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The map label for this gene is phoP [H]

Identifier: 17231152

GI number: 17231152

Start: 4417145

End: 4417822

Strand: Reverse

Name: phoP [H]

Synonym: all3660

Alternate gene names: 17231152

Gene position: 4417822-4417145 (Counterclockwise)

Preceding gene: 17231156

Following gene: 17231148

Centisome position: 68.88

GC content: 45.28

Gene sequence:

>678_bases
ATGGATCGAAGCGCGACAAGTGCCACTGCTATGAAAGAGCCCAGCATGAAAGATCACAAACGACTTCTATTGATTGATGA
TGACCCTAACCTCATCTTGCTGGTGAAGGACTACTTGGAATTCAGAGGATATGAAGTCATCACGGCGGAAAACGGACGAG
AAGCTCTGGAAATTCTCGAACATGATGTTCCAGATATGATCATCTGTGACGTGATGATGCCAGAAATGGACGGATATACC
TTTGTCGAACAAGTCCGGCAAAACGAACGCACCAGTTGGATTCCTGTTTTGTTCCTGTCAGCAAAAGGACAAAGTGCAGA
CCGAGTTAAAGGTCTAAACAAAGGTGCAGATGTTTATATGGTCAAGCCTTTTGAACCAGAAGAACTCGTAGCACAAGTAG
AATCTTCACTGAAACAAACTATCCGTTGGAAGGAACACCAAGCCAAAGGTGGGGAAAACGGTTCTCGCATCCAAGTTCCC
TTCGATGTGCAGTTAACCCCAACCGAACTGAAGGTAGTGCAGTTTGTAGCTAGGGGTCTAGCTAACCGGGAAATTGCTGA
AGAATTAAATGTTAGTCAGCGCACAGTTGAAAGCCATGTGTCCAATATGTTGGGCAAAACCAATCTTCACAACCGCACCG
AACTAGCACGGTGGGCGATTGAAAATCAAATGGCTTAA

Upstream 100 bases:

>100_bases
AAAACCACTTTTAAGACTCCAAGGAAGAAAGGGCAACTTAAGTGGGAAAAATGACAACATCTCAACAATCCACCATAAAG
GATAACCATTCAAGACCTTG

Downstream 100 bases:

>100_bases
ATAGCTATCAGCACTCAGCCGTCAGCTTTAAAAAATTAACTGACAGCTGACAGCTGATAGCTTAAATTATTTGGTTGGTA
ATGGGTAATAGCTCACAGGT

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MDRSATSATAMKEPSMKDHKRLLLIDDDPNLILLVKDYLEFRGYEVITAENGREALEILEHDVPDMIICDVMMPEMDGYT
FVEQVRQNERTSWIPVLFLSAKGQSADRVKGLNKGADVYMVKPFEPEELVAQVESSLKQTIRWKEHQAKGGENGSRIQVP
FDVQLTPTELKVVQFVARGLANREIAEELNVSQRTVESHVSNMLGKTNLHNRTELARWAIENQMA

Sequences:

>Translated_225_residues
MDRSATSATAMKEPSMKDHKRLLLIDDDPNLILLVKDYLEFRGYEVITAENGREALEILEHDVPDMIICDVMMPEMDGYT
FVEQVRQNERTSWIPVLFLSAKGQSADRVKGLNKGADVYMVKPFEPEELVAQVESSLKQTIRWKEHQAKGGENGSRIQVP
FDVQLTPTELKVVQFVARGLANREIAEELNVSQRTVESHVSNMLGKTNLHNRTELARWAIENQMA
>Mature_225_residues
MDRSATSATAMKEPSMKDHKRLLLIDDDPNLILLVKDYLEFRGYEVITAENGREALEILEHDVPDMIICDVMMPEMDGYT
FVEQVRQNERTSWIPVLFLSAKGQSADRVKGLNKGADVYMVKPFEPEELVAQVESSLKQTIRWKEHQAKGGENGSRIQVP
FDVQLTPTELKVVQFVARGLANREIAEELNVSQRTVESHVSNMLGKTNLHNRTELARWAIENQMA

Specific function: Member of the two-component regulatory system phoP/phoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788394, Length=207, Percent_Identity=30.4347826086957, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI2367329, Length=208, Percent_Identity=35.0961538461538, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI1786599, Length=208, Percent_Identity=27.8846153846154, Blast_Score=94, Evalue=8e-21,
Organism=Escherichia coli, GI1786747, Length=181, Percent_Identity=28.7292817679558, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1789809, Length=124, Percent_Identity=31.4516129032258, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87082012, Length=119, Percent_Identity=36.9747899159664, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1788521, Length=203, Percent_Identity=30.5418719211823, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI1787473, Length=215, Percent_Identity=32.5581395348837, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1788550, Length=132, Percent_Identity=33.3333333333333, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1788905, Length=129, Percent_Identity=34.1085271317829, Blast_Score=77, Evalue=7e-16,
Organism=Escherichia coli, GI1790437, Length=123, Percent_Identity=34.1463414634146, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1789402, Length=198, Percent_Identity=30.8080808080808, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1790299, Length=116, Percent_Identity=33.6206896551724, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI1790552, Length=198, Percent_Identity=30.3030303030303, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787375, Length=153, Percent_Identity=30.0653594771242, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1790102, Length=199, Percent_Identity=31.1557788944724, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI1790860, Length=116, Percent_Identity=33.6206896551724, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1786784, Length=119, Percent_Identity=34.453781512605, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1786911, Length=118, Percent_Identity=33.0508474576271, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787487, Length=106, Percent_Identity=33.0188679245283, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI145693157, Length=112, Percent_Identity=33.9285714285714, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1788222, Length=211, Percent_Identity=26.5402843601896, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1790863, Length=121, Percent_Identity=29.7520661157025, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1787229, Length=136, Percent_Identity=25.7352941176471, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788713, Length=117, Percent_Identity=34.1880341880342, Blast_Score=61, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25597; Mature: 25597

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRSATSATAMKEPSMKDHKRLLLIDDDPNLILLVKDYLEFRGYEVITAENGREALEILE
CCCCCCCHHHHCCCCCCCCCEEEEEECCCCEEEEEEHHHHHCCEEEEECCCCHHHHHHHH
HDVPDMIICDVMMPEMDGYTFVEQVRQNERTSWIPVLFLSAKGQSADRVKGLNKGADVYM
CCCCCEEEHHHHCCCCCCHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHCCCCCCCEEE
VKPFEPEELVAQVESSLKQTIRWKEHQAKGGENGSRIQVPFDVQLTPTELKVVQFVARGL
ECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEECHHHHHHHHHHHHHH
ANREIAEELNVSQRTVESHVSNMLGKTNLHNRTELARWAIENQMA
CCHHHHHHHCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MDRSATSATAMKEPSMKDHKRLLLIDDDPNLILLVKDYLEFRGYEVITAENGREALEILE
CCCCCCCHHHHCCCCCCCCCEEEEEECCCCEEEEEEHHHHHCCEEEEECCCCHHHHHHHH
HDVPDMIICDVMMPEMDGYTFVEQVRQNERTSWIPVLFLSAKGQSADRVKGLNKGADVYM
CCCCCEEEHHHHCCCCCCHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHCCCCCCCEEE
VKPFEPEELVAQVESSLKQTIRWKEHQAKGGENGSRIQVPFDVQLTPTELKVVQFVARGL
ECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEECHHHHHHHHHHHHHH
ANREIAEELNVSQRTVESHVSNMLGKTNLHNRTELARWAIENQMA
CCHHHHHHHCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1454550; 3036763; 9387221; 9384377; 8045898; 3142862 [H]