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The map label for this gene is aroE [C]

Identifier: 17230300

GI number: 17230300

Start: 3417568

End: 3418416

Strand: Reverse

Name: aroE [C]

Synonym: all2808

Alternate gene names: 17230300

Gene position: 3418416-3417568 (Counterclockwise)

Preceding gene: 17230302

Following gene: 17230298

Centisome position: 53.3

GC content: 42.76

Gene sequence:

>849_bases
ATGAATAATCTCAAACTGATCTCAGAATATCAAAGCTTTGGCGGTAAACTCGGCTTTTATTCTCATCCGTCTTCTACCTG
TAACGGGGAAATGCGTTTTGCTGTTTATCAGCCACCGCAAGCAGCCGAAAAACCTCTACCAGTCCTCTATTTTCTTTCTG
GTTTGACTTGTACAGAAGAAAATTTTATGGCTAAAGCTGGGGCGCAACGTTACGCGGCTGAGTATGGATTAATTTTGGTT
GCGCCAGACACTAGCCCCCGCAATACTGGAATTGCTGGTGAAGATGACGAGTGGGATTTTGGTACAGGTGCGGGTTTTTA
TGTGGATGCGACGGAAAAACCTTGGCGATCGCACTACCAAATGTATAGTTATATTGTGCAGGAATTACCTGCTTTGATTG
CGGCTAATTTCCCTATACAAGCTGAGAAACAAGGGATTTTTGGTCACTCGATGGGTGGACATGGGGCGCTGGTCTGTGCT
TTGCGTAATCCCCATATTTTTAAATCTGTGTCGGCTTTTGCACCGATTGTTACACCTATGGGCTGTCCTTGGGGTCAAAA
GGCTTTTAGTCGTTATCTCGGAAATAATCAAGCAAGCTGGCTGGCTTATGATGCTAGTGAATTAGTTAAACAGTTGGGAT
ATCACAGCCAAATTCTCATAGACCAAGGTACGTCTGATAAATTTTTAACTGAACAATTATTAACAGATGTATTTGCCCAA
GCTTGTCAAGCAGTTAACCAACCGCTTAATTTACGTTATCAAGCAGGCTATGACCACAGTTATTATTTCATTGCTAGTTT
TATAGCAGATCATATCCGTCATCATGCAACCTCTTTGGAGCGTAGCTGA

Upstream 100 bases:

>100_bases
AATATTTCCCAACCCTAACCACCTTCTTCCCACGGAACTTTCAACGATGAGCGATCGCTTCTATCCGGGTATACCTACAA
CAGATGATTTAATTAAGTAG

Downstream 100 bases:

>100_bases
GTGCTAATTTCCTACCGTTAAGGAAAGGTTTCGTAGGGTGCATCAGTGGGATAGAACCTAACTATACTTAGAAAGTATTC
ATACTGACGCACCCTACTGG

Product: S-formylglutathione hydrolase

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MNNLKLISEYQSFGGKLGFYSHPSSTCNGEMRFAVYQPPQAAEKPLPVLYFLSGLTCTEENFMAKAGAQRYAAEYGLILV
APDTSPRNTGIAGEDDEWDFGTGAGFYVDATEKPWRSHYQMYSYIVQELPALIAANFPIQAEKQGIFGHSMGGHGALVCA
LRNPHIFKSVSAFAPIVTPMGCPWGQKAFSRYLGNNQASWLAYDASELVKQLGYHSQILIDQGTSDKFLTEQLLTDVFAQ
ACQAVNQPLNLRYQAGYDHSYYFIASFIADHIRHHATSLERS

Sequences:

>Translated_282_residues
MNNLKLISEYQSFGGKLGFYSHPSSTCNGEMRFAVYQPPQAAEKPLPVLYFLSGLTCTEENFMAKAGAQRYAAEYGLILV
APDTSPRNTGIAGEDDEWDFGTGAGFYVDATEKPWRSHYQMYSYIVQELPALIAANFPIQAEKQGIFGHSMGGHGALVCA
LRNPHIFKSVSAFAPIVTPMGCPWGQKAFSRYLGNNQASWLAYDASELVKQLGYHSQILIDQGTSDKFLTEQLLTDVFAQ
ACQAVNQPLNLRYQAGYDHSYYFIASFIADHIRHHATSLERS
>Mature_282_residues
MNNLKLISEYQSFGGKLGFYSHPSSTCNGEMRFAVYQPPQAAEKPLPVLYFLSGLTCTEENFMAKAGAQRYAAEYGLILV
APDTSPRNTGIAGEDDEWDFGTGAGFYVDATEKPWRSHYQMYSYIVQELPALIAANFPIQAEKQGIFGHSMGGHGALVCA
LRNPHIFKSVSAFAPIVTPMGCPWGQKAFSRYLGNNQASWLAYDASELVKQLGYHSQILIDQGTSDKFLTEQLLTDVFAQ
ACQAVNQPLNLRYQAGYDHSYYFIASFIADHIRHHATSLERS

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=278, Percent_Identity=59.7122302158273, Blast_Score=350, Evalue=6e-97,
Organism=Escherichia coli, GI1786551, Length=276, Percent_Identity=53.2608695652174, Blast_Score=304, Evalue=4e-84,
Organism=Escherichia coli, GI1788477, Length=278, Percent_Identity=52.158273381295, Blast_Score=280, Evalue=8e-77,
Organism=Caenorhabditis elegans, GI17510185, Length=279, Percent_Identity=49.8207885304659, Blast_Score=276, Evalue=8e-75,
Organism=Saccharomyces cerevisiae, GI6322393, Length=296, Percent_Identity=40.2027027027027, Blast_Score=215, Evalue=6e-57,
Organism=Drosophila melanogaster, GI45551932, Length=285, Percent_Identity=52.6315789473684, Blast_Score=301, Evalue=3e-82,
Organism=Drosophila melanogaster, GI24648347, Length=286, Percent_Identity=52.4475524475524, Blast_Score=301, Evalue=4e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 31294; Mature: 31294

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNLKLISEYQSFGGKLGFYSHPSSTCNGEMRFAVYQPPQAAEKPLPVLYFLSGLTCTEE
CCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCHHHCCCCCHHHHHCCCCCCCH
NFMAKAGAQRYAAEYGLILVAPDTSPRNTGIAGEDDEWDFGTGAGFYVDATEKPWRSHYQ
HHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHH
MYSYIVQELPALIAANFPIQAEKQGIFGHSMGGHGALVCALRNPHIFKSVSAFAPIVTPM
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCC
GCPWGQKAFSRYLGNNQASWLAYDASELVKQLGYHSQILIDQGTSDKFLTEQLLTDVFAQ
CCCCCHHHHHHHHCCCCCEEEEECHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHH
ACQAVNQPLNLRYQAGYDHSYYFIASFIADHIRHHATSLERS
HHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNNLKLISEYQSFGGKLGFYSHPSSTCNGEMRFAVYQPPQAAEKPLPVLYFLSGLTCTEE
CCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCHHHCCCCCHHHHHCCCCCCCH
NFMAKAGAQRYAAEYGLILVAPDTSPRNTGIAGEDDEWDFGTGAGFYVDATEKPWRSHYQ
HHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHH
MYSYIVQELPALIAANFPIQAEKQGIFGHSMGGHGALVCALRNPHIFKSVSAFAPIVTPM
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCC
GCPWGQKAFSRYLGNNQASWLAYDASELVKQLGYHSQILIDQGTSDKFLTEQLLTDVFAQ
CCCCCHHHHHHHHCCCCCEEEEECHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHH
ACQAVNQPLNLRYQAGYDHSYYFIASFIADHIRHHATSLERS
HHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]