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The map label for this gene is purM [H]

Identifier: 17231017

GI number: 17231017

Start: 4247375

End: 4248652

Strand: Direct

Name: purM [H]

Synonym: alr3525

Alternate gene names: 17231017

Gene position: 4247375-4248652 (Clockwise)

Preceding gene: 17231016

Following gene: 17231019

Centisome position: 66.22

GC content: 49.22

Gene sequence:

>1278_bases
GTGTACGGGTGTAAGGGTATAGGGGGAGAATTTTCCCAATCCCCAATCCCCAATCCCCAATCCCCAATCCCCAATCCCCA
ATCCCCAATCCCAATCCCCAATCCCCAATCCCCAGTCCCCAATCCCAACAAAGTAACTCTGATGACTCAAGCACTCGATC
AAGTCGATTACAATACTTTAGATGCGGCCAAGCTTCGCTTTATTGAGGCCGCAAAACGCACATTGCAGTTTGCACCCACT
TATGGAAAAGTACCTGCTTCCGGGCTGGGGGGAAGTGCTAACGCCTTTAGTTTCAACCTAGCGCCCTACTTGCAGACGGG
AACACCAGAACTTTTTGTGAGCCTTGTTCCTGAAGGACTGGGTACTGCTGATGATGCCCGTCCTGATGACCTCTCGGAGG
AAGAATTGCGACGGTTTTGGTGGAACATTGGTATCAAAATTCTCTCGTGTCTGACCAATGATGCTGCATCGTCGGGAATG
CAAACCGTACTTCTGGGATTGTATTTACCCTCAAGCACCCCGGAAAGCGTATTTACTCCCGCCTTTTTGGATGGATTTCT
GGATGGTGTAGTTGAAGGATGCAAACGCATCGGCTGTGTTTACATTTCTGGGGAAACGCCACAACTCAAAACTAAGATGA
TTCCAGGGCGACTGGATATTGCCGGTTCTGTATTTGGCGTAATGCCCCCTGGTGTGACTCCTATTGATGGTACACGGCTA
GCTGAAGGTAATGCGATCGTTTTGGTGGAAAGTACCGGACTCCATGAAAACGGCTTTACCCCCGTGCGAAAACTAGCCGA
ATCACTCCCCGATGGCTACAGAACAAAACTACCCAGTGGGCAGGAGTTATGGGCAGCGATGAATGCTGCTTCTCATCTCT
ACACGCCACTGGTGCAAGCGGTGTTGAGTGAGGGTATTCGTCCCACCGCGATGGAGAATATCACCGGTCATGGATGGCAG
AAACTTATGCGGTCAGCCAAACCACTACGGTATGTCATTGAAAAATTGTTACCAGTTCCCGAAATCTTTCAGTTTGTCGA
AAGTCAACTAGAAGGAGGGAAAGAAATGATGTTGTCCGTGTTCAATTACGGCGCAGGTTTTGCATTTTATACAGAAACAG
AACAGGATGGGGAGAGAATTGTTCAGCTAGCAAAAGAGCAAGGATTAACAGCTGCGATCGCTGGTAGAGTCGAAGCATCC
CCCACCCGTGAAGTCGTCATCACACCATTTAATATCACACTAAAGGGAGAGTCTTTCGGCATCGCCAGAGGCGCATAG

Upstream 100 bases:

>100_bases
TATCACCACAGGCAGACCGCGATCGCCCCAGCAATTCGCACAACTGAACTCGGAAGCCGTTATTCATAATCCAGAAGGGG
CGAGGGGGTAAGAATTAGGG

Downstream 100 bases:

>100_bases
CCTATTATATTGAGGAAAGTATTAGACCGTCCCAACCTTGGTCAAAATAGACCACTTCCTAGCAAGGATCACTACTACTG
TTTCTAAGATACAAGGTTGG

Product: phosphoribosylformylglycinamidine cyclo-ligase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MYGCKGIGGEFSQSPIPNPQSPIPNPQSPIPIPNPQSPVPNPNKVTLMTQALDQVDYNTLDAAKLRFIEAAKRTLQFAPT
YGKVPASGLGGSANAFSFNLAPYLQTGTPELFVSLVPEGLGTADDARPDDLSEEELRRFWWNIGIKILSCLTNDAASSGM
QTVLLGLYLPSSTPESVFTPAFLDGFLDGVVEGCKRIGCVYISGETPQLKTKMIPGRLDIAGSVFGVMPPGVTPIDGTRL
AEGNAIVLVESTGLHENGFTPVRKLAESLPDGYRTKLPSGQELWAAMNAASHLYTPLVQAVLSEGIRPTAMENITGHGWQ
KLMRSAKPLRYVIEKLLPVPEIFQFVESQLEGGKEMMLSVFNYGAGFAFYTETEQDGERIVQLAKEQGLTAAIAGRVEAS
PTREVVITPFNITLKGESFGIARGA

Sequences:

>Translated_425_residues
MYGCKGIGGEFSQSPIPNPQSPIPNPQSPIPIPNPQSPVPNPNKVTLMTQALDQVDYNTLDAAKLRFIEAAKRTLQFAPT
YGKVPASGLGGSANAFSFNLAPYLQTGTPELFVSLVPEGLGTADDARPDDLSEEELRRFWWNIGIKILSCLTNDAASSGM
QTVLLGLYLPSSTPESVFTPAFLDGFLDGVVEGCKRIGCVYISGETPQLKTKMIPGRLDIAGSVFGVMPPGVTPIDGTRL
AEGNAIVLVESTGLHENGFTPVRKLAESLPDGYRTKLPSGQELWAAMNAASHLYTPLVQAVLSEGIRPTAMENITGHGWQ
KLMRSAKPLRYVIEKLLPVPEIFQFVESQLEGGKEMMLSVFNYGAGFAFYTETEQDGERIVQLAKEQGLTAAIAGRVEAS
PTREVVITPFNITLKGESFGIARGA
>Mature_425_residues
MYGCKGIGGEFSQSPIPNPQSPIPNPQSPIPIPNPQSPVPNPNKVTLMTQALDQVDYNTLDAAKLRFIEAAKRTLQFAPT
YGKVPASGLGGSANAFSFNLAPYLQTGTPELFVSLVPEGLGTADDARPDDLSEEELRRFWWNIGIKILSCLTNDAASSGM
QTVLLGLYLPSSTPESVFTPAFLDGFLDGVVEGCKRIGCVYISGETPQLKTKMIPGRLDIAGSVFGVMPPGVTPIDGTRL
AEGNAIVLVESTGLHENGFTPVRKLAESLPDGYRTKLPSGQELWAAMNAASHLYTPLVQAVLSEGIRPTAMENITGHGWQ
KLMRSAKPLRYVIEKLLPVPEIFQFVESQLEGGKEMMLSVFNYGAGFAFYTETEQDGERIVQLAKEQGLTAAIAGRVEAS
PTREVVITPFNITLKGESFGIARGA

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=330, Percent_Identity=25.7575757575758, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI209869995, Length=330, Percent_Identity=25.7575757575758, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI209869993, Length=330, Percent_Identity=25.7575757575758, Blast_Score=89, Evalue=7e-18,
Organism=Escherichia coli, GI1788845, Length=268, Percent_Identity=23.8805970149254, Blast_Score=73, Evalue=4e-14,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 45704; Mature: 45704

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYGCKGIGGEFSQSPIPNPQSPIPNPQSPIPIPNPQSPVPNPNKVTLMTQALDQVDYNTL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHCCCCCH
DAAKLRFIEAAKRTLQFAPTYGKVPASGLGGSANAFSFNLAPYLQTGTPELFVSLVPEGL
HHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHCCCC
GTADDARPDDLSEEELRRFWWNIGIKILSCLTNDAASSGMQTVLLGLYLPSSTPESVFTP
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCH
AFLDGFLDGVVEGCKRIGCVYISGETPQLKTKMIPGRLDIAGSVFGVMPPGVTPIDGTRL
HHHHHHHHHHHHHHHHCCEEEECCCCCCHHHCCCCCCEECCCCCCCCCCCCCCCCCCCEE
AEGNAIVLVESTGLHENGFTPVRKLAESLPDGYRTKLPSGQELWAAMNAASHLYTPLVQA
CCCCEEEEEECCCCCCCCCCHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHH
VLSEGIRPTAMENITGHGWQKLMRSAKPLRYVIEKLLPVPEIFQFVESQLEGGKEMMLSV
HHHCCCCCHHHHHCCCHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHH
FNYGAGFAFYTETEQDGERIVQLAKEQGLTAAIAGRVEASPTREVVITPFNITLKGESFG
HHCCCCEEEEECCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCEEEEEEEEEEECCCCCC
IARGA
CCCCC
>Mature Secondary Structure
MYGCKGIGGEFSQSPIPNPQSPIPNPQSPIPIPNPQSPVPNPNKVTLMTQALDQVDYNTL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHCCCCCH
DAAKLRFIEAAKRTLQFAPTYGKVPASGLGGSANAFSFNLAPYLQTGTPELFVSLVPEGL
HHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHCCCC
GTADDARPDDLSEEELRRFWWNIGIKILSCLTNDAASSGMQTVLLGLYLPSSTPESVFTP
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCH
AFLDGFLDGVVEGCKRIGCVYISGETPQLKTKMIPGRLDIAGSVFGVMPPGVTPIDGTRL
HHHHHHHHHHHHHHHHCCEEEECCCCCCHHHCCCCCCEECCCCCCCCCCCCCCCCCCCEE
AEGNAIVLVESTGLHENGFTPVRKLAESLPDGYRTKLPSGQELWAAMNAASHLYTPLVQA
CCCCEEEEEECCCCCCCCCCHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHH
VLSEGIRPTAMENITGHGWQKLMRSAKPLRYVIEKLLPVPEIFQFVESQLEGGKEMMLSV
HHHCCCCCHHHHHCCCHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHH
FNYGAGFAFYTETEQDGERIVQLAKEQGLTAAIAGRVEASPTREVVITPFNITLKGESFG
HHCCCCEEEEECCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCEEEEEEEEEEECCCCCC
IARGA
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA