCCAAGGACGCTTTGGACGCTTTGG
CGGTAAGTATGTGCCGGAAACCTTGATGCCGGCTTTAGCTGAACTAGAAACAGCTTATCAACAATACCGCAATGACCCCG
GTTTTCAAGCAGAACTGCAACAATTGTTGCGTGACTATGTAGGACGCGCCACACCATTGTATTTCGCTGAACGCCTCACC
GCTCATTATGCCCGACCAGATGGTACAGGAGCGCAAATTTATTTAAAACGCGAAGATTTAAATCATACAGGCGCTCACAA
AATCAATAACGCCCTTGGTCAAGTATTATTAGCCAAGCGCATGGGTAAGCAGCGCATTATTGCCGAAACTGGTGCCGGAC
AACATGGTGTAGCAACAGCCACGGTTTGCGCTCGGTTTGGGTTGGAATGTGTGATTTATATGGGTGTTCACGATATGGAA
CGCCAAGCTTTGAATGTGTTTAGAATGCGGCTGATGGGGGCTGAAGTTCGTCCGGTGGCGGCTGGGACGGGAACTCTCAA
GGACGCTACATCTGAGGCGATTCGGGATTGGGTGACGAATGTGGAAACTACTCACTACATTTTGGGTTCCGTTGCCGGGC
CTCATCCTTACCCAATGATGGTACGGGATTTCCATGCAGTCATTGGACAAGAAACTCGCGCTCAAGCTTTGGAAAAATGG
GGTGGTTTACCCGACATTCTTTTAGCTTGTGTGGGTGGCGGGTCTAATGCGATGGGATTATTTTACGAGTTTGTGAATGA
GTCATCCATTAAGTTAATTGGAGTAGAAGCAGCAGGAGAGGGTGTCAACACAGAAAAACACGCCGCCACCTTGACAAAAG
GACGAGTTGGTGTATTGCACGGGGCGATGAGTTATCTACTGCAAGATGAGGATGGCCAGGTAATTGAAGCGCACTCGATT
AGCGCGGGGTTAGATTACCCTGGTGTGGGGCCAGAACACAGCTACTTGAAAGATGTTGGTCGTGCAGAATATTACAGTGT
GACGGACGAGGAAGCTTTGGCTGCGTTCCAGCGATTATCCCGCTTGGAAGGAATTATCCCAGCCCTGGAAACAGCCCATG
CGATCGCTTACTTAGAAACCCTCTGTCCCCAACTTGACGGCAGCCCCCGCATTGTGATCAACTGCTCTGGACGTGGTGAT
AAAGATGTCCAAACTGTAGCTAAGTTTTTAATCCCACAATAA

Upstream 100 bases:

>100_bases
CGAACTGGTTTAATGTTTTCCTTGTGGAGTCACATTGCATTCTCTGTGCCTCAGACTTTCCTATAATAATTAAGTCTATC
CCATCATCAAAAATCATTCC

Downstream 100 bases:

>100_bases
ATCTATCTTTAGACAGATATTTTGTCGAAGATTTATAAATTTACACAGGCTGTTTTGCCGCATTTTTCGGGAAAATTTAG
GGAAAAATCAGACTAATGAG

Product: tryptophan synthase subunit beta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 413; Mature: 412

Protein sequence:

>413_residues
MTTTPLSPSTPSNVQVPDIQGRFGRFGGKYVPETLMPALAELETAYQQYRNDPGFQAELQQLLRDYVGRATPLYFAERLT
AHYARPDGTGAQIYLKREDLNHTGAHKINNALGQVLLAKRMGKQRIIAETGAGQHGVATATVCARFGLECVIYMGVHDME
RQALNVFRMRLMGAEVRPVAAGTGTLKDATSEAIRDWVTNVETTHYILGSVAGPHPYPMMVRDFHAVIGQETRAQALEKW
GGLPDILLACVGGGSNAMGLFYEFVNESSIKLIGVEAAGEGVNTEKHAATLTKGRVGVLHGAMSYLLQDEDGQVIEAHSI
SAGLDYPGVGPEHSYLKDVGRAEYYSVTDEEALAAFQRLSRLEGIIPALETAHAIAYLETLCPQLDGSPRIVINCSGRGD
KDVQTVAKFLIPQ

Sequences:

>Translated_413_residues
MTTTPLSPSTPSNVQVPDIQGRFGRFGGKYVPETLMPALAELETAYQQYRNDPGFQAELQQLLRDYVGRATPLYFAERLT
AHYARPDGTGAQIYLKREDLNHTGAHKINNALGQVLLAKRMGKQRIIAETGAGQHGVATATVCARFGLECVIYMGVHDME
RQALNVFRMRLMGAEVRPVAAGTGTLKDATSEAIRDWVTNVETTHYILGSVAGPHPYPMMVRDFHAVIGQETRAQALEKW
GGLPDILLACVGGGSNAMGLFYEFVNESSIKLIGVEAAGEGVNTEKHAATLTKGRVGVLHGAMSYLLQDEDGQVIEAHSI
SAGLDYPGVGPEHSYLKDVGRAEYYSVTDEEALAAFQRLSRLEGIIPALETAHAIAYLETLCPQLDGSPRIVINCSGRGD
KDVQTVAKFLIPQ
>Mature_412_residues
TTTPLSPSTPSNVQVPDIQGRFGRFGGKYVPETLMPALAELETAYQQYRNDPGFQAELQQLLRDYVGRATPLYFAERLTA
HYARPDGTGAQIYLKREDLNHTGAHKINNALGQVLLAKRMGKQRIIAETGAGQHGVATATVCARFGLECVIYMGVHDMER
QALNVFRMRLMGAEVRPVAAGTGTLKDATSEAIRDWVTNVETTHYILGSVAGPHPYPMMVRDFHAVIGQETRAQALEKWG
GLPDILLACVGGGSNAMGLFYEFVNESSIKLIGVEAAGEGVNTEKHAATLTKGRVGVLHGAMSYLLQDEDGQVIEAHSIS
AGLDYPGVGPEHSYLKDVGRAEYYSVTDEEALAAFQRLSRLEGIIPALETAHAIAYLETLCPQLDGSPRIVINCSGRGDK
DVQTVAKFLIPQ

Specific function: The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine

COG id: COG0133

COG function: function code E; Tryptophan synthase beta chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpB family

Homologues:

Organism=Escherichia coli, GI1787515, Length=389, Percent_Identity=57.3264781491003, Blast_Score=454, Evalue=1e-129,
Organism=Saccharomyces cerevisiae, GI6321412, Length=390, Percent_Identity=59.2307692307692, Blast_Score=471, Evalue=1e-134,

Paralogues:

None

Copy number: 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 5,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): TRPB2_NOSS1 (Q8YQM6)

Other databases:

- EMBL:   BA000019
- PIR:   AC2280
- RefSeq:   NP_487834.1
- ProteinModelPortal:   Q8YQM6
- SMR:   Q8YQM6
- STRING:   Q8YQM6
- GeneID:   1107392
- GenomeReviews:   BA000019_GR
- KEGG:   ana:all3794
- NMPDR:   fig|103690.1.peg.4101
- eggNOG:   COG0133
- HOGENOM:   HBG303148
- OMA:   LKREDLC
- PhylomeDB:   Q8YQM6
- ProtClustDB:   PRK04346
- BioCyc:   NSP103690:ALL3794-MONOMER
- HAMAP:   MF_00133
- InterPro:   IPR001926
- InterPro:   IPR006653
- InterPro:   IPR006654
- InterPro:   IPR023026
- TIGRFAMs:   TIGR00263

Pfam domain/function: PF00291 PALP; SSF53686 PyrdxlP-dep_enz_bsu

EC number: =4.2.1.20

Molecular weight: Translated: 44813; Mature: 44681

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS00168 TRP_SYNTHASE_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTPLSPSTPSNVQVPDIQGRFGRFGGKYVPETLMPALAELETAYQQYRNDPGFQAELQ
CCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHH
QLLRDYVGRATPLYFAERLTAHYARPDGTGAQIYLKREDLNHTGAHKINNALGQVLLAKR
HHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHH
MGKQRIIAETGAGQHGVATATVCARFGLECVIYMGVHDMERQALNVFRMRLMGAEVRPVA
CCCHHEEEECCCCCCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCEEC
AGTGTLKDATSEAIRDWVTNVETTHYILGSVAGPHPYPMMVRDFHAVIGQETRAQALEKW
CCCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHH
GGLPDILLACVGGGSNAMGLFYEFVNESSIKLIGVEAAGEGVNTEKHAATLTKGRVGVLH
CCCHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHCCCHHHHH
GAMSYLLQDEDGQVIEAHSISAGLDYPGVGPEHSYLKDVGRAEYYSVTDEEALAAFQRLS
HHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHCCCCHHCCCCCHHHHHHHHHHH
RLEGIIPALETAHAIAYLETLCPQLDGSPRIVINCSGRGDKDVQTVAKFLIPQ
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
TTTPLSPSTPSNVQVPDIQGRFGRFGGKYVPETLMPALAELETAYQQYRNDPGFQAELQ
CCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHH
QLLRDYVGRATPLYFAERLTAHYARPDGTGAQIYLKREDLNHTGAHKINNALGQVLLAKR
HHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHH
MGKQRIIAETGAGQHGVATATVCARFGLECVIYMGVHDMERQALNVFRMRLMGAEVRPVA
CCCHHEEEECCCCCCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCEEC
AGTGTLKDATSEAIRDWVTNVETTHYILGSVAGPHPYPMMVRDFHAVIGQETRAQALEKW
CCCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHH
GGLPDILLACVGGGSNAMGLFYEFVNESSIKLIGVEAAGEGVNTEKHAATLTKGRVGVLH
CCCHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHCCCHHHHH
GAMSYLLQDEDGQVIEAHSISAGLDYPGVGPEHSYLKDVGRAEYYSVTDEEALAAFQRLS
HHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHCCCCHHCCCCCHHHHHHHHHHH
RLEGIIPALETAHAIAYLETLCPQLDGSPRIVINCSGRGDKDVQTVAKFLIPQ
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11759840