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The map label for this gene is ykcC [H]

Identifier: 17230262

GI number: 17230262

Start: 3365520

End: 3366758

Strand: Reverse

Name: ykcC [H]

Synonym: all2770

Alternate gene names: 17230262

Gene position: 3366758-3365520 (Counterclockwise)

Preceding gene: 17230264

Following gene: 17230259

Centisome position: 52.49

GC content: 42.62

Gene sequence:

>1239_bases
ATGAGTATCAATAAAACTCAGTCATTGTTGCCAGTACCCGCAGGTAATTTACAAGTTCCTGAGTTTCCACCTAGTGATTC
GGGTGTGACTGGTCAACCCATCCAGTTTTCTCTCATTATTCCTACTTATAAAGAGAGCGGGAATATTAGGAATGTCATTG
AGAGATTAAGTCAGATACTGGATGAGTTTATACCGGGAGATTATGAACTGATTGTAGTAGATGATGATAGCCCAGATGGC
ACTTGGGAGGTAGCCCTATCTTTGACGGCAGAATATCCACAGTTACGAGTGATGCGACGGCAGGAAGAAAGAGGACTATC
TACAGCCGTAATTCGTGGGTGGCAAGTAGCTAGAGGTAGCATTTTAGGGGTCATTGATGGAGATTTGCAGCATCCACCCC
ATGTATTGCTGGAACTTTTAAGTAAAATCCATAGGGGTGCAGATTTAGCTGTAGCTAGTCGTCACGTAGATGGCGGTGGT
GTAAGTAGCTGGAGTTTTATCAGACGTTTTTTGTCTCGTGGGGCGCAATTATTAGGACTAGTCATTCTACCCAGTGTATT
GGGTAGGGTTTCTGACCCGATGAGTGGTTATTTTATGGTGCGGCGCAACTGTATTACCAATGCCACCTTTAATCCGGTAG
GATACAAAATTTTATTAGAAGTGATTGGGCGAGGTAAAGTAGACGAAATTGCCGAAGCGGGTTATGTATTCTGTGAACGC
CAAGAAGGTGAGAGCAAAGTTACTTGGAAGCAGTATGTAGATTACATCCACCATTTAATTCGCTTGCGAGTCTCCACCGG
CAGATTGCAAAGGATTCATCAAAGCTTTCCCTTGGATAAATTCATCCGTTTTGGTTTGGTAGGGTTGAGTGGTGTATTTG
TAGATATGGTAATACTTTACCTACTAAGTGACCCATCAACACTAGCCTGGCCACTGACCCGCAGTAAAATTATTGCTTCA
GAAATAGCGATTTTCAACAATTTTCTCTGGAATGATGCCTGGACATTTGCCGACGTATCAATGCAGCAAAGAGGTTGGAA
TCAACGTGTGAAGCGATTTTTAAAATTTAATATTGTTTGTCTAGCCGGGGTAGTGCTGAATGTACTGATATTGAATATTA
TCTTTAATTATCTCATTCCTAACCGCTATATTGCCAACCTGATTGCGATCGCCATAGCCACTGTTTGGAACTTCTGGGTA
AACTTGCGCCTCAGTTGGCGAGTCACTCAAGTCAAATAA

Upstream 100 bases:

>100_bases
ATATTGAAGATTTCATGAAGAATATCTACTGACTCTATGTATACTTAAGCAGATACAGTTAATGTCATAAAAGAATCTTC
TACCACCTGAATTCTAATAC

Downstream 100 bases:

>100_bases
GTATAGCAATCCGATTTGATTTCTGAATCACTCGTAGAGGTAAGGGACTGGGGACTGGGGAAGGTGGGGCCCCCTCTGGG
GATAAGGGGTAATGGGGATT

Product: dolichyl-phosphate-mannose synthase

Products: GDP; dolichyl D-mannosyl phosphate

Alternate protein names: NA

Number of amino acids: Translated: 412; Mature: 411

Protein sequence:

>412_residues
MSINKTQSLLPVPAGNLQVPEFPPSDSGVTGQPIQFSLIIPTYKESGNIRNVIERLSQILDEFIPGDYELIVVDDDSPDG
TWEVALSLTAEYPQLRVMRRQEERGLSTAVIRGWQVARGSILGVIDGDLQHPPHVLLELLSKIHRGADLAVASRHVDGGG
VSSWSFIRRFLSRGAQLLGLVILPSVLGRVSDPMSGYFMVRRNCITNATFNPVGYKILLEVIGRGKVDEIAEAGYVFCER
QEGESKVTWKQYVDYIHHLIRLRVSTGRLQRIHQSFPLDKFIRFGLVGLSGVFVDMVILYLLSDPSTLAWPLTRSKIIAS
EIAIFNNFLWNDAWTFADVSMQQRGWNQRVKRFLKFNIVCLAGVVLNVLILNIIFNYLIPNRYIANLIAIAIATVWNFWV
NLRLSWRVTQVK

Sequences:

>Translated_412_residues
MSINKTQSLLPVPAGNLQVPEFPPSDSGVTGQPIQFSLIIPTYKESGNIRNVIERLSQILDEFIPGDYELIVVDDDSPDG
TWEVALSLTAEYPQLRVMRRQEERGLSTAVIRGWQVARGSILGVIDGDLQHPPHVLLELLSKIHRGADLAVASRHVDGGG
VSSWSFIRRFLSRGAQLLGLVILPSVLGRVSDPMSGYFMVRRNCITNATFNPVGYKILLEVIGRGKVDEIAEAGYVFCER
QEGESKVTWKQYVDYIHHLIRLRVSTGRLQRIHQSFPLDKFIRFGLVGLSGVFVDMVILYLLSDPSTLAWPLTRSKIIAS
EIAIFNNFLWNDAWTFADVSMQQRGWNQRVKRFLKFNIVCLAGVVLNVLILNIIFNYLIPNRYIANLIAIAIATVWNFWV
NLRLSWRVTQVK
>Mature_411_residues
SINKTQSLLPVPAGNLQVPEFPPSDSGVTGQPIQFSLIIPTYKESGNIRNVIERLSQILDEFIPGDYELIVVDDDSPDGT
WEVALSLTAEYPQLRVMRRQEERGLSTAVIRGWQVARGSILGVIDGDLQHPPHVLLELLSKIHRGADLAVASRHVDGGGV
SSWSFIRRFLSRGAQLLGLVILPSVLGRVSDPMSGYFMVRRNCITNATFNPVGYKILLEVIGRGKVDEIAEAGYVFCERQ
EGESKVTWKQYVDYIHHLIRLRVSTGRLQRIHQSFPLDKFIRFGLVGLSGVFVDMVILYLLSDPSTLAWPLTRSKIIASE
IAIFNNFLWNDAWTFADVSMQQRGWNQRVKRFLKFNIVCLAGVVLNVLILNIIFNYLIPNRYIANLIAIAIATVWNFWVN
LRLSWRVTQVK

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 2 family. GtrB subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503363, Length=241, Percent_Identity=31.9502074688797, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71999402, Length=241, Percent_Identity=33.195020746888, Blast_Score=114, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6325441, Length=240, Percent_Identity=33.75, Blast_Score=133, Evalue=6e-32,
Organism=Drosophila melanogaster, GI24585265, Length=240, Percent_Identity=30.4166666666667, Blast_Score=104, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001173 [H]

Pfam domain/function: PF00535 Glycos_transf_2 [H]

EC number: 2.4.1.83

Molecular weight: Translated: 46515; Mature: 46383

Theoretical pI: Translated: 9.43; Mature: 9.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSINKTQSLLPVPAGNLQVPEFPPSDSGVTGQPIQFSLIIPTYKESGNIRNVIERLSQIL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHH
DEFIPGDYELIVVDDDSPDGTWEVALSLTAEYPQLRVMRRQEERGLSTAVIRGWQVARGS
HHHCCCCEEEEEEECCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHCCC
ILGVIDGDLQHPPHVLLELLSKIHRGADLAVASRHVDGGGVSSWSFIRRFLSRGAQLLGL
EEEEECCCCCCCHHHHHHHHHHHHCCCCEEHEEEECCCCCCCHHHHHHHHHHCCHHHHHH
VILPSVLGRVSDPMSGYFMVRRNCITNATFNPVGYKILLEVIGRGKVDEIAEAGYVFCER
HHHHHHHHHCCCCCCCHHHEEHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHCCEEEEEC
QEGESKVTWKQYVDYIHHLIRLRVSTGRLQRIHQSFPLDKFIRFGLVGLSGVFVDMVILY
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
LLSDPSTLAWPLTRSKIIASEIAIFNNFLWNDAWTFADVSMQQRGWNQRVKRFLKFNIVC
HHCCCCCEEECCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHH
LAGVVLNVLILNIIFNYLIPNRYIANLIAIAIATVWNFWVNLRLSWRVTQVK
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEEEEEEEEEECC
>Mature Secondary Structure 
SINKTQSLLPVPAGNLQVPEFPPSDSGVTGQPIQFSLIIPTYKESGNIRNVIERLSQIL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHH
DEFIPGDYELIVVDDDSPDGTWEVALSLTAEYPQLRVMRRQEERGLSTAVIRGWQVARGS
HHHCCCCEEEEEEECCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHCCC
ILGVIDGDLQHPPHVLLELLSKIHRGADLAVASRHVDGGGVSSWSFIRRFLSRGAQLLGL
EEEEECCCCCCCHHHHHHHHHHHHCCCCEEHEEEECCCCCCCHHHHHHHHHHCCHHHHHH
VILPSVLGRVSDPMSGYFMVRRNCITNATFNPVGYKILLEVIGRGKVDEIAEAGYVFCER
HHHHHHHHHCCCCCCCHHHEEHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHCCEEEEEC
QEGESKVTWKQYVDYIHHLIRLRVSTGRLQRIHQSFPLDKFIRFGLVGLSGVFVDMVILY
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
LLSDPSTLAWPLTRSKIIASEIAIFNNFLWNDAWTFADVSMQQRGWNQRVKRFLKFNIVC
HHCCCCCEEECCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHH
LAGVVLNVLILNIIFNYLIPNRYIANLIAIAIATVWNFWVNLRLSWRVTQVK
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: GDPmannose; dolichyl phosphate

Specific reaction: GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]