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The map label for this gene is cofG [H]

Identifier: 17231065

GI number: 17231065

Start: 4316746

End: 4317765

Strand: Direct

Name: cofG [H]

Synonym: alr3573

Alternate gene names: 17231065

Gene position: 4316746-4317765 (Clockwise)

Preceding gene: 17231063

Following gene: 17231068

Centisome position: 67.3

GC content: 44.02

Gene sequence:

>1020_bases
ATGACAGTTGCCAAATCTACTTGTGCCTCAGTATCCACAAAGCCTGCCGTAGGAAAGCCGACCAACGGTATCGCCACTTA
TAGTCCTGCATATACGATTGTTCCTACCTATGAGTGTTTCAATCGTTGTACCTACTGCAATTTTCGCACCGACCCAGGCG
AAAGTTCGTGGATGACCCTATCAGCAGCAGAAGATATTTTCCAACGGCTGCAAAATGAGCAAGTCTGTGAAATTCTGATC
CTTAGTGGAGAGGTACACCCCCATTCACCAAAGCGTCAGGCATGGTTCCAGAGAATCTATGATTTATGTAAACTAGCCTT
AACATCGGGTTTTCTCCCACATACCAATGCCGGGCCTTTGAGTTTCGCAGAGATGCAGGAATTGAAAAGCGTCAATGTTT
CAATGGGTTTGATGTTGGAACAGTTAACACCAAAATTATTAGAAACAGTCCATCGTCACGCACCAAGTAAGTTACCAGAA
CTCAGGTTGCAACAATTAGAGTGGGCGGGAGATTTGCAAATTCCCTTTACAACAGGTTTGCTGTTGGGAATTGGGGAAGG
TATAGATGATTGCTGGGAGACATTGGAAACTATATCGAAGTTACATCAGCGTTACCATCATATTCAAGAAGTTATTTTAC
AACCCCACAGCCCAGGAAATCAGCAGACATTTGATGCACCTGCTTTTAATCCGCATCAGCTACCAGAAGTTATTGCCAAA
GCACGGCAGATTTTACCGCCAGATATTACAATTCAAATTCCACCGAATTTAGTTCAAGATGAGCAATGGTTAGTGGCTTG
TGTAGAAGCTGGTGCAAGAGATTTAGGGGGAATTGGGCCGAAAGATGAAGTGAATCCTGATTATCCTCATCTTCAGGCGG
AGGAATTGAGAGAAATTTTACAGCCTGTGGGTTGGGAGTTAGTACCACGTTTGCCAGTATATCCACAGTTTGATGGTTGG
TTGTCGAAGGAGTTGCAGGCAAGTGTGAGAAGGTGGAGGGAACTGGTAATTTATTTTTGA

Upstream 100 bases:

>100_bases
CTGAAAAGCACTGTTTACAATAGTTTTGGGTGTAAATAAAAATGAGTTTCGCTGAATACGGCTCGAAAAATGGTTACATT
TCTTGAGGAAAATCTGTTTT

Downstream 100 bases:

>100_bases
TATACGGTGGGGATTAAAATCCCATGTTTGGGGCTGAATAACAATGCCAATAGGAATAGTCCTGAAACTACTAAAACGAT
CGCTGGGCCGGAAGGTAAAT

Product: FO synthase subunit 1

Products: NA

Alternate protein names: 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase subunit 1 [H]

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MTVAKSTCASVSTKPAVGKPTNGIATYSPAYTIVPTYECFNRCTYCNFRTDPGESSWMTLSAAEDIFQRLQNEQVCEILI
LSGEVHPHSPKRQAWFQRIYDLCKLALTSGFLPHTNAGPLSFAEMQELKSVNVSMGLMLEQLTPKLLETVHRHAPSKLPE
LRLQQLEWAGDLQIPFTTGLLLGIGEGIDDCWETLETISKLHQRYHHIQEVILQPHSPGNQQTFDAPAFNPHQLPEVIAK
ARQILPPDITIQIPPNLVQDEQWLVACVEAGARDLGGIGPKDEVNPDYPHLQAEELREILQPVGWELVPRLPVYPQFDGW
LSKELQASVRRWRELVIYF

Sequences:

