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The map label for this gene is resE [H]

Identifier: 17231163

GI number: 17231163

Start: 4426595

End: 4427818

Strand: Direct

Name: resE [H]

Synonym: alr3671

Alternate gene names: 17231163

Gene position: 4426595-4427818 (Clockwise)

Preceding gene: 17231162

Following gene: 17231164

Centisome position: 69.02

GC content: 42.73

Gene sequence:

>1224_bases
GTGCTTGCTAATAACAACATCCCTATTACCCTTCGGCATGACATGAGTTCACAATCTTCTCAATCTGGCAAAATTCTAGT
TGTTGATGATTCTCCAGATAACGTGTTTTTGATTAAAACCATTTTGGAGGAAGAAGGCTATACAGTTAGTACCGCCGAAA
ATGGCATCTCAGCATTAGCAGAATTGCAAGCATCCCCTTGTGATTTGGTGTTATTGGATCTAATGATGCCAGGGATGGAT
GGTTATGAAGTCACTAGGCGAGTGCGGGGGGAAATGAAGTTACCGCAATACATCCCCATTTTATTGATTACCGCCCATGA
TGCCCCGAATGTAGCGCATGGATTAGATTTGGGTGCTGATGATTTTATTCGTAAACCTGTCACGGTGGACGAATTACTGG
CAAGAGTGCGATCGCTTCTCCGTTTGAAGCATAGTATGGATGAACGTGACGAAATAGCTCGCCAACGCGAAGATTTTGTC
TCTCGTCTCACCCACGATTTACGTACTCCCTTGGTAGCGGCTGATCGGATGCTGGCACTATTTCAACAAGGTGCTTTGGG
AAATTTATCACCCCAAATGCAGGAAGTAATCGCTATTATGGCGCGGAGTAATATTAACCTGTTGTCAATGGTGAATACTT
TATTAGAGGTTTATCGCTTTGAAGCTGGTCGCAAAACCTTGGCATTTCAACCAGTCGATCTTAGCCAATTATTAAATGAG
GTGATTGCAGAACTGACACCCTTGGCTCAAGAAAAAAACTTGGCAATTAATAGCTATTTGGGCGACGCATCAACACCAAA
TATACTAGGCGTTGGCGTTCCGCCCACCGTAGGTGATCGCTTAGAATTGCATCGCTTATTTACCAACCTTATCGGTAACG
CCATCAAATTTACCGCCTCTGGCTCAGTGACTATCCGCCTCAAAGCCCTTATATTAAATGCTAAACAAGATTTTTCTGAC
CTTTCCTTACCTTCTAGCAACATCGACTATATACAAGTTGAAATCGCAGATACAGGCGCAGGTATTCCATTAGAAGAACA
CGCCACATTATTTGAAAGATTTCGTCAAGGTAGTCATAAAATCTCTGGTAGTGGTCTAGGCTTGTATCTTTCTCGGCGCA
TTGTTGAGGCTCATCACGGTAAAATAGTAGTTAATTCAGAGTTAGGAAAAGGCAGTGTTTTTGTCGTTAGTTTACCTATT
CAAATAGTAGGGAAAGCAGACTAG

Upstream 100 bases:

>100_bases
ATTTTAACATTCGGATTAATTCCATCAAATTTTCAATTGCCAGATTGTTTATAGGGAGCTATCCTACTCTACGGAAGAGT
CAAGCCTGATATTTAGCTCA

Downstream 100 bases:

>100_bases
ATGAAAATATTTTGAGAGTTTGAGAAAGTAGAAAATTAAGGGCTAGAAAAGATGCTTACTATTGAAACCTCAAAAATCAA
GGAAATAATTCAACAACAAC

Product: two-component hybrid sensor and regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MLANNNIPITLRHDMSSQSSQSGKILVVDDSPDNVFLIKTILEEEGYTVSTAENGISALAELQASPCDLVLLDLMMPGMD
GYEVTRRVRGEMKLPQYIPILLITAHDAPNVAHGLDLGADDFIRKPVTVDELLARVRSLLRLKHSMDERDEIARQREDFV
SRLTHDLRTPLVAADRMLALFQQGALGNLSPQMQEVIAIMARSNINLLSMVNTLLEVYRFEAGRKTLAFQPVDLSQLLNE
VIAELTPLAQEKNLAINSYLGDASTPNILGVGVPPTVGDRLELHRLFTNLIGNAIKFTASGSVTIRLKALILNAKQDFSD
LSLPSSNIDYIQVEIADTGAGIPLEEHATLFERFRQGSHKISGSGLGLYLSRRIVEAHHGKIVVNSELGKGSVFVVSLPI
QIVGKAD

Sequences:

>Translated_407_residues
MLANNNIPITLRHDMSSQSSQSGKILVVDDSPDNVFLIKTILEEEGYTVSTAENGISALAELQASPCDLVLLDLMMPGMD
GYEVTRRVRGEMKLPQYIPILLITAHDAPNVAHGLDLGADDFIRKPVTVDELLARVRSLLRLKHSMDERDEIARQREDFV
SRLTHDLRTPLVAADRMLALFQQGALGNLSPQMQEVIAIMARSNINLLSMVNTLLEVYRFEAGRKTLAFQPVDLSQLLNE
VIAELTPLAQEKNLAINSYLGDASTPNILGVGVPPTVGDRLELHRLFTNLIGNAIKFTASGSVTIRLKALILNAKQDFSD
LSLPSSNIDYIQVEIADTGAGIPLEEHATLFERFRQGSHKISGSGLGLYLSRRIVEAHHGKIVVNSELGKGSVFVVSLPI
QIVGKAD
>Mature_407_residues
MLANNNIPITLRHDMSSQSSQSGKILVVDDSPDNVFLIKTILEEEGYTVSTAENGISALAELQASPCDLVLLDLMMPGMD
GYEVTRRVRGEMKLPQYIPILLITAHDAPNVAHGLDLGADDFIRKPVTVDELLARVRSLLRLKHSMDERDEIARQREDFV
SRLTHDLRTPLVAADRMLALFQQGALGNLSPQMQEVIAIMARSNINLLSMVNTLLEVYRFEAGRKTLAFQPVDLSQLLNE
VIAELTPLAQEKNLAINSYLGDASTPNILGVGVPPTVGDRLELHRLFTNLIGNAIKFTASGSVTIRLKALILNAKQDFSD
LSLPSSNIDYIQVEIADTGAGIPLEEHATLFERFRQGSHKISGSGLGLYLSRRIVEAHHGKIVVNSELGKGSVFVVSLPI
QIVGKAD

Specific function: Member of the two-component regulatory system resD/resE involved in the global regulation of aerobic and anaerobic respiration. Probably phosphorylates resD [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=248, Percent_Identity=31.8548387096774, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI145693157, Length=280, Percent_Identity=28.2142857142857, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI48994928, Length=272, Percent_Identity=28.6764705882353, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1788713, Length=249, Percent_Identity=26.1044176706827, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI87082128, Length=250, Percent_Identity=26.4, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI87082012, Length=139, Percent_Identity=34.5323741007194, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788393, Length=293, Percent_Identity=28.3276450511945, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1786784, Length=142, Percent_Identity=35.9154929577465, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI87081816, Length=272, Percent_Identity=24.6323529411765, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1789809, Length=123, Percent_Identity=38.2113821138211, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1788394, Length=207, Percent_Identity=28.0193236714976, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1786599, Length=119, Percent_Identity=34.453781512605, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1786912, Length=263, Percent_Identity=26.9961977186312, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1789402, Length=119, Percent_Identity=37.8151260504202, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1790552, Length=132, Percent_Identity=37.1212121212121, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1790437, Length=124, Percent_Identity=34.6774193548387, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1787229, Length=132, Percent_Identity=33.3333333333333, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790436, Length=284, Percent_Identity=26.4084507042254, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790860, Length=122, Percent_Identity=31.1475409836066, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786783, Length=271, Percent_Identity=22.8782287822878, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1790299, Length=117, Percent_Identity=32.4786324786325, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1788549, Length=244, Percent_Identity=25.8196721311475, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1788905, Length=169, Percent_Identity=33.1360946745562, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI2367329, Length=127, Percent_Identity=38.5826771653543, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1790861, Length=268, Percent_Identity=26.4925373134328, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI1786911, Length=121, Percent_Identity=35.5371900826446, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI1790863, Length=121, Percent_Identity=33.0578512396694, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 44584; Mature: 44584

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLANNNIPITLRHDMSSQSSQSGKILVVDDSPDNVFLIKTILEEEGYTVSTAENGISALA
CCCCCCCCEEEECCCCCCCCCCCEEEEEECCCCCEEEEEEEHHCCCCEEECHHHHHHHHH
ELQASPCDLVLLDLMMPGMDGYEVTRRVRGEMKLPQYIPILLITAHDAPNVAHGLDLGAD
HHCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHCCCCCCH
DFIRKPVTVDELLARVRSLLRLKHSMDERDEIARQREDFVSRLTHDLRTPLVAADRMLAL
HHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
FQQGALGNLSPQMQEVIAIMARSNINLLSMVNTLLEVYRFEAGRKTLAFQPVDLSQLLNE
HHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHH
VIAELTPLAQEKNLAINSYLGDASTPNILGVGVPPTVGDRLELHRLFTNLIGNAIKFTAS
HHHHHCCCCHHCCCEEEECCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEEC
GSVTIRLKALILNAKQDFSDLSLPSSNIDYIQVEIADTGAGIPLEEHATLFERFRQGSHK
CCEEEEEEEEEEECCCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCE
ISGSGLGLYLSRRIVEAHHGKIVVNSELGKGSVFVVSLPIQIVGKAD
ECCCCCCHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECEEEEECCC
>Mature Secondary Structure
MLANNNIPITLRHDMSSQSSQSGKILVVDDSPDNVFLIKTILEEEGYTVSTAENGISALA
CCCCCCCCEEEECCCCCCCCCCCEEEEEECCCCCEEEEEEEHHCCCCEEECHHHHHHHHH
ELQASPCDLVLLDLMMPGMDGYEVTRRVRGEMKLPQYIPILLITAHDAPNVAHGLDLGAD
HHCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHCCCCCCH
DFIRKPVTVDELLARVRSLLRLKHSMDERDEIARQREDFVSRLTHDLRTPLVAADRMLAL
HHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
FQQGALGNLSPQMQEVIAIMARSNINLLSMVNTLLEVYRFEAGRKTLAFQPVDLSQLLNE
HHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHH
VIAELTPLAQEKNLAINSYLGDASTPNILGVGVPPTVGDRLELHRLFTNLIGNAIKFTAS
HHHHHCCCCHHCCCEEEECCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEEC
GSVTIRLKALILNAKQDFSDLSLPSSNIDYIQVEIADTGAGIPLEEHATLFERFRQGSHK
CCEEEEEEEEEEECCCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCE
ISGSGLGLYLSRRIVEAHHGKIVVNSELGKGSVFVVSLPIQIVGKAD
ECCCCCCHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7934829; 9384377; 8631715 [H]