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The map label for this gene is orrA [H]

Identifier: 17231260

GI number: 17231260

Start: 4555491

End: 4556213

Strand: Direct

Name: orrA [H]

Synonym: alr3768

Alternate gene names: 17231260

Gene position: 4555491-4556213 (Clockwise)

Preceding gene: 17231255

Following gene: 17231261

Centisome position: 71.03

GC content: 46.06

Gene sequence:

>723_bases
ATGAGTGAAATCAGCATTATTTTAATTGAAGATCATGACCTAACCAGAATGGGGCTAAGAGCTGCGTTACAGGCCAACAC
TGGCATCAAAGTAATTGGTGAAGCGGCTAACGCCACTCAAGGGCTGAAACTTTTGGAAACGGCGAAGCCGGATGTAGCGG
TGGTAGATATTGGCTTGCCGGACATGGATGGTATTGAACTCACTCGCAAGTTTAGGCGTTATCAAGCTGAGAGTGGGCAA
ACCCACACCAAGATTCTCATCCTGACAATGGATCATACCGAAGATGCGGTACTGGCGGCTTTTGCGGCTGGGGCAGATTC
TTACTACATGAAAGAAACCAGCATTAGTAGGCTAACAGAAGCAATTCAAGCTACTTTTGGTGGTAACTCATGGATTGATC
CAGCGATCGCTAATGTAGTATTACAGAAGATGCGCCAAGGCATCCCCGGAGAGAGCCAATCATCTGATAAGCCCAAAACC
GTCAAAATTGAGGCTCTGCCTTCTGAATACGAACAAGTATTAGAAACCTACCCCCTTACACAACGGGAATTAGAAATTCT
AGAGTTGATTGTTGCTGGCTGTAGCAACGGTCAAATTGCGGAGAAACTTTATATTACTGTTGGTACGGTTAAAACCCACG
TCCGCAACATCCTAAATAAACTCTGCGCTGATGACCGTACCCAAGCGGCTGTACGTGCTTTGCGTTCTGGGTTAGTAGCT
TAA

Upstream 100 bases:

>100_bases
CATCAAGATATCATCTATCTTTGGTTTGGGAAAATAATAGAAGTGACTGAAAAAATAGCTTAGTTTGCAAGAAGCAATTA
GACAAAGAGTGAGTGTAACG

Downstream 100 bases:

>100_bases
ACATGAAACCATAACGCACCTACCAAAATTTAACACCCATACCCTAACCTTGGTTTCTCCGGCAATCAAGGTTTTAGCTT
TTTGCGCTAATTTCCTTAAC

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 240; Mature: 239

Protein sequence:

>240_residues
MSEISIILIEDHDLTRMGLRAALQANTGIKVIGEAANATQGLKLLETAKPDVAVVDIGLPDMDGIELTRKFRRYQAESGQ
THTKILILTMDHTEDAVLAAFAAGADSYYMKETSISRLTEAIQATFGGNSWIDPAIANVVLQKMRQGIPGESQSSDKPKT
VKIEALPSEYEQVLETYPLTQRELEILELIVAGCSNGQIAEKLYITVGTVKTHVRNILNKLCADDRTQAAVRALRSGLVA

Sequences:

>Translated_240_residues
MSEISIILIEDHDLTRMGLRAALQANTGIKVIGEAANATQGLKLLETAKPDVAVVDIGLPDMDGIELTRKFRRYQAESGQ
THTKILILTMDHTEDAVLAAFAAGADSYYMKETSISRLTEAIQATFGGNSWIDPAIANVVLQKMRQGIPGESQSSDKPKT
VKIEALPSEYEQVLETYPLTQRELEILELIVAGCSNGQIAEKLYITVGTVKTHVRNILNKLCADDRTQAAVRALRSGLVA
>Mature_239_residues
SEISIILIEDHDLTRMGLRAALQANTGIKVIGEAANATQGLKLLETAKPDVAVVDIGLPDMDGIELTRKFRRYQAESGQT
HTKILILTMDHTEDAVLAAFAAGADSYYMKETSISRLTEAIQATFGGNSWIDPAIANVVLQKMRQGIPGESQSSDKPKTV
KIEALPSEYEQVLETYPLTQRELEILELIVAGCSNGQIAEKLYITVGTVKTHVRNILNKLCADDRTQAAVRALRSGLVA

Specific function: Member of the two-component regulatory system liaS/liaR probably involved in response to a subset of cell wall-active antibiotics that interfere with the lipid II cycle in the cytoplasmic membrane (bacitracin, nisin, ramoplanin and vancomycin). Seems also

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788521, Length=228, Percent_Identity=29.3859649122807, Blast_Score=95, Evalue=3e-21,
Organism=Escherichia coli, GI1788222, Length=236, Percent_Identity=30.5084745762712, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI1787473, Length=227, Percent_Identity=30.8370044052863, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1786747, Length=221, Percent_Identity=24.4343891402715, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1786911, Length=126, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI1788712, Length=218, Percent_Identity=25.2293577981651, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787375, Length=127, Percent_Identity=32.2834645669291, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 26121; Mature: 25990

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEISIILIEDHDLTRMGLRAALQANTGIKVIGEAANATQGLKLLETAKPDVAVVDIGLP
CCCEEEEEECCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCEEEEEECCC
DMDGIELTRKFRRYQAESGQTHTKILILTMDHTEDAVLAAFAAGADSYYMKETSISRLTE
CCCHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHH
AIQATFGGNSWIDPAIANVVLQKMRQGIPGESQSSDKPKTVKIEALPSEYEQVLETYPLT
HHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHCCCC
QRELEILELIVAGCSNGQIAEKLYITVGTVKTHVRNILNKLCADDRTQAAVRALRSGLVA
HHHHHHHHHHHHCCCCCCEEEEEEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SEISIILIEDHDLTRMGLRAALQANTGIKVIGEAANATQGLKLLETAKPDVAVVDIGLP
CCEEEEEECCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCEEEEEECCC
DMDGIELTRKFRRYQAESGQTHTKILILTMDHTEDAVLAAFAAGADSYYMKETSISRLTE
CCCHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHH
AIQATFGGNSWIDPAIANVVLQKMRQGIPGESQSSDKPKTVKIEALPSEYEQVLETYPLT
HHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHCCCC
QRELEILELIVAGCSNGQIAEKLYITVGTVKTHVRNILNKLCADDRTQAAVRALRSGLVA
HHHHHHHHHHHHCCCCCCEEEEEEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]