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The map label for this gene is rfbC [H]

Identifier: 17230322

GI number: 17230322

Start: 3446346

End: 3446915

Strand: Direct

Name: rfbC [H]

Synonym: alr2830

Alternate gene names: 17230322

Gene position: 3446346-3446915 (Clockwise)

Preceding gene: 17230321

Following gene: 17230323

Centisome position: 53.73

GC content: 39.12

Gene sequence:

>570_bases
ATGATTTTTACCGCTACATCACTCAAAGACGCATTTATTATTGATTTAGAAGAAAAACCAGATCATCGTGGTTTTTTTGC
CAGAACTTTTTGTGCTAATGAATTTGCCAATCATGGTTTAAAACCAGTAGTTGCTCAGTGTAACTTATCTTATAACTATA
AAAAAGGTACACTGCGGGGGATGCACTATCAACTCAGACCAGCCGCCGAAACAAAATTAATTCGTTGTATTAAAGGCGCT
ATCTACGATGTAATTATTGATATGCGTCCCGAATCACCGACATTTTTATCACATATTGGTGTAGAACTCACGGCTGATAA
TCGTCGCGCTTTGTATGTACCAGAGATGTTTGCTCATGGTTATCAAGCCCTCACCGATGATGCAGAAGTGGTTTATCAAG
TAGGTGAATTTTATACCCCAGGATATGAAAAAGGCCTGCGTTACAATGACCCATTCTTTAATATTGAATGGCCTTTAGAT
GTCACTGTAATTTCTGACAAGGATGCCAGTTGGCCTTTGTTAGAAACTATCCCTATCGGTAGCCCAGACCCAGTAGAAGC
AGTTTGTTAA

Upstream 100 bases:

>100_bases
ACCAAATTATAGCTAAAGTTCCTGTTTAGCTTATTCATCTTTGTAAAGACTAAGTGATTAGTCATTATTCTCCCATCATT
AATTCATAGTTGAGAAACCC

Downstream 100 bases:

>100_bases
AAAATACTGAGTTGTGAGTAAGATATTCTGCTTCTGTTGCTTGTTTTAGAAAATAAAGGATTAAGCAAAATGATTATTAT
TGATAACGCCTTAAAAGCTC

Product: dTDP-4-dehydrorhamnose 3,5-epimerase

Products: NA

Alternate protein names: Thymidine diphospho-4-keto-rhamnose 3,5-epimerase; dTDP-4-keto-6-deoxyglucose 3,5-epimerase; dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 189; Mature: 189

Protein sequence:

>189_residues
MIFTATSLKDAFIIDLEEKPDHRGFFARTFCANEFANHGLKPVVAQCNLSYNYKKGTLRGMHYQLRPAAETKLIRCIKGA
IYDVIIDMRPESPTFLSHIGVELTADNRRALYVPEMFAHGYQALTDDAEVVYQVGEFYTPGYEKGLRYNDPFFNIEWPLD
VTVISDKDASWPLLETIPIGSPDPVEAVC

Sequences:

>Translated_189_residues
MIFTATSLKDAFIIDLEEKPDHRGFFARTFCANEFANHGLKPVVAQCNLSYNYKKGTLRGMHYQLRPAAETKLIRCIKGA
IYDVIIDMRPESPTFLSHIGVELTADNRRALYVPEMFAHGYQALTDDAEVVYQVGEFYTPGYEKGLRYNDPFFNIEWPLD
VTVISDKDASWPLLETIPIGSPDPVEAVC
>Mature_189_residues
MIFTATSLKDAFIIDLEEKPDHRGFFARTFCANEFANHGLKPVVAQCNLSYNYKKGTLRGMHYQLRPAAETKLIRCIKGA
IYDVIIDMRPESPTFLSHIGVELTADNRRALYVPEMFAHGYQALTDDAEVVYQVGEFYTPGYEKGLRYNDPFFNIEWPLD
VTVISDKDASWPLLETIPIGSPDPVEAVC

Specific function: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose [H]

COG id: COG1898

COG function: function code M; dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI1788350, Length=158, Percent_Identity=36.7088607594937, Blast_Score=115, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17550412, Length=169, Percent_Identity=33.7278106508876, Blast_Score=100, Evalue=7e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR000888
- InterPro:   IPR014710
- ProDom:   PD001462 [H]

Pfam domain/function: PF00908 dTDP_sugar_isom [H]

EC number: =5.1.3.13 [H]

Molecular weight: Translated: 21417; Mature: 21417

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFTATSLKDAFIIDLEEKPDHRGFFARTFCANEFANHGLKPVVAQCNLSYNYKKGTLRG
CEEECCCCCCEEEEEECCCCCCCCEEHHHHHHHHHHHCCCCEEEEEECCEEEECCCCEEC
MHYQLRPAAETKLIRCIKGAIYDVIIDMRPESPTFLSHIGVELTADNRRALYVPEMFAHG
CEEEECCCHHHHHHHHHHHHHEEEEEECCCCCCHHHHHCCEEEEECCCEEEECCHHHHCC
YQALTDDAEVVYQVGEFYTPGYEKGLRYNDPFFNIEWPLDVTVISDKDASWPLLETIPIG
HHHHCCCHHHHHHHHHHCCCCHHCCCCCCCCEEEEECCEEEEEECCCCCCCCEEEEECCC
SPDPVEAVC
CCCCCCCCC
>Mature Secondary Structure
MIFTATSLKDAFIIDLEEKPDHRGFFARTFCANEFANHGLKPVVAQCNLSYNYKKGTLRG
CEEECCCCCCEEEEEECCCCCCCCEEHHHHHHHHHHHCCCCEEEEEECCEEEECCCCEEC
MHYQLRPAAETKLIRCIKGAIYDVIIDMRPESPTFLSHIGVELTADNRRALYVPEMFAHG
CEEEECCCHHHHHHHHHHHHHEEEEEECCCCCCHHHHHCCEEEEECCCEEEECCHHHHCC
YQALTDDAEVVYQVGEFYTPGYEKGLRYNDPFFNIEWPLDVTVISDKDASWPLLETIPIG
HHHHCCCHHHHHHHHHHCCCCHHCCCCCCCCEEEEECCEEEEEECCCCCCCCEEEEECCC
SPDPVEAVC
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8170390; 8157605; 12384590; 12704152 [H]