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The map label for this gene is fabL [H]

Identifier: 17230744

GI number: 17230744

Start: 3926771

End: 3927790

Strand: Direct

Name: fabL [H]

Synonym: alr3252

Alternate gene names: 17230744

Gene position: 3926771-3927790 (Clockwise)

Preceding gene: 17230743

Following gene: 17230750

Centisome position: 61.22

GC content: 45.88

Gene sequence:

>1020_bases
GTGAGGCAGTTAACAGTCAACCGTCAACAAACAATTATGAAACTCCTAGAGGGGAAAGTGGCGTTAGTTACCGGCGCTAC
ACGCGGTCTTGGTAAGGGAATTGCGATAGGACTTGGTGAAGCCGGCGCAATTGTCTACATTACCGGACGTAGGCTGGATA
ATAACTCAACTTCTGGCAACGATGTCTCAGGCAGTCTTAATGAGACTAAAATAGCCGTTGAAGAAGCTGGTGGTATATGT
ATTCCTGTACAAGTAGACCACAGTAACGATGAACAGGTGCGTTTACTCTTTGAACGTATCCAAAATGAACAAAATGGACA
GCTTGACTTATTAGTTAACAATGCTTACGCCGGAGTGCAAGCATTAACCAATGCCCAGGGAAAACCCTTTTGGGAGAATG
AGCCTAGCCTTTGGGATGCTTGTAACAATGTGGGATTGCGGAGCCACTATATAGCCAGTGTTTATGCTGCCCAAATGATG
TCCAAACGACAGCAGGGATTGATTTGTACAATTTCCTCTTGGGGTGGGATGGCTTATCTATTCGGTGCAGCTTATGGCGC
AGGTAAGGCAGGATGCGATCGCCTAGCAGCTGATATGGCTGTAGAATTACAACCCTATAATGTAGCTTCCCTTTCCATCT
GGCCAGGCATTGTTGGCACTGAACTCTTCTCCCGCCTCGCCTCAGAAATGAGCGACAATCACACAGATAACGGCAAAAAT
TCGGCGATCGCCGAGCGTTACAATTGGGAAACTCCCCTACTCACAGGTAGAGTCATAGCTAAACTCGCTGCTGAGACAAA
TGTCATCAATCGTACAGGACGCGTCCAAGTTGTTGCGGAACTAGCTAAACAATACAGTCTTGTGGATCAAGAAGGCAATT
TACCTGTATCACTGCGCTCTCTCCGTTTTCTCATACCCTTGGCACTACCCACATTGAGAAAGCATTCCTGGCTTATACCC
GATATTAAAGTACCTTGGTCAATACTATTACTAAGTATCCTCAAATCACCGAAGATTTAA

Upstream 100 bases:

>100_bases
TTTTAGACGGCGAAGACATGACCTCTTGGCTATACTTCCAAAAGCACTTTCAGGCTTACCTAGCAGGTGAAATCTTTCCC
CTCCCCGCAGATGAAGAAGT

Downstream 100 bases:

>100_bases
ATCTATTGACTATTGAGCTTTAGTCATTAGCCGAACTTGATATTACGTCTCCAACCTCAAAAACTTGCCCCGCCACCGTC
ACGCGATCGCTTGATACTAA

Product: hypothetical protein

Products: NA

Alternate protein names: Enoyl-acyl carrier protein reductase III; NADPH-dependent enoyl-ACP reductase [H]

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MRQLTVNRQQTIMKLLEGKVALVTGATRGLGKGIAIGLGEAGAIVYITGRRLDNNSTSGNDVSGSLNETKIAVEEAGGIC
IPVQVDHSNDEQVRLLFERIQNEQNGQLDLLVNNAYAGVQALTNAQGKPFWENEPSLWDACNNVGLRSHYIASVYAAQMM
SKRQQGLICTISSWGGMAYLFGAAYGAGKAGCDRLAADMAVELQPYNVASLSIWPGIVGTELFSRLASEMSDNHTDNGKN
SAIAERYNWETPLLTGRVIAKLAAETNVINRTGRVQVVAELAKQYSLVDQEGNLPVSLRSLRFLIPLALPTLRKHSWLIP
DIKVPWSILLLSILKSPKI

Sequences:

>Translated_339_residues
MRQLTVNRQQTIMKLLEGKVALVTGATRGLGKGIAIGLGEAGAIVYITGRRLDNNSTSGNDVSGSLNETKIAVEEAGGIC
IPVQVDHSNDEQVRLLFERIQNEQNGQLDLLVNNAYAGVQALTNAQGKPFWENEPSLWDACNNVGLRSHYIASVYAAQMM
SKRQQGLICTISSWGGMAYLFGAAYGAGKAGCDRLAADMAVELQPYNVASLSIWPGIVGTELFSRLASEMSDNHTDNGKN
SAIAERYNWETPLLTGRVIAKLAAETNVINRTGRVQVVAELAKQYSLVDQEGNLPVSLRSLRFLIPLALPTLRKHSWLIP
DIKVPWSILLLSILKSPKI
>Mature_339_residues
MRQLTVNRQQTIMKLLEGKVALVTGATRGLGKGIAIGLGEAGAIVYITGRRLDNNSTSGNDVSGSLNETKIAVEEAGGIC
IPVQVDHSNDEQVRLLFERIQNEQNGQLDLLVNNAYAGVQALTNAQGKPFWENEPSLWDACNNVGLRSHYIASVYAAQMM
SKRQQGLICTISSWGGMAYLFGAAYGAGKAGCDRLAADMAVELQPYNVASLSIWPGIVGTELFSRLASEMSDNHTDNGKN
SAIAERYNWETPLLTGRVIAKLAAETNVINRTGRVQVVAELAKQYSLVDQEGNLPVSLRSLRFLIPLALPTLRKHSWLIP
DIKVPWSILLLSILKSPKI

Specific function: Catalyzes A Reversible Reduction Of 5-Ketoglutanate To Form D-Gluconate. Dependent On Nadp, Almost Inactive With NAD. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI209862901, Length=283, Percent_Identity=44.8763250883392, Blast_Score=236, Evalue=2e-62,
Organism=Homo sapiens, GI19923983, Length=283, Percent_Identity=44.8763250883392, Blast_Score=236, Evalue=2e-62,
Organism=Homo sapiens, GI4503817, Length=258, Percent_Identity=28.6821705426357, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1790717, Length=220, Percent_Identity=28.1818181818182, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17555612, Length=290, Percent_Identity=46.2068965517241, Blast_Score=262, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI71997099, Length=320, Percent_Identity=42.1875, Blast_Score=245, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI86565303, Length=322, Percent_Identity=37.2670807453416, Blast_Score=205, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17560220, Length=217, Percent_Identity=30.4147465437788, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17562910, Length=226, Percent_Identity=28.3185840707965, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17562906, Length=220, Percent_Identity=30.4545454545455, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17562908, Length=218, Percent_Identity=27.5229357798165, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI193204405, Length=222, Percent_Identity=30.6306306306306, Blast_Score=68, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17558628, Length=204, Percent_Identity=26.4705882352941, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17544670, Length=223, Percent_Identity=25.1121076233184, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322067, Length=206, Percent_Identity=26.6990291262136, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21357041, Length=216, Percent_Identity=29.6296296296296, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21355319, Length=223, Percent_Identity=29.1479820627803, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI28571526, Length=215, Percent_Identity=27.906976744186, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21357673, Length=203, Percent_Identity=26.6009852216749, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.10 [H]

Molecular weight: Translated: 36844; Mature: 36844

Theoretical pI: Translated: 8.30; Mature: 8.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQLTVNRQQTIMKLLEGKVALVTGATRGLGKGIAIGLGEAGAIVYITGRRLDNNSTSGN
CCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCEEEEECCCCEEEEEECCEECCCCCCCC
DVSGSLNETKIAVEEAGGICIPVQVDHSNDEQVRLLFERIQNEQNGQLDLLVNNAYAGVQ
CCCCCCCHHEEEEECCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCEEEEEEECCHHHHH
ALTNAQGKPFWENEPSLWDACNNVGLRSHYIASVYAAQMMSKRQQGLICTISSWGGMAYL
HHHCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHH
FGAAYGAGKAGCDRLAADMAVELQPYNVASLSIWPGIVGTELFSRLASEMSDNHTDNGKN
HHHHCCCCHHHHHHHHHHHEEEECCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCC
SAIAERYNWETPLLTGRVIAKLAAETNVINRTGRVQVVAELAKQYSLVDQEGNLPVSLRS
CHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEEHHH
LRFLIPLALPTLRKHSWLIPDIKVPWSILLLSILKSPKI
HHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MRQLTVNRQQTIMKLLEGKVALVTGATRGLGKGIAIGLGEAGAIVYITGRRLDNNSTSGN
CCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCEEEEECCCCEEEEEECCEECCCCCCCC
DVSGSLNETKIAVEEAGGICIPVQVDHSNDEQVRLLFERIQNEQNGQLDLLVNNAYAGVQ
CCCCCCCHHEEEEECCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCEEEEEEECCHHHHH
ALTNAQGKPFWENEPSLWDACNNVGLRSHYIASVYAAQMMSKRQQGLICTISSWGGMAYL
HHHCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHH
FGAAYGAGKAGCDRLAADMAVELQPYNVASLSIWPGIVGTELFSRLASEMSDNHTDNGKN
HHHHCCCCHHHHHHHHHHHEEEECCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCC
SAIAERYNWETPLLTGRVIAKLAAETNVINRTGRVQVVAELAKQYSLVDQEGNLPVSLRS
CHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEEHHH
LRFLIPLALPTLRKHSWLIPDIKVPWSILLLSILKSPKI
HHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8946165; 9202460; 9384377 [H]