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The map label for this gene is garR [H]

Identifier: 17230850

GI number: 17230850

Start: 4064099

End: 4064977

Strand: Direct

Name: garR [H]

Synonym: alr3358

Alternate gene names: 17230850

Gene position: 4064099-4064977 (Clockwise)

Preceding gene: 17230849

Following gene: 17230853

Centisome position: 63.37

GC content: 44.94

Gene sequence:

>879_bases
ATGAAGGTGGCATTTCTGGGAACTGGACTTATGGGACTACCAATGGCCCAAAGATTGTTAGCAGCAAATATAGAGGTAGT
TGCCTATAACCGCACCCCAGAAAAACTAGCACCATTACAAGCAGCTGGCGCGGAAGTGGTGACACATCCCCGCTACGCAA
TTCGAGAAGCTGAGTGTGTCATCCTCATGCTGACCAACGCCGCAGCAATATATCATGTGTTGCTTTCGGATACTTCTTGG
CGGACTCTCCAAGGACGCACCATCATTCAGATGGGAACCATTACCTCCACCCAAAGCCAAGAAATTCGAGATTCCATAGT
GGGTGGTGGCGGCGAATATATAGAAGCACCAGTGTTAGGAAGTATTCCTGAAGCCCAAGCTGGTACTCTGACAGTAATGG
TAGGCGCTGAACCTCAACAATATGAACGCTGCCTAAATTTACTCAAGAATTTTGGCCCAGATCCTTTACTTATAGGGCCA
GTGGGAACTGCATCAGGCTTAAAACTAGCCCTAAATCAGCTCATTGCTTCCTTAACTACAAGCTTTGCCCTCAGTTTAGC
TTTTGTGCAGCGTCAAGGTATTGATGTAGACAAATTTATGCAGGTACTACGCGAAAGTGCGCTGTATGCGCCAACTTTTG
ATAAAAAGCTGCAAAGGATGTTAGATGGCAATTATAGCAATCCCAACTTTCCGACAAAACACTTGCTCAAAGACACCGAC
TTGTTTATTTCCGAAGCTCAATACCTTGGTTTGGATCTCAGCAGTATTGAAACTGTGCAGAAACTTTTGCAAACAACCAT
GAAAATGTCATTTGCCAATGATGATTATTCTGCCCTATTTTCTGTCATCAGAGATTGGGGAGAAGCAAGTGGCGGTTAA

Upstream 100 bases:

>100_bases
GACGTAGGGAGTAGAAAAAACGTAAATCTGTTCATTAACTACTCCCTGACAACCTACAATCAAACGATGGAAAAGCGGCT
GAATCAAAGGAACGTAAAAC

Downstream 100 bases:

>100_bases
GTGAATGGGTGACGAGAAAAAAAACAAATAACTATTGACTATTGACTAGAGTAAAGGTAGTAGGATTTCAAACTTTGTAC
CGATGCCTAGTTTGGAAGAG

Product: 3-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MKVAFLGTGLMGLPMAQRLLAANIEVVAYNRTPEKLAPLQAAGAEVVTHPRYAIREAECVILMLTNAAAIYHVLLSDTSW
RTLQGRTIIQMGTITSTQSQEIRDSIVGGGGEYIEAPVLGSIPEAQAGTLTVMVGAEPQQYERCLNLLKNFGPDPLLIGP
VGTASGLKLALNQLIASLTTSFALSLAFVQRQGIDVDKFMQVLRESALYAPTFDKKLQRMLDGNYSNPNFPTKHLLKDTD
LFISEAQYLGLDLSSIETVQKLLQTTMKMSFANDDYSALFSVIRDWGEASGG

Sequences:

>Translated_292_residues
MKVAFLGTGLMGLPMAQRLLAANIEVVAYNRTPEKLAPLQAAGAEVVTHPRYAIREAECVILMLTNAAAIYHVLLSDTSW
RTLQGRTIIQMGTITSTQSQEIRDSIVGGGGEYIEAPVLGSIPEAQAGTLTVMVGAEPQQYERCLNLLKNFGPDPLLIGP
VGTASGLKLALNQLIASLTTSFALSLAFVQRQGIDVDKFMQVLRESALYAPTFDKKLQRMLDGNYSNPNFPTKHLLKDTD
LFISEAQYLGLDLSSIETVQKLLQTTMKMSFANDDYSALFSVIRDWGEASGG
>Mature_292_residues
MKVAFLGTGLMGLPMAQRLLAANIEVVAYNRTPEKLAPLQAAGAEVVTHPRYAIREAECVILMLTNAAAIYHVLLSDTSW
RTLQGRTIIQMGTITSTQSQEIRDSIVGGGGEYIEAPVLGSIPEAQAGTLTVMVGAEPQQYERCLNLLKNFGPDPLLIGP
VGTASGLKLALNQLIASLTTSFALSLAFVQRQGIDVDKFMQVLRESALYAPTFDKKLQRMLDGNYSNPNFPTKHLLKDTD
LFISEAQYLGLDLSSIETVQKLLQTTMKMSFANDDYSALFSVIRDWGEASGG

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40556376, Length=283, Percent_Identity=25.0883392226148, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI23308751, Length=291, Percent_Identity=25.7731958762887, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI145693186, Length=282, Percent_Identity=29.0780141843972, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1786719, Length=289, Percent_Identity=28.0276816608997, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1789092, Length=286, Percent_Identity=25.1748251748252, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1790315, Length=287, Percent_Identity=23.6933797909408, Blast_Score=68, Evalue=7e-13,
Organism=Drosophila melanogaster, GI28574115, Length=279, Percent_Identity=24.7311827956989, Blast_Score=118, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24655230, Length=292, Percent_Identity=23.6301369863014, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI19922568, Length=292, Percent_Identity=23.6301369863014, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 31733; Mature: 31733

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVAFLGTGLMGLPMAQRLLAANIEVVAYNRTPEKLAPLQAAGAEVVTHPRYAIREAECV
CEEEEECCCCHHHHHHHHHHHCCCEEEEECCCHHHHCCHHHCCCHHHCCCHHHHCCCCEE
ILMLTNAAAIYHVLLSDTSWRTLQGRTIIQMGTITSTQSQEIRDSIVGGGGEYIEAPVLG
EEEECCHHHHHHHHHCCCCCEEECCCEEEEECCCCCCHHHHHHHHHCCCCCCEEECCCCC
SIPEAQAGTLTVMVGAEPQQYERCLNLLKNFGPDPLLIGPVGTASGLKLALNQLIASLTT
CCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHH
SFALSLAFVQRQGIDVDKFMQVLRESALYAPTFDKKLQRMLDGNYSNPNFPTKHLLKDTD
HHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHH
LFISEAQYLGLDLSSIETVQKLLQTTMKMSFANDDYSALFSVIRDWGEASGG
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKVAFLGTGLMGLPMAQRLLAANIEVVAYNRTPEKLAPLQAAGAEVVTHPRYAIREAECV
CEEEEECCCCHHHHHHHHHHHCCCEEEEECCCHHHHCCHHHCCCHHHCCCHHHHCCCCEE
ILMLTNAAAIYHVLLSDTSWRTLQGRTIIQMGTITSTQSQEIRDSIVGGGGEYIEAPVLG
EEEECCHHHHHHHHHCCCCCEEECCCEEEEECCCCCCHHHHHHHHHCCCCCCEEECCCCC
SIPEAQAGTLTVMVGAEPQQYERCLNLLKNFGPDPLLIGPVGTASGLKLALNQLIASLTT
CCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHH
SFALSLAFVQRQGIDVDKFMQVLRESALYAPTFDKKLQRMLDGNYSNPNFPTKHLLKDTD
HHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHH
LFISEAQYLGLDLSSIETVQKLLQTTMKMSFANDDYSALFSVIRDWGEASGG
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]