>Translated_339_residues
MTVAKSTCASVSTKPAVGKPTNGIATYSPAYTIVPTYECFNRCTYCNFRTDPGESSWMTLSAAEDIFQRLQNEQVCEILI
LSGEVHPHSPKRQAWFQRIYDLCKLALTSGFLPHTNAGPLSFAEMQELKSVNVSMGLMLEQLTPKLLETVHRHAPSKLPE
LRLQQLEWAGDLQIPFTTGLLLGIGEGIDDCWETLETISKLHQRYHHIQEVILQPHSPGNQQTFDAPAFNPHQLPEVIAK
ARQILPPDITIQIPPNLVQDEQWLVACVEAGARDLGGIGPKDEVNPDYPHLQAEELREILQPVGWELVPRLPVYPQFDGW
LSKELQASVRRWRELVIYF
>Mature_338_residues
TVAKSTCASVSTKPAVGKPTNGIATYSPAYTIVPTYECFNRCTYCNFRTDPGESSWMTLSAAEDIFQRLQNEQVCEILIL
SGEVHPHSPKRQAWFQRIYDLCKLALTSGFLPHTNAGPLSFAEMQELKSVNVSMGLMLEQLTPKLLETVHRHAPSKLPEL
RLQQLEWAGDLQIPFTTGLLLGIGEGIDDCWETLETISKLHQRYHHIQEVILQPHSPGNQQTFDAPAFNPHQLPEVIAKA
RQILPPDITIQIPPNLVQDEQWLVACVEAGARDLGGIGPKDEVNPDYPHLQAEELREILQPVGWELVPRLPVYPQFDGWL
SKELQASVRRWRELVIYF

Specific function: Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) [H]

COG id: COG1060

COG function: function code HR; Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. CofG family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR019939
- InterPro:   IPR007197 [H]

Pfam domain/function: PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 38248; Mature: 38117

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVAKSTCASVSTKPAVGKPTNGIATYSPAYTIVPTYECFNRCTYCNFRTDPGESSWMTL
CCCCHHHHHCCCCCCCCCCCCCCCEECCCCEEEEECHHHHCCCEECCCCCCCCCCCEEEH
SAAEDIFQRLQNEQVCEILILSGEVHPHSPKRQAWFQRIYDLCKLALTSGFLPHTNAGPL
HHHHHHHHHHCCCHHEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
SFAEMQELKSVNVSMGLMLEQLTPKLLETVHRHAPSKLPELRLQQLEWAGDLQIPFTTGL
CHHHHHHHHHCCHHHHHHHHHHCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHH
LLGIGEGIDDCWETLETISKLHQRYHHIQEVILQPHSPGNQQTFDAPAFNPHQLPEVIAK
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHH
ARQILPPDITIQIPPNLVQDEQWLVACVEAGARDLGGIGPKDEVNPDYPHLQAEELREIL
HHHCCCCCEEEECCCCCCCCHHHHHHHHHHCHHHHCCCCCCCCCCCCCCCCCHHHHHHHH
QPVGWELVPRLPVYPQFDGWLSKELQASVRRWRELVIYF
HHCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TVAKSTCASVSTKPAVGKPTNGIATYSPAYTIVPTYECFNRCTYCNFRTDPGESSWMTL
CCCHHHHHCCCCCCCCCCCCCCCEECCCCEEEEECHHHHCCCEECCCCCCCCCCCEEEH
SAAEDIFQRLQNEQVCEILILSGEVHPHSPKRQAWFQRIYDLCKLALTSGFLPHTNAGPL
HHHHHHHHHHCCCHHEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
SFAEMQELKSVNVSMGLMLEQLTPKLLETVHRHAPSKLPELRLQQLEWAGDLQIPFTTGL
CHHHHHHHHHCCHHHHHHHHHHCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHH
LLGIGEGIDDCWETLETISKLHQRYHHIQEVILQPHSPGNQQTFDAPAFNPHQLPEVIAK
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHH
ARQILPPDITIQIPPNLVQDEQWLVACVEAGARDLGGIGPKDEVNPDYPHLQAEELREIL
HHHCCCCCEEEECCCCCCCCHHHHHHHHHHCHHHHCCCCCCCCCCCCCCCCCHHHHHHHH
QPVGWELVPRLPVYPQFDGWLSKELQASVRRWRELVIYF
HHCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA