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The map label for this gene is fabF [H]

Identifier: 17230835

GI number: 17230835

Start: 4038834

End: 4040084

Strand: Direct

Name: fabF [H]

Synonym: alr3343

Alternate gene names: 17230835

Gene position: 4038834-4040084 (Clockwise)

Preceding gene: 17230834

Following gene: 17230836

Centisome position: 62.97

GC content: 49.88

Gene sequence:

>1251_bases
ATGACAGATTATAATCGTAAACGCGTTGTTGTCACGGGTGTTGGCGCGATTACACCTATTGGTAACACAGCCTCTGAATA
TTGGGAAGGATTGTTAAGCGGACGCAATGGCATTGACTACATCACCCACTTTGATGCGTCTAGCCATGATTGTCGGATTG
CTGGTGAAGTGAAAAACTTCGACCCCCATGAGTACTTGGAGCGCAAAGAAGCCAAGCGCATGGATCGGTTTTCCCAATTT
GCAGTTGCAGCAGCCAAACAAGCACTTGTGGATTCCCAGTTAGTCATTAATGAACTGAACGCCGAACAAGTGGGGGTTAT
TATTGGTTCTGGGGTAGGCGGACTCAAGGTCATGGAAGACCAGCAAACCATCTATCTCAACCGGGGGCCTGATCGCTGTA
GTCCCTTCATGATTCCCATGATGATCGCCAACATGGCGGCTGGACTGACAGCAATTCACACTGGTGCCAAAGGGCCAAAT
AACTGTACTGTCACCGCTTGCGCCGCAGGCTCTAATGCGATCGGCGACGCTTTCCGCCTAGTCCAAGGTGGTTATGCCCA
AGCCATGATTTGTGGTGGGGCTGAGGCAGCAATTACACCATTAGGTGTGGCTGGGTTTGCGGCTGCAAGGGCGTTATCAA
CTCGCAATGATGACCCAGCTCATGCTTGTCGTCCCTTTGACCGCGATCGCGATGGATTTGTCATGGGTGAAGGTGCGGGA
ATTCTCATTCTGGAAGAGCTGCAACACGCCATAAGTCGCGGCGCTCGCATTTATGCCGAAATCGTTGGTTATGGTATGAC
TTGCGATGCCTACCACATGACATCCCCAGTCCCTGGCGGCGAAGGAGCCTCCAGAGCCATCCAACTGGCACTCAAAGACG
CAAACATCACCCCAGAACAAGTTAGCTACATTAATGCTCACGGTACCAGCACCTCAGCAAACGATACCACCGAAACCGCA
GCGATTAAACGAGCGCTAGGAGACCATGCTTATAAAATAGCAGTCAGCTCCACCAAATCGATGACAGGTCATCTTTTGGG
TGGTTCTGGCGGTATTGAAGCTGTAGCCACAGTGTTGGCAACTGCTCATGACCAAATTCCACCTACAATTAATATTGAAA
ACCTTGACCCAGATTGTGACCTAGATTACGTGCCTGACTCTAGTCGCGCTCACAAAGTCCAGGTAGCATTGTCTAATTCT
TTTGGATTTGGTGGTCATAATGTCACACTAGCTTTCAAAAAGTACGTGTGA

Upstream 100 bases:

>100_bases
CAGGGCAAGCCTGCCCTTCGCCTTCTGCCCCTTGCCTCTTCCTCATCCCTAGTCTTTAGTCCCTAATTTTTGCAGCTTTC
TCGCCACCTTTAACTGAGTC

Downstream 100 bases:

>100_bases
AAAAGCCAAGAGGTAGGGAGAGAAACTTTTAAATTTATATCTCCCCACTCTCCACTTGTCGGCTCTCCTGAAATCAACCA
GCTAAAAGTATCATAGATAT

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MTDYNRKRVVVTGVGAITPIGNTASEYWEGLLSGRNGIDYITHFDASSHDCRIAGEVKNFDPHEYLERKEAKRMDRFSQF
AVAAAKQALVDSQLVINELNAEQVGVIIGSGVGGLKVMEDQQTIYLNRGPDRCSPFMIPMMIANMAAGLTAIHTGAKGPN
NCTVTACAAGSNAIGDAFRLVQGGYAQAMICGGAEAAITPLGVAGFAAARALSTRNDDPAHACRPFDRDRDGFVMGEGAG
ILILEELQHAISRGARIYAEIVGYGMTCDAYHMTSPVPGGEGASRAIQLALKDANITPEQVSYINAHGTSTSANDTTETA
AIKRALGDHAYKIAVSSTKSMTGHLLGGSGGIEAVATVLATAHDQIPPTINIENLDPDCDLDYVPDSSRAHKVQVALSNS
FGFGGHNVTLAFKKYV

Sequences:

>Translated_416_residues
MTDYNRKRVVVTGVGAITPIGNTASEYWEGLLSGRNGIDYITHFDASSHDCRIAGEVKNFDPHEYLERKEAKRMDRFSQF
AVAAAKQALVDSQLVINELNAEQVGVIIGSGVGGLKVMEDQQTIYLNRGPDRCSPFMIPMMIANMAAGLTAIHTGAKGPN
NCTVTACAAGSNAIGDAFRLVQGGYAQAMICGGAEAAITPLGVAGFAAARALSTRNDDPAHACRPFDRDRDGFVMGEGAG
ILILEELQHAISRGARIYAEIVGYGMTCDAYHMTSPVPGGEGASRAIQLALKDANITPEQVSYINAHGTSTSANDTTETA
AIKRALGDHAYKIAVSSTKSMTGHLLGGSGGIEAVATVLATAHDQIPPTINIENLDPDCDLDYVPDSSRAHKVQVALSNS
FGFGGHNVTLAFKKYV
>Mature_415_residues
TDYNRKRVVVTGVGAITPIGNTASEYWEGLLSGRNGIDYITHFDASSHDCRIAGEVKNFDPHEYLERKEAKRMDRFSQFA
VAAAKQALVDSQLVINELNAEQVGVIIGSGVGGLKVMEDQQTIYLNRGPDRCSPFMIPMMIANMAAGLTAIHTGAKGPNN
CTVTACAAGSNAIGDAFRLVQGGYAQAMICGGAEAAITPLGVAGFAAARALSTRNDDPAHACRPFDRDRDGFVMGEGAGI
LILEELQHAISRGARIYAEIVGYGMTCDAYHMTSPVPGGEGASRAIQLALKDANITPEQVSYINAHGTSTSANDTTETAA
IKRALGDHAYKIAVSSTKSMTGHLLGGSGGIEAVATVLATAHDQIPPTINIENLDPDCDLDYVPDSSRAHKVQVALSNSF
GFGGHNVTLAFKKYV

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=415, Percent_Identity=45.3012048192771, Blast_Score=361, Evalue=1e-100,
Organism=Homo sapiens, GI223972627, Length=174, Percent_Identity=47.7011494252874, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI41872631, Length=426, Percent_Identity=26.2910798122066, Blast_Score=113, Evalue=4e-25,
Organism=Escherichia coli, GI1787337, Length=411, Percent_Identity=51.338199513382, Blast_Score=401, Evalue=1e-113,
Organism=Escherichia coli, GI1788663, Length=411, Percent_Identity=36.9829683698297, Blast_Score=232, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI71983541, Length=415, Percent_Identity=34.6987951807229, Blast_Score=251, Evalue=5e-67,
Organism=Caenorhabditis elegans, GI71983535, Length=264, Percent_Identity=39.0151515151515, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI212642053, Length=358, Percent_Identity=25.1396648044693, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17550940, Length=285, Percent_Identity=24.5614035087719, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320904, Length=443, Percent_Identity=35.4401805869075, Blast_Score=272, Evalue=9e-74,
Organism=Drosophila melanogaster, GI24644341, Length=427, Percent_Identity=45.4332552693208, Blast_Score=358, Evalue=3e-99,
Organism=Drosophila melanogaster, GI221330659, Length=429, Percent_Identity=24.009324009324, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI19920632, Length=429, Percent_Identity=24.009324009324, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24581345, Length=427, Percent_Identity=21.7798594847775, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43907; Mature: 43776

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDYNRKRVVVTGVGAITPIGNTASEYWEGLLSGRNGIDYITHFDASSHDCRIAGEVKNF
CCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCEEEECCCCCCCEEEECCCCCC
DPHEYLERKEAKRMDRFSQFAVAAAKQALVDSQLVINELNAEQVGVIIGSGVGGLKVMED
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEC
QQTIYLNRGPDRCSPFMIPMMIANMAAGLTAIHTGAKGPNNCTVTACAAGSNAIGDAFRL
CEEEEEECCCCCCCCHHHHHHHHHHHHCHHEEECCCCCCCCCEEEEECCCCCHHHHHHHH
VQGGYAQAMICGGAEAAITPLGVAGFAAARALSTRNDDPAHACRPFDRDRDGFVMGEGAG
HCCCCEEEEEECCCCHHCCCCCHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCEEEECCCC
ILILEELQHAISRGARIYAEIVGYGMTCDAYHMTSPVPGGEGASRAIQLALKDANITPEQ
EEEHHHHHHHHHCCCEEEEHHHCCCCCCCCEECCCCCCCCCCCCCEEEEEEECCCCCHHH
VSYINAHGTSTSANDTTETAAIKRALGDHAYKIAVSSTKSMTGHLLGGSGGIEAVATVLA
HEEEECCCCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCCCHHHHHHHHH
TAHDQIPPTINIENLDPDCDLDYVPDSSRAHKVQVALSNSFGFGGHNVTLAFKKYV
HHHCCCCCEEEECCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEEECC
>Mature Secondary Structure 
TDYNRKRVVVTGVGAITPIGNTASEYWEGLLSGRNGIDYITHFDASSHDCRIAGEVKNF
CCCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCEEEECCCCCCCEEEECCCCCC
DPHEYLERKEAKRMDRFSQFAVAAAKQALVDSQLVINELNAEQVGVIIGSGVGGLKVMED
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEC
QQTIYLNRGPDRCSPFMIPMMIANMAAGLTAIHTGAKGPNNCTVTACAAGSNAIGDAFRL
CEEEEEECCCCCCCCHHHHHHHHHHHHCHHEEECCCCCCCCCEEEEECCCCCHHHHHHHH
VQGGYAQAMICGGAEAAITPLGVAGFAAARALSTRNDDPAHACRPFDRDRDGFVMGEGAG
HCCCCEEEEEECCCCHHCCCCCHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCEEEECCCC
ILILEELQHAISRGARIYAEIVGYGMTCDAYHMTSPVPGGEGASRAIQLALKDANITPEQ
EEEHHHHHHHHHCCCEEEEHHHCCCCCCCCEECCCCCCCCCCCCCEEEEEEECCCCCHHH
VSYINAHGTSTSANDTTETAAIKRALGDHAYKIAVSSTKSMTGHLLGGSGGIEAVATVLA
HEEEECCCCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCCCHHHHHHHHH
TAHDQIPPTINIENLDPDCDLDYVPDSSRAHKVQVALSNSFGFGGHNVTLAFKKYV
HHHCCCCCEEEECCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231; 11152607 [H]