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The map label for this gene is groEL [H]

Identifier: 17231154

GI number: 17231154

Start: 4419169

End: 4420803

Strand: Direct

Name: groEL [H]

Synonym: alr3662

Alternate gene names: 17231154

Gene position: 4419169-4420803 (Clockwise)

Preceding gene: 17231153

Following gene: 17231155

Centisome position: 68.9

GC content: 47.89

Gene sequence:

>1635_bases
ATGGCAAAGCGCATTATCTACAACGAAAACGCTCGTCGCGCTCTAGAACGAGGCATCGATATCCTGGCTGAGGCTGTAGC
TGTTACCCTTGGCCCCAAAGGTCGTAACGTAGTATTAGAGAAAAAATTTGGTGCGCCGCAAATCGTTAATGACGGTGTAA
CCATCGCTAAAGAAATAGAATTAGAAGATCATATTGAAAACACTGGTGTTGCTCTGATTCGCCAAGCTGCTTCCAAAACA
AACGATGCAGCAGGTGACGGTACAACCACTGCAACCGTTTTGGCTCACGCCATTGTCAAAGAAGGTTTGCGGAACGTAGC
GGCTGGCGCTAACGCAATTCTGTTGAAGCGCGGTATTGATAAAGCTACCGGTTTCTTGGTTGACAGAATCAAAGAACACG
CTCGTCCTGTAGAAGATTCTAAATCTATTGCTCAAGTTGGCTCAATCTCTGCTGGTAACGACGATGAAGTCGGTCAGATG
ATTGCCGAAGCAATGGACAAAGTAGGTAAAGAAGGCGTTATCTCTCTAGAAGAAGGTAAGTCTGTAACTACCGAATTGGA
AATCACCGAAGGGATGCGCTTTGACAAAGGCTATATCTCCCCCTACTTCGCTACCGACCCAGAGCGGATGGAAGCGATTT
TCGATGAGCCTTTCTTGTTGTTGACCGATAAGAAAATTGCTCTCGTCCAAGATTTAGTACCAGTTCTAGAGCAAGTAGCT
CGTGCTGGTCGTCCTCTGGTGATTATCGCTGAAGATATTGAAAAAGAAGCTCTAGCAACCCTAGTAGTTAACCGTTTACG
CGGTGTACTCAACGTTGCTGCTGTGAAGGCTCCTGGCTTTGGCGATCGCCGTAAGGCTATGCTAGAAGATATCGCTATCC
TCACCGGCGGTCAACTAATCACCGAAGATGCTGGTCTGAAGCTGGAAAACACTAAGCTGGAAAGCTTGGGTAAAGCGCGC
CGCATCACCATCACCAAAGACAGCACCACAATTGTTGCTGAAGGTAACGACGTTGCCGTCAAAGGTCGTGTAGAACAAAT
CCGTCGTCAAATGGAAGAAACTGAATCTTCCTACGACAAAGAAAAACTACAAGAACGTTTGGCTAAACTTTCTGGTGGTG
TAGCTGTAGTTAAAGTTGGTGCAGCTACCGAAACCGAAATGAAAGACAAGAAACTCCGCCTAGAAGACGCTATCAACGCT
ACCAAGGCGGCTGTGGAAGAAGGTATCGTTCCTGGTGGCGGTACAACCCTAGCTCACCTCACTCCTGAATTGGAAGTTTG
GGCTAACAGCAACCTCAAAGATGAAGAGTTGACTGGTGCTTTGATTGTCGCTCGTGCATTACCCGCACCTCTGAAGAGAA
TTGCGGAAAACGCTGGTCAAAACGGCGCTGTAATTGCTGAACGCGTCAAAGAAAAAGCGTTCAACGTTGGTTTCAACGCT
GCTACCAACGAATTTGTAGATATGTTCGAGGCTGGTATCGTTGACCCCGCGAAGGTTACACGTTCTGCACTGCAAAACGC
TGCTTCCATCGCTGGAATGGTGTTGACAACCGAGTGCATCGTTGTTGACAAGCCAGAACCCAAAGATAACGCTCCTGCTG
GCGCTGGCGCTGGCGGCGGTGACTTCGATTACTAA

Upstream 100 bases:

>100_bases
GCTAATGGGTAATAAGTAATAGGTAATCGCAATACCTATTTACTGATGATCAAATTTCACGACACAAAACTTGATTTAAC
TTCCTGAGATTTAGACACCT

Downstream 100 bases:

>100_bases
TATTCTGTAGTCACATAAGTTTAAAAAATAGCTGCTTCCACAAAGGAAGTAGCTATTTTTTTCAATCAAATATAAAGGTA
CAAGGGACAATGTAGGAATA

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 1; Protein Cpn60 1 [H]

Number of amino acids: Translated: 544; Mature: 543

Protein sequence:

>544_residues
MAKRIIYNENARRALERGIDILAEAVAVTLGPKGRNVVLEKKFGAPQIVNDGVTIAKEIELEDHIENTGVALIRQAASKT
NDAAGDGTTTATVLAHAIVKEGLRNVAAGANAILLKRGIDKATGFLVDRIKEHARPVEDSKSIAQVGSISAGNDDEVGQM
IAEAMDKVGKEGVISLEEGKSVTTELEITEGMRFDKGYISPYFATDPERMEAIFDEPFLLLTDKKIALVQDLVPVLEQVA
RAGRPLVIIAEDIEKEALATLVVNRLRGVLNVAAVKAPGFGDRRKAMLEDIAILTGGQLITEDAGLKLENTKLESLGKAR
RITITKDSTTIVAEGNDVAVKGRVEQIRRQMEETESSYDKEKLQERLAKLSGGVAVVKVGAATETEMKDKKLRLEDAINA
TKAAVEEGIVPGGGTTLAHLTPELEVWANSNLKDEELTGALIVARALPAPLKRIAENAGQNGAVIAERVKEKAFNVGFNA
ATNEFVDMFEAGIVDPAKVTRSALQNAASIAGMVLTTECIVVDKPEPKDNAPAGAGAGGGDFDY

Sequences:

>Translated_544_residues
MAKRIIYNENARRALERGIDILAEAVAVTLGPKGRNVVLEKKFGAPQIVNDGVTIAKEIELEDHIENTGVALIRQAASKT
NDAAGDGTTTATVLAHAIVKEGLRNVAAGANAILLKRGIDKATGFLVDRIKEHARPVEDSKSIAQVGSISAGNDDEVGQM
IAEAMDKVGKEGVISLEEGKSVTTELEITEGMRFDKGYISPYFATDPERMEAIFDEPFLLLTDKKIALVQDLVPVLEQVA
RAGRPLVIIAEDIEKEALATLVVNRLRGVLNVAAVKAPGFGDRRKAMLEDIAILTGGQLITEDAGLKLENTKLESLGKAR
RITITKDSTTIVAEGNDVAVKGRVEQIRRQMEETESSYDKEKLQERLAKLSGGVAVVKVGAATETEMKDKKLRLEDAINA
TKAAVEEGIVPGGGTTLAHLTPELEVWANSNLKDEELTGALIVARALPAPLKRIAENAGQNGAVIAERVKEKAFNVGFNA
ATNEFVDMFEAGIVDPAKVTRSALQNAASIAGMVLTTECIVVDKPEPKDNAPAGAGAGGGDFDY
>Mature_543_residues
AKRIIYNENARRALERGIDILAEAVAVTLGPKGRNVVLEKKFGAPQIVNDGVTIAKEIELEDHIENTGVALIRQAASKTN
DAAGDGTTTATVLAHAIVKEGLRNVAAGANAILLKRGIDKATGFLVDRIKEHARPVEDSKSIAQVGSISAGNDDEVGQMI
AEAMDKVGKEGVISLEEGKSVTTELEITEGMRFDKGYISPYFATDPERMEAIFDEPFLLLTDKKIALVQDLVPVLEQVAR
AGRPLVIIAEDIEKEALATLVVNRLRGVLNVAAVKAPGFGDRRKAMLEDIAILTGGQLITEDAGLKLENTKLESLGKARR
ITITKDSTTIVAEGNDVAVKGRVEQIRRQMEETESSYDKEKLQERLAKLSGGVAVVKVGAATETEMKDKKLRLEDAINAT
KAAVEEGIVPGGGTTLAHLTPELEVWANSNLKDEELTGALIVARALPAPLKRIAENAGQNGAVIAERVKEKAFNVGFNAA
TNEFVDMFEAGIVDPAKVTRSALQNAASIAGMVLTTECIVVDKPEPKDNAPAGAGAGGGDFDY

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=531, Percent_Identity=46.1393596986817, Blast_Score=471, Evalue=1e-133,
Organism=Homo sapiens, GI31542947, Length=531, Percent_Identity=46.1393596986817, Blast_Score=471, Evalue=1e-133,
Organism=Escherichia coli, GI1790586, Length=526, Percent_Identity=57.9847908745247, Blast_Score=607, Evalue=1e-175,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=46.5028355387524, Blast_Score=471, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI193210679, Length=210, Percent_Identity=44.2857142857143, Blast_Score=174, Evalue=7e-44,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=49.8098859315589, Blast_Score=499, Evalue=1e-142,
Organism=Saccharomyces cerevisiae, GI6322350, Length=576, Percent_Identity=24.6527777777778, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322524, Length=556, Percent_Identity=22.841726618705, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=48.7666034155598, Blast_Score=489, Evalue=1e-138,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=48.7666034155598, Blast_Score=489, Evalue=1e-138,
Organism=Drosophila melanogaster, GI45550936, Length=526, Percent_Identity=45.4372623574144, Blast_Score=457, Evalue=1e-129,
Organism=Drosophila melanogaster, GI45550132, Length=526, Percent_Identity=45.4372623574144, Blast_Score=457, Evalue=1e-129,
Organism=Drosophila melanogaster, GI45550935, Length=526, Percent_Identity=45.4372623574144, Blast_Score=457, Evalue=1e-129,
Organism=Drosophila melanogaster, GI17864606, Length=545, Percent_Identity=41.1009174311927, Blast_Score=407, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24584129, Length=532, Percent_Identity=36.4661654135338, Blast_Score=307, Evalue=1e-83,
Organism=Drosophila melanogaster, GI19921262, Length=532, Percent_Identity=36.4661654135338, Blast_Score=307, Evalue=1e-83,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57952; Mature: 57821

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKRIIYNENARRALERGIDILAEAVAVTLGPKGRNVVLEKKFGAPQIVNDGVTIAKEIE
CCCCEEECCHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEECCCCCCEECCCCEEEEECC
LEDHIENTGVALIRQAASKTNDAAGDGTTTATVLAHAIVKEGLRNVAAGANAILLKRGID
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
KATGFLVDRIKEHARPVEDSKSIAQVGSISAGNDDEVGQMIAEAMDKVGKEGVISLEEGK
HHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCC
SVTTELEITEGMRFDKGYISPYFATDPERMEAIFDEPFLLLTDKKIALVQDLVPVLEQVA
CEEEEEEECCCCEECCCCCCCCCCCCHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHH
RAGRPLVIIAEDIEKEALATLVVNRLRGVLNVAAVKAPGFGDRRKAMLEDIAILTGGQLI
HCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEE
TEDAGLKLENTKLESLGKARRITITKDSTTIVAEGNDVAVKGRVEQIRRQMEETESSYDK
ECCCCCEEECCHHHHCCCCEEEEEECCCEEEEECCCCEEECCHHHHHHHHHHHHHHHCCH
EKLQERLAKLSGGVAVVKVGAATETEMKDKKLRLEDAINATKAAVEEGIVPGGGTTLAHL
HHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEE
TPELEVWANSNLKDEELTGALIVARALPAPLKRIAENAGQNGAVIAERVKEKAFNVGFNA
CCCEEEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCC
ATNEFVDMFEAGIVDPAKVTRSALQNAASIAGMVLTTECIVVDKPEPKDNAPAGAGAGGG
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEEEEEEEEEECCCCCCCCCCCCCCCCC
DFDY
CCCC
>Mature Secondary Structure 
AKRIIYNENARRALERGIDILAEAVAVTLGPKGRNVVLEKKFGAPQIVNDGVTIAKEIE
CCCEEECCHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEECCCCCCEECCCCEEEEECC
LEDHIENTGVALIRQAASKTNDAAGDGTTTATVLAHAIVKEGLRNVAAGANAILLKRGID
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
KATGFLVDRIKEHARPVEDSKSIAQVGSISAGNDDEVGQMIAEAMDKVGKEGVISLEEGK
HHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCC
SVTTELEITEGMRFDKGYISPYFATDPERMEAIFDEPFLLLTDKKIALVQDLVPVLEQVA
CEEEEEEECCCCEECCCCCCCCCCCCHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHH
RAGRPLVIIAEDIEKEALATLVVNRLRGVLNVAAVKAPGFGDRRKAMLEDIAILTGGQLI
HCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEE
TEDAGLKLENTKLESLGKARRITITKDSTTIVAEGNDVAVKGRVEQIRRQMEETESSYDK
ECCCCCEEECCHHHHCCCCEEEEEECCCEEEEECCCCEEECCHHHHHHHHHHHHHHHCCH
EKLQERLAKLSGGVAVVKVGAATETEMKDKKLRLEDAINATKAAVEEGIVPGGGTTLAHL
HHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEE
TPELEVWANSNLKDEELTGALIVARALPAPLKRIAENAGQNGAVIAERVKEKAFNVGFNA
CCCEEEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCC
ATNEFVDMFEAGIVDPAKVTRSALQNAASIAGMVLTTECIVVDKPEPKDNAPAGAGAGGG
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEEEEEEEEEECCCCCCCCCCCCCCCCC
DFDY
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA