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The map label for this gene is tkt

Identifier: 17230836

GI number: 17230836

Start: 4040456

End: 4042468

Strand: Direct

Name: tkt

Synonym: alr3344

Alternate gene names: 17230836

Gene position: 4040456-4042468 (Clockwise)

Preceding gene: 17230835

Following gene: 17230837

Centisome position: 63.0

GC content: 47.94

Gene sequence:

>2013_bases
ATGGCTGTTGCAACCCAATCCCTCGAAGAACTTTCTATTAATGCGATTCGTTTCTTGGCTGTTGATGCCATAGAAAAGGC
AAAATCGGGACACCCCGGACTACCGATGGGCGCGGCTCCAATGGCTTTTGTGCTGTGGAACCGCTTTATGCGGTATAACC
CGAAAAATCCCAAATGGTTTAACCGCGATCGCTTTGTTTTGTCTGCTGGTCATGGTTCCATGTTGCAGTATGCCCTGCTC
TACCTGACAGGCTACGATAGCGTCAGCATTGAGGACATCAAGCAATTCCGCCAGTGGGAATCCAAAACCCCCGGACACCC
AGAAAACTTCATGACCGCAGGTGTAGAAGTCACCACTGGGCCACTAGGTCAAGGTATTGCCAATGGTGTTGGTTTAGCGA
TCGCAGAAGCTCACCTCGCAGCTAAGTTCAACAAACCCGATGCCAAGATTGTTGACCATTATACCTATGTAATTTTAGGT
GATGGTTGCAACATGGAAGGCGTTTCTGGTGAAGCAGCCTCTTTTGCTGGACACTTGGGATTAGGTAAACTGATCGCTCT
GTACGACGACAACCACATTTCCATCGATGGTTCTACAGATGTAGCCTTTACCGAAGATGTTTCCAAGCGTTTTGAATCTT
ATGGCTGGCACGTCATCCATGTTAAAGATGGCAACACCGATTTAGAAGCAATTCACAAAGCTATTGAAGAGGCAAAAGCT
GTCACCGATAAGCCCACCATGATTAAGGTGACAACCATTATCGGTTACGGTTCCCCTAACAAATCTAATACTGCCGGGGT
TCACGGTGCAGCATTGGGTGGAGATGAAGTAGCCTTAACTCGTCAAAATCTAGGTTGGTCACACGACCCATTTGTTGTTC
CCGAAGATGTCCTCAACTATACCCGTAAAGCAGTAGAGCGCGGTGCAGGCTACGAATCTGACTGGAACAAAACCTACGCA
GATTACAAAGCTAAATATCCCCAAGAAGCGGCTGAATTTGAGCGTTACTTAAGCGGCAAACTGGCTGATGGTTGGGATAA
GGTACTACCATCCTACACCCCCGAAGATAAAGGACTTCCCACCCGTAAGCATTCAGAAACCTGCCTCAACAAATTGGCGG
CGGTTCTACCTGAACTCATTGGTGGTTCGGCTGACTTGACCCATTCCAACCTCACCGAAATCAAGGGCAAAGGCGACTTC
CAAAAAGGACAATACCAAAATCCCAACATCCACTTTGGTGTCCGGGAACATGGTATGGGCGCAATCTGTAACGGTATTGC
GCTGCATGGTTCGGGATTAATTCCCTATGGCGCTACCTTCTTAATCTTCAGTGATTATATGCGCGCTCCCATCCGTTTAT
CTGCCCTGTCTCAAGCCGGCTCGATTTGGGTGATGACCCACGATTCCATCGGTCAAGGTGAAGACGGCCCGACCCACCAA
CCAATCGAAACGCTGGCCTCACTCCGTGCTATTCCTAACCTGACAGTAATTCGTCCCGCCGACGGTAACGAAACCTCCGG
CGCTTACAAAGTAGCAATTGAGAGAGCTAAGAACAACGCTCCTACTTTGTTGGCGTTTACTCGTCAAAATGTTCCCAACT
TGGCAGGTACATCGATTGATGACGTAGCTAAGGGCGGATACATTGTTGTAGATACCGATGGCACACCAGATTTAATCCTG
ATTGGTACTGGTTCAGAATTGAGCCTCTGTGTCACCGCAGCCGAGAAACTCAAAGCTGAAGGCAAGAAAGTTCGTGTAGT
CTCCTTGGCTGCTTGGGATTTGTTTGATGCACAAGATGCAGCTTACAAAGAATCAGTTCTACCTAAAGCTGTCACCAAGC
GTTTAGCTGTAGAAGCGGCTAGCAGCTTCGGCTGGCACAAATATATTGGTAGTGAAGGCGATGCTGTAACTATAGACCGC
TTCGGTGCTTCTGCTCCTGGCGGCGTTTGTTTGGAGAAATTTGGTTTTAGCGTTGATAATGTATTAGCTAAAGCTAAACA
ATTGTTGGGTTAA

Upstream 100 bases:

>100_bases
CCTATCTTGATAACTGTTAACTGTTAACTGCTAGCTGAGAAAAACAACCCCAGTAAAAGTAGCTTGAAGAGTGCTAACCC
GTCGTTAAGAACAAGAGATT

Downstream 100 bases:

>100_bases
TAGCAACAGAATATTCTCTTACATTAATTATTGGGTGGGCATAATGCCTGCCCTTTTTTGTGGCATAAAAGTGCAAAATC
ATAATTCCTGATAATTTATA

Product: transketolase

Products: NA

Alternate protein names: TK

Number of amino acids: Translated: 670; Mature: 669

Protein sequence:

>670_residues
MAVATQSLEELSINAIRFLAVDAIEKAKSGHPGLPMGAAPMAFVLWNRFMRYNPKNPKWFNRDRFVLSAGHGSMLQYALL
YLTGYDSVSIEDIKQFRQWESKTPGHPENFMTAGVEVTTGPLGQGIANGVGLAIAEAHLAAKFNKPDAKIVDHYTYVILG
DGCNMEGVSGEAASFAGHLGLGKLIALYDDNHISIDGSTDVAFTEDVSKRFESYGWHVIHVKDGNTDLEAIHKAIEEAKA
VTDKPTMIKVTTIIGYGSPNKSNTAGVHGAALGGDEVALTRQNLGWSHDPFVVPEDVLNYTRKAVERGAGYESDWNKTYA
DYKAKYPQEAAEFERYLSGKLADGWDKVLPSYTPEDKGLPTRKHSETCLNKLAAVLPELIGGSADLTHSNLTEIKGKGDF
QKGQYQNPNIHFGVREHGMGAICNGIALHGSGLIPYGATFLIFSDYMRAPIRLSALSQAGSIWVMTHDSIGQGEDGPTHQ
PIETLASLRAIPNLTVIRPADGNETSGAYKVAIERAKNNAPTLLAFTRQNVPNLAGTSIDDVAKGGYIVVDTDGTPDLIL
IGTGSELSLCVTAAEKLKAEGKKVRVVSLAAWDLFDAQDAAYKESVLPKAVTKRLAVEAASSFGWHKYIGSEGDAVTIDR
FGASAPGGVCLEKFGFSVDNVLAKAKQLLG

Sequences:

>Translated_670_residues
MAVATQSLEELSINAIRFLAVDAIEKAKSGHPGLPMGAAPMAFVLWNRFMRYNPKNPKWFNRDRFVLSAGHGSMLQYALL
YLTGYDSVSIEDIKQFRQWESKTPGHPENFMTAGVEVTTGPLGQGIANGVGLAIAEAHLAAKFNKPDAKIVDHYTYVILG
DGCNMEGVSGEAASFAGHLGLGKLIALYDDNHISIDGSTDVAFTEDVSKRFESYGWHVIHVKDGNTDLEAIHKAIEEAKA
VTDKPTMIKVTTIIGYGSPNKSNTAGVHGAALGGDEVALTRQNLGWSHDPFVVPEDVLNYTRKAVERGAGYESDWNKTYA
DYKAKYPQEAAEFERYLSGKLADGWDKVLPSYTPEDKGLPTRKHSETCLNKLAAVLPELIGGSADLTHSNLTEIKGKGDF
QKGQYQNPNIHFGVREHGMGAICNGIALHGSGLIPYGATFLIFSDYMRAPIRLSALSQAGSIWVMTHDSIGQGEDGPTHQ
PIETLASLRAIPNLTVIRPADGNETSGAYKVAIERAKNNAPTLLAFTRQNVPNLAGTSIDDVAKGGYIVVDTDGTPDLIL
IGTGSELSLCVTAAEKLKAEGKKVRVVSLAAWDLFDAQDAAYKESVLPKAVTKRLAVEAASSFGWHKYIGSEGDAVTIDR
FGASAPGGVCLEKFGFSVDNVLAKAKQLLG
>Mature_669_residues
AVATQSLEELSINAIRFLAVDAIEKAKSGHPGLPMGAAPMAFVLWNRFMRYNPKNPKWFNRDRFVLSAGHGSMLQYALLY
LTGYDSVSIEDIKQFRQWESKTPGHPENFMTAGVEVTTGPLGQGIANGVGLAIAEAHLAAKFNKPDAKIVDHYTYVILGD
GCNMEGVSGEAASFAGHLGLGKLIALYDDNHISIDGSTDVAFTEDVSKRFESYGWHVIHVKDGNTDLEAIHKAIEEAKAV
TDKPTMIKVTTIIGYGSPNKSNTAGVHGAALGGDEVALTRQNLGWSHDPFVVPEDVLNYTRKAVERGAGYESDWNKTYAD
YKAKYPQEAAEFERYLSGKLADGWDKVLPSYTPEDKGLPTRKHSETCLNKLAAVLPELIGGSADLTHSNLTEIKGKGDFQ
KGQYQNPNIHFGVREHGMGAICNGIALHGSGLIPYGATFLIFSDYMRAPIRLSALSQAGSIWVMTHDSIGQGEDGPTHQP
IETLASLRAIPNLTVIRPADGNETSGAYKVAIERAKNNAPTLLAFTRQNVPNLAGTSIDDVAKGGYIVVDTDGTPDLILI
GTGSELSLCVTAAEKLKAEGKKVRVVSLAAWDLFDAQDAAYKESVLPKAVTKRLAVEAASSFGWHKYIGSEGDAVTIDRF
GASAPGGVCLEKFGFSVDNVLAKAKQLLG

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family

Homologues:

Organism=Homo sapiens, GI205277463, Length=587, Percent_Identity=28.9608177172061, Blast_Score=170, Evalue=4e-42,
Organism=Homo sapiens, GI4507521, Length=587, Percent_Identity=28.9608177172061, Blast_Score=170, Evalue=4e-42,
Organism=Homo sapiens, GI133778974, Length=577, Percent_Identity=27.209705372617, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI225637459, Length=587, Percent_Identity=22.9982964224872, Blast_Score=109, Evalue=8e-24,
Organism=Homo sapiens, GI225637463, Length=501, Percent_Identity=23.9520958083832, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI225637461, Length=501, Percent_Identity=23.9520958083832, Blast_Score=103, Evalue=6e-22,
Organism=Escherichia coli, GI48994911, Length=670, Percent_Identity=54.0298507462687, Blast_Score=700, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=663, Percent_Identity=53.5444947209653, Blast_Score=692, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=598, Percent_Identity=28.0936454849498, Blast_Score=153, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6325331, Length=669, Percent_Identity=52.3168908819133, Blast_Score=671, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319593, Length=672, Percent_Identity=50.5952380952381, Blast_Score=649, Evalue=0.0,
Organism=Drosophila melanogaster, GI45551847, Length=692, Percent_Identity=27.0231213872832, Blast_Score=179, Evalue=5e-45,
Organism=Drosophila melanogaster, GI45550715, Length=692, Percent_Identity=27.0231213872832, Blast_Score=179, Evalue=5e-45,
Organism=Drosophila melanogaster, GI24645119, Length=650, Percent_Identity=26.9230769230769, Blast_Score=162, Evalue=5e-40,
Organism=Drosophila melanogaster, GI24666278, Length=678, Percent_Identity=25.811209439528, Blast_Score=148, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TKT_NOSS1 (Q8YRU9)

Other databases:

- EMBL:   BA000019
- PIR:   AI2223
- RefSeq:   NP_487384.1
- HSSP:   P27302
- ProteinModelPortal:   Q8YRU9
- SMR:   Q8YRU9
- STRING:   Q8YRU9
- GeneID:   1106942
- GenomeReviews:   BA000019_GR
- KEGG:   ana:alr3344
- NMPDR:   fig|103690.1.peg.3651
- eggNOG:   COG0021
- HOGENOM:   HBG565885
- OMA:   CNMEGVS
- PhylomeDB:   Q8YRU9
- ProtClustDB:   PRK05899
- BioCyc:   NSP103690:ALR3344-MONOMER
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- PANTHER:   PTHR11624:SF1
- SMART:   SM00861
- TIGRFAMs:   TIGR00232

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N; SSF52922 Transketo_C_like

EC number: =2.2.1.1

Molecular weight: Translated: 72071; Mature: 71940

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: ACT_SITE 106-106

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVATQSLEELSINAIRFLAVDAIEKAKSGHPGLPMGAAPMAFVLWNRFMRYNPKNPKWF
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
NRDRFVLSAGHGSMLQYALLYLTGYDSVSIEDIKQFRQWESKTPGHPENFMTAGVEVTTG
CCCEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCHHHEECCCEEECC
PLGQGIANGVGLAIAEAHLAAKFNKPDAKIVDHYTYVILGDGCNMEGVSGEAASFAGHLG
CCCHHHHCCHHHHHHHHHHHHHCCCCCCEEEEEEEEEEEECCCCCCCCCCCHHHHHHHCC
LGKLIALYDDNHISIDGSTDVAFTEDVSKRFESYGWHVIHVKDGNTDLEAIHKAIEEAKA
CCEEEEEEECCEEEECCCCCEEEHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHH
VTDKPTMIKVTTIIGYGSPNKSNTAGVHGAALGGDEVALTRQNLGWSHDPFVVPEDVLNY
CCCCCCEEEEEEEEECCCCCCCCCCCCCEEECCCCCEEEECCCCCCCCCCCCCCHHHHHH
TRKAVERGAGYESDWNKTYADYKAKYPQEAAEFERYLSGKLADGWDKVLPSYTPEDKGLP
HHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCC
TRKHSETCLNKLAAVLPELIGGSADLTHSNLTEIKGKGDFQKGQYQNPNIHFGVREHGMG
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCCCCCCCCEEEEEHHCCCC
AICNGIALHGSGLIPYGATFLIFSDYMRAPIRLSALSQAGSIWVMTHDSIGQGEDGPTHQ
HHHCCEEEECCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCEEEEECCCCCCCCCCCCCC
PIETLASLRAIPNLTVIRPADGNETSGAYKVAIERAKNNAPTLLAFTRQNVPNLAGTSID
HHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEEECCCCCCEEEEEECCCCCCCCCCCHH
DVAKGGYIVVDTDGTPDLILIGTGSELSLCVTAAEKLKAEGKKVRVVSLAAWDLFDAQDA
HHHCCCEEEEECCCCCCEEEEECCCCCEEEHHHHHHHHCCCCEEEEEEEEEECCCCCCHH
AYKESVLPKAVTKRLAVEAASSFGWHKYIGSEGDAVTIDRFGASAPGGVCLEKFGFSVDN
HHHHHCCHHHHHHHHHHHHHHCCCHHHHCCCCCCEEEEECCCCCCCCCHHHHHHCCCHHH
VLAKAKQLLG
HHHHHHHHCC
>Mature Secondary Structure 
AVATQSLEELSINAIRFLAVDAIEKAKSGHPGLPMGAAPMAFVLWNRFMRYNPKNPKWF
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
NRDRFVLSAGHGSMLQYALLYLTGYDSVSIEDIKQFRQWESKTPGHPENFMTAGVEVTTG
CCCEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCHHHEECCCEEECC
PLGQGIANGVGLAIAEAHLAAKFNKPDAKIVDHYTYVILGDGCNMEGVSGEAASFAGHLG
CCCHHHHCCHHHHHHHHHHHHHCCCCCCEEEEEEEEEEEECCCCCCCCCCCHHHHHHHCC
LGKLIALYDDNHISIDGSTDVAFTEDVSKRFESYGWHVIHVKDGNTDLEAIHKAIEEAKA
CCEEEEEEECCEEEECCCCCEEEHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHH
VTDKPTMIKVTTIIGYGSPNKSNTAGVHGAALGGDEVALTRQNLGWSHDPFVVPEDVLNY
CCCCCCEEEEEEEEECCCCCCCCCCCCCEEECCCCCEEEECCCCCCCCCCCCCCHHHHHH
TRKAVERGAGYESDWNKTYADYKAKYPQEAAEFERYLSGKLADGWDKVLPSYTPEDKGLP
HHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCC
TRKHSETCLNKLAAVLPELIGGSADLTHSNLTEIKGKGDFQKGQYQNPNIHFGVREHGMG
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCCCCCCCCEEEEEHHCCCC
AICNGIALHGSGLIPYGATFLIFSDYMRAPIRLSALSQAGSIWVMTHDSIGQGEDGPTHQ
HHHCCEEEECCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCEEEEECCCCCCCCCCCCCC
PIETLASLRAIPNLTVIRPADGNETSGAYKVAIERAKNNAPTLLAFTRQNVPNLAGTSID
HHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEEECCCCCCEEEEEECCCCCCCCCCCHH
DVAKGGYIVVDTDGTPDLILIGTGSELSLCVTAAEKLKAEGKKVRVVSLAAWDLFDAQDA
HHHCCCEEEEECCCCCCEEEEECCCCCEEEHHHHHHHHCCCCEEEEEEEEEECCCCCCHH
AYKESVLPKAVTKRLAVEAASSFGWHKYIGSEGDAVTIDRFGASAPGGVCLEKFGFSVDN
HHHHHCCHHHHHHHHHHHHHHCCCHHHHCCCCCCEEEEECCCCCCCCCHHHHHHCCCHHH
VLAKAKQLLG
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11759840