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The map label for this gene is trpC [H]

Identifier: 17230727

GI number: 17230727

Start: 3907782

End: 3908627

Strand: Direct

Name: trpC [H]

Synonym: alr3235

Alternate gene names: 17230727

Gene position: 3907782-3908627 (Clockwise)

Preceding gene: 17230726

Following gene: 17230730

Centisome position: 60.93

GC content: 41.49

Gene sequence:

>846_bases
ATGATGTTGTACCCTAGCGCCATTAATACCAACCGTCTGCAACCAATTATTAGAGAAATTGTTTGGCAGAAAAAGCAAGA
AGTTGCACAACTACACCAACAGATGTCATTGGCTTCTTTACAACGCCAATTAACTGCTGCGCCAACCGTGCGGGATTTCT
TGACAGCTTTGCAGCAAAATCCTTACCAACCTAGCCTGATTGCAGAAATACAAAAAGCCTCACCCAATCATGGCATGATT
CGCGCTGATTTTGATCCAGTAGCGATCGCCAAAGCTTATGAACGAGGTGGTGCAGCTTGTCTATCAGTAGTGACAGATAG
CTCATTTTTTCATGGTAGTTTTGAAATTCTCCGTGCTATCCGCCAACGGGTTCCACTACCCATATTATGCAAAGAATTTA
TTATCGACCCCTGCCAAATTTATTTAGCACGAGCAGCAGGAGCCGATGCAGTACTATTAATTGCAGCCATTCTCACAGAC
AGAGAACTAAAAGATTTTTTGCGAATAATTCACTTTTTGGGAATGAATGCCTTAGTCGCAGTTCATAGTTTAGCTGAACT
AGATAGGATACTTAAATTAGACGATGTTCGCTTAATCGAAATTAATAACCAAAGCCTGCAAGATTTTACCACAGATATCA
GTACCACCCAAAACTTATTAACAGCCAGGCGATCGCATCTACAAAACTTGGGTATCACCGTCGTCAGCGAATCTGGATTG
TATACACACACAGATTTATCCTTAGTAGCGGAAGCTGGCGCAAATGCAGTGATAGTTGGAGAATCTTTAATTAAAGAACA
AGATATCGAGCAGGCTGTACGTTACCTGCTTACAGGGGATAAATAA

Upstream 100 bases:

>100_bases
AGTAAATATTGGATATAAGAACATAGGGAATAATGGCCCCCACACCCCTATACCCTTATACCCTTTCTTAATTATCCCCT
CTCCAGATTCGTAGCAGGTT

Downstream 100 bases:

>100_bases
TATCATGTCCAGTTGAAACTAGAGAAAAACTTCTGGTAGTTATCAGGAAATAGCTGAGAACAAATTGTAGTATCAACTAC
TTATCTCAGCGAAACCCTGA

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MMLYPSAINTNRLQPIIREIVWQKKQEVAQLHQQMSLASLQRQLTAAPTVRDFLTALQQNPYQPSLIAEIQKASPNHGMI
RADFDPVAIAKAYERGGAACLSVVTDSSFFHGSFEILRAIRQRVPLPILCKEFIIDPCQIYLARAAGADAVLLIAAILTD
RELKDFLRIIHFLGMNALVAVHSLAELDRILKLDDVRLIEINNQSLQDFTTDISTTQNLLTARRSHLQNLGITVVSESGL
YTHTDLSLVAEAGANAVIVGESLIKEQDIEQAVRYLLTGDK

Sequences:

>Translated_281_residues
MMLYPSAINTNRLQPIIREIVWQKKQEVAQLHQQMSLASLQRQLTAAPTVRDFLTALQQNPYQPSLIAEIQKASPNHGMI
RADFDPVAIAKAYERGGAACLSVVTDSSFFHGSFEILRAIRQRVPLPILCKEFIIDPCQIYLARAAGADAVLLIAAILTD
RELKDFLRIIHFLGMNALVAVHSLAELDRILKLDDVRLIEINNQSLQDFTTDISTTQNLLTARRSHLQNLGITVVSESGL
YTHTDLSLVAEAGANAVIVGESLIKEQDIEQAVRYLLTGDK
>Mature_281_residues
MMLYPSAINTNRLQPIIREIVWQKKQEVAQLHQQMSLASLQRQLTAAPTVRDFLTALQQNPYQPSLIAEIQKASPNHGMI
RADFDPVAIAKAYERGGAACLSVVTDSSFFHGSFEILRAIRQRVPLPILCKEFIIDPCQIYLARAAGADAVLLIAAILTD
RELKDFLRIIHFLGMNALVAVHSLAELDRILKLDDVRLIEINNQSLQDFTTDISTTQNLLTARRSHLQNLGITVVSESGL
YTHTDLSLVAEAGANAVIVGESLIKEQDIEQAVRYLLTGDK

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=269, Percent_Identity=37.9182156133829, Blast_Score=165, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6322638, Length=241, Percent_Identity=32.7800829875519, Blast_Score=118, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 31209; Mature: 31209

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMLYPSAINTNRLQPIIREIVWQKKQEVAQLHQQMSLASLQRQLTAAPTVRDFLTALQQN
CEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCC
PYQPSLIAEIQKASPNHGMIRADFDPVAIAKAYERGGAACLSVVTDSSFFHGSFEILRAI
CCCCHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHH
RQRVPLPILCKEFIIDPCQIYLARAAGADAVLLIAAILTDRELKDFLRIIHFLGMNALVA
HHHCCCCHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHCHHHHHH
VHSLAELDRILKLDDVRLIEINNQSLQDFTTDISTTQNLLTARRSHLQNLGITVVSESGL
HHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCC
YTHTDLSLVAEAGANAVIVGESLIKEQDIEQAVRYLLTGDK
EEECHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MMLYPSAINTNRLQPIIREIVWQKKQEVAQLHQQMSLASLQRQLTAAPTVRDFLTALQQN
CEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCC
PYQPSLIAEIQKASPNHGMIRADFDPVAIAKAYERGGAACLSVVTDSSFFHGSFEILRAI
CCCCHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHH
RQRVPLPILCKEFIIDPCQIYLARAAGADAVLLIAAILTDRELKDFLRIIHFLGMNALVA
HHHCCCCHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHCHHHHHH
VHSLAELDRILKLDDVRLIEINNQSLQDFTTDISTTQNLLTARRSHLQNLGITVVSESGL
HHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCC
YTHTDLSLVAEAGANAVIVGESLIKEQDIEQAVRYLLTGDK
EEECHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA