Click here to switch to the map view.

The map label for this gene is panC [H]

Identifier: 17230428

GI number: 17230428

Start: 3573576

End: 3575180

Strand: Direct

Name: panC [H]

Synonym: alr2936

Alternate gene names: 17230428

Gene position: 3573576-3575180 (Clockwise)

Preceding gene: 17230427

Following gene: 17230429

Centisome position: 55.72

GC content: 46.29

Gene sequence:

>1605_bases
GTGCGCCTGTTGACAACAGTTGCGGCTTTACGCTGCTATTTAAATAAACGTCGCTGGGAAAGTCGGCTGACAGCATCAGA
AGAACAGATACTAGATAGTATGACTAGCTGGTATCAAACTGCGATTGGCCTGGTGCCAACAATGGGGAGTTTACATCAAG
GCCATTTGAGCCTGATTGAACGAGCGCGGCACGAAAACTCTACTGTAATTGTGAGTATTTTTATCAATCCTCTGCAATTT
GGCCCAAATGAGGATTATGGAAGGTATCCCCGCACTTTAGAACAAGACCGACAATTGTGCGAGCAAGGGGGAGTTGATGC
GATTTTTGCCCCTTCTCCGGAAGAATTAGGCATACCTCAGAAAAATATACAAGAATCTCAAGTTACACAAGTAATCCCTC
CATCTGTTATGATATCTGGCTTGTGTGGTCATTCTCGGTTAGGTCACTTTCAGGGTGTGGCGACGATTGTGACCAAGCTT
TTGAACTTGGTACAACCTGACCGAGCTTATTTCGGTCAAAAAGATGGTCAGCAGTTAGCTGTGATTAAACGGCTGGTGGC
TGATTTAGATTTGCCTGTAGAAATTGTTGCTTGTCCCACTGTGCGGGAAGCATCGGGTTTAGCCTGTAGCTCTCGCAACC
AGTATTTAACTGCTCAAGAAAAACAGCAAGCAGCAGTATTGTATCGTGGCTTGCTGCAAGCTGAGGCTGCATTTAAGGCA
GGTGTCCGCTATAGCAGTAGGTTGCGAGAAGTGGTACGGCAGGAATTAGCCAAGGTTAGTAGTGTTTTAGTGGAATATAT
AGAATTGGTTGAACCGACTACGTTAATGCCATTAGATAAAATTCAGGAGGAAGGAATGCTGGCGATCGCTGCTCGTCTTG
GCTCTACACGTTTGATTGACAATACCATTTTGCGCGATCGCCAACCTATCATCGCTATTGATGGGCCAGCCGGTGCAGGA
AAATCCACCGTGGCTCGTCAAGTAGCAACTAAACTCGGTCTAGTGTATCTAGATACAGGAGCGATGTATCGTGCTGTGAC
TTGGTTGGTGCTACAACAGGGTATTGCCATTGACGATGATTGCGCGATCGCTGAATTAGCGAGCAAGTGTAAAATCGAGC
TAACTCCTAGCCAAGATTTACAATCTCCGGTGCGTGTTTGGATTAATGATACTGATGTTACCCAGAACATTCGCACGATT
GAGGTGACTTCTCAAGTATCGGCGATCGCTGCTCAAGCTGCTGTACGTCAAGCGCTAGTGAAGCAACAACAACGCTGGGG
TAAACGCGGTGGACTGGTAGCTGAAGGTAGAGATATTGGTACTCACGTATTTCCTGACGCTGAAGTAAAAATCTTTTTAA
CCGCCTCCGTGGGTGAACGCGCTCGTCGTCGCCAGCAAGACTTTCAAAAACAAGGTCAACCAGAAGTCAGTCTAGAACAG
CTAGAAAAAGACATCGCTGAACGCGATTGGAAAGATAGCACTCGCAAAGTTTCCCCTCTACAAAAAGCAGCAGATGCAGT
TGAACTGCAAACAGATGGACTCAGCATATCGGATGTTGCTAGCCAAATTGTTGATTACTACCAACAACGCTTGTCTCAAT
GGTAG

Upstream 100 bases:

>100_bases
TACCCAACCCCCAATTCCTCTAGTTCACTCATCTCTTACCCCTATTTCAGATATAAACTAACGGGGGAGAGGTTCAATGA
GGAACTAGGGGTATTTTTTT

Downstream 100 bases:

>100_bases
TCATGGTCAACTGTTGTTAGTTTTGGATTTTTTCAACTTATTAGGGAGTAAGTGTACAACATTGACTCCCTATTTTTTAT
GCTATGGCCGTAGCCAGATA

Product: bifunctional pantoate ligase/cytidylate kinase

Products: NA

Alternate protein names: Pantoate--beta-alanine ligase; Pantoate-activating enzyme; Pantothenate synthetase; Cytidylate kinase; CK; Cytidine monophosphate kinase; CMP kinase [H]

Number of amino acids: Translated: 534; Mature: 534

Protein sequence:

>534_residues
MRLLTTVAALRCYLNKRRWESRLTASEEQILDSMTSWYQTAIGLVPTMGSLHQGHLSLIERARHENSTVIVSIFINPLQF
GPNEDYGRYPRTLEQDRQLCEQGGVDAIFAPSPEELGIPQKNIQESQVTQVIPPSVMISGLCGHSRLGHFQGVATIVTKL
LNLVQPDRAYFGQKDGQQLAVIKRLVADLDLPVEIVACPTVREASGLACSSRNQYLTAQEKQQAAVLYRGLLQAEAAFKA
GVRYSSRLREVVRQELAKVSSVLVEYIELVEPTTLMPLDKIQEEGMLAIAARLGSTRLIDNTILRDRQPIIAIDGPAGAG
KSTVARQVATKLGLVYLDTGAMYRAVTWLVLQQGIAIDDDCAIAELASKCKIELTPSQDLQSPVRVWINDTDVTQNIRTI
EVTSQVSAIAAQAAVRQALVKQQQRWGKRGGLVAEGRDIGTHVFPDAEVKIFLTASVGERARRRQQDFQKQGQPEVSLEQ
LEKDIAERDWKDSTRKVSPLQKAADAVELQTDGLSISDVASQIVDYYQQRLSQW

Sequences:

>Translated_534_residues
MRLLTTVAALRCYLNKRRWESRLTASEEQILDSMTSWYQTAIGLVPTMGSLHQGHLSLIERARHENSTVIVSIFINPLQF
GPNEDYGRYPRTLEQDRQLCEQGGVDAIFAPSPEELGIPQKNIQESQVTQVIPPSVMISGLCGHSRLGHFQGVATIVTKL
LNLVQPDRAYFGQKDGQQLAVIKRLVADLDLPVEIVACPTVREASGLACSSRNQYLTAQEKQQAAVLYRGLLQAEAAFKA
GVRYSSRLREVVRQELAKVSSVLVEYIELVEPTTLMPLDKIQEEGMLAIAARLGSTRLIDNTILRDRQPIIAIDGPAGAG
KSTVARQVATKLGLVYLDTGAMYRAVTWLVLQQGIAIDDDCAIAELASKCKIELTPSQDLQSPVRVWINDTDVTQNIRTI
EVTSQVSAIAAQAAVRQALVKQQQRWGKRGGLVAEGRDIGTHVFPDAEVKIFLTASVGERARRRQQDFQKQGQPEVSLEQ
LEKDIAERDWKDSTRKVSPLQKAADAVELQTDGLSISDVASQIVDYYQQRLSQW
>Mature_534_residues
MRLLTTVAALRCYLNKRRWESRLTASEEQILDSMTSWYQTAIGLVPTMGSLHQGHLSLIERARHENSTVIVSIFINPLQF
GPNEDYGRYPRTLEQDRQLCEQGGVDAIFAPSPEELGIPQKNIQESQVTQVIPPSVMISGLCGHSRLGHFQGVATIVTKL
LNLVQPDRAYFGQKDGQQLAVIKRLVADLDLPVEIVACPTVREASGLACSSRNQYLTAQEKQQAAVLYRGLLQAEAAFKA
GVRYSSRLREVVRQELAKVSSVLVEYIELVEPTTLMPLDKIQEEGMLAIAARLGSTRLIDNTILRDRQPIIAIDGPAGAG
KSTVARQVATKLGLVYLDTGAMYRAVTWLVLQQGIAIDDDCAIAELASKCKIELTPSQDLQSPVRVWINDTDVTQNIRTI
EVTSQVSAIAAQAAVRQALVKQQQRWGKRGGLVAEGRDIGTHVFPDAEVKIFLTASVGERARRRQQDFQKQGQPEVSLEQ
LEKDIAERDWKDSTRKVSPLQKAADAVELQTDGLSISDVASQIVDYYQQRLSQW

Specific function: Pantothenate biosynthesis; last step. [C]

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786325, Length=263, Percent_Identity=42.2053231939163, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI1787139, Length=224, Percent_Identity=40.625, Blast_Score=156, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6322046, Length=293, Percent_Identity=39.2491467576792, Blast_Score=173, Evalue=8e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004821
- InterPro:   IPR003136
- InterPro:   IPR011994
- InterPro:   IPR003721
- InterPro:   IPR014729 [H]

Pfam domain/function: PF02224 Cytidylate_kin; PF02569 Pantoate_ligase [H]

EC number: =6.3.2.1; =2.7.4.14 [H]

Molecular weight: Translated: 59177; Mature: 59177

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLTTVAALRCYLNKRRWESRLTASEEQILDSMTSWYQTAIGLVPTMGSLHQGHLSLIE
CHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
RARHENSTVIVSIFINPLQFGPNEDYGRYPRTLEQDRQLCEQGGVDAIFAPSPEELGIPQ
HHHCCCCEEEEEEEEEHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEECCCCHHCCCCH
KNIQESQVTQVIPPSVMISGLCGHSRLGHFQGVATIVTKLLNLVQPDRAYFGQKDGQQLA
HCCCHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCHHHH
VIKRLVADLDLPVEIVACPTVREASGLACSSRNQYLTAQEKQQAAVLYRGLLQAEAAFKA
HHHHHHHCCCCCEEEEECCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GVRYSSRLREVVRQELAKVSSVLVEYIELVEPTTLMPLDKIQEEGMLAIAARLGSTRLID
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCHHHHHHHHCCCHHHH
NTILRDRQPIIAIDGPAGAGKSTVARQVATKLGLVYLDTGAMYRAVTWLVLQQGIAIDDD
HHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHCEEEECCCHHHHHHHHHHHHCCCCCCCC
CAIAELASKCKIELTPSQDLQSPVRVWINDTDVTQNIRTIEVTSQVSAIAAQAAVRQALV
HHHHHHHHHCEEEECCCHHHCCCCEEEECCCHHHCCCEEEEEHHHHHHHHHHHHHHHHHH
KQQQRWGKRGGLVAEGRDIGTHVFPDAEVKIFLTASVGERARRRQQDFQKQGQPEVSLEQ
HHHHHHHHCCCEEECCCCCCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHCCCCCCHHHH
LEKDIAERDWKDSTRKVSPLQKAADAVELQTDGLSISDVASQIVDYYQQRLSQW
HHHHHHHCCCCCHHHHCCHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRLLTTVAALRCYLNKRRWESRLTASEEQILDSMTSWYQTAIGLVPTMGSLHQGHLSLIE
CHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
RARHENSTVIVSIFINPLQFGPNEDYGRYPRTLEQDRQLCEQGGVDAIFAPSPEELGIPQ
HHHCCCCEEEEEEEEEHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEECCCCHHCCCCH
KNIQESQVTQVIPPSVMISGLCGHSRLGHFQGVATIVTKLLNLVQPDRAYFGQKDGQQLA
HCCCHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCHHHH
VIKRLVADLDLPVEIVACPTVREASGLACSSRNQYLTAQEKQQAAVLYRGLLQAEAAFKA
HHHHHHHCCCCCEEEEECCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GVRYSSRLREVVRQELAKVSSVLVEYIELVEPTTLMPLDKIQEEGMLAIAARLGSTRLID
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCHHHHHHHHCCCHHHH
NTILRDRQPIIAIDGPAGAGKSTVARQVATKLGLVYLDTGAMYRAVTWLVLQQGIAIDDD
HHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHCEEEECCCHHHHHHHHHHHHCCCCCCCC
CAIAELASKCKIELTPSQDLQSPVRVWINDTDVTQNIRTIEVTSQVSAIAAQAAVRQALV
HHHHHHHHHCEEEECCCHHHCCCCEEEECCCHHHCCCEEEEEHHHHHHHHHHHHHHHHHH
KQQQRWGKRGGLVAEGRDIGTHVFPDAEVKIFLTASVGERARRRQQDFQKQGQPEVSLEQ
HHHHHHHHCCCEEECCCCCCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHCCCCCCHHHH
LEKDIAERDWKDSTRKVSPLQKAADAVELQTDGLSISDVASQIVDYYQQRLSQW
HHHHHHHCCCCCHHHHCCHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA