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The map label for this gene is ygcA [C]

Identifier: 17231146

GI number: 17231146

Start: 4409748

End: 4411130

Strand: Direct

Name: ygcA [C]

Synonym: alr3654

Alternate gene names: 17231146

Gene position: 4409748-4411130 (Clockwise)

Preceding gene: 17231141

Following gene: 17231147

Centisome position: 68.75

GC content: 44.54

Gene sequence:

>1383_bases
ATGACTAAATCTACTTGGCATCAGGGTGAATTAATTGAAGTAGCGATCGCCGACTTGAGTGATACTGGTGATGGTGTGGG
ACGATTTGCCGAACGGGTAGTGTTTGTCCCAGATACTGTACCAGGCGATCGTGTTTTGGTACGCTTATTACACGTCAAGC
CCAATTATGCCCACGGCAAACTTCACCAGCTACTAGAACCATCTCCTCATCGCATTCGTCCCGGTTGTATTGTGGCTGAC
AAGTGCGGCGGTTGTCAGTGGCAACATATAGATTATGAATATCAGTTAATTGCTAAACGCCACCAAGTTATCCAAGCCTT
ACAACGGATTGGTGGTTTTGCTCAACCACCAGTAGATCCCGTATTGGTGACAGCCTCATCTTTAGGCTATCGCAATAAAG
CTACCTATCCCCTCGATGTTTCTGCTACAGGTCAAGTACAAGCTGGTTACTATCAAAAAGGTAGCCATCATGTAGTTAAC
TTAAATCAATGCCCAGTCCAAGATCCCCGCTTAAATCCTTTACTGGCACAAGTTAAGCAAGATATCCAACAGCGCGACTG
GCCTATCTACGATGAAAAACGCCACCAAGGGCAAATTCGCCATCTTGGTTTACGTATCGGTAGGCGCACAGGTGAAATTT
TATTAACTTTAGTTGTCAAAGATGGCAACTTACCAGGAATTGAACAGCAAGCCCAGGAATGGTTGCAGCGCTATCCCCAG
TTGGTGGGTGTGTCCTTAAATCGTAATCCCGAACGCACCAATGCGATTTTTGGTCGAGAAACCAGATGTATTGCTGGGGT
TCCCTATTTGCGAGAAATATTTGCTGGACTAGAGTTTCAAGTCCGCCCCGATACATTTTTTCAGGTTTTTACAGAAACAG
CCGAAGCATTATTACAAGTAATTGAGTCACAACTAAATCTGCAAGGGCATGAGACGTTAATTGATGCTTACTGTGGCATT
GGCACCTTAACCTTGCCTTTAAGTAAACAAGTACGCCAAGCTATAGGATTGGAATTGCAACCAGAAGCTGTACAACAGGC
AATTGTCAATGCCCAACACAATGGTATTAATAATGTGGAATTTCAAGTGGGGGCCGTTGAGAAATTGCTGCCCAAGATGG
GAATAATACCAGATGTGGTATTACTAGACCCACCGCGTAAAGGGTGCGATCGCATTGTCATCGAATCTCTATTAGCATCG
AAACCTGCCCGCATTGTTTACGTCAGCTGTAAAGTAGCCACTCTTGCTCGTGACCTCAAGTTACTGTGTACAGATGGAAC
ATATACTATCCAACGTATCCAAAGCGCCGATTTTTTCCCTCAAACATCTCATGTGGAAGTTGCCGCTTTTCTTGTGCTAT
CACAGTCTGGTAAGGATAATTAA

Upstream 100 bases:

>100_bases
ACGGGTACTCTCCGAGAACCCCTCCGGGGAACAGCAGTTGCTACAAGTCGGGGAACCCGCCCAACGCACTGCTTCACAAC
GAACAATTGACAACTGACAA

Downstream 100 bases:

>100_bases
TCCTTGAGAAAAACTCAAATCTCAAATTTGTAGTCTATTGCATAGTAAAAATGCTAAGATCGAATTAACTTAAACATAGC
AATGATTTTGTTAAAAAAAT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 460; Mature: 459

Protein sequence:

>460_residues
MTKSTWHQGELIEVAIADLSDTGDGVGRFAERVVFVPDTVPGDRVLVRLLHVKPNYAHGKLHQLLEPSPHRIRPGCIVAD
KCGGCQWQHIDYEYQLIAKRHQVIQALQRIGGFAQPPVDPVLVTASSLGYRNKATYPLDVSATGQVQAGYYQKGSHHVVN
LNQCPVQDPRLNPLLAQVKQDIQQRDWPIYDEKRHQGQIRHLGLRIGRRTGEILLTLVVKDGNLPGIEQQAQEWLQRYPQ
LVGVSLNRNPERTNAIFGRETRCIAGVPYLREIFAGLEFQVRPDTFFQVFTETAEALLQVIESQLNLQGHETLIDAYCGI
GTLTLPLSKQVRQAIGLELQPEAVQQAIVNAQHNGINNVEFQVGAVEKLLPKMGIIPDVVLLDPPRKGCDRIVIESLLAS
KPARIVYVSCKVATLARDLKLLCTDGTYTIQRIQSADFFPQTSHVEVAAFLVLSQSGKDN

Sequences:

>Translated_460_residues
MTKSTWHQGELIEVAIADLSDTGDGVGRFAERVVFVPDTVPGDRVLVRLLHVKPNYAHGKLHQLLEPSPHRIRPGCIVAD
KCGGCQWQHIDYEYQLIAKRHQVIQALQRIGGFAQPPVDPVLVTASSLGYRNKATYPLDVSATGQVQAGYYQKGSHHVVN
LNQCPVQDPRLNPLLAQVKQDIQQRDWPIYDEKRHQGQIRHLGLRIGRRTGEILLTLVVKDGNLPGIEQQAQEWLQRYPQ
LVGVSLNRNPERTNAIFGRETRCIAGVPYLREIFAGLEFQVRPDTFFQVFTETAEALLQVIESQLNLQGHETLIDAYCGI
GTLTLPLSKQVRQAIGLELQPEAVQQAIVNAQHNGINNVEFQVGAVEKLLPKMGIIPDVVLLDPPRKGCDRIVIESLLAS
KPARIVYVSCKVATLARDLKLLCTDGTYTIQRIQSADFFPQTSHVEVAAFLVLSQSGKDN
>Mature_459_residues
TKSTWHQGELIEVAIADLSDTGDGVGRFAERVVFVPDTVPGDRVLVRLLHVKPNYAHGKLHQLLEPSPHRIRPGCIVADK
CGGCQWQHIDYEYQLIAKRHQVIQALQRIGGFAQPPVDPVLVTASSLGYRNKATYPLDVSATGQVQAGYYQKGSHHVVNL
NQCPVQDPRLNPLLAQVKQDIQQRDWPIYDEKRHQGQIRHLGLRIGRRTGEILLTLVVKDGNLPGIEQQAQEWLQRYPQL
VGVSLNRNPERTNAIFGRETRCIAGVPYLREIFAGLEFQVRPDTFFQVFTETAEALLQVIESQLNLQGHETLIDAYCGIG
TLTLPLSKQVRQAIGLELQPEAVQQAIVNAQHNGINNVEFQVGAVEKLLPKMGIIPDVVLLDPPRKGCDRIVIESLLASK
PARIVYVSCKVATLARDLKLLCTDGTYTIQRIQSADFFPQTSHVEVAAFLVLSQSGKDN

Specific function: Could Be A 23s rRNA (Uracil-5-)-Methyltransferase. [C]

COG id: COG2265

COG function: function code J; SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRAM domain

Homologues:

Organism=Homo sapiens, GI34222389, Length=358, Percent_Identity=28.7709497206704, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI51173878, Length=358, Percent_Identity=28.7709497206704, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI269784678, Length=202, Percent_Identity=30.1980198019802, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI269784680, Length=202, Percent_Identity=30.1980198019802, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI269784676, Length=202, Percent_Identity=30.1980198019802, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI20149688, Length=202, Percent_Identity=30.1980198019802, Blast_Score=95, Evalue=2e-19,
Organism=Escherichia coli, GI1789148, Length=442, Percent_Identity=30.7692307692308, Blast_Score=174, Evalue=8e-45,
Organism=Escherichia coli, GI1787083, Length=377, Percent_Identity=26.2599469496021, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1790403, Length=181, Percent_Identity=28.1767955801105, Blast_Score=69, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6322909, Length=441, Percent_Identity=24.7165532879819, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24666579, Length=413, Percent_Identity=25.90799031477, Blast_Score=129, Evalue=5e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y3654_NOSS1 (Q8YR05)

Other databases:

- EMBL:   BA000019
- PIR:   AG2262
- RefSeq:   NP_487694.1
- ProteinModelPortal:   Q8YR05
- STRING:   Q8YR05
- GeneID:   1107252
- GenomeReviews:   BA000019_GR
- KEGG:   ana:alr3654
- NMPDR:   fig|103690.1.peg.3961
- eggNOG:   COG2265
- HOGENOM:   HBG690163
- OMA:   RKGCDEA
- PhylomeDB:   Q8YR05
- ProtClustDB:   CLSK892819
- BioCyc:   NSP103690:ALR3654-MONOMER
- InterPro:   IPR016027
- InterPro:   IPR001566
- InterPro:   IPR002792
- InterPro:   IPR010280
- TIGRFAMs:   TIGR00479

Pfam domain/function: PF01938 TRAM; PF05958 tRNA_U5-meth_tr; SSF50249 Nucleic_acid_OB

EC number: NA

Molecular weight: Translated: 51241; Mature: 51109

Theoretical pI: Translated: 7.79; Mature: 7.79

Prosite motif: PS50926 TRAM; PS01230 TRMA_1; PS01231 TRMA_2

Important sites: ACT_SITE 410-410 BINDING 288-288 BINDING 317-317 BINDING 317-317 BINDING 338-338 BINDING 383-383

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKSTWHQGELIEVAIADLSDTGDGVGRFAERVVFVPDTVPGDRVLVRLLHVKPNYAHGK
CCCCCCCCCCEEEEEEECCCCCCCHHHHHHCEEEECCCCCCCHHHHHHHHHCCCCCCCHH
LHQLLEPSPHRIRPGCIVADKCGGCQWQHIDYEYQLIAKRHQVIQALQRIGGFAQPPVDP
HHHHCCCCCCCCCCCEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
VLVTASSLGYRNKATYPLDVSATGQVQAGYYQKGSHHVVNLNQCPVQDPRLNPLLAQVKQ
EEEEEHHCCCCCCCCCEEECCCCCCEECCCEECCCCEEEECCCCCCCCCCCCHHHHHHHH
DIQQRDWPIYDEKRHQGQIRHLGLRIGRRTGEILLTLVVKDGNLPGIEQQAQEWLQRYPQ
HHHHCCCCCCCCHHHCCHHHHHHHHHCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHCHH
LVGVSLNRNPERTNAIFGRETRCIAGVPYLREIFAGLEFQVRPDTFFQVFTETAEALLQV
HEEEECCCCCCHHHHHCCCCCCEEECCHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHH
IESQLNLQGHETLIDAYCGIGTLTLPLSKQVRQAIGLELQPEAVQQAIVNAQHNGINNVE
HHHHHCCCCHHHHHHHHCCCCEEECCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEE
FQVGAVEKLLPKMGIIPDVVLLDPPRKGCDRIVIESLLASKPARIVYVSCKVATLARDLK
EEECHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHCCE
LLCTDGTYTIQRIQSADFFPQTSHVEVAAFLVLSQSGKDN
EEECCCCCEEHHHHCCCCCCCCCCHHEEEEEEEECCCCCC
>Mature Secondary Structure 
TKSTWHQGELIEVAIADLSDTGDGVGRFAERVVFVPDTVPGDRVLVRLLHVKPNYAHGK
CCCCCCCCCEEEEEEECCCCCCCHHHHHHCEEEECCCCCCCHHHHHHHHHCCCCCCCHH
LHQLLEPSPHRIRPGCIVADKCGGCQWQHIDYEYQLIAKRHQVIQALQRIGGFAQPPVDP
HHHHCCCCCCCCCCCEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
VLVTASSLGYRNKATYPLDVSATGQVQAGYYQKGSHHVVNLNQCPVQDPRLNPLLAQVKQ
EEEEEHHCCCCCCCCCEEECCCCCCEECCCEECCCCEEEECCCCCCCCCCCCHHHHHHHH
DIQQRDWPIYDEKRHQGQIRHLGLRIGRRTGEILLTLVVKDGNLPGIEQQAQEWLQRYPQ
HHHHCCCCCCCCHHHCCHHHHHHHHHCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHCHH
LVGVSLNRNPERTNAIFGRETRCIAGVPYLREIFAGLEFQVRPDTFFQVFTETAEALLQV
HEEEECCCCCCHHHHHCCCCCCEEECCHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHH
IESQLNLQGHETLIDAYCGIGTLTLPLSKQVRQAIGLELQPEAVQQAIVNAQHNGINNVE
HHHHHCCCCHHHHHHHHCCCCEEECCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEE
FQVGAVEKLLPKMGIIPDVVLLDPPRKGCDRIVIESLLASKPARIVYVSCKVATLARDLK
EEECHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHCCE
LLCTDGTYTIQRIQSADFFPQTSHVEVAAFLVLSQSGKDN
EEECCCCCEEHHHHCCCCCCCCCCHHEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11759840