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The map label for this gene is sdhA [H]

Identifier: 17230462

GI number: 17230462

Start: 3612905

End: 3614632

Strand: Reverse

Name: sdhA [H]

Synonym: all2970

Alternate gene names: 17230462

Gene position: 3614632-3612905 (Counterclockwise)

Preceding gene: 17230463

Following gene: 17230461

Centisome position: 56.36

GC content: 48.38

Gene sequence:

>1728_bases
ATGCTAGAGCATGATGTGATTATTGTCGGGGGTGGGCTGGCGGGATGTCGGGCGGCTGTGGAAATTGCCCGTACTGACCC
TAGTTTAAATGTGGCGGTGGTTGCCAAAACTCACCCCATTCGTTCCCACTCTGTTGCAGCTCAAGGTGGTATGGCTGCAT
CACTGAAAAATGTAGATTCTACTGATACTTGGGAAGCTCACGCTTTTGATACTGTCAAAGGTTCTGATTATTTAGCAGAC
CAAGATGCAGTGGCAATTCTGACTCAGGAAGCCCCAGATGTGGTGATAGACCTGGAACACATGGGGGTTTTATTCTCACG
TCTCCCTGATGGTCGGATTGCTCAACGGGCTTTTGGTGGACACTCCCACAACCGCACCTGTTACGCAGCTGATAAGACTG
GTCACGCCATTCTACACGAGTTGGTAAATAATTTGCGGCGTTACGGTGTGCATATTTACCAAGAGTGGTACGTGATGCGC
CTGATTTTGGAAGAAAATGAGGCGAAGGGTTTAGTCATGTACAGCCTATTAGACGGACATATTGAGGTTGTCCGGGCTAA
GGCGGTGATGTTTGCCACAGGGGGTTATGGTCGCGTTTATAACACCACCTCCAATGATTATGCGTCTACTGGAGATGGCT
TGGCAATGACAGCGATCGCCGGTTTACCTCTGGAAGATATGGAGTTTGTCCAATTCCATCCCACGGGTTTGTATCCGGTG
GGTGTCTTGATTTCCGAGGCTGTACGGGGGGAAGGGGCGTATTTAATTAATAGTGAAGGCGATCGCTTCATGGCGACCTA
TGCACCCAGTCGCATGGAACTAGCACCCCGCGATATTACCTCACGGGCGATCGCTTATGAAATTCGGGCTGGACGTGGTG
TAAATTTGGATGGTAGCCCAGGCGGCCCCTTTGTCTATCTGGATTTGCGCCACATGGGCAAAGAAAAAATCATGAGTCGC
GTTCCCTTCTGTTGGGAAGAAGCCCACCGCTTAGTCGGTGTGGATGCAGTCACTCAACCCATGCCAGTCCGTCCGACAAT
TCACTATTGTATGGGTGGTATCCCTGTAAACACTGATGGTAGAGTCCGCAGTAGTGGCGATGGCTTAGTTGAAGGGTTTT
TTGCGGCTGGTGAGACATCTTGTGTATCCGTCCACGGGGCAAATCGTCTCGGTAGTAATTCGCTATTAGAATGTGTAGTC
TATGGTAAACGAACTGGGGCGGCGATCGCTCAATATGTGCAGAAACGTAAATTACCTGCCATAGATGAACAACGTTACAT
CAAACAAGCCCAGCAAGAAATCCAAGCCCTACTGGAACAGCCGGGAGAGTACCGAATCAACCAAGTCCGCCAAGCTTTCC
AAGATGCGATGACAGATTACTGTGGCGTTTTCCGTACTCAAGAGTTAATGAGCCAAGGTTGGCAAAAAATTACAGAAATA
CAACAAAAATACAGTCAAATATACTTAGACGATAAAGGCAGTTGTTGGAATACTGAACTAGTAGAAGCTTTAGAGTTGCG
GAGTTTAATGATAGTCGGACAGACGATTTTAGCCTCTGCTTTAAATCGTCAAGAAAGTCGTGGCGCACATTTCCGCGAAG
ATTACCCACAGCGAGATGATACCAAGTTCCTGCAACACACAATGGCTTACTATTCACCCGCCGGGATTGACATTCAATAT
CGCCCAGTCACCATTACCATGTTTGAACCACAGGAGCGGAAGTATTAG

Upstream 100 bases:

>100_bases
CCCTGTCTACTGGCAGGGAATTTTTTTGTAAAAATGCAAAACTGCTGAGTGAATCACCTCTCTACAATAGAACAGCAGTG
TTTTGCAGTCGGTGGCTAAT

Downstream 100 bases:

>100_bases
ATCAACTCAGTAAATTGAGACGAGAAACGCAAAACTACGCTTCTCGTCCTACCCAAAAAAGTTGATGTGTTTTTTGTCAC
TATAATAAAATGCTTGACTT

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 575; Mature: 575

Protein sequence:

>575_residues
MLEHDVIIVGGGLAGCRAAVEIARTDPSLNVAVVAKTHPIRSHSVAAQGGMAASLKNVDSTDTWEAHAFDTVKGSDYLAD
QDAVAILTQEAPDVVIDLEHMGVLFSRLPDGRIAQRAFGGHSHNRTCYAADKTGHAILHELVNNLRRYGVHIYQEWYVMR
LILEENEAKGLVMYSLLDGHIEVVRAKAVMFATGGYGRVYNTTSNDYASTGDGLAMTAIAGLPLEDMEFVQFHPTGLYPV
GVLISEAVRGEGAYLINSEGDRFMATYAPSRMELAPRDITSRAIAYEIRAGRGVNLDGSPGGPFVYLDLRHMGKEKIMSR
VPFCWEEAHRLVGVDAVTQPMPVRPTIHYCMGGIPVNTDGRVRSSGDGLVEGFFAAGETSCVSVHGANRLGSNSLLECVV
YGKRTGAAIAQYVQKRKLPAIDEQRYIKQAQQEIQALLEQPGEYRINQVRQAFQDAMTDYCGVFRTQELMSQGWQKITEI
QQKYSQIYLDDKGSCWNTELVEALELRSLMIVGQTILASALNRQESRGAHFREDYPQRDDTKFLQHTMAYYSPAGIDIQY
RPVTITMFEPQERKY

Sequences:

>Translated_575_residues
MLEHDVIIVGGGLAGCRAAVEIARTDPSLNVAVVAKTHPIRSHSVAAQGGMAASLKNVDSTDTWEAHAFDTVKGSDYLAD
QDAVAILTQEAPDVVIDLEHMGVLFSRLPDGRIAQRAFGGHSHNRTCYAADKTGHAILHELVNNLRRYGVHIYQEWYVMR
LILEENEAKGLVMYSLLDGHIEVVRAKAVMFATGGYGRVYNTTSNDYASTGDGLAMTAIAGLPLEDMEFVQFHPTGLYPV
GVLISEAVRGEGAYLINSEGDRFMATYAPSRMELAPRDITSRAIAYEIRAGRGVNLDGSPGGPFVYLDLRHMGKEKIMSR
VPFCWEEAHRLVGVDAVTQPMPVRPTIHYCMGGIPVNTDGRVRSSGDGLVEGFFAAGETSCVSVHGANRLGSNSLLECVV
YGKRTGAAIAQYVQKRKLPAIDEQRYIKQAQQEIQALLEQPGEYRINQVRQAFQDAMTDYCGVFRTQELMSQGWQKITEI
QQKYSQIYLDDKGSCWNTELVEALELRSLMIVGQTILASALNRQESRGAHFREDYPQRDDTKFLQHTMAYYSPAGIDIQY
RPVTITMFEPQERKY
>Mature_575_residues
MLEHDVIIVGGGLAGCRAAVEIARTDPSLNVAVVAKTHPIRSHSVAAQGGMAASLKNVDSTDTWEAHAFDTVKGSDYLAD
QDAVAILTQEAPDVVIDLEHMGVLFSRLPDGRIAQRAFGGHSHNRTCYAADKTGHAILHELVNNLRRYGVHIYQEWYVMR
LILEENEAKGLVMYSLLDGHIEVVRAKAVMFATGGYGRVYNTTSNDYASTGDGLAMTAIAGLPLEDMEFVQFHPTGLYPV
GVLISEAVRGEGAYLINSEGDRFMATYAPSRMELAPRDITSRAIAYEIRAGRGVNLDGSPGGPFVYLDLRHMGKEKIMSR
VPFCWEEAHRLVGVDAVTQPMPVRPTIHYCMGGIPVNTDGRVRSSGDGLVEGFFAAGETSCVSVHGANRLGSNSLLECVV
YGKRTGAAIAQYVQKRKLPAIDEQRYIKQAQQEIQALLEQPGEYRINQVRQAFQDAMTDYCGVFRTQELMSQGWQKITEI
QQKYSQIYLDDKGSCWNTELVEALELRSLMIVGQTILASALNRQESRGAHFREDYPQRDDTKFLQHTMAYYSPAGIDIQY
RPVTITMFEPQERKY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=570, Percent_Identity=42.1052631578947, Blast_Score=448, Evalue=1e-126,
Organism=Escherichia coli, GI1786942, Length=599, Percent_Identity=41.9031719532554, Blast_Score=417, Evalue=1e-118,
Organism=Escherichia coli, GI1790597, Length=566, Percent_Identity=39.9293286219081, Blast_Score=399, Evalue=1e-112,
Organism=Escherichia coli, GI1788928, Length=553, Percent_Identity=34.5388788426763, Blast_Score=262, Evalue=5e-71,
Organism=Caenorhabditis elegans, GI17505833, Length=583, Percent_Identity=40.6518010291595, Blast_Score=435, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI17550100, Length=582, Percent_Identity=40.3780068728522, Blast_Score=433, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6322416, Length=589, Percent_Identity=43.2937181663837, Blast_Score=467, Evalue=1e-132,
Organism=Saccharomyces cerevisiae, GI6322701, Length=561, Percent_Identity=41.8894830659537, Blast_Score=458, Evalue=1e-129,
Organism=Saccharomyces cerevisiae, GI6322511, Length=481, Percent_Identity=27.6507276507277, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320788, Length=311, Percent_Identity=28.2958199356913, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI17137288, Length=551, Percent_Identity=41.7422867513612, Blast_Score=431, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24655642, Length=551, Percent_Identity=41.7422867513612, Blast_Score=431, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24655647, Length=551, Percent_Identity=41.7422867513612, Blast_Score=431, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24663005, Length=577, Percent_Identity=37.7816291161178, Blast_Score=399, Evalue=1e-111,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 63743; Mature: 63743

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEHDVIIVGGGLAGCRAAVEIARTDPSLNVAVVAKTHPIRSHSVAAQGGMAASLKNVDS
CCCCCEEEEECCCHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCHHCCCCHHHHCCCCC
TDTWEAHAFDTVKGSDYLADQDAVAILTQEAPDVVIDLEHMGVLFSRLPDGRIAQRAFGG
CCCCCCCEEECCCCCCCCCCCCCEEEEECCCCCEEEEHHHHHHHHHHCCCCHHHHHHCCC
HSHNRTCYAADKTGHAILHELVNNLRRYGVHIYQEWYVMRLILEENEAKGLVMYSLLDGH
CCCCCEEEEECCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHEEECCCCCCEEEEEEHHCH
IEVVRAKAVMFATGGYGRVYNTTSNDYASTGDGLAMTAIAGLPLEDMEFVQFHPTGLYPV
HHEEEEEEEEEEECCCCEEEECCCCCCCCCCCCEEEEHCCCCCCCCCCEEEECCCCCCHH
GVLISEAVRGEGAYLINSEGDRFMATYAPSRMELAPRDITSRAIAYEIRAGRGVNLDGSP
HHHHHHHHCCCCEEEECCCCCEEEEEECCCCCCCCCCHHHHHEEEEEEECCCCCCCCCCC
GGPFVYLDLRHMGKEKIMSRVPFCWEEAHRLVGVDAVTQPMPVRPTIHYCMGGIPVNTDG
CCCEEEEEHHHCCHHHHHHHCCHHHHHHHHEECCHHHCCCCCCCCHHHHHCCCEEECCCC
RVRSSGDGLVEGFFAAGETSCVSVHGANRLGSNSLLECVVYGKRTGAAIAQYVQKRKLPA
CEECCCCCHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCC
IDEQRYIKQAQQEIQALLEQPGEYRINQVRQAFQDAMTDYCGVFRTQELMSQGWQKITEI
CCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QQKYSQIYLDDKGSCWNTELVEALELRSLMIVGQTILASALNRQESRGAHFREDYPQRDD
HHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHCCCCCCH
TKFLQHTMAYYSPAGIDIQYRPVTITMFEPQERKY
HHHHHHHHHHCCCCCCEEEEEEEEEEEECCCCCCC
>Mature Secondary Structure
MLEHDVIIVGGGLAGCRAAVEIARTDPSLNVAVVAKTHPIRSHSVAAQGGMAASLKNVDS
CCCCCEEEEECCCHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCHHCCCCHHHHCCCCC
TDTWEAHAFDTVKGSDYLADQDAVAILTQEAPDVVIDLEHMGVLFSRLPDGRIAQRAFGG
CCCCCCCEEECCCCCCCCCCCCCEEEEECCCCCEEEEHHHHHHHHHHCCCCHHHHHHCCC
HSHNRTCYAADKTGHAILHELVNNLRRYGVHIYQEWYVMRLILEENEAKGLVMYSLLDGH
CCCCCEEEEECCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHEEECCCCCCEEEEEEHHCH
IEVVRAKAVMFATGGYGRVYNTTSNDYASTGDGLAMTAIAGLPLEDMEFVQFHPTGLYPV
HHEEEEEEEEEEECCCCEEEECCCCCCCCCCCCEEEEHCCCCCCCCCCEEEECCCCCCHH
GVLISEAVRGEGAYLINSEGDRFMATYAPSRMELAPRDITSRAIAYEIRAGRGVNLDGSP
HHHHHHHHCCCCEEEECCCCCEEEEEECCCCCCCCCCHHHHHEEEEEEECCCCCCCCCCC
GGPFVYLDLRHMGKEKIMSRVPFCWEEAHRLVGVDAVTQPMPVRPTIHYCMGGIPVNTDG
CCCEEEEEHHHCCHHHHHHHCCHHHHHHHHEECCHHHCCCCCCCCHHHHHCCCEEECCCC
RVRSSGDGLVEGFFAAGETSCVSVHGANRLGSNSLLECVVYGKRTGAAIAQYVQKRKLPA
CEECCCCCHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCC
IDEQRYIKQAQQEIQALLEQPGEYRINQVRQAFQDAMTDYCGVFRTQELMSQGWQKITEI
CCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QQKYSQIYLDDKGSCWNTELVEALELRSLMIVGQTILASALNRQESRGAHFREDYPQRDD
HHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHCCCCCCH
TKFLQHTMAYYSPAGIDIQYRPVTITMFEPQERKY
HHHHHHHHHHCCCCCCEEEEEEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA