Click here to switch to the map view.

The map label for this gene is lpxD [H]

Identifier: 17230566

GI number: 17230566

Start: 3724431

End: 3725480

Strand: Direct

Name: lpxD [H]

Synonym: alr3074

Alternate gene names: 17230566

Gene position: 3724431-3725480 (Clockwise)

Preceding gene: 17230565

Following gene: 17230569

Centisome position: 58.07

GC content: 44.19

Gene sequence:

>1050_bases
ATGAAATTTAGCGACATCATATCAAAGCTAGAGGTTACAAACCATAGCCTCACTCAAAACCCAAACAATGACCCTGAAAT
TACAGGGATGGCAGCTATTGATGAAGCCACAAGTGCTAATCTCAGCTATATAGAGGGTGCAAAGTTTGCATCTTTTATCG
CTCAGACAAATGCTAGTGCTTTGATTTTGCCACAAAATGAAGCGATGCAGGCTCAAGCTCAAGCGCGGGGTATTGTTTGG
ATGACGACACCAGAACCGCGATTGTTGTTTGCTAAAGCGATCGCTCTATTCTACCAACCATACACCCCAACCCCAGAAAT
TCATCCCACAGCCGTCATTCACCCCACAGCCAAAATTGGTAATGATGTTTACATCGGCCCCCATGTCGTGATTCAACCAG
GGGTAGAAATTGGTAACGGTGTAATTATTCACCCCAATGTAGTCATTTACCCTTATGTAAAAATAGGCGATCGCTCCATC
TTACACGCTAACTGTACCATCGAAGAACGCAGCCAAATTGGTGCAGATTGCATTATTCACAGTGGCGCTGTCATCGGCGG
AGAAGGCTTTGGTTTTGTTCCTACCCGGACTGGTTGGTACAAAATGGAACAATCAGGCTATGTAGTTTTAGAAGATCGCG
TAGATATAGGTTGTAACACTACCATTGATCGGCCTTCAGTGGGAGAAACTAGAGTGGGATACGATACCAAAATTGATAAC
TTAGTTCAGATTGCTCATGGTTGCCAGATTGGTGCAGGATGTGCGATCGCTGCCCAAACTGGTATGGCTGGAGGTGTAAA
ATTAGGCAAACGCGTGATTTTGGCAGGACAAGTAGGAATTGCAAATCAAGCGAAAATGGGTGACGGCTCGACTGCTTCTG
CTCAAACAGGTATTCTCCACGATGTTAAACCAGGGGAAGTTGTCTCTGGTACTCCGGCAATTCCTCACAAAATTTATCTT
AAAATAGGTGCTATTTACAGCCGCTTACCAGAGATGTACCAAGCTTTTAGACAATTACAACGTCAATCAGACAAGGAAAG
TAAAAGGTAA

Upstream 100 bases:

>100_bases
GTAAGCAGATGAAAAATCTCCAAGTACAGCCGTAGTGAAACTGATAAACTAGCAAGTTATCAACCATCAGCAACGGTAAC
TTTTTAGTAGTTAGCTCAAC

Downstream 100 bases:

>100_bases
TTAATTTGGTAATTGGTAGTTGGTAGTTGGTAATGGGTGATTGGTAATTGGTAATTGAGAGGGAAGTGTTACCTATTAGC
TATTACCTATTACCAGCACT

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MKFSDIISKLEVTNHSLTQNPNNDPEITGMAAIDEATSANLSYIEGAKFASFIAQTNASALILPQNEAMQAQAQARGIVW
MTTPEPRLLFAKAIALFYQPYTPTPEIHPTAVIHPTAKIGNDVYIGPHVVIQPGVEIGNGVIIHPNVVIYPYVKIGDRSI
LHANCTIEERSQIGADCIIHSGAVIGGEGFGFVPTRTGWYKMEQSGYVVLEDRVDIGCNTTIDRPSVGETRVGYDTKIDN
LVQIAHGCQIGAGCAIAAQTGMAGGVKLGKRVILAGQVGIANQAKMGDGSTASAQTGILHDVKPGEVVSGTPAIPHKIYL
KIGAIYSRLPEMYQAFRQLQRQSDKESKR

Sequences:

>Translated_349_residues
MKFSDIISKLEVTNHSLTQNPNNDPEITGMAAIDEATSANLSYIEGAKFASFIAQTNASALILPQNEAMQAQAQARGIVW
MTTPEPRLLFAKAIALFYQPYTPTPEIHPTAVIHPTAKIGNDVYIGPHVVIQPGVEIGNGVIIHPNVVIYPYVKIGDRSI
LHANCTIEERSQIGADCIIHSGAVIGGEGFGFVPTRTGWYKMEQSGYVVLEDRVDIGCNTTIDRPSVGETRVGYDTKIDN
LVQIAHGCQIGAGCAIAAQTGMAGGVKLGKRVILAGQVGIANQAKMGDGSTASAQTGILHDVKPGEVVSGTPAIPHKIYL
KIGAIYSRLPEMYQAFRQLQRQSDKESKR
>Mature_349_residues
MKFSDIISKLEVTNHSLTQNPNNDPEITGMAAIDEATSANLSYIEGAKFASFIAQTNASALILPQNEAMQAQAQARGIVW
MTTPEPRLLFAKAIALFYQPYTPTPEIHPTAVIHPTAKIGNDVYIGPHVVIQPGVEIGNGVIIHPNVVIYPYVKIGDRSI
LHANCTIEERSQIGADCIIHSGAVIGGEGFGFVPTRTGWYKMEQSGYVVLEDRVDIGCNTTIDRPSVGETRVGYDTKIDN
LVQIAHGCQIGAGCAIAAQTGMAGGVKLGKRVILAGQVGIANQAKMGDGSTASAQTGILHDVKPGEVVSGTPAIPHKIYL
KIGAIYSRLPEMYQAFRQLQRQSDKESKR

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=348, Percent_Identity=32.4712643678161, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI1786378, Length=218, Percent_Identity=28.4403669724771, Blast_Score=76, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD [H]

EC number: 2.3.1.-

Molecular weight: Translated: 37431; Mature: 37431

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFSDIISKLEVTNHSLTQNPNNDPEITGMAAIDEATSANLSYIEGAKFASFIAQTNASA
CCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCEECCCHHHHHHHHHCCCCE
LILPQNEAMQAQAQARGIVWMTTPEPRLLFAKAIALFYQPYTPTPEIHPTAVIHPTAKIG
EEEECCHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEECHHHCC
NDVYIGPHVVIQPGVEIGNGVIIHPNVVIYPYVKIGDRSILHANCTIEERSQIGADCIIH
CEEEECCEEEEECCCCCCCEEEECCCEEEEEEEEECCCEEEEEECCCHHHHHCCCEEEEE
SGAVIGGEGFGFVPTRTGWYKMEQSGYVVLEDRVDIGCNTTIDRPSVGETRVGYDTKIDN
CCEEECCCCCCCCCCCCCEEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHH
LVQIAHGCQIGAGCAIAAQTGMAGGVKLGKRVILAGQVGIANQAKMGDGSTASAQTGILH
HHHHHHCCCCCCCEEEEECCCCCCCHHHCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEE
DVKPGEVVSGTPAIPHKIYLKIGAIYSRLPEMYQAFRQLQRQSDKESKR
CCCCCCEECCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKFSDIISKLEVTNHSLTQNPNNDPEITGMAAIDEATSANLSYIEGAKFASFIAQTNASA
CCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCEECCCHHHHHHHHHCCCCE
LILPQNEAMQAQAQARGIVWMTTPEPRLLFAKAIALFYQPYTPTPEIHPTAVIHPTAKIG
EEEECCHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEECHHHCC
NDVYIGPHVVIQPGVEIGNGVIIHPNVVIYPYVKIGDRSILHANCTIEERSQIGADCIIH
CEEEECCEEEEECCCCCCCEEEECCCEEEEEEEEECCCEEEEEECCCHHHHHCCCEEEEE
SGAVIGGEGFGFVPTRTGWYKMEQSGYVVLEDRVDIGCNTTIDRPSVGETRVGYDTKIDN
CCEEECCCCCCCCCCCCCEEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHH
LVQIAHGCQIGAGCAIAAQTGMAGGVKLGKRVILAGQVGIANQAKMGDGSTASAQTGILH
HHHHHHCCCCCCCEEEEECCCCCCCHHHCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEE
DVKPGEVVSGTPAIPHKIYLKIGAIYSRLPEMYQAFRQLQRQSDKESKR
CCCCCCEECCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